Cited by 473Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsGenetic Associations and Epidemiology

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Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study

Wilson, Peter W. F.·1994·JAMA

DOI 10.1001/jama.1994.03520210050031

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Abstract

Objective To describe the association between apolipoprotein E alleles (epsilon 2, epsilon 3, and epsilon 4), dyslipidemias, and coronary heart disease (CHD). Design Cross-sectional prevalence study. Setting and participants Community-based sample of men (n = 1034) and women (n = 916) aged 40 to 77 years who are participating in a long-term study of cardiovascular disease. Study participants underwent fasting lipid measurements, coronary risk factor determinations, and a comprehensive evaluation for the presence of current or previous CHD. Results Compared with the epsilon 3 allele, the epsilon 4 allele was associated with elevated low-density lipoprotein cholesterol values (> or = 4.14 mmol/L [160 mg/dL]) in women, the epsilon 2 and epsilon 4 alleles were associated with moderately elevated triglyceride values (> or = 2.82 mmol/L [250 mg/dL]) in men, and the epsilon 2 allele was associated with severely elevated triglyceride values (> or = 5.64 mmol/L [500 mg/dL]) in men. The apolipoprotein E alleles were not associated with hypertension, obesity, smoking, or diabetes, but the epsilon 4 allele frequency was reduced in women after 60 years of age. The age-adjusted prevalence of CHD was associated with the epsilon 4 allele in both men (relative odds = 1.53, P = .04) and women (relative odds = 1.99, P = .05). In analyses for women and for both sexes combined, this relation persisted after adjustment by hypertension, smoking, obesity, diabetes, high-density lipoprotein cholester…

