Cited by 793Schizophrenia research and treatmentMental Health and PsychiatryMultiple Sclerosis Research Studies

The DOI matches its Crossref record; 255 of the 258 references it cites were found in a registry or an index.

White Matter Changes in Schizophrenia: Evidence for Myelin-Related Dysfunction

Davis, Kenneth L., Stewart, Daniel G., Friedman, Joseph I., Buchsbaum, Monte, Harvey, Philip D., Hof, Patrick R., Buxbaum, Joseph, Haroutunian, Vahram·2003·Archives of General Psychiatry

DOI 10.1001/archpsyc.60.5.443

Open this paper in CoChat — free account

Abstract

Numerous lines of inquiry implicate connectivity as a central abnormality in schizophrenia. Myelination and factors that affect myelination, such as the function of oligodendroglia, are critical processes that could profoundly affect neuronal connectivity, especially given the diffuse distribution of oligodendrocytes and the widespread distribution of brain regions that have been implicated in schizophrenia. Multiple lines of evidence now converge to implicate oligodendroglia and myelin in schizophrenia. Imaging and neurocytochemical evidence, similarities with demyelinating diseases, age-related changes in white matter, myelin-related gene abnormalities, and morphologic abnormalities in the oligodendroglia demonstrated in schizophrenic brains are all examined in light of the hypothesis that oligodendroglial dysfunction and even death, with subsequent abnormalities in myelin maintenance and repair, contribute to the schizophrenic syndrome.

Integrity signals

Registry

Crossref · 10.1001/archpsyc.60.5.443

Cites

255 of 255 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Brain development during childhood and adolescence: a longitudinal MRI study
Giedd, J. N., Blumenthal, J., Jeffries, N. O., Castellanos, F. X., Liu, H., Zijdenbos, A., Paus, T., Evans, A. C., & Rapoport, J. L. (1999) · Nature Neuroscience · doi:10.1038/13158 · Cited by 5,552
The Molecular Biology of Axon Guidance
Tessier‐Lavigne, M., & Goodman, C. S. (1996) · Science · doi:10.1126/science.274.5290.1123 · Cited by 3,311
Synaptic density in human frontal cortex —Developmental changes and effects of aging
Peter R., H. (1979) · Brain Research · doi:10.1016/0006-8993(79)90349-4 · Cited by 2,645
Excitotoxic cell death
Choi, D. W. (1992) · Journal of Neurobiology · doi:10.1002/neu.480230915 · Cited by 2,329
Cognitive dysfunction in multiple sclerosis.
Rao, S. M., Leo, G. J., Bernardin, L., & Unverzagt, F. W. (1991) · Neurology · doi:10.1212/wnl.41.5.685 · Cited by 2,136
Regional Development of the Brain in Early Life
(1968) · Archives of Disease in Childhood · doi:10.1136/adc.43.229.388 · Cited by 2,107
Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793
Glutamate receptor dysfunction and schizophrenia
Olney, J. W. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240016004 · Cited by 1,685
Meta-analysis of regional brain volumes in schizophrenia
Wright, I. C., Rabe-Hesketh, S., Woodruff, P. W. R., David, A. S., Murray, R. M., & Bullmore, E. T. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.16 · Cited by 1,662
Glutamate neurotoxicity in cortical cell culture
Choi, D. W., Maulucci-Gedde, M., & Kriegstein, A. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00357.1987 · Cited by 1,506

Flagged first, then by citations

Show all 258 references

3 of the 258 references couldn’t be matched to a known paper.

