Constitutive genetic deletion of the growth regulator Nogo-A induces schizophrenia-related endophenotypes
Open accessAbstract
The membrane protein Nogo-A, which is predominantly expressed by oligodendrocytes in the adult CNS and by neurons mainly during development, is well known for limiting neurite outgrowth and regeneration in the injured mammalian CNS. In addition, it has recently been proposed that abnormal Nogo-A expression or Nogo receptor (NgR) mutations may confer genetic risks for neuropsychiatric disorders of presumed neurodevelopmental origin, such as schizophrenia. We therefore evaluated whether Nogo-A deletion may lead to schizophrenia-like abnormalities in a mouse model of genetic Nogo-A deficiency. Here, we show that systemic, lifelong knock-out of the Nogo-A gene can lead to specific behavioral abnormalities resembling schizophrenia-related endophenotypes: deficient sensorimotor gating, disrupted latent inhibition, perseverative behavior, and increased sensitivity to the locomotor stimulating effects of amphetamine. These behavioral phenotypes were accompanied by altered monoaminergic transmitter levels in specific striatal and limbic structures, as well as changes in dopamine D2 receptor expression in the same brain regions. Nogo-A deletion was further associated with elevated expression of growth-related markers. In contrast, acute antibody-mediated Nogo-A neutralization in adult wild-type mice failed to produce such phenotypes, suggesting that the phenotypes observed in the knock-out mice might be of developmental origin, and that Nogo-A normally subserves critical functions in neurodevelopment. This study provides the first experimental demonstration that Nogo-A bears neuropsychiatric relevance, and alterations in its expression may be one etiological factor in schizophrenia and related disorders.
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Nogo and NgR have been implicated in schizophrenia pathophysiology.
“Interestingly, Nogo and NgR have previously been implicated in the pathophysiology schizophrenia (Willi and Schwab, 2013)(Willi et al., 2010)(Tews et al., 2013)(Budel et al., 2008).”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Willi et al., 2010
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Cites
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,167 · see citing works
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724 · see citing works
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020 · see citing works
BRAFF, D. L., Geyer, M. A., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100810 · Cited by 1,701 · see citing works
The neuropathology of schizophrenia
Harrison, P. J. (1999) · Brain · doi:10.1093/brain/122.4.593 · Cited by 1,677 · see citing works
Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6
Smith, S. E. P., Li, J., Garbett, K., Mirnics, K., & Patterson, P. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2178-07.2007 · Cited by 1,605 · see citing works
Glial inhibition of CNS axon regeneration
Yiu, G. C., & He, Z. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1956 · Cited by 1,500 · see citing works
Laruelle, M., Abi-Dargham, A., van Dyck, C. H., Gil, R., D'Souza, C. D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S. S., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9235 · Cited by 1,291 · see citing works
Fritschy, J., & Mohler, H. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903590111 · Cited by 1,244 · see citing works
Schizophrenia as a Disorder of Neurodevelopment
Lewis, D. A., & Levitt, P. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142754 · Cited by 1,163 · see citing works
The neurodevelopmental model of schizophrenia: update 2005
Rapoport, J. L., Addington, A. M., Frangou, S., & Psych, M. R. C. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001642 · Cited by 993 · see citing works
Positron Emission Tomography Reveals Elevated D 2 Dopamine Receptors in Drug-Naive Schizophrenics
Wong, D. F., Wagner, H. N., Tune, L. E., Dannals, R. F., Pearlson, G. D., Links, J. M., Tamminga, C. A., Broussolle, E., Ravert, H. T., Wilson, A. A., et al. (1986) · Science · doi:10.1126/science.2878495 · Cited by 928 · see citing works
Dopamine receptors and the dopamine hypothesis of schizophrenia
Seeman, P. M. (1987) · Synapse · doi:10.1002/syn.890010203 · Cited by 880 · see citing works
Fone, K. C. F., & Porkess, M. V. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.003 · Cited by 864 · see citing works
Latent inhibition: The effect of nonreinforced pre-exposure to the conditional stimulus.
