Genetic moderation of environmental risk for depression and anxiety in adolescent girls
Open accessAbstract
BACKGROUND: There is huge individual variation in people's response to negative life events. AIMS: To test the hypothesis that genetic factors moderate susceptibility to the environmentally mediated risks associated with negative life events. METHOD: The Virginia Twin Study of Adolescent Behavioral Development (VTSABD) was used to study the effects of independent life events (assessed from maternal interview) on depression/anxiety (assessed from child interview) in 184 same-gender female twin pairs, aged 14--7 years, measured on two occasions. RESULTS: There was no genetic effect on the independent negative life events studied. A significant gene-environment interaction was found using structural equation modelling. There was no effect of independent life events on adolescents' depression in the absence of parental emotional disorder, but a significant effect in its presence. CONCLUSIONS: There is an environmentally mediated effect of life events on depression/anxiety. Genetic factors play a significant role in individual differences in susceptibility to these environmentally mediated risks.
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- Authors
- Silberg, J., Rutter, M., Neale, M., & Eaves, L.
- Affiliations
- Virginia Commonwealth University (US)
- King's College London (GB)
- Corresponding author
- Silberg, Judy
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2001-08
- Volume
- 179
- Issue
- 2
- Pages
- 116-121
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2144250533
- Cited by
- 285
- References
- 29
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 11 · 2016: 10 · 2015: 9 · 2014: 17 · 2013: 13 · 2012: 14
- FWCI
- 20.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institute of Mental Health (R29MH055557, MH45268, R01MH045268, MH-55557)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- gene-environment interaction, depression, anxiety, adolescent girls, negative life events, twin pairs, environmental risk, genetic susceptibility
- MeSH terms
- Adolescent, Anxiety Disorders, Data Interpretation, Statistical, Depressive Disorder, Female, Humans, Life Change Events, Models, Genetic, Psychiatric Status Rating Scales, Risk Factors
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