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Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786
Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol.
Warnick, G. R., Benderson, J., & Albers, J. J. (1982) · Clinical Chemistry · doi:10.1093/clinchem/28.6.1379 · Cited by 2,154
Apolipoprotein E polymorphism and atherosclerosis.
Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981
Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.
Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9649 · Cited by 1,525
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.
Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8098 · Cited by 1,363
Untitled work
(1985) · PubMed · Cited by 706
Abnormal lipoprotein receptor‐binding activity of the human E apoprotein due to cysteine‐arginine interchange at a single site
Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34954-8 · Cited by 673
Hyperlipidemia in Coronary Heart Disease I. LIPID LEVELS IN 500 SURVIVORS OF MYOCARDIAL INFARCTION
Goldstein, J. L., Hazzard, W. R., Schrott, H. G., Bierman, E. L., & Motulsky, A. G. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107331 · Cited by 621
Automated enzymatic standardized lipid analyses for plasma and lipoprotein fractions
McNamara, J. R., & Schaefer, E. J. (1987) · Clinica Chimica Acta · doi:10.1016/0009-8981(87)90188-4 · Cited by 524
Modulation of plasma triglyceride levels by apoE phenotype: a meta-analysis.
Dallongeville, J., Lussier‐Cacan, S., & Davignon, J. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41611-6 · Cited by 444
Polymorphism of apolipoprotein E
Utermann, G., Vogelberg, K. H., Steinmetz, A., Schoenborn, W., Pruin, N., Jaeschke, M., Hees, M. T. I. W. S.-V., & Canzler, H. (1979) · Clinical Genetics · doi:10.1111/j.1399-0004.1979.tb02027.x · Cited by 408
Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations.
Ehnholm, C., Lukka, M., Kuusi, T., Nikkilä, E. A., & Utermann, G. (1987) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38833-7 · Cited by 403
Apolipoprotein E polymorphism and coronary artery disease.
Menzel, H. J., Kladetzky, R. G., & Assmann, G. (1983) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.3.4.310 · Cited by 344
NIH Consensus conference. Triglyceride, high-density lipoprotein, and coronary heart disease. NIH Consensus Development Panel on Triglyceride, High-Density Lipoprotein, and Coronary Heart Disease
(1993) · JAMA · doi:10.1001/jama.269.4.505 · Cited by 316
Apolipoprotein E polymorphisms affect atherosclerosis in young males. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group.
Hixson, J. E. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.5.1237 · Cited by 286
The use of measured genotype information in the analysis of quantitative phenotypes in man.
Boerwinkle, E., & Sing, C. F. (1987) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1987.tb00874.x · Cited by 277
Untitled work
(1988) · PubMed · Cited by 250
Polymorphism at the Apoprotein‐E locus in relation to risk of coronary disease
Cumming, A. M., & Robertson, F. W. (1984) · Clinical Genetics · doi:10.1111/j.1399-0004.1984.tb01995.x · Cited by 249
Relation of apolipoprotein E phenotype to myocardial infarction and mortality from coronary artery disease
Eichner, J. E., Kuller, L. H., Orchard, T. J., Grandits, G. A., McCallum, L. M., Ferrell, R. E., & Neaton, J. D. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)90732-r · Cited by 247
Apolipoprotein E isoform phenotyping methodology and population frequency with identification of apoE1 and apoE5 isoforms
Ordovas, J. M., Litwack-Klein, L., Wilson, P. W., Schaefer, M. M., & Schaefer, E. J. (1987) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38690-9 · Cited by 238
Self-citation
Type III Hyperlipoproteinemia: Diagnosis, Molecular Defects, Pathology, and Treatment
BREWER, H. B., ZECH, L. A., GREGG, R. E., SCHWARTZ, D., & SCHAEFER, E. J. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-98-5-623 · Cited by 226
Effects of gender and menopausal status on the association of apolipoprotein E phenotype with plasma lipoprotein levels. Results from the Framingham Offspring Study.
Schaefer, E. J., Lamon‐Fava, S., Johnson, S., Ordovás, J. M., Schaefer, M. M., Castelli, W. P., & Wilson, P. W. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.7.1105 · Cited by 198
Self-citation
Apolipoprotein ∈4 homozygosity in young men with coronary heart disease
BOCKXMEER, F. M. V., & Mamotte, C. D. S. (1992) · The Lancet · doi:10.1016/0140-6736(92)93288-x · Cited by 191
Association of apolipoprotein E polymorphism, low-density lipoprotein cholesterol, and coronary artery disease.
Lenzen, H. J., Assmann, G., Buchwalsky, R., & Schulte, H. (1986) · Clinical Chemistry · doi:10.1093/clinchem/32.5.778 · Cited by 180
Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians.
Louhija, J., Miettinen, H. E., KONTULA, K. K., Tikkanen, M. J., Miettinen, T. A., & Tilvis, R. S. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.7.1084 · Cited by 172
Apoprotein E polymorphism and coronary artery disease. Increased prevalence of apolipoprotein E-4 in angiographically verified coronary patients.
Kuusi, T., Nieminen, M. S., Ehnholm, C., Yki‐Järvinen, H., Valle, M., Nikkilä, E. A., & Taskinen, M. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.2.237 · Cited by 159
The Prevalence of High Blood Cholesterol Levels Among Adults in the United States
Sempos, C. T. (1989) · JAMA · doi:10.1001/jama.1989.03430010057031 · Cited by 159
Apolipoprotein E phenotypes in patients with myocardial infarction
