The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The Interaction of Stressful Life Events and a Serotonin Transporter Polymorphism in the Prediction of Episodes of Major Depression: A Replication
Abstract
CONTEXT: Prior evidence from twin studies suggested genetic moderation of the depressogenic effects of stressful life events (SLEs). Can the specific genes involved in this effect be identified? OBJECTIVE: To replicate and extend a recent study that a functional variant in the serotonin transporter (5-HTT) might in part explain these findings. DESIGN: Characterizing risk for major depression and generalized anxiety syndrome in the last year as a function of 5-HTT genotype, sex, and the occurrence of SLEs and ratings of the SLE-associated level of threat. SETTING: A population-based sample of adult twins. PARTICIPANTS: Five hundred forty-nine male and female twins with a mean age at participation of 34.9 years (SD 9.1). MAIN OUTCOME MEASURE: Episodes of major depression and generalized anxiety syndrome in the last year with onset measured to the nearest month. RESULTS: Individuals with 2 short (S) alleles at the 5-HTT locus were more sensitive to the depressogenic effects of all SLEs than were those with 1 or 2 long (L) alleles. When level of SLE-associated threat was examined, the interaction between genotype and SLE resulted from an increased sensitivity of SS individuals to the depressogenic effects of common low-threat events. These events had little impact on risk for those possessing the SL and LL genotypes. The 5-HTT genotype did not modify the effects of SLEs on risk for generalized anxiety syndrome. CONCLUSION: Variation at the 5-HTT moderates the sensitivity of individuals to the depressogenic effects of SLEs largely by producing, in SS individuals, an increased sensitivity to the impact of mild stressors. Replication of these intriguing results is needed.
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Citations
Cites
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Causal Relationship Between Stressful Life Events and the Onset of Major Depression
Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.837 · Cited by 2,566 · cited 1×
“S TRESSFUL LIFE EVENTS (SLES) precede the onset of episodes of major depression (MD) more frequently than expected by chance,(1,2) and this relationship is probably causal.(3) However, humans display wide variation in response to adversity.”
BackgroundSelf-citationTHE EFFECTS OF STRESSFUL LIFE EVENTS ON DEPRESSION
Kessler, R. C. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.191 · Cited by 2,111
Lohmueller, K. E., Pearce, C. L., Pike, M., Lander, E. S., & Hirschhorn, J. N. (2003) · Nature Genetics · doi:10.1038/ng1071 · Cited by 1,900
Stressful life events, genetic liability, and onset of an episode of major depression in women
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.6.833 · Cited by 1,063
Self-citationKendler, K. S., Hettema, J. M., Butera, F., Gardner, C. O., & Prescott, C. A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.789 · Cited by 966
Self-citationGene–environment interaction analysis of serotonin system markers with adolescent depression
Eley, T. C., Sugden, K., Corsico, A., Gregory, A. M., Sham, P., McGuffin, P., Plomin, R., & Craig, I. W. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001546 · Cited by 663
A Population-Based Twin Study of Lifetime Major Depression in Men and Women
Kendler, K. S., & Prescott, C. A. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.1.39 · Cited by 512
Self-citationLife Events, Stress and Depression: A Review of Recent Findings
Tennant, C. (2002) · Australian & New Zealand Journal of Psychiatry · doi:10.1046/j.1440-1614.2002.01007.x · Cited by 478
Genetic moderation of environmental risk for depression and anxiety in adolescent girls
Silberg, J., Rutter, M., Neale, M., & Eaves, L. (2001) · British Journal of Psychiatry · doi:10.1192/bjp.179.2.116 · Cited by 285
Cited by
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704
Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J., & Merikangas, K. R. (2009) · JAMA · doi:10.1001/jama.2009.878 · Cited by 1,655
“Chipman et al,16 2007 2095 (1089) 23 (20-24) 33 46 21 Cross sectional No List of Threatening Eventsb Depression rating scale Failed to replicate”
BackgroundInfluentialPsychological well-being: evidence regarding its causes and consequences
Huppert, F. A. (2009) · Applied Psychology: Health and Well-Being · doi:10.1111/j.1758-0854.2009.01008.x · Cited by 1,583
The Evolution of the Cognitive Model of Depression and Its Neurobiological Correlates
Beck, A. T. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08050721 · Cited by 1,537
Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., Taylor, A., Arseneault, L., Williams, B., Braithwaite, A., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.026 · Cited by 1,409
Metadata
- Authors
- Kendler, K. S., Kuhn, J. W., Vittum, J., Prescott, C. A., & Riley, B.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2005-05-01
- Volume
- 62
- Issue
- 5
- Pages
- 529
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W4248629646
- Cited by
- 669
- References
- 11
- FWCI
- 25.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kendler, K. S., Kuhn, J. W., Vittum, J., Prescott, C. A., & Riley, B. (2005). The Interaction of Stressful Life Events and a Serotonin Transporter Polymorphism in the Prediction of Episodes of Major Depression: A Replication. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.62.5.529
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