Sorted by citations

Items 301–400 of 793

Single-neuron and genetic correlates of autistic behavior in macaque
Yoshida, K., Go, Y., Kushima, I., Toyoda, A., Fujiyama, A., Imai, H., Saito, N., Iriki, A., Ozaki, N., & Isoda, M. (2016) · Science Advances · doi:10.1126/sciadv.1600558 · Cited by 55
Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia
Zinkstok, J., Schmitz, N., van Amelsvoort, T., Moeton, M., Baas, F., & Linszen, D. H. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00326.x · Cited by 56
Altered White Matter/Gray Matter Proportions in the Striatum of Patients With Schizophrenia: A Volumetric MRI Study
Tamagaki, C., Sedvall, G. C., Jönsson, E. G., Okugawa, G., Hall, H., Pauli, S., & Agartz, I. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.12.2315 · Cited by 55
Convergent Functional Genomics of bipolar disorder: From animal model pharmacogenomics to human genetics and biomarkers
Le-Niculescu, H., McFarland, M. J., Mamidipalli, S., Ogden, C. A., Kuczenski, R. T., Kurian, S. M., Salomon, D. R., Tsuang, M. T., Nürnberger, J. I., & Niculescu, A. B. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.05.008 · Cited by 54
Targeted Multiplexed Selected Reaction Monitoring Analysis Evaluates Protein Expression Changes of Molecular Risk Factors for Major Psychiatric Disorders
Wesseling, H., Gottschalk, M. G., & Bahn, S. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu015 · Cited by 54
From Molecules to the Clinic: Linking Schizophrenia and Metabolic Syndrome through Sphingolipids Metabolism
Castillo-Passi, R. I., Rojo, L. E., Henríquez‐Henríquez, M., Hernán Silva, I., Maturana, A., Villar, M. J., Fuentes, M., & Gaspar, P. A. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00488 · Cited by 59
Probing Brain Developmental Patterns of Myelination and Associations With Psychopathology in Youths Using Gray/White Matter Contrast
Norbom, L. B., Doan, N. T., Alnæs, D., Kaufmann, T., Moberget, T., Rokicki, J., Andreassen, O. A., Westlye, L. T., & Tamnes, C. K. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.09.027 · Cited by 55
The discoidin domain receptor 1 as a novel susceptibility gene for schizophrenia
Roig, B., Virgos, C., Franco, N., Martorell, L., Valero, J., Costas, J., Carracedo, A., Labad, A., & Vilella, E. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001995 · Cited by 56
Global expression-profiling studies and oligodendrocyte dysfunction in schizophrenia and bipolar disorder
Davis, K. L., & Haroutunian, V. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14297-3 · Cited by 53
Self-citation
Possible Contributions of Myelin and Oligodendrocyte Dysfunction to Schizophrenia
Stewart, D. G., & Davis, K. L. (2004) · International review of neurobiology · doi:10.1016/s0074-7742(04)59015-3 · Cited by 54
Self-citation
Constitutive genetic deletion of the growth regulator Nogo-A induces schizophrenia-related endophenotypes
Willi, R., Weinmann, O., Winter, C., Klein, J., Sohr, R., Schnell, L., Yee, B. K., Feldon, J., & Schwab, M. E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4393-09.2010 · Cited by 52
Conditioned Hallucinations and Prior Overweighting Are State-Sensitive Markers of Hallucination SusceptibilityPreprint
Kafadar, E., Fisher, V., Quagan, B., Hammer, A., Jaeger, H., Mourgues, C., Thomas, R., Chen, L., Imtiaz, A., Sibarium, E., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.05.007 · Cited by 50
Reversal of schizophrenia-like symptoms and immune alterations in mice by immunomodulatory drugs
Araújo, T. D. S., Filho, A. J. M. C., Monte, A. S., Queiroz, A. I. D. G., Cordeiro, R. C., Machado, M. D. J. S., Lima, R. D. F., de Lucena, D. F., Maes, M. H. J., & Macêdo, D. S. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.09.017 · Cited by 55
Axonal myelin decrease in the splenium in major depressive disorder
Williams, M. R., Sharma, P. K., Macdonald, C. L., Pearce, R. K. B., Hirsch, S. R., & Maier, M. (2018) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-018-0904-4 · Cited by 52
Long-Range Amplitude Coupling Is Optimized for Brain Networks That Function at Criticality
Avrămiea, A.-E., Masood, A., Mansvelder, H. D., & Linkenkaer‐Hansen, K. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1095-21.2022 · Cited by 51
Methods for identifying subject‐specific abnormalities in neuroimaging data
Mayer, A. R., Bedrick, E. J., Ling, J. M., Toulouse, T., & Dodd, A. B. (2014) · Human Brain Mapping · doi:10.1002/hbm.22563 · Cited by 52
Age-Related Increase in the Number of Oligodendrocytes Is Dysregulated in Schizophrenia and Mood Disorders
