Vitamins for the prevention of colds
Abstract
Repeated studies have shown that both animals and man have a decreased resistance to infections of various kinds when suffering from vitamin deficiencies. Apparently this may be true for each of the better known vitamins. On the other hand, it has not been shown by adequately controlled experiments that the addition of any of the vitamins to a reasonably adequate diet produces increased resistance to infections of the upper respiratory tract, the millions of dollars' worth of vitamin preparations which are sold each year for this alleged purpose notwithstanding. Most of the studies of vitamins for the prevention of colds have been limited to vitamin A alone or to vitamins A and D as contained in cod liver oil. The experiments with vitamin A have resulted almost uniformly in negative results, while cod liver oil has been reported by a number of authors to reduce the severity and by some
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Cites
DOES OUR DIETARY REQUIRE VITAMIN A SUPPLEMENT?
HESS, A. F. (1933) · JAMA · doi:10.1001/jama.1933.02740340009003 · Cited by 33 · see citing works
THE EFFECT OF VITAMIN A ON THE COMMON COLD
SHIBLEY, G. S. (1934) · JAMA · doi:10.1001/jama.1934.02750520023006 · Cited by 18 · see citing works
MASSIVE DOSES OF VITAMINS A AND D IN THE PREVENTION OF THE COMMON COLD
Spiesman, I. G. (1941) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.1941.00660040843010 · Cited by 13 · see citing works
Kuttner, A. G. (1940) · Journal of Clinical Investigation · doi:10.1172/jci101184 · Cited by 11 · see citing works
Vitamin “A” as a prophylactic against the common “Cold” in groups of school children
Tress, E. M. (1934) · American Journal of Digestive Diseases and Nutrition · doi:10.1007/bf02999609 · Cited by 11 · see citing works
Holmes, A. D., Pigott, M. G., Sawyer, W. A., et al. (1936) · Industrial medicine and surgery · Cited by 11 · see citing works
Prophylaxis of the Common Cold.
Sherman, J. (1938) · Cited by 3 · see citing works
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Vitamin C for preventing and treating the common cold
Hemilä, H., & Chalker, E. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000980.pub4 · Cited by 869 · see citing works
Hemilä, H. (2017) · Nutrients · doi:10.3390/nu9040339 · Cited by 461 · see citing works
Effects of ascorbic acid on the common cold
Chalmers, T. C. (1975) · The American Journal of Medicine · doi:10.1016/0002-9343(75)90127-8 · Cited by 155 · see citing works
Hemilä, H. (1992) · British Journal Of Nutrition · doi:10.1079/bjn19920004 · Cited by 143 · see citing works
Evaluation of the efficacy of ascorbic acid in prophylaxis of induced rhinovirus 44 infection in man
Schwartz, A. R., Togo, Y., Hornick, R. B., Tominaga, S., & Gleckman, R. A. (1973) · Journal of Infectious Diseases · doi:10.1093/infdis/128.4.500 · Cited by 74 · see citing works
Antihistaminic agents and ascorbic acid in the early treatment of the common cold
COWAN, D. W. (1950) · Journal of the American Medical Association · doi:10.1001/jama.1950.02910400013004 · Cited by 49 · see citing works
Self-citationZhu, Z., Zhu, X., Chu, Y., Zhang, B., & Chen, Y. (2025) · EClinicalMedicine · doi:10.1016/j.eclinm.2025.103479 · Cited by 4 · see citing works
- Authors
- COWAN, D. W., DIEHL, H. S., & BAKER, A. B.
- Venue
- Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1942-12-19
- Volume
- 120
- Issue
- 16
- Pages
- 1268
- ISSN
- 0002-9955 (ISSN-L)
- OpenAlex
- W2010388721
- Cited by
- 84
- References
- 7
- Citations by year
- 2026: 3 · 2025: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 2 · 2014: 1 · 2013: 1
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Keywords
- vitamin deficiency, common cold, cold prevention, infection resistance, vitamin A, vitamin D, cod liver oil, upper respiratory tract infection, vitamin supplementation
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