CoChat
Sign Up
Cited by 95Treatment of Major DepressionSleep and related disordersSleep and Wakefulness Research

The timing and duration of sleep in partial sleep deprivation therapy of depression

Sack, D. A., Duncan, W., Rosenthal, N. E., Mendelson, W. E., Wehr, T. A.·1988·Acta Psychiatrica Scandinavica
DOI 10.1111/j.1600-0447.1988.tb05104.x
Open this paper in CoChat — free account

Abstract

ABSTRACT— The antidepressant response to partial sleep deprivation early in the night (PSD‐E) was compared with the response to partial sleep deprivation late in the night (PSD‐L) in 16 drug‐free depressed inpatients using a balanced order crossover design. PSD‐L had a significantly greater antidepressant effect that PSD‐E. The response to PSD‐L was sustained and enhanced by a second night of treatment. Patients had significantly shorter sleep durations and reduced REM sleep on PSD‐L that did not occur in the PSD‐E situation. There was a significant negative correlation between response to PSD and sleep duration, and in particular, REM sleep duration, in the late sleep deprivation situation. Thus, the amount and timing of sleep appear to be factors in the response to PSD, but additional studies are needed to evaluate the relative importance of these parameters.

Integrity signals

Registry

Crossref · 10.1111/j.1600-0447.1988.tb05104.x

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Disrupting sleep of bipolar patients can induce mania and restoring sleep can induce depression.

    “Experiments have shown that disrupting sleep of bipolar patients can induce mania and restoring sleep can induce depression4–8.”

    From Bipolar mood cycles associated with lunar entrainment of a circadian rhythm (2018) · cites this paper as [6]

  • Being awake or being asleep during a circadian interval that normally coincides with sleep in the second half of the sleep period will determine whether the patient subsequently will be manic or depressed, respectively.

    “These results can be summarized as showing that being awake or being asleep during a circadian interval that normally coincides with sleep in the second half of the sleep period will determine whether the patient subsequently will be manic or depressed, respectively2–8.”

    From Bipolar mood cycles associated with lunar entrainment of a circadian rhythm (2018) · cites this paper as [6]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Sack, D. A., Duncan, W., Rosenthal, N. E., Mendelson, W. E., & Wehr, T. A.
Affiliations
National Institute of Mental Health (US)
Corresponding author
Sack, D. A.
ORCID
Venue
Acta Psychiatrica Scandinavica
Publisher
Wiley
Published
1988-02
Volume
77
Issue
2
Pages
219-224
ISSN
  • 0001-690X (ISSN-L)
  • 1600-0447
DOI
10.1111/j.1600-0447.1988.tb05104.x
OpenAlex
W2067092744
Cited by
94
References
18
Citations by year
2026: 2 · 2025: 1 · 2022: 1 · 2021: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2013: 2 · 2012: 3
FWCI
5.93
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7143 d)
Locations
  • Acta Psychiatrica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
sleep restriction, depression, sleep timing, sleep duration, REM sleep, antidepressant response, inpatient depression treatment, crossover design
MeSH terms
Adult, Aged, Bipolar Disorder, Circadian Rhythm, Depressive Disorder, Electroencephalography, Female, Humans, Male, Middle Aged, Sleep Deprivation, Sleep, REM, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review