Cited by 473Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsGenetic Associations and Epidemiology

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Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study

Wilson, Peter W. F.·1994·JAMA

DOI 10.1001/jama.1994.03520210050031

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Abstract

Objective To describe the association between apolipoprotein E alleles (epsilon 2, epsilon 3, and epsilon 4), dyslipidemias, and coronary heart disease (CHD). Design Cross-sectional prevalence study. Setting and participants Community-based sample of men (n = 1034) and women (n = 916) aged 40 to 77 years who are participating in a long-term study of cardiovascular disease. Study participants underwent fasting lipid measurements, coronary risk factor determinations, and a comprehensive evaluation for the presence of current or previous CHD. Results Compared with the epsilon 3 allele, the epsilon 4 allele was associated with elevated low-density lipoprotein cholesterol values (> or = 4.14 mmol/L [160 mg/dL]) in women, the epsilon 2 and epsilon 4 alleles were associated with moderately elevated triglyceride values (> or = 2.82 mmol/L [250 mg/dL]) in men, and the epsilon 2 allele was associated with severely elevated triglyceride values (> or = 5.64 mmol/L [500 mg/dL]) in men. The apolipoprotein E alleles were not associated with hypertension, obesity, smoking, or diabetes, but the epsilon 4 allele frequency was reduced in women after 60 years of age. The age-adjusted prevalence of CHD was associated with the epsilon 4 allele in both men (relative odds = 1.53, P = .04) and women (relative odds = 1.99, P = .05). In analyses for women and for both sexes combined, this relation persisted after adjustment by hypertension, smoking, obesity, diabetes, high-density lipoprotein cholester…

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Authors: Wilson, P. W. F.
Corresponding author: Wilson, Peter W. F.
ORCID: Wilson, Peter W. F.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 1994-12-07
Volume: 272
Issue: 21
Pages: 1666
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1994.03520210050031
OpenAlex: W4237709179
Cited by: 468
References: 59
Citations by year: 2025: 1 · 2024: 3 · 2023: 10 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 2 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 14 · 2012: 9
FWCI: 21.68
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: apolipoprotein E, apolipoprotein E ε4 allele, dyslipidemia, coronary artery disease, LDL cholesterol, triglycerides, sex differences, genetic risk factors, Framingham Offspring Study

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Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study

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