Cited by 793Schizophrenia research and treatmentMental Health and PsychiatryMultiple Sclerosis Research Studies

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White Matter Changes in Schizophrenia: Evidence for Myelin-Related Dysfunction

Davis, Kenneth L., Stewart, Daniel G., Friedman, Joseph I., Buchsbaum, Monte, Harvey, Philip D., Hof, Patrick R., Buxbaum, Joseph, Haroutunian, Vahram·2003·Archives of General Psychiatry

DOI 10.1001/archpsyc.60.5.443

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Abstract

Numerous lines of inquiry implicate connectivity as a central abnormality in schizophrenia. Myelination and factors that affect myelination, such as the function of oligodendroglia, are critical processes that could profoundly affect neuronal connectivity, especially given the diffuse distribution of oligodendrocytes and the widespread distribution of brain regions that have been implicated in schizophrenia. Multiple lines of evidence now converge to implicate oligodendroglia and myelin in schizophrenia. Imaging and neurocytochemical evidence, similarities with demyelinating diseases, age-related changes in white matter, myelin-related gene abnormalities, and morphologic abnormalities in the oligodendroglia demonstrated in schizophrenic brains are all examined in light of the hypothesis that oligodendroglial dysfunction and even death, with subsequent abnormalities in myelin maintenance and repair, contribute to the schizophrenic syndrome.

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Authors: Davis, K. L., Stewart, D. G., Friedman, J. I., Buchsbaum, M., Harvey, P. D., Hof, P. R., Buxbaum, J., & Haroutunian, V.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
ORCID: Davis, Kenneth L.
Friedman, Joseph I.
Buchsbaum, Monte
Harvey, Philip D.
Hof, Patrick R.
Buxbaum, Joseph
Haroutunian, Vahram
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 2003-05-01
Volume: 60
Issue: 5
Pages: 443
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.60.5.443
OpenAlex: W2049973822
Cited by: 793
References: 258
Citations by year: 2026: 9 · 2025: 12 · 2024: 20 · 2023: 11 · 2022: 17 · 2021: 14 · 2020: 25 · 2019: 35 · 2018: 28 · 2017: 27 · 2016: 36 · 2015: 41 · 2014: 34 · 2013: 32 · 2012: 50
FWCI: 24.15
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: schizophrenia, white matter, myelination, oligodendrocytes, myelin, neuronal connectivity, demyelinating disease, oligodendrocyte dysfunction, age-related white matter changes, neuroimaging
MeSH terms: Age Factors, Brain, Demyelinating Diseases, Humans, Myelin Sheath, Nerve Fibers, Myelinated, Oligodendroglia, Schizophrenia, Anisotropy, Cell Death, Protein Array Analysis

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White Matter Changes in Schizophrenia: Evidence for Myelin-Related Dysfunction

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