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Cited by 778Physical Activity and HealthDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and Research

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

A Prospective Study of Exercise and Incidence of Diabetes Among US Male Physicians

Manson, JoAnn E.·1992·JAMA: The Journal of the American Medical Association
DOI 10.1001/jama.1992.03490010065031
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Abstract

OBJECTIVE: To examine prospectively the association between regular exercise and the subsequent development of non-insulin-dependent diabetes mellitus (NIDDM). DESIGN: Prospective cohort study including 5 years of follow-up. PARTICIPANTS: 21,271 US male physicians participating in the Physicians' Health Study, aged 40 to 84 years and free of diagnosed diabetes mellitus, myocardial infarction, cerebrovascular disease, and cancer at baseline. Morbidity follow-up was 99.7% complete. MAIN OUTCOME MEASURE: Incidence of NIDDM. RESULTS: At baseline, information was obtained about frequency of vigorous exercise and other risk indicators. During 105,141 person-years of follow-up, 285 new cases of NIDDM were reported. The age-adjusted incidence of NIDDM ranged from 369 cases per 100,000 person-years in men who engaged in vigorous exercise less than once weekly to 214 cases per 100,000 person-years in those exercising at least five times per week (P, trend, less than .001). Men who exercised at least once per week had an age-adjusted relative risk (RR) of NIDDM of 0.64 (95% Cl, 0.51 to 0.82; P = .0003) compared with those who exercised less frequently. The age-adjusted RR of NIDDM decreased with increasing frequency of exercise: 0.77 for once weekly, 0.62 for two to four times per week, and 0.58 for five or more times per week (P, trend, .0002). A significant reduction in risk of NIDDM persisted after adjustment for both age and body-mass index: RR, 0.71 (95% Cl, 0.56 to 0.91; P = .006) for at least once per week compared with less than once weekly, and P, trend, .009, for increasing frequency of exercise. Further control for smoking, hypertension, and other coronary risk factors did not materially alter these associations. The inverse relation of exercise to risk of NIDDM was particularly pronounced among overweight men. CONCLUSIONS: Exercise appears to reduce the development of NIDDM even after adjusting for body-mass index. Increased physical activity may be a promising approach to the primary prevention of NIDDM.

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Metadata

Authors
Manson, J. E.
Corresponding author
Manson, JoAnn E.
ORCID
Manson, JoAnn E.
Venue
JAMA: The Journal of the American Medical Association
Publisher
American Medical Association (AMA)
Published
1992-07-01
Volume
268
Issue
1
Pages
63
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.1992.03490010065031
OpenAlex
W4242270851
Cited by
778
References
0
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 9 · 2020: 17 · 2019: 15 · 2018: 18 · 2017: 18 · 2016: 17 · 2015: 8 · 2014: 26 · 2013: 23 · 2012: 39
FWCI
9.47
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Cancer Institute (CA-40356)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 36798, R01DK036798)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
physical activity, type 2 diabetes, type 2 diabetes incidence, diabetes prevention, male physicians, body mass index, overweight, primary prevention, risk factors, smoking, hypertension, coronary risk factors, Physicians' Health Study, exercise frequency, high-intensity exercise, cancer risk reduction, quality of life
MeSH terms
Adult, Aged, Aged, 80 and over, Diabetes Mellitus, Type 2, Follow-Up Studies, Humans, Male, Middle Aged, Physicians, Prospective Studies, United States, Health Behavior, Exercise, Incidence, Logistic Models

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