Vm, V., & Uranova, N. A. (2011) · Schizophrenia Research and Treatment · doi:10.1155/2011/174689 · Cited by 51
Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients
Parlapani, E., Schmitt, A., Wirths, O., Bauer, M., Sommer, C., Rueb, U., Skowronek, M. H., Treutlein, J., Petroianu, G. A., Rietschel, M., et al. (2008) · The World Journal of Biological Psychiatry · doi:10.3109/15622970802022376 · Cited by 53
Psychiatric disorders biochemical pathways unraveled by human brain proteomics
Saia-Cereda, V. M., Cassoli, J. S., Martins‐de‐Souza, D., & Nascimento, J. M. (2016) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-016-0709-2 · Cited by 52
Post-translational protein modifications in schizophrenia
Mueller, T., & Meador‐Woodruff, J. H. (2020) · Schizophrenia · doi:10.1038/s41537-020-0093-9 · Cited by 53
Neurotoxicity, Neuroplasticity, and Magnetic Resonance Imaging Morphometry
Mathalon, D. H., Rapoport, J. L., Davis, K. L., & Krystal, J. H. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.846 · Cited by 51
Self-citation
Recovery of Behavioral Changes and Compromised White Matter in C57BL/6 Mice Exposed to Cuprizone: Effects of Antipsychotic Drugs
Xu, H., Yang, H.-J., Rose, G. M., & Li, X. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00031 · Cited by 49
Microstructural white matter changes are correlated with the stage of psychiatric illness
Lagopoulos, J., Hermens, D. F., Hatton, S. N., Battisti, R. A., Tobias‐Webb, J., White, D., Naismith, S. L., Scott, E. M., Ryder, W. J., Bennett, M. R., et al. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.25 · Cited by 49
Overlapping and distinct gray and white matter abnormalities in schizophrenia and bipolar I disorder
Anderson, D., Ardekani, B. A., Burdick, K. E., Robinson, D. G., John, M., Malhotra, A. K., & Szeszko, P. R. (2013) · Bipolar Disorders · doi:10.1111/bdi.12096 · Cited by 53
Therapeutic applications of oligodendrocyte precursors derived from human embryonic stem cells
Sharp, J., & Keirstead, H. S. (2007) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2007.10.006 · Cited by 50
Mediation of Developmental Risk Factors for Psychosis by White Matter Microstructure in Young Adults With Psychotic Experiences
Drakesmith, M., Dutt, A., Fonville, L., Zammit, S., Reichenberg, A., Evans, J., Lewis, G., Jones, D. K., & David, A. S. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.3375 · Cited by 50
Neuropsychological Profile and Neuroimaging in Patients with 22Q11.2 Deletion Syndrome: A Review Keywords:
Zinkstok, J., & van Amelsvoort, T. (2005) · Child Neuropsychology · doi:10.1080/09297040590911194 · Cited by 49
The cuprizone-induced changes in 1H-MRS metabolites and oxidative parameters in C57BL/6 mouse brain: Effects of quetiapine
Xuan, Y., Yan, G., Wu, R., Huang, Q., Li, X., & Xu, H. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.08.015 · Cited by 50
Exploring neural dysfunction in ‘clinical high risk’ for psychosis: A quantitative review of fMRI studies
Dutt, A., Tseng, H., Fonville, L., Drakesmith, M., Su, L., Evans, J., Zammit, S., Jones, D. K., Lewis, G., & David, A. S. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.08.018 · Cited by 48
Auditory verbal hallucinations and the interhemispheric auditory pathway in chronic schizophrenia
Wigand, M. C. C., Kubicki, M. R., von Hohenberg, C. C., Leicht, G., Karch, S., Eckbo, R., Pelavin, P. E., Hawley, K. J., Rujescu, D., Sylvain Bouix, A., et al. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2014.948063 · Cited by 48
Alterations in frontal white matter neurochemistry and microstructure in schizophrenia: implications for neuroinflammation
Chiappelli, J., Hong, L. E., Wijtenburg, S. A., Du, X. M., Gaston, F. E., Kochunov, P., & Rowland, L. M. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.43 · Cited by 48
Increased expression of receptor phosphotyrosine phosphatase-β/ζ is associated with molecular, cellular, behavioral and cognitive schizophrenia phenotypes
Takahashi, N., Sakurai, T., Bozdagi-Gunal, O., Dorr, N. P., Moy, J., Krug, L., Gama-Sosa, M. A., Elder, G. A., Koch, R. J., Walker, R. H., et al. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.8 · Cited by 49
Self-citation
Skin Ceramide Alterations in First-Episode Schizophrenia Indicate Abnormal Sphingolipid Metabolism
Smesny, S., Schmelzer, C. E. H., Hinder, A., Köhler, A., Schneider, C., Rudzok, M., Schmidt, U., Milleit, B., Milleit, C., Nenadić, I., et al. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs058 · Cited by 48
