Exercise prevents sleep deprivation-associated anxiety-like behavior in rats: Potential role of oxidative stress mechanisms
Abstract
Our previous work suggests that pharmacological induction of oxidative stress causes anxiety-like behavior in rats. Interestingly, sleep deprivation is reported to cause oxidative damage in the brain and is also reported to be anxiogenic. Minimal mechanistic insights are available. In this study, using a behavioral and biochemical approach, we investigated involvement of oxidative stress mechanisms in sleep deprivation-induced anxiety-like behavior of rats and the protective role of treadmill exercise in this process. We report that acute sleep deprivation (SD) increases oxidative stress in the cortex, hippocampus and amygdala while prior treadmill exercise prevents this increase. Serum corticosterones also increase with SD but its levels are normalized in exercised sleep-deprived rats. Also, anxiety-like behavior of rats significantly increases with SD while prior treadmill exercise prevents this increase. Protein expression of two enzymes involved in antioxidant defense, glyoxalase (GLO)-1 and glutathione reductase (GSR)-1 increased after 24h SD in the hippocampus, cortex and amygdala while their levels were normalized in exercised sleep-deprived rats. It is plausible that oxidative stress via regulation of GLO1 and GSR1 is involved in sleep deprivation-induced anxiety-like behavior of rats.
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Mounting evidence indicates that sleep loss induces an oxidative metabolic state.
“Mounting evidence points to sleep loss inducing an oxidative metabolic state (8,48).”
From Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt (2015) · cites this paper as [48]
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- Authors
- Vollert, C., Zagaar, M., Hovatta, I., Taneja, M., Vu, A., Dao, A., Levine, A., Alkadhi, K., & Salim, S.
- Affiliations
- University of Houston (US)
- Corresponding author
- Salim, Samina
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 224
- Issue
- 2
- Pages
- 233-240
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W1971390912
- Cited by
- 207
- References
- 67
- Citations by year
- 2026: 2 · 2025: 15 · 2024: 6 · 2023: 13 · 2022: 16 · 2021: 7 · 2020: 8 · 2019: 13 · 2018: 11 · 2017: 20 · 2016: 14 · 2015: 25 · 2014: 21 · 2013: 21 · 2012: 12
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Funders
- University of Houston
- Institut National de la Santé et de la Recherche Médicale
- Academy of Finland
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, anxiety-like behavior, treadmill exercise, oxidative stress, glyoxalase I, corticosterone, hippocampus, amygdala, cerebral cortex, antioxidant defense
- MeSH terms
- Animals, Antioxidants, Anxiety, Behavior, Animal, Brain, Brain Chemistry, Corticosterone, Darkness, Glutathione Reductase, Lactoylglutathione Lyase, Light, Male, Motor Activity, Physical Conditioning, Animal, Sleep Deprivation, Blotting, Western, Dinoprost, Rats, Wistar, Oxidative Stress, Rats, Sedentary Behavior
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