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Cited by 51Respiratory viral infections researchVitamin C and Antioxidants ResearchHerbal Medicine Research Studies

Antihistaminic agents and ascorbic acid in the early treatment of the common cold

COWAN, DONALD W.·1950·Journal of the American Medical Association
DOI 10.1001/jama.1950.02910400013004
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Abstract

Recently there has been widespread interest in the use of antihistaminic drugs in the treatment of the common cold. Several enthusiastic papers have appeared in the medical literature. These reports have been widely publicized in the lay press, and, since some of the antihistaminic drugs have been released for over-the-counter sale, a tremendous advertising campaign has gotten under way. Brewster's reports1of 1947 and 1949were on the use of diphenhydramine (benadryl®) hydrochloride, tripelennamine (pyribenzamine®) hydrochloride, pyranisamine maleate (neo-antergan®) and methapyrilene (histadyl® and thenylene®) hydrochloride. He was the first to emphasize the importance of the early use of these drugs in the treatment of the common cold. In his 1949 series, all symptoms were aborted in 19 of 21 patients who started medication within the first hour and in 48 of 55 patients who started medication within two hours of onset. One may reasonably ask how many of these patients

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Crossref · 10.1001/jama.1950.02910400013004

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4 of 4 references verified0 citation errors · 0 not checkable

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  • Cowan 1950 used a therapeutic dose of about 3 g/day in the first two days of illness and found no effect on common cold duration.

    “Cowan 1950 used a therapeutic dose of about 3 g/day in the first two days of illness with no effect on common cold duration.”

    From Vitamin C for preventing and treating the common cold (2013) · cites this paper as Cowan 1950

  • Several studies with 3 to 4 g/day failed to find therapeutic benefit.

    “Several studies with 3 to 4 g/day failed to find therapeutic benefit (Cowan 1950, Elwood 1977, Tyrrell 1977, Audera 2001).”

    From Vitamin C for preventing and treating the common cold (2013) · cites this paper as Cowan 1950

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Authors
COWAN, D. W.
Corresponding author
COWAN, DONALD W.
Venue
Journal of the American Medical Association
Publisher
American Medical Association (AMA)
Published
1950-06-03
Volume
143
Issue
5
Pages
421
ISSN
0002-9955 (ISSN-L)
DOI
10.1001/jama.1950.02910400013004
OpenAlex
W2083193829
Cited by
49
References
4
Citations by year
2021: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2013: 1
FWCI
18.04
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
  • Health Sciences › Medicine › Complementary and alternative medicine › Herbal Medicine Research Studies
Keywords
common cold, antihistamines, vitamin C, diphenhydramine, tripelennamine, methapyrilene, early treatment, over-the-counter drugs
MeSH terms
Ascorbic Acid, Common Cold, Histamine, Humans, Vitamins

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