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Cited by 538Psychotherapy Techniques and ApplicationsChild and Adolescent Psychosocial and Emotional DevelopmentAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

A Randomized Effectiveness Trial of Interpersonal Psychotherapy forDepressed Adolescents

Mufson, Laura, Dorta, Kristen Pollack, Wickramaratne, Priya, Nomura, Yoko, Olfson, Mark, Weissman, Myrna M.·2004·Archives of General Psychiatry
DOI 10.1001/archpsyc.61.6.577
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Abstract

CONTEXT: Adolescent depression is highly prevalent and has substantial morbidity, including suicide attempts, school dropout, and substance abuse, but many depressed adolescents are untreated. The school-based health clinic offers the potential for accessible and efficient treatment, although it is unknown whether school-based clinicians can be trained to implement evidence-based psychotherapies for depression in routine care. OBJECTIVE: To assess the effectiveness of interpersonal psychotherapy modified for depressed adolescents (IPT-A) compared with treatment as usual (TAU) in school-based mental health clinics. DESIGN: A 16-week randomized clinical trial was conducted from April 1, 1999, through July 31, 2002. SETTING: Five school-based mental health clinics in New York City, NY. Patients Sixty-three adolescents referred for a mental health intake visit who met eligibility criteria. Eligible patients had a mean Hamilton Depression Rating Scale score of 18.6 (SD, 5.5) and a mean Children's Global Assessment Scale score of 52.6 (SD, 5.5) and met DSM-IV criteria for major depressive disorder, dysthymia, depression disorder not otherwise specified, or adjustment disorder with depressed mood. Mean age was 15.1 years (SD, 1.9 years). The sample was predominantly female (n = 53 [84%]), Hispanic (n = 45 [71%]), and of low socioeconomic status. Intervention Patients were randomly assigned to receive IPT-A (n = 34) or TAU (n = 29) from school-based health clinic clinicians. MAIN OUTCOME MEASURES: The Hamilton Depression Rating Scale, Beck Depression Inventory, Children's Global Assessment Scale, Clinical Global Impressions scale, and the Social Adjustment Scale-Self-Report. RESULTS: Adolescents treated with IPT-A compared with TAU showed greater symptom reduction and improvement in overall functioning. Analysis of covariance showed that compared with the TAU group, the IPT-A group showed significantly fewer clinician-reported depression symptoms on the Hamilton Depression Rating Scale (P =.04), significantly better functioning on the Children's Global Assessment Scale (P =.04), significantly better overall social functioning on the Social Adjustment Scale-Self-Report (P =.01), significantly greater clinical improvement (P =.03), and significantly greater decrease in clinical severity (P =.03) on the Clinical Global Impressions scale. CONCLUSIONS: Interpersonal psychotherapy delivered in school-based health clinics is an effective therapy for adolescent depression. This effort is a significant step toward closing the gap between treatment conducted in the laboratory and community clinic.

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  • IPT-A is an effective treatment for adolescent depression.

    “Specifically, Interpersonal Psychotherapy for Adolescents (IPT-A) is an efficacious treatment for depression (Mufson et al. 2004)”

    From Life stress and suicide in adolescents (2019) · cites this paper as Mufson et al. 2004

  • IPT-A targets specific interpersonal problems and teaches communication and problem-solving skills to improve coping.

    “and focuses on particular interpersonal problems by equipping adolescents with communication and problem solving skills to bolster coping.”

    From Life stress and suicide in adolescents (2019) · cites this paper as Mufson et al. 2004

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Authors
Mufson, L., Dorta, K. P., Wickramaratne, P., Nomura, Y., Olfson, M., & Weissman, M. M.
Affiliations
New York State Psychiatric Institute (US)
ORCID
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
2004-06-01
Volume
61
Issue
6
Pages
577
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.61.6.577
OpenAlex
W2110204260
Cited by
537
References
39
Citations by year
2026: 8 · 2025: 11 · 2024: 15 · 2023: 12 · 2022: 14 · 2021: 14 · 2020: 27 · 2019: 17 · 2018: 20 · 2017: 24 · 2016: 25 · 2015: 34 · 2014: 26 · 2013: 20 · 2012: 39
FWCI
44.39
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Agency for Healthcare Research and Quality (6HS5 SM52671-02-1)
  • National Institute of Mental Health (P30MH060570, 5 P30 MH60570-03)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
interpersonal psychotherapy, adolescent depression, usual care, major depressive disorder, social functioning, treatment effectiveness, Latino youth, social adaptation, child mental health services, community mental health services, suicide attempts, substance abuse
MeSH terms
Adolescent, Age Factors, Delivery of Health Care, Depressive Disorder, Female, Follow-Up Studies, Humans, Interviews as Topic, Male, Patient Compliance, Personality Inventory, Psychiatric Status Rating Scales, Psychotherapy, Psychotherapy, Brief, School Health Services, Severity of Illness Index, Social Adjustment, Treatment Outcome

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