Cited by 47Schizophrenia research and treatmentNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Visual gamma oscillations in schizophrenia: implications for understanding neural circuitry abnormalities

Spencer, Kevin M.·2008·Clinical EEG and Neuroscience

Abstract

Gamma oscillations may play an important role in the representation of information in the brain by synchronizing the firing of neurons in local and distributed neural circuits. The Bleulerian conceptualization of schizophrenia as "disintegration of thought and personality" suggests that neural mechanisms responsible for the integration of neural activity, such as gamma oscillations, might be particularly disrupted in this disorder. Here we review studies of gamma oscillations in healthy and schizophrenic individuals performing visual perception tasks. The findings suggest that schizophrenia is associated with a variety of abnormalities of visual gamma oscillations, which appear to be linked to core symptoms and cognitive deficits of schizophrenia. The relationships between these abnormalities and neural circuitry abnormalities in schizophrenia are discussed.

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Crossref · 10.1177/155005940803900208

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  • In the prefrontal cortex, PNN degradation may affect gamma oscillatory activity originating from interneurons expressing parvalbumin.

    “In the prefrontal cortex, PNN degradation may affect gamma oscillatory activity originating from interneurons expressing parvalbumin (Carter et al., 1998; Kim and Webster, 2010; Lewis and Gonzalez-Burgos, 2008; Manoach et al., 1999; Spencer, 2008; Uhlhaas and Singer, 2010; Woo et al., 2010).”

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Authors
Spencer, K. M.
Affiliations
Harvard University (US)
Corresponding author
Spencer, Kevin M.
Venue
Clinical EEG and Neuroscience
Published
2008-04
Volume
39
Issue
2
Pages
65-68
ISSN
  • 1550-0594 (ISSN-L)
  • 2169-5202
OpenAlex
W2071609766
Cited by
47
References
41
Citations by year
2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 2 · 2013: 2 · 2012: 4
FWCI
3.02
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical EEG and Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R03MH076760)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
gamma oscillations, schizophrenia, visual perception, neuronal synchronization, cognitive impairment, core symptoms
MeSH terms
Brain Mapping, Electroencephalography, Evoked Potentials, Visual, Humans, Schizophrenia, Visual Perception

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