Visual gamma oscillations in schizophrenia: implications for understanding neural circuitry abnormalities
Spencer, K. M. (2008) · Clinical EEG and Neuroscience · doi:10.1177/155005940803900208 · Cited by 47
Phospholipase A2 activity is associated with structural brain changes in schizophrenia
Smesny, S., Milleit, B., Nenadić, I., Preul, C., Kinder, D., Lasch, J., Willhardt, I., Sauer, H., & Gaser, C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.05.009 · Cited by 46
White matter microstructure predicts cognitive training-induced improvements in attention and executive functioning in schizophrenia
Subramaniam, K., Gill, J. S., Fisher, M., Mukherjee, P., Nagarajan, S. S., & Vinogradov, S. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.06.062 · Cited by 47
Functional genomics indicate that schizophrenia may be an adult vascular-ischemic disorder
Moises, H. W., Wollschläger, D., & Binder, H. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.103 · Cited by 46
Accelerated white matter aging in schizophrenia: role of white matter blood perfusion
Wright, S. N., Kochunov, P., Chiappelli, J., McMahon, R. P., Muellerklein, F., Wijtenburg, S. A., White, M. G., Rowland, L. M., & Hong, L. E. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.016 · Cited by 46
Stochastic tractography study of Inferior Frontal Gyrus anatomical connectivity in schizophrenia
Kubicki, M. R., Alvarado, J. L., Westin, C., Tate, D. F., Markant, D. B., Terry, D. P., Whitford, T. J., Siebenthal, J. D., Sylvain Bouix, A., McCarley, R. W., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.01.047 · Cited by 48
Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia
Pinner, A. L., Tucholski, J., Haroutunian, V. H., McCullumsmith, R. E., & Meador‐Woodruff, J. H. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.01.054 · Cited by 46
Self-citation
Dystrophic Serotonin Axons in Postmortem Brains from Young Autism Patients
Azmitia, E. C., Singh, J. S., Hou, X. P., & Węgiel, J. (2011) · The Anatomical Record · doi:10.1002/ar.21243 · Cited by 46
Profile of minocycline and its potential in the treatment of schizophrenia
Zhang, L., & Zhao, J. (2014) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s64236 · Cited by 45
White matter changes in early phase schizophrenia and cannabis use: An update and systematic review of diffusion tensor imaging studies
Cookey, J., Bernier, D. C., & Tibbo, P. G. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.04.026 · Cited by 45
Nogo and Nogo receptor: Relevance to schizophrenia?
Willi, R., & Schwab, M. E. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.01.011 · Cited by 44
Cortical white-matter microstructure in schizophrenia
Andreone, N., Tansella, M., Cerini, R., Versace, A., Rambaldelli, G., Perlini, C., Dusi, N., Pelizza, L., Balestrieri, M., Barbui, C., et al. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.105.020990 · Cited by 45
Quantitative temporal proteomic analysis of human embryonic stem cell differentiation into oligodendrocyte progenitor cells
Chaerkady, R., Letzen, B. S., Renuse, S., Sahasrabuddhe, N. A., Kumar, P., All, A. H., Thakor, N. V., Delanghe, B., Gearhart, J. D., Pandey, A., et al. (2011) · PROTEOMICS · doi:10.1002/pmic.201100107 · Cited by 44
Absence of Claudin 11 in CNS Myelin Perturbs Behavior and Neurotransmitter Levels in Mice
Maheras, K. J., Peppi, M., Ghoddoussi, F., Galloway, M. P., Perrine, S. A., & Gow, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-22047-9 · Cited by 44
Prenatal inflammation and risk for schizophrenia: A role for immune proteins in neurodevelopment
Allswede, D. M., & Cannon, T. D. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000317 · Cited by 46
Spatial distribution and density of oligodendrocytes in the cingulum bundle are unaltered in schizophrenia
Segal, D., Schmitz, C., & Hof, P. R. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0379-x · Cited by 44
Self-citation
Altered proteins of the anterior cingulate cortex white matter proteome in schizophrenia
Clark, D., Dedova, I. V., Cordwell, S. J., & Matsumoto, I. (2007) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200600541 · Cited by 43
Oligodendrocyte generation during mouse development
Takebayashi, H., & Ikenaka, K. (2015) · Glia · doi:10.1002/glia.22863 · Cited by 44
The Nogo-66 receptor family in the intact and diseased CNS
Borrie, S. C., Baeumer, B. E., & Bandtlow, C. E. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1332-9 · Cited by 44