Utermann, G., Hardewig, A., & Zimmer, F. (1984) · Human Genetics · doi:10.1007/bf00286509 · Cited by 150
Apolipoprotein E polymorphism and hyperlipidemia.
Assmann, G., Schmitz, G., Menzel, H. J., & Schulte, H. (1984) · Clinical Chemistry · doi:10.1093/clinchem/30.5.641 · Cited by 135
The response to lovastatin treatment in patients with heterozygous familial hypercholesterolemia is modulated by apolipoprotein E polymorphism
Carmena, R., Roederer, G. O., Mailloux, H., Lussier‐Cacan, S., & Davignon, J. (1993) · Metabolism · doi:10.1016/0026-0495(93)90066-w · Cited by 117
Apolipoprotein E in Hyperlipidemia
Walden, C. C., & Hegele, R. A. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-120-12-199406150-00009 · Cited by 110
Increased prevalence of apolipoprotein E4 in type V hyperlipoproteinemia.
Ghiselli, G., Schaefer, E. J., Zech, L. A., Gregg, R. E., & Brewer, H. B. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110638 · Cited by 108
Impact of National Guidelines for Cholesterol Risk Factor Screening
Wilson, P. W. F. (1989) · JAMA · doi:10.1001/jama.262.1.41 · Cited by 100
Self-citation
Lipoproteins and their genetic variation in subjects with and without angiographically verified coronary artery disease.
Nieminen, M. S., Mattila, K. J., Aalto‐Setälä, K., Kuusi, T., Kontula, K., Kauppinen-Mäkelin, R., Ehnholm, C., Jauhiainen, M., Valle, M., & Taskinen, M. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.1.58 · Cited by 96
The influence of apolipoprotein E phenotype on the response to lovastatin therapy in patients with heterozygous familial hypercholesterolemia
O'Malley, J. P., & Illingworth, D. R. (1990) · Metabolism · doi:10.1016/0026-0495(90)90068-n · Cited by 88
Apolipoprotein E phenotype is related to macro- and microangiopathy in patients with non-insulin-dependent diabetes mellitus
Ukkola, O. H., Kervinen, K., Salmela, P. I., von Dickhoff, K., Laakso, M., & Kesäniemi, Y. A. (1993) · Atherosclerosis · doi:10.1016/0021-9150(93)90096-d · Cited by 86
Genetic Defects in Lipoprotein Metabolism
Mahley, R. W. (1991) · JAMA · doi:10.1001/jama.265.1.78 · Cited by 84
Increased frequencies of apolipoprotein ε2 and ε4 alleles in patients with ischemic heart disease
Eto, M., Watanabe, K., & Makino, I. (1989) · Clinical Genetics · doi:10.1111/j.1399-0004.1989.tb03186.x · Cited by 83
Influence of apo E polymorphism on the response to simvastatin treatment in patients with heterozygous familial hypercholesterolemia
Kniiff, P. D., Stalenhoef, A. F. H., Mol, M. J. T. M., Leuven, J. A. G., Smit, J. W. A., Erkelens, D. W., Schouten, J., Frants, R. R., & Havekes, L. M. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90134-5 · Cited by 83
Impact of apolipoprotein E polymorphism in determining interindividual variation in total cholesterol and low density lipoprotein cholesterol in Hispanics and non-Hispanic whites
Kamboh, M. I., Aston, C. E., Ferrell, R. E., & Hamman, R. F. (1993) · Atherosclerosis · doi:10.1016/0021-9150(93)90129-i · Cited by 78
Influence of dietary fat, apolipoprotein E phenotype, and sex on plasma lipoprotein levels.
Cobb, M. M., Teitlebaum, H., RISCH, N. J., Jekel, J., & Ostfeld, A. M. (1992) · Circulation · doi:10.1161/01.cir.86.3.849 · Cited by 78
Effect of apolipoprotein E polymorphism and Xbal polymorphism of apolipoprotein B on response to lovastatin treatment in familial and non‐familial hypercholesterolaemia
Ojala, J.-P., Helve, E., Ehnholm, C., Aalto‐Setälä, K., KONTULA, K. K., & Tikkanen, M. J. (1991) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1991.tb00464.x · Cited by 73
Logistic discriminant analysis of lipids and apolipoproteins in a population of coronary bypass patients and the significance of apolipoproteins C-III and E
Chivot, L., Mainard, F., Bigot‐Corbel, E., Bard, J., Auget, J.-L., Madec, Y., & Fruchart, J. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90042-h · Cited by 60
Phenotypic effects of apolipoprotein structural variation on lipid profiles. III. Contribution of apolipoprotein E phenotype to prediction of total cholesterol, apolipoprotein B, and low density lipoprotein cholesterol in the healthy women study.
Eichner, J. E., Kuller, L. H., Ferrell, R. E., Meilahn, E. N., & Kamboh, M. I. (1990) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.10.3.379 · Cited by 54
Fluorescence flow cytometry of human leukocytes in the detection of LDL receptor defects in the differential diagnosis of hypercholesterolemia.
Schmitz, G., Brüning, T., Kovacs, E., & Barlage, S. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.7.1053 · Cited by 44
Apolipoprotein E Polymorphism Modifies Relation of Hyperinsulinemia to Hypertriglyceridemia
Després, J., Verdon, M.-F., Moorjani, S., Pouliot, M., Nadeau, A., Bouchard, C., Tremblay, A., & Lupien, P. J. (1993) · Diabetes · doi:10.2337/diab.42.10.1474 · Cited by 43
Apolipoprotein E phenotypes, serum lipoproteins and apolipoproteins. in angiographically assessed coronary heart disease
Stuyt, P. M. J., Brenninkmeijer, B. J., Demacker, P. N. M., Hendriks, J. C. M., van Elteren, P., Stalenhoef, A. F. H., & Laar, A. V. '. (1991) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519109091636 · Cited by 32
Hyperlipoproteinemia as a risk factor for ischemic heart disease.
Yamamura, T., Tajima, S., Miyake, Y., NOMURA, S., Yamamoto, A., Haze, K., & Hiramori, K. (1990) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.54.448 · Cited by 21
Gender differences in a Type 2 (non-insulin-dependent) diabetic population with respect to apolipoprotein E phenotype frequencies
Boemi, M., James, R. W., Romagnoli, F., Gerber, P., