The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Childhood Adversity, Monoamine Oxidase A Genotype, and Risk for ConductDisorder
Abstract
BACKGROUND: Very little is known about how different sets of risk factors interact to influence risk for psychiatric disorder. OBJECTIVE: To replicate a recent report of a genotype-environment interaction that predicts risk for antisocial behavior in boys. DESIGN: Characterizing risk for conduct disorder in boys in association with monoamine oxidase A genotype and exposure to familial adversity, defined by interparental violence, parental neglect, and inconsistent discipline. SETTING: A community-based sample of twin boys. PARTICIPANTS: Five hundred fourteen male twins aged 8 to 17 years. MAIN OUTCOME MEASURE: Conduct disorder. RESULTS: There was a main effect of adversity but not of monoamine oxidase A on risk for conduct disorder. Low monoamine oxidase A activity increased risk for conduct disorder only in the presence of an adverse childhood environment. Neither a passive nor an evocative genotype-environment correlation accounted for the interaction. CONCLUSION: This study replicates a recent report of a genotype-environment interaction that predicts individual variation in risk for antisocial behavior in boys.
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In the citing paper
“A functional polymorphism in the monoamine oxidase A (MAOA) gene has been found to moderate the effects of a risk environment on the development of antisocial behavior (Caspi et al., 2002;Foley et al., 2004).”
From Heritability for adolescent antisocial behavior differs with socioeconomic status: gene–environment interaction (2006) · cites this paper as Foley et al., 2004
In the citing paper
“Further research has replicated and extended the finding by noting that parent neglect as well as abuse in conjunction with the polymorphism increase risk for conduct problems and violence (Foley et al. 2004, Jaffee et al. 2005).”
From Mediators and Mechanisms of Change in Psychotherapy Research (2007) · cites this paper as Foley et al. 2004
In the citing paper
“The association between maltreatment and mental health problems was significantly stronger in the group of males with a genotype conferring low versus high MAO-A activity.”
From Human Aggression Across the Lifespan (2011) · cites this paper as Foley et al., 2004
In the citing paper
“So far, there have only been a few replications of this important finding (Foley et al., 2004; Kim-Cohen et al., 2006; Nilsson et al., 2006).”
From Human Aggression Across the Lifespan (2011) · cites this paper as Foley et al., 2004
Citations
Cites
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Role of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842
Searching for genetic determinants in the new millennium
Risch, N. J. (2000) · Nature · doi:10.1038/35015718 · Cited by 1,839
A functional polymorphism in the monoamine oxidase A gene promoter
Sabol, S. Z., Hu, S., & Hamer, D. (1998) · Human Genetics · doi:10.1007/s004390050816 · Cited by 1,079
Stressful life events, genetic liability, and onset of an episode of major depression in women
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.6.833 · Cited by 1,063
Self-citationThe Child and Adolescent Psychiatric Assessment (CAPA)
Angold, A., Prendergast, M., Cox, A., Harrington, R., Simonoff, E., & Rutter, M. (1995) · Psychological Medicine · doi:10.1017/s003329170003498x · Cited by 968
Biosocial studies of antisocial and violent behavior in children and adults: A review
Raine, A. (2002) · Journal of Abnormal Child Psychology · doi:10.1023/a:1015754122318 · Cited by 824
Oppositional Defiant Disorder and Conduct Disorder: A Review of the Past 10 Years, Part II
Burke, J. D., Loeber, R., & Birmaher, B. B. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200211000-00009 · Cited by 604
Models for the joint effect of genotype and environment on liability to psychiatric illness
Kendler, K. S., & Eaves, L. J. (1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.3.279 · Cited by 549
Self-citationEaves, L. J., Silberg, J. L., Meyer, J. M., Maes, H. H., Simonoff, E., Pickles, A., Rutter, M., Reynolds, C. A., Heath, A. C., Truett, K. R., et al. (1997) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1997.tb01614.x · Cited by 489
Self-citationThe influence of genetic factors and life stress on depression among adolescent girls
Silberg, J., Pickles, A., Rutter, M., Hewitt, J., Simonoff, E., Maes, H., Carbonneau, R., Murrelle, L., Foley, D., & Eaves, L. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.3.225 · Cited by 398
Self-citationGene–Environment Interaction: Definitions and Study Design
Ottman, R. (1996) · Preventive Medicine · doi:10.1006/pmed.1996.0117 · Cited by 338
Exposure to Interparental Violence in Childhood and Psychosocial Adjustment in Young Adulthood
Fergusson, D. M., & Horwood, L. J. (1998) · Child Abuse & Neglect · doi:10.1016/s0145-2134(98)00004-0 · Cited by 280
Predictors of antisocial personality
Simonoff, E. A., Elander, J., Holmshaw, J., Pickles, A. R., Murray, R. M., & Rutter, M. L. (2004) · The British Journal of Psychiatry · doi:10.1192/bjp.184.2.118 · Cited by 263