Reduced density of ADAM 12-immunoreactive oligodendrocytes in the anterior cingulate white matter of patients with schizophrenia
Farkas, N., Lendeckel, U., Dobrowolny, H., Funke, S., Steiner, J. H., Keilhoff, G., Schmitt, A., Bogerts, B., & Bernstein, H. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622970903497936 · Cited by 43
Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls
Wang, F., Jiang, T., Sun, Z., Teng, S.-L. M., Luο, X., Zhu, Z., Zang, Y., Zhang, H., Yue, W., Qu, M., et al. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0924 · Cited by 43
Biomarkers for Psychiatric Disorders
Turck, C. W. (2009) · Springer eBooks · doi:10.1007/978-0-387-79251-4 · Cited by 42
Possible association of the MAG locus with schizophrenia in a Chinese Han cohort of family trios
Yang, Y., Qin, W. D., Shugart, Y. Y., He, G., Liu, X. M., Zhou, J. P., Zhao, X., Chen, Q., La, Y., Xu, Y., et al. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.11.013 · Cited by 43
Introduction to the Special Section: Myelin and oligodendrocyte abnormalities in schizophrenia
Haroutunian, V. H., & Davis, K. L. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145706007449 · Cited by 42
Self-citation
Temporal characteristics of tract-specific anisotropy abnormalities in schizophrenia
Carpenter, D. M., Tang, C. Y., Friedman, J. I., Hof, P. R., Stewart, D. G., Buchsbaum, M. S., Harvey, P. D., Gorman, J., & Davis, K. L. (2008) · Neuroreport · doi:10.1097/wnr.0b013e32830abc35 · Cited by 41
Self-citation
Hypothesis of an Energetic Function for Myelin
Morelli, A. M., Ravera, S., & Panfoli, I. (2011) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-011-9174-8 · Cited by 41
Expression of Transcripts for Myelin Related Genes in Postmortem Brain from Cocaine Abusers
Kristiansen, L. V., Bannon, M. J., & Meador‐Woodruff, J. H. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9655-3 · Cited by 41
Immediate Early Genes Anchor a Biological Pathway of Proteins Required for Memory Formation, Long-Term Depression and Risk for Schizophrenia
Marballi, K. K., & Gallitano, A. L. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00023 · Cited by 42
A pilot study assessing retinal pathology in psychosis using optical coherence tomography: Choroidal and macular thickness
Joe, P., Ahmad, M. T., Riley, G., Weissman, J. D., Smith, R. T., & Malaspina, D. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.03.011 · Cited by 41
Reduction of the Internal Capsule in Families Affected with Schizophrenia
Wobrock, T., Kamer, T., Roy, A., Vogeley, K. T., Schneider-Axmann, T., Wagner, M., Maier, W., Rietschel, M., Schulze, T. G., Scherk, H., et al. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.02.026 · Cited by 42
Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis
Gjerde, P. B., Dieset, I., Simonsen, C., Hoseth, E. Z., Iversen, T., Lagerberg, T. V., Lyngstad, S. H., Mørch, R. H., Skrede, S., Andreassen, O. A., et al. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.10.042 · Cited by 42
Differential effects of antipsychotics on the development of rat oligodendrocyte precursor cells exposed to cuprizone
Xu, H., Yang, H.-J., & Li, X. (2013) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0414-3 · Cited by 39
Genetic underpinnings of white matter ‘connectivity’: Heritability, risk, and heterogeneity in schizophrenia
Voineskos, A. N. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.03.034 · Cited by 39
Reduced white matter integrity correlated with cortico–subcortical gray matter deficits in schizophrenia
Miyata, J., Hirao, K., Namiki, C., Fujiwara, H., Shimizu, M., Fukuyama, H., Sawamoto, N., Hayashi, T., & Murai, T. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.03.010 · Cited by 40
Spatial Characteristics of White Matter Abnormalities in Schizophrenia
White, T. J. H., Ehrlich, S., Ho, B., Manoach, D. S., Caprihan, A., Schulz, S., Andreasen, N. C., Gollub, R. L., Calhoun, V. D., & Magnotta, V. A. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs106 · Cited by 39
Cerebral white matter structure is associated with DSM-5 schizophrenia symptom dimensions
Viher, P. V., Stegmayer, K., Giezendanner, S., Federspiel, A., Bohlhalter, S., Vanbellingen, T., Wiest, R., Strik, W. K., & Walther, S. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.06.013 · Cited by 38
Avolition-Apathy and White Matter Connectivity in Schizophrenia: Reduced Fractional Anisotropy Between Amygdala and Insular Cortex
Amodio, A., Quarantelli, M., Mucci, A., Prinster, A., Soricelli, A., Vignapiano, A., Giordano, G. M., Merlotti, E., Nicita, A., & Galderisi, S. (2017) · Clinical EEG and Neuroscience · doi:10.1177/1550059417745934 · Cited by 41