Lubow, R. E., & Moore, A. U. (1959) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0046700 · Cited by 806 · see citing works
White Matter Changes in Schizophrenia: Evidence for Myelin-Related Dysfunction
Davis, K. L., Stewart, D. G., Friedman, J. I., Buchsbaum, M., Harvey, P. D., Hof, P. R., Buxbaum, J., & Haroutunian, V. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.5.443 · Cited by 793 · see citing works
Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.
Kistner, A., Gossen, M., Zimmermann, F., Jerecic, J., Ullmer, C., Lübbert, H., & Bujard, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10933 · Cited by 780 · see citing works
Meyer, U., Nyffeler, M., Engler, A., Urwyler, A., Schedlowski, M., Knuesel, I., Yee, B. K., & Feldon, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0099-06.2006 · Cited by 774 · see citing works
Self-citationInteractions between monoamines, glutamate, and GABA in schizophrenia: new evidence.
Carlsson, A., Waters, N., Holm-Waters, S., Tedroff, J., Nilsson, M., & Carlsson, M. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.237 · Cited by 742 · see citing works
Ross, C. A., Margolis, R. L., Reading, S. A. J., Pletnikov, M. V., & Coyle, J. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.015 · Cited by 697 · see citing works
To Model a Psychiatric Disorder in Animals Schizophrenia As a Reality Test
Lipska, B. K. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00137-8 · Cited by 650 · see citing works
Experience-driven plasticity of visual cortex limited by myelin and nogo receptor
McGee, A. W., Yang, Y., Fischer, Q. S., Daw, N. W., & Strittmatter, S. M. (2005) · Science · doi:10.1126/science.1114362 · Cited by 643 · see citing works
Schwab, M. E. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.01.004 · Cited by 613 · see citing works
Self-citationDifferential Performance of Acute and Chronic Schizophrenics in a Latent Inhibition Task
Baruch, I., HEMSLEY, D. R., & Gray, J. A. (1988) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198810000-00004 · Cited by 612 · see citing works
A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice
Enard, W., Gehre, S., Hammerschmidt, K., Hölter, S. M., Blass, T., Somel, M., Brückner, M. K., Schreiweis, C., Winter, C., Sohr, R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.03.041 · Cited by 605 · see citing works
Self-citationVoorn, P., Kalsbeek, A., Jorritsma‐Byham, B., & Groenewegen, H. J. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90041-3 · Cited by 503 · see citing works
Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia
Meyer, U., Feldon, J., Schedlowski, M., & Yee, B. K. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.10.012 · Cited by 494 · see citing works
Self-citationPatterns of Nogo mRNA and Protein Expression in the Developing and Adult Rat and After CNS Lesions
Huber, A. B., Weinmann, O., Brösamle, C., Oertle, T., & Schwab, M. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03553.2002 · Cited by 455 · see citing works
Self-citationA regulatory system for use in gene transfer.
Wang, Y., O’Malley, B. W., Tsai, S. Y., & O’Malley, B. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8180 · Cited by 430 · see citing works
Simonen, M., Pedersen, V., Weinmann, O., Schnell, L., Buss, A., Ledermann, B., Christ, F., Sansig, G., van der Putten, H., & Schwab, M. E. (2003) · Neuron · doi:10.1016/s0896-6273(03)00226-5 · Cited by 401 · see citing works
Self-citationSchizophrenia-Relevant Behavioral Testing in Rodent Models: A Uniquely Human Disorder?
Powell, C. M., & Miyakawa, T. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.008 · Cited by 368 · see citing works
Localization of Nogo-A and Nogo-66 Receptor Proteins at Sites of Axon–Myelin and Synaptic Contact
Wang, X., Chun, S.-J., Treloar, H. B., et al. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05505.2002 · Cited by 352 · see citing works
Sensorimotor gating deficits in adults with autism
Perry, W., Minassian, A., Lopez, B., Maron, L., & Lincoln, A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.025 · Cited by 352 · see citing works
Modeling madness in mice: one piece at a time
Arguello, P. A., & Gogos, J. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.023 · Cited by 309 · see citing works
Meyer, U., Yee, B. K., & Feldon, J. (2007) · The Neuroscientist · doi:10.1177/1073858406296401 · Cited by 303 · see citing works
Self-citationThe psychology of perseverative and stereotyped behaviour
Ridley, R. M. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90039-6 · Cited by 287 · see citing works
Schizophrenia: More dopamine, more D <sub>2</sub> receptors
Seeman, P., & Kapur, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.7673 · Cited by 279 · see citing works
Abolition of latent inhibition in acute, but not chronic, schizophrenics
Gray, N. S. (1992) · Neurology Psychiatry and Brain Research · Cited by 263 · see citing works
Acoustic variables in the modification of startle reaction in the rat.
Hoffman, H. S., & Searle, J. L. (1965) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0022325 · Cited by 250 · see citing works
Schizophrenia-Related Neural and Behavioral Phenotypes in Transgenic Mice Expressing TruncatedDisc1
Shen, S., Lang, B., Nakamoto, C., Zhang, F., Pu, J., Kuan, S. L., Chatzi, C. A., He, S., Mackie, I., Brandon, N. J., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3299-08.2008 · Cited by 250 · see citing works
Social approach in genetically engineered mouse lines relevant to autism
Moy, S. S., Nadler, J. J., Young, N. B., Nonneman, R. J., Grossman, A. W., Murphy, D. L., D’Ercole, A. J., Crawley, J. N., Magnuson, T. R., & Lauder, J. M. (2009) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2008.00452.x · Cited by 246 · see citing works
The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia
Wolinsky, T., Swanson, C., Smith, K. E., Zhong, H., Borowsky, B., Seeman, P., Branchek, T., & Gerald, C. (2007) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2006.00292.x · Cited by 245 · see citing works
Winter, C., Djodari-Irani, A., Sohr, R., Morgenstern, R., Feldon, J., Juckel, G., & Meyer, U. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009206 · Cited by 242 · see citing works
Self-citationMeyer, U., Nyffeler, M., Schwendener, S., Knuesel, I., Yee, B. K., & Feldon, J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301413 · Cited by 215 · see citing works
Self-citationBrain maturational processes and delayed onset in schizophrenia
Keshavan, M. S., & Hogarty, G. E. (1999) · Development and Psychopathology · doi:10.1017/s0954579499002199 · Cited by 202 · see citing works
Bareyre, F. M., Haudenschild, B., & Schwab, M. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07097.2002 · Cited by 201 · see citing works
Self-citationGenetic variation in the 22q11 locus and susceptibility to schizophrenia
Liu, H., Abecasis, G. R., Heath, S. C., Knowles, A., Demars, S., Chen, Y., Roos, J. L., Rapoport, J. L., Gogos, J. A., & Karayiorgou, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232186099 · Cited by 201 · see citing works
The Neurochemical Circuitry of Schizophrenia
Carlsson, A. (2006) · Pharmacopsychiatry · doi:10.1055/s-2006-931483 · Cited by 199 · see citing works
Prepulse inhibition and latent inhibition: the role of dopamine in the medial prefrontal cortex
Ellenbroek, B. A., Budde, S., & Cools, A. R. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00307-7 · Cited by 197 · see citing works
O’Donnell, P., & Grace, A. A. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033325 · Cited by 191 · see citing works
Salahpour, A., Ramsey, A., Medvedev, I., Kile, B. M., Sotnikova, T. D., Holmstrand, E., Ghisi, V., Nicholls, P., Wong, L., Murphy, K. L., et al. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0707646105 · Cited by 189 · see citing works
Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia
Grace, A. A. (1993) · Journal of Neural Transmission · doi:10.1007/bf01245228 · Cited by 185 · see citing works
Perseveration in Schizophrenia
Crider, A. B. (1997) · Schizophrenia Bulletin · doi:10.1093/schbul/23.1.63 · Cited by 174 · see citing works
Buffo, A., Zagrebelsky, M., Huber, A. B., Skerra, A., Schwab, M. E., Strata, P., & Rossi, F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02275.2000 · Cited by 170 · see citing works
Self-citationNogo-A-Deficient Mice Reveal Strain-Dependent Differences in Axonal Regeneration
Dimou, L., Schnell, L., Montani, L., Duncan, C. S., Simonen, M., Schneider, R., Liebscher, T., Gullo, M., & Schwab, M. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1103-06.2006 · Cited by 162 · see citing works
Self-citationPerrone-Bizzozero, N. I., Sower, A. C., Bird, E. D., Benowitz, L. I., Ivins, K. J., & Neve, R. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14182 · Cited by 162 · see citing works
Increased Caudate Dopamine D2 Receptor Availability as a Genetic Marker for Schizophrenia
Hirvonen, J., van Erp, T. G. M., Huttunen, J., Aalto, S., Någren, K., HUTTUNEN, M. O., Lönnqvist, J. K., Kaprio, J. A., Hietala, J. A., & Cannon, T. D. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.4.371 · Cited by 161 · see citing works
Nogo-A, -B, and -C Are Found on the Cell Surface and Interact Together in Many Different Cell Types
Dodd, D. A., Niederoest, B., Bloechlinger, S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411827200 · Cited by 158 · see citing works
Glial cell dysfunction in schizophrenia indicated by increased S100B in the CSF
Rothermundt, M., Falkai, P., Ponath, G. D., Abel, S., Bürkle, H., Diedrich, M., Hetzel, G., Peters, M., Siegmund, A., Pedersen, A., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001548 · Cited by 148 · see citing works
Yee, B. K., Balic, E., Singer, P., Schwerdel, C., Grampp, T., Gabernet, L., Knuesel, I., Benke, D., Feldon, J., Möhler, H., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5120-05.2006 · Cited by 137 · see citing works
Self-citationRoffler-Tarlov, S. K., & Graybiel, A. M. (1984) · Nature · doi:10.1038/307062a0 · Cited by 136 · see citing works
Schizophrenia: a disorder of neurodevelopment?
Harrison, P. J. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80018-9 · Cited by 131 · see citing works
Genetic Mouse Models of Schizophrenia: From Hypothesis-Based To Susceptibility Gene-Based Models
Chen, J., Lipska, B. K., & Weinberger, D. R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.024 · Cited by 108 · see citing works
Budel, S., Padukkavidana, T., Liu, B. P., Feng, Z., Hu, F., Johnson, S., Lauren, J., Park, J. H., McGee, A. W., Liao, J., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3828-08.2008 · Cited by 107 · see citing works
Schizophrenia and Nogo: elevated mRNA in cortex, and high prevalence of a homozygous CAA insert
Novak, G., Kim, D., Seeman, P. M., & Tallerico, T. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00492-8 · Cited by 102 · see citing works
Alterations of Serotonin Transmission in Schizophrenia
Abi‐Dargham, A. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(06)78005-9 · Cited by 98 · see citing works
The myelin-pathogenesis puzzle in schizophrenia: a literature review
Karoutzou, G., Emrich, H. M., & Dietrich, D. E. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002096 · Cited by 92 · see citing works
Weinmann, O., Schnell, L., Ghosh, A., Montani, L., Wießner, C., Wannier, T., Rouiller, E. M., Mir, A. K., & Schwab, M. E. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.03.007 · Cited by 89 · see citing works
Self-citationLipska, B. K., Lerman, D. N., Khaing, Z. Z., & Weinberger, D. R. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03047.x · Cited by 78 · see citing works
Hsu, R., Woodroffe, A., Lai, W., Cook, M. N., Mukai, J., Dunning, J. P., Swanson, D. J., Roos, J. L., Abecasis, G. R., Karayiorgou, M., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001234 · Cited by 77 · see citing works
Mingorance, A., Zheng, B., Soriano, E., & del Rı́o, J. A. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl146 · Cited by 77 · see citing works
The Role of Extrastriatal Dopamine D2 Receptors in Schizophrenia
Takahashi, H., Higuchi, M., & Suhara, T. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.01.022 · Cited by 75 · see citing works
Coon, H. H., Myles‐Worsley, M., Tiobech, J., Hoff, M., Rosenthal, J., Bennett, P., Reimherr, F. W., Wender, P. H., Dale, P. W., Polloi, A., et al. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000453 · Cited by 75 · see citing works
Mutations of the Nogo-66 receptor (RTN4R) gene in schizophrenia
Sinibaldi, L., Luca, A. D., Bellacchio, E., et al. (2004) · Human Mutation · doi:10.1002/humu.9292 · Cited by 72 · see citing works
Catching up on schizophrenia: natural history and neurobiology.
