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Excessive Intake of Zinc Impairs Immune Responses
Abstract
The effect of administration of large amounts of zinc on immune response and serum lipoproteins was examined. Eleven healthy adult men ingested 150 mg of elemental zinc twice a day for six weeks. This was associated with a reduction in lymphocyte stimulation response to phytohemagglutinin as well as chemotaxis and phagocytosis of bacteria by polymorphonuclear leukocytes. Serum high-density lipoprotein concentration decreased significantly and low-density lipoprotein level increased slightly. The common food fad of zinc supplementation with resultant excessive intake could have deleterious effects in healthy persons.
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Citations
Cited by
Zinc and immune function: the biological basis of altered resistance to infection
Shankar, A. H., & Prasad, A. S. (1998) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.2.447s · Cited by 1,606
Chandra, R. K. (1992) · The Lancet · doi:10.1016/0140-6736(92)93151-c · Cited by 523
Self-citationRetractedExercise, nutrition and immune function
Gleeson, M., Nieman, D. C., & Pedersen, B. K. (2004) · Journal of Sports Sciences · doi:10.1080/0264041031000140590 · Cited by 362
Effects of zinc supplementation on diabetes mellitus: A systematic review and meta-analysis
Jayawardena, R., Ranasinghe, P., Galappatthy, P., Malkanthi, R., Constantine, G., & Katulanda, P. (2012) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-4-13 · Cited by 346
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Sampson, B., Fagerhol, M. K., Sunderkötter, C., Golden, B. E., Richmond, P., Klein, N., Kovar, I. Z., Beattie, J. H., Wolska-Kusnierz, B., Saito, Y., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11683-7 · Cited by 122
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Thompson, C., & Fuhrman, M. P. (2005) · Nutrition in Clinical Practice · doi:10.1177/0115426505020003331 · Cited by 99
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Ahmad, R., Shaju, R., Atfi, A., & Razzaque, M. S. (2024) · Cells · doi:10.3390/cells13161359 · Cited by 77
Prentice, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01641 · Cited by 52
Ambra, R., Mocchegiani, E., Giacconi, R., Canali, R., Rinna, A., Malavolta, M., & Virgili, F. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.07.009 · Cited by 49
Shafiei Neek, L., Gaeini, A. A., & Choobineh, S. (2011) · Biological Trace Element Research · doi:10.1007/s12011-011-9138-2 · Cited by 48
Nutritional Strategies to Minimise Exercise-Induced Immunosuppression in Athletes
Gleeson, M., Lancaster, G. I., & Bishop, N. C. (2001) · Canadian Journal of Applied Physiology · doi:10.1139/h2001-039 · Cited by 43
Alterations of lipid metabolism in Wilson disease
Seessle, J., Gohdes, A., Gotthardt, D. N., Pfeiffenberger, J., Eckert, N., Stremmel, W., Reuner, U., & Weiss, K. H. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-83 · Cited by 42
Serum zinc and serum lipid profiles in 778 adults
Hiller, R., Seigel, D., Sperduto, R. D., Blair, N., Burton, T. C., Farber, M. D., Gragoudas, E. S., Gunter, E. W., Haller, J., Seddon, J. M., et al. (1995) · Annals of Epidemiology · doi:10.1016/1047-2797(95)00066-6 · Cited by 28
Metadata
- Authors
- Chandra, R. K.
- Venue
- JAMA: The Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1984-09-21
- Volume
- 252
- Issue
- 11
- Pages
- 1443
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1971775177
- Cited by
- 478
- References
- 0
- FWCI
- 8.69
- Type
- journal article
- Language
- en
- Open access
- closed
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