Glia‐related genes and their contribution to schizophrenia
Wang, C., Aleksić, B., & Ozaki, N. (2015) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12290 · Cited by 39
Cortisol Reactivity to Stress and Its Association With White Matter Integrity in Adults With Schizophrenia
Nugent, K. L., Chiappelli, J., Sampath, H., Rowland, L. M., Thangavelu, K., Davis, B. J., Du, X. M., Muellerklein, F., Daughters, S. B., Kochunov, P., et al. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000215 · Cited by 39
Predicting response to electroconvulsive therapy combined with antipsychotics in schizophrenia using multi-parametric magnetic resonance imaging
Gong, J., Cui, L., Xi, Y., Zhao, Y.-S., Yang, X., Xu, Z., Sun, J., Liu, P., Jia, J., Li, P., et al. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.11.046 · Cited by 39
Decreased interhemispheric connectivity and increased cortical excitability in unmedicated schizophrenia: A prefrontal interleaved TMS fMRI study
Webler, R. D., Hamady, C., Molnar, C., Johnson, K. A., Bonilha, L., Anderson, B. S., Bruin, C., Bohning, D. E., George, M. S., & Nahas, Z. H. (2020) · Brain stimulation · doi:10.1016/j.brs.2020.06.017 · Cited by 38
Specific brain structural abnormalities in first-episode schizophrenia.
Crespo‐Facorro, B., Roiz‐Santiáñez, R., Pérez‐Iglesias, R., Tordesillas‐Gutiérrez, D., Mata, I. F., Rodríguez-Sánchez, J. M., de Lucas, E. M., & Vázquez‐Barquero, J. L. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.09.007 · Cited by 38
Association between myelin basic protein expression and left entorhinal cortex pre-alpha cell layer disorganization in schizophrenia
Parlapani, E., Schmitt, A., Erdmann, A., Bernstein, H., Breunig, B., Gruber, O., Petroianu, G. A., von Wilmsdorff, M., Schneider-Axmann, T., Honer, W. G., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.007 · Cited by 38
Molecular Profiling of Antipsychotic Drug Function: Convergent Mechanisms in the Pathology and Treatment of Psychiatric Disorders
Thomas, E. A. (2006) · Molecular Neurobiology · doi:10.1385/mn:34:2:109 · Cited by 40
The Relationship of Developmental Changes in White Matter to the Onset of Psychosis
Karlsgodt, K. H., Jacobson, S. C., Seal, M. L., & Fusar‐Poli, P. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799316073 · Cited by 35
Quetiapine Ameliorates Schizophrenia-Like Behaviors and Protects Myelin Integrity in Cuprizone Intoxicated Mice: The Involvement of Notch Signaling Pathway
Wang, H., Liu, G.-H., Zhang, R., Xue, F., Wu, D., Chen, Y.-C., Ye, P., Peng, Z., & Tan, Q.-R. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv088 · Cited by 37
Fornix Structural Connectivity and Allostatic Load: Empirical Evidence From Schizophrenia Patients and Healthy Controls
Savransky, A., Chiappelli, J., Rowland, L. M., Wisner, K., Shukla, D. K., Kochunov, P., & Hong, L. E. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000487 · Cited by 39
Cerebral atrophy and white matter disruption in chronic schizophrenia
Andreone, N., Tansella, M., Cerini, R., Rambaldelli, G., Versace, A., Marrella, G., Perlini, C., Dusi, N., Pelizza, L., Balestrieri, M., et al. (2006) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-006-0675-1 · Cited by 37
Antipsychotics promote the differentiation of oligodendrocyte progenitor cells by regulating oligodendrocyte lineage transcription factors 1 and 2
Fang, F., Zhang, H., Zhang, Y., Xu, H., Huang, Q., Adilijiang, A., Wang, J., Zhang, Z., Zhang, D., Tan, Q., et al. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.08.004 · Cited by 36
Arecoline attenuates memory impairment and demyelination in a cuprizone-induced mouse model of schizophrenia
Xu, Z., Adilijiang, A., Wang, W., You, P., Lin, D., Li, X., & He, J. (2018) · Neuroreport · doi:10.1097/wnr.0000000000001172 · Cited by 36
Altered diffusion in motor white matter tracts in psychosis patients with catatonia
Viher, P. V., Stegmayer, K., Federspiel, A., Bohlhalter, S., Wiest, R., & Walther, S. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.03.017 · Cited by 38
Haloperidol promotes proliferation but inhibits differentiation in rat oligodendrocyte progenitor cell culturesThis paper is one of a selection of papers published in this special issue entitled “Second International Symposium on Recent Advances in Basic, Clinical, and Social Medicine” and has undergone the Journal's usual peer review process.