Lewis, D. A., & Lieberman, J. A. (2000) · Neuron · doi:10.1016/s0896-6273(00)00111-2 · Cited by 71 · see citing works
Broersen, L. M., Feldon, J., & Weiner, I. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00287-0 · Cited by 65 · see citing works
Self-citationNeves-Pereira, M., Bassett, A. S., Honer, W. G., Lang, D. J., King, N. A., & Kennedy, J. L. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980907)81:5 · Cited by 63 · see citing works
Sheu, F., Azmitia, E. C., Marshak, D. R., et al. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90378-6 · Cited by 55 · see citing works
Blennow, K., Bogdanović, N., Gottfries, C., & Davidsson, P. (1999) · Journal of Molecular Neuroscience · doi:10.1385/jmn:13:1-2:101 · Cited by 53 · see citing works
Hagenbuch, N., Feldon, J., & Yee, B. K. (2005) · Behavioural Pharmacology · doi:10.1097/01.fbp.0000189811.77049.3e · Cited by 52 · see citing works
Self-citationPrinssen, E. P. M. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00348-7 · Cited by 46 · see citing works
Tan, E., Chong, S., Wang, H., Lim, E. C. P., & Teo, Y. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.05.010 · Cited by 35 · see citing works
Behavioral characterization of mice lacking the neurite outgrowth inhibitor Nogo‐A
Willi, R., Aloy, E. M., Yee, B. K., Feldon, J., & Schwab, M. E. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2008.00460.x · Cited by 35 · see citing works
Self-citationA developmental study of the mouse neostriatum.
Rr, S. (1980) · PubMed · Cited by 34 · see citing works
Marek, G. J. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(06)78006-0 · Cited by 25 · see citing works
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Perineuronal nets and schizophrenia: The importance of neuronal coatings
Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.018 · Cited by 95 · see citing works
Tews, B., Schönig, K., Arzt, M. E., Clementi, S., Rioult-Pedotti, M.-S., Zemmar, A., Berger, S. M., Schneider, M., Enkel, T., Weinmann, O., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217665110 · Cited by 56 · see citing works
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- Authors
- Willi, R., Weinmann, O., Winter, C., Klein, J., Sohr, R., Schnell, L., Yee, B. K., Feldon, J., & Schwab, M. E.
- Affiliations
- University of Zurich (CH)
- Charité – Universitätsmedizin Berlin (DE)
- ETH Zurich (CH)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-01-13
- Volume
- 30
- Issue
- 2
- Pages
- 556-567
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6633005
- OpenAlex
- W2092550024
- Cited by
- 52
- References
- 85
- Citations by year
- 2026: 1 · 2023: 3 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 2
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by-nc-sa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- ETH Zürich Research Collection
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- Christopher and Dana Reeve Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (3100AO-122527/1, 122527)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- Nogo-A, schizophrenia, gene deletion, Nogo receptor, sensorimotor gating, latent inhibition, perseveration, amphetamine sensitivity, dopamine D2 receptor, monoamines, striatum, limbic system, brain development, oligodendrocytes, antibody neutralization, mouse model
- MeSH terms
- Nogo Proteins, Acoustic Stimulation, Amphetamine, Central Nervous System Stimulants, Analysis of Variance, Animals, Antibodies, Brain, Chromatography, High Pressure Liquid, Disease Models, Animal, Exploratory Behavior, Gene Expression Regulation, Glial Fibrillary Acidic Protein, Inhibition, Psychological, Interpersonal Relations, Learning, Locomotion, Male, Mice, Inbred C57BL, Myelin Proteins, Phenotype, Schizophrenia, Sequence Deletion, Prefrontal Cortex, Receptors, Dopamine D2, Mice, Knockout, Neurotransmitter Agents, Maze Learning, Mice, Sensory Gating
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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