Eaves, L. J., Last, K., Martin, N. G., & Jinks, J. (1977) · British Journal of Mathematical and Statistical Psychology · doi:10.1111/j.2044-8317.1977.tb00722.x · Cited by 253
Self-citationTHE INTERACTION OF NATURE AND NURTURE
Haldane, J. B. S. (1946) · Annals of Eugenics · doi:10.1111/j.1469-1809.1946.tb02358.x · Cited by 237
Yang, Q., & Khoury, M. J. (1997) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a017944 · Cited by 184
Investigation of the functional effect of monoamine oxidase polymorphisms in human brain
Balciuniene, J., Emilsson, L., Oreland, L., Pettersson, U., & JAZIN, E. E. (2001) · Human Genetics · doi:10.1007/s00439-001-0652-8 · Cited by 163
Hamer, D. H. (2002) · Science · doi:10.1126/science.1077582 · Cited by 154
Resolving multiple epigenetic pathways to adolescent depression
Eaves, L. J., Silberg, J. L., & Erkanli, A. (2003) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00185 · Cited by 154
Self-citationBiometrical Genetics: The Study of Continuous Variation
Mather, K., & Jinks, J. L. (1949) · Medical Entomology and Zoology · Cited by 149
Hewitt, J. K., Rutter, M. L., Simonoff, E. A., Pickles, A. R., Loeber, R., Heath, A. C., Reynolds, C. A., Silberg, J. L., Meyer, J. M., MAES, H. H. M., et al. (1997) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1997.tb01613.x · Cited by 134
Self-citationBoomsma, D. I., & Martin, N. G. (2002) · Biological Psychiatry · doi:10.1002/0470854871.chxiii · Cited by 124
Childhood adversities and psychosocial disorders
Maughan, B., & McCarthy, G. (1997) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a011597 · Cited by 122
Conduct Disorder: A Biopsychosocial Review
Bassarath, L. (2001) · The Canadian Journal of Psychiatry · doi:10.1177/070674370104600704 · Cited by 121
Depression spectrum disease, I: The role of gene-environment interaction
Cadoret, R. J., Winokur, G., Langbehn, D. R., Troughton, E. P., Yates, W. R., & Stewart, M. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.7.892 · Cited by 104
Recent progress in psychiatric genetics--some hope but no hype
Stoltenberg, S. F. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.6.927 · Cited by 103
Gene–Environment Interactions and the Etiology of Common Complex Disease
Cooper, R. S. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-5_part_2-200309021-00011 · Cited by 82
Strict and inconsistent discipline in childhood: Consequences for adolescent mental health
Feehan, M., McGee, R. O., Stanton, W. R., & Silva, P. A. (1991) · British Journal of Clinical Psychology · doi:10.1111/j.2044-8260.1991.tb00953.x · Cited by 42
Meyer, J. M., Silberg, J. L., Simonoff, E. A., Kendler, K. S., & Hewitt, J. K. (1996) · Psychological Medicine · doi:10.1017/s0033291700035844 · Cited by 40
Self-citationNon-linear genotype × environment interactions
Pooni, H. S., & Jinks, J. L. (1980) · Heredity · doi:10.1038/hdy.1980.81 · Cited by 26
The importance of cultural inheritance in psychiatric genetics
Peedicayil, J. (2002) · Medical Hypotheses · doi:10.1054/mehy.2001.1503 · Cited by 17
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Burden and consequences of child maltreatment in high-income countries
Gilbert, R., Widom, C. S., Browne, K., Fergusson, D., Webb, E., & Janson, S. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61706-7 · Cited by 3,876
Beyond diathesis stress: differential susceptibility to environmental influences
Belsky, J., & Pluess, M. (2009) · Psychological Bulletin · doi:10.1037/a0017376 · Cited by 3,039
Mediators and Mechanisms of Change in Psychotherapy Research
Kazdin, A. E. (2007) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.3.022806.091432 · Cited by 2,504
Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., Taylor, A., Arseneault, L., Williams, B., Braithwaite, A., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.026 · Cited by 1,409
Binder, E. B. (2008) · JAMA · doi:10.1001/jama.299.11.1291 · Cited by 1,362
Metadata
- Authors
- Foley, D. L., Eaves, L. J., Wormley, B., Silberg, J. L., Maes, H. H., Kuhn, J., & Riley, B.
- Affiliations
- Virginia Commonwealth University (US)
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2004-07-01
- Volume
- 61
- Issue
- 7
- Pages
- 738
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2147817341
- Cited by
- 564
- References
- 33
- Citations by year
- 2026: 4 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 12 · 2019: 6 · 2018: 15 · 2017: 13 · 2016: 26 · 2015: 26 · 2014: 33 · 2013: 33 · 2012: 32
- FWCI
- 69.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH57761, MH45268, R01MH045268, P30MH057761)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- conduct disorder, monoamine oxidase A, childhood adversity, gene-environment interaction, antisocial behavior, interparental violence, parental neglect, inconsistent discipline, risk factors
- MeSH terms
- Adolescent, Antisocial Personality Disorder, Child, Child Abuse, Diseases in Twins, Genotype, Humans, Life Change Events, Male, Monoamine Oxidase, Risk Factors, Sex Factors, Social Environment, Virginia, Child of Impaired Parents, Domestic Violence, Conduct Disorder, Genetic Predisposition to Disease
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