Niu, J., Mei, F., Li, N., Wang, H., Li, X., Kong, J., & Xiao, L. (2010) · Biochemistry and Cell Biology · doi:10.1139/o09-178 · Cited by 36
Metabotropic Glutamate Receptor 2 and 3 Gene Expression in The Human Prefrontal Cortex and Mesencephalon in Schizophrenia
Ghose, S., Crook, J. M., Bartus, C. L., Sherman, T. G., Herman, M. M., Hyde, T. M., Kleinman, J. E., & Akil, M. (2008) · International Journal of Neuroscience · doi:10.1080/00207450802330702 · Cited by 36
Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia
Wright, S. N., Hong, L. E., Winkler, A. M., Chiappelli, J., Nugent, K. L., Muellerklein, F., Du, X., Rowland, L. M., Wang, D. J. J., & Kochunov, P. (2015) · Human Brain Mapping · doi:10.1002/hbm.22878 · Cited by 35
Statistical analysis of fiber bundles using multi-tensor tractography: application to first-episode schizophrenia
Yogesh Rathi, A., Kubicki, M. R., Sylvain Bouix, A., Westin, C., Goldstein, J. M., Seidman, L. J., Mesholam‐Gately, R. I., McCarley, R. W., & Shenton, M. E. (2011) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2010.10.005 · Cited by 35
Alterations in Retrotransposition, Synaptic Connectivity, and Myelination Implicated by Transcriptomic Changes Following Maternal Immune Activation in Nonhuman Primates
Page, N. F., Gandal, M. J., Estes, M. L., Cameron, S., Buth, J. E., Parhami, S., Ramaswami, G., Murray, K. D., Amaral, D. G., de Water, J. V., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.10.016 · Cited by 35
Acid sphingomyelinase/ceramide system in schizophrenia: implications for therapeutic intervention as a potential novel target
Zhuo, C., Zhao, F., Tian, H., Chen, J., Li, Q., Yang, L. X., Ping, J., Li, R., Wang, L., Xu, Y. J., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01999-7 · Cited by 35
Expression of the tyrosine kinase discoidin domain receptor 1 (DDR1) in human central nervous system myelin
Roig, B., Franco‐Pons, N., Martorell, L., Tomàs-Roig, J., Vogel, W. F., & Vilella, E. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.099 · Cited by 35
Gender-specific association of insertion/deletion polymorphisms in the nogo gene and chronic schizophrenia
Tan, E., Chong, S., Wang, H., Lim, E. C. P., & Teo, Y. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.05.010 · Cited by 35
Diffusion tensor analysis in chronic schizophrenia A preliminary study on a high–field (3.0T) system
Kitamura, H., Matsuzawa, H., Shioiri, T., Someya, T., Kwee, I. L., & Nakada, T. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0564-z · Cited by 35
Synaptic changes in psychiatric and neurological disorders: State-of-the art of in vivo imaging
Howes, O., Marcinkowska, J., Turkheimer, F. E., & Carr, R. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-024-01943-x · Cited by 34
Abnormal bihemispheric responses in schizophrenia patients following cathodal transcranial direct stimulation
Hasan, A., Aborowa, R., Nitsche, M. A., Marshall, L., Schmitt, A., Gruber, O., Falkai, P., & Wobrock, T. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0298-7 · Cited by 35
The peripheral cerebrospinal fluid outflow pathway – physiology and pathophysiology of CSF recirculation: A review and hypothesis
Bechter, K. (2011) · Neurology Psychiatry and Brain Research · doi:10.1016/j.npbr.2011.06.003 · Cited by 33
Structural abnormalities revealed by magnetic resonance imaging in rats prenatally exposed to methylazoxymethanol acetate parallel cerebral pathology in schizophrenia
Chin, C., Curzon, P., Schwartz, A. J., O'Connor, E. M., Rueter, L. E., Fox, G. B., Day, M., & Basso, A. M. (2010) · Synapse · doi:10.1002/syn.20857 · Cited by 34
Abnormal Trajectory of Intracortical Myelination in Schizophrenia Implicates White Matter in Disease Pathophysiology and the Therapeutic Mechanism of Action of Antipsychotics
Tishler, T. A., Bartzokis, G., Lu, P. H., Raven, E. P., Khanoyan, M., Kirkpatrick, C. J., Pyle, M., Villablanca, J. P., Altshuler, L. L., Mintz, J., et al. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.03.007 · Cited by 36
Reverse engineering human brain evolution using organoid models
Mostajo-Radji, M. A., Schmitz, M. T., Torres, S., & Pollen, A. A. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146582 · Cited by 36
Global hypomyelination of the brain white and gray matter in schizophrenia: quantitative imaging using macromolecular proton fraction
Smirnova, L. P., Yarnykh, V. L., Parshukova, D. A., Kornetova, E. G., Semke, A. V., Usova, A. V., Pishchelko, A. O., Khodanovich, M. Y., & Ivanova, S. А. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01475-8 · Cited by 34

Authors: Davis, K. L., Stewart, D. G., Friedman, J. I., Buchsbaum, M., Harvey, P. D., Hof, P. R., Buxbaum, J., & Haroutunian, V.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
ORCID: Davis, Kenneth L.
Friedman, Joseph I.
Buchsbaum, Monte
Harvey, Philip D.
Hof, Patrick R.
Buxbaum, Joseph
Haroutunian, Vahram
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 2003-05-01
Volume: 60
Issue: 5
Pages: 443
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.60.5.443
OpenAlex: W2049973822
Cited by: 793
References: 258
Citations by year: 2026: 9 · 2025: 12 · 2024: 20 · 2023: 11 · 2022: 17 · 2021: 14 · 2020: 25 · 2019: 35 · 2018: 28 · 2017: 27 · 2016: 36 · 2015: 41 · 2014: 34 · 2013: 32 · 2012: 50
FWCI: 24.15
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: schizophrenia, white matter, myelination, oligodendrocytes, myelin, neuronal connectivity, demyelinating disease, oligodendrocyte dysfunction, age-related white matter changes, neuroimaging
MeSH terms: Age Factors, Brain, Demyelinating Diseases, Humans, Myelin Sheath, Nerve Fibers, Myelinated, Oligodendroglia, Schizophrenia, Anisotropy, Cell Death, Protein Array Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

White Matter Changes in Schizophrenia: Evidence for Myelin-Related Dysfunction

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks