The functional anatomy of auditory hallucinations in schizophrenia
Abstract
We used continuous whole brain functional magnetic resonance imaging (fMRI) with a 3-T magnet to map the cerebral activation associated with auditory hallucinations in four subjects with schizophrenia. The subjects experienced episodes of hallucination whilst in the scanner so that periods of hallucination could be compared with periods of rest in the same individuals. Group analysis demonstrated shared areas of activation in right and left superior temporal gyri, left inferior parietal cortex and left middle frontal gyrus. When the data were examined on an individual basis, the temporal cortex and prefrontal cortex areas were activated during episodes of hallucination in all four subjects. These findings support the theory that auditory hallucination reflects abnormal activation of normal auditory pathways.
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The ventral aspect of BA46 lies in IFG, participates in language processes, and has been implicated in the genesis of AVHs.
“Although BA46 is typically viewed as a middle frontal region, its ventral aspect lies in IFG and participates in language processes (51–53) and has been implicated in the genesis of AVHs (26,54).”
From Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia (2011) · cites this paper as [54]
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- Authors
- Lennox, B. R., Park, S. B. G., Medley, I., Morris, P. G., & Jones, P. B.
- Affiliations
- University of Cambridge (GB)
- University of Nottingham (GB)
- Corresponding author
- Lennox, Belinda R.
- Venue
- Psychiatry Research Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2000-11
- Volume
- 100
- Issue
- 1
- Pages
- 13-20
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W1975404871
- Cited by
- 277
- References
- 22
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 10 · 2020: 7 · 2019: 7 · 2018: 1 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 13 · 2013: 9 · 2012: 19
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- auditory hallucinations, schizophrenia, functional anatomy, superior temporal gyrus, inferior parietal cortex, middle frontal gyrus, prefrontal cortex, temporal cortex, auditory pathway
- MeSH terms
- Adult, Auditory Pathways, Brain, Dominance, Cerebral, Female, Hallucinations, Humans, Magnetic Resonance Imaging, Male, Models, Neurological, Parietal Lobe, Schizophrenia, Temporal Lobe, Prefrontal Cortex
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