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Efficacy of Interpersonal Psychotherapy for Depressed Adolescents
Abstract
BACKGROUND: Psychotherapy is widely used for depressed adolescents, but evidence supporting its efficacy is sparse. METHODS: In a controlled, 12-week, clinical trial of Interpersonal Psychotherapy for Depressed Adolescents (IPT-A), 48 clinic-referred adolescents (aged 12-18 years) who met the criteria for DSM-III-R major depressive disorder were randomly assigned to either weekly IPT-A or clinical monitoring. Patients were seen biweekly by a "blind" independent evaluator to assess their symptoms, social functioning, and social problem-solving skills. Thirty-two of the 48 patients completed the protocol (21 IPT-A-assigned patients and 11 patients in the control group). RESULTS: Patients who received IPT-A reported a notably greater decrease in depressive symptoms and greater improvement in overall social functioning, functioning with friends, and specific problem-solving skills. In the intent-to-treat sample, 18 (75%) of 24 patients who received IPT-A compared with 11 patients (46%) in the control condition met recovery criterion (Hamilton Rating Scale for Depression score < or =6) at week 12. CONCLUSIONS: These preliminary findings support the feasibility, acceptability, and efficacy of 12 weeks of IPT-A in acutely depressed adolescents in reducing depressive symptoms and improving social functioning and interpersonal problem-solving skills. Because it is a small sample consisting largely of Latino, low socioeconomic status adolescents, further studies must be conducted with other adolescent populations to confirm the generalizability of the findings.
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“It has been shown to be effective in reducing symptoms of depression and in improving overall performance and social functioning of patients (23, 24).”
From Ultra-Brief Crisis IPT-A Based Intervention for Suicidal Children and Adolescents (IPT-A-SCI) Pilot Study Results (2020) · cites this paper as [23]
In the citing paper
“Our intervention, Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training (CATCH-IT), is based on face-to-face interventions of demonstrated efficacy.42-45”
From Adolescent and parent experiences with a primary care/Internet-based depression prevention intervention (CATCH-IT) (2011) · cites this paper as [44]
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Metadata
- Authors
- Mufson, L.
- Affiliations
- New York State Psychiatric Institute (US)
- Corresponding author
- Mufson, L.
- ORCID
- Mufson, L.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1999-06-01
- Volume
- 56
- Issue
- 6
- Pages
- 573-579
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2158366999
- Cited by
- 552
- References
- 38
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 12 · 2023: 11 · 2022: 13 · 2021: 21 · 2020: 15 · 2019: 12 · 2018: 14 · 2017: 17 · 2016: 18 · 2015: 27 · 2014: 25 · 2013: 18 · 2012: 28
- FWCI
- 23.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r01mh043873-01, 5r29mh048715-05)
- National Institute of Mental Health (MH43873-09, MH48715)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- interpersonal psychotherapy, adolescent depression, major depressive disorder, social functioning, interpersonal problem-solving skills, depressive symptom reduction, treatment efficacy, Latino adolescents
- MeSH terms
- Adolescent, Age Factors, Child, Depressive Disorder, Female, Humans, Interpersonal Relations, Male, Patient Dropouts, Problem Solving, Psychiatric Status Rating Scales, Psychotherapy, Research Design, Social Adjustment, Social Class, Treatment Outcome, Patient Selection
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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