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Cited by 170Treatment of Major DepressionSleep and related disordersCircadian rhythm and melatonin

Partial Sleep Deprivation as Therapy for Depression

Tölle, B. Schilgen, R.·1980·Archives of General Psychiatry
DOI 10.1001/archpsyc.1980.01780160037003
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Abstract

We investigated the influence of partial sleep deprivation on depressive symptoms in 30 patients with endogenous depression. The patients were awakened during the second half of the night and remained awake until the following evening. Antidepressant pharmacotherapy was not interrupted. Partial sleep deprivation significantly reduced the depression symptoms (mean value, 30.1%). The interindividual variations were considerable; deterioration was rare, and in 75% of the cases improvement occurred. Execution is simple, less stressful for the patient than total sleep deprivation, and can be carried out at home. Partial sleep deprivation has no contraindications except in the case of severe physical illness. The duration of the therapeutic effect is varied; repetition is possible. We discuss chronobiological hypothesis to explain the effect of sleep deprivation.

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Crossref · 10.1001/archpsyc.1980.01780160037003

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8 of 8 references verified0 citation errors · 0 not checkable

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  • Disrupting sleep of bipolar patients can induce mania and restoring sleep can induce depression.

    “Experiments have shown that disrupting sleep of bipolar patients can induce mania and restoring sleep can induce depression4–8.”

    From Bipolar mood cycles associated with lunar entrainment of a circadian rhythm (2018) · cites this paper as [5]

  • Being awake or being asleep during a circadian interval that normally coincides with sleep in the second half of the sleep period will determine whether the patient subsequently will be manic or depressed, respectively.

    “These results can be summarized as showing that being awake or being asleep during a circadian interval that normally coincides with sleep in the second half of the sleep period will determine whether the patient subsequently will be manic or depressed, respectively2–8.”

    From Bipolar mood cycles associated with lunar entrainment of a circadian rhythm (2018) · cites this paper as [5]

  • Shifts in the timing of circadian rhythms relative to the timing of sleep have been shown to cause switches from depression to mania.

    “This type of shift in the timing of circadian rhythms relative to the timing of sleep has been shown to cause switches from depression to mania”

    From Bipolar mood cycles and lunar tidal cycles (2018) · cites this paper as [25]

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Authors
Tölle, B. S.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1980-03-01
Volume
37
Issue
3
Pages
267
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1980.01780160037003
OpenAlex
W2163022746
Cited by
170
References
8
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2022: 2 · 2020: 3 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 3
FWCI
3.39
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
sleep restriction, endogenous depression, depressive symptoms, antidepressant treatment, chronobiology, circadian rhythm, home-based therapy, treatment response variability
MeSH terms
Aged, Antidepressive Agents, Tricyclic, Circadian Rhythm, Depression, Evaluation Studies as Topic, Female, Humans, Male, Methods, Middle Aged, Psychological Tests, Sleep Deprivation

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