The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Mapping Auditory Hallucinations in Schizophrenia Using Functional Magnetic Resonance Imaging
Abstract
BACKGROUND: Perceptions of speech in the absence of an auditory stimulus (auditory verbal hallucinations) are a cardinal feature of schizophrenia. Functional neuroimaging provides a powerful means of measuring neural activity during auditory hallucinations, but the results from previous studies have been inconsistent. This may reflect the acquisition of small numbers of images in each subject and the confounding effects of patients actively signaling when hallucinations occur. METHODS: We examined 6 patients with schizophrenia who were experiencing frequent auditory hallucinations, using a novel functional magnetic resonance imaging method that permitted the measurement of spontaneous neural activity without requiring subjects to signal when hallucinations occurred. Approximately 50 individual scans were acquired at unpredictable intervals in each subject while they were intermittently hallucinating. Immediately after each scan, subjects reported whether they had been hallucinating at that instant. Neural activity when patients were and were not experiencing hallucinations was compared in each subject and the group as a whole. RESULTS: Auditory hallucinations were associated with activation in the inferior frontal/insular, anterior cingulate, and temporal cortex bilaterally (with greater responses on the right), the right thalamus and inferior colliculus, and the left hippocampus and parahippocampal cortex (P<.0001). CONCLUSIONS: Auditory hallucinations may be mediated by a distributed network of cortical and subcortical areas. Previous neuroimaging studies of auditory hallucinations may have identified different components of this network.
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In the citing paper
“Wernicke’s-seeded FC was computed for subregions of the left IFG based on studies highlighting the critical involvement of the latter during self-generated auditory imagery of spoken speech (22,23), perception of external speech (24,25), and AVHs themselves (26,27).”
From Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia (2011) · cites this paper as [26]
In the citing paper
“Although BA46 is typically viewed as a middle frontal region, its ventral aspect lies in IFG and participates in language processes (51–53) and has been implicated in the genesis of AVHs (26,54).”
From Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia (2011) · cites this paper as [26]
In the citing paper
“The first two were in the putamen and thalamus, which are involved in initiating and organizing language representations ordinarily (56–58), and have been shown to be activated coincident with AVH occurrences in two reports (26,59).”
From Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia (2011) · cites this paper as [26]
Citations
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Silbersweig, D. A., Stern, E., Frith, C., Cahill, C., Holmes, A., Grootoonk, S., Seaward, J., McKenna, P., Chua, S. E., Schnorr, L., et al. (1995) · Nature · doi:10.1038/378176a0 · Cited by 906 · cited 2×
“Thus, our earlier work using SPET linked auditory hallucinations with activation in the left inferior frontal cortex,(15) while other studies, mainly using PET, respectively implicated the anterior cingulate gyrus,(16) the left(3,17) and the right temporal cortex,(2,3) the left parahippocampal region(18) and the thala…”
BackgroundResultPatterns of Cerebral Blood Flow in Schizophrenia
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Activation of Heschl’s Gyrus during Auditory Hallucinations
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Cited by
Sorted by citations
Lefaucheur, J.-P., André-Obadia, N., Antal, A., Ayache, S. S., Baeken, C., Benninger, D. H., Cantello, R. M., Cincotta, M., de Carvalho, M., De Ridder, D., et al. (2014) · Clinical Neurophysiology · doi:10.1016/j.clinph.2014.05.021 · Cited by 2,119
“During auditory hallucinations, brain areas involved in the perception of speech (primary auditory cortex and associative areas of language in the left hemisphere) show pathological hyperactivity, as determined by neuroimaging studies (Silbersweig et al., 1995; Shergill et al., 2000).”
The spatial and temporal signatures of word production components
Indefrey, P., & Levelt, W. J. M. (2004) · Cognition · doi:10.1016/j.cognition.2002.06.001 · Cited by 2,144
Perceiving is believing: a Bayesian approach to explaining the positive symptoms of schizophrenia
Fletcher, P. C., & Frith, C. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2536 · Cited by 1,462
Brain states: top-down influences in sensory processing.
Gilbert, C., & Sigman, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.019 · Cited by 1,008
Consciousness without a cerebral cortex: A challenge for neuroscience and medicine
Merker, B. (2007) · Behavioral and Brain Sciences · doi:10.1017/s0140525x07000891 · Cited by 868
“…activity elaborating the content of conscious experience in these states are paralleled by corresponding activity changes in the superior colliculus, in contrast to Merker’s testable prediction, although the inferior colliculus was active during auditory hallucinations (Shergill et al. 2000).”
Result
Metadata
- Authors
- Shergill, S. S., Brammer, M. J., Williams, S. C. R., Murray, R. M., & McGuire, P. K.
- Affiliations
- King's College London (GB)
- ORCID
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2000-11-01
- Volume
- 57
- Issue
- 11
- Pages
- 1033
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2022503841
- Cited by
- 666
- References
- 36
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 12 · 2023: 18 · 2022: 20 · 2021: 14 · 2020: 13 · 2019: 17 · 2018: 22 · 2017: 20 · 2016: 22 · 2015: 20 · 2014: 28 · 2013: 30 · 2012: 43
- FWCI
- 11.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- auditory verbal hallucinations, schizophrenia, spontaneous neuronal activity, inferior frontal cortex, insula, anterior cingulate cortex, thalamus, inferior colliculus, hippocampus, parahippocampal cortex, temporal cortex, distributed neural networks
- MeSH terms
- Auditory Perception, Brain Mapping, Hallucinations, Humans, Magnetic Resonance Imaging, Schizophrenia, Schizophrenic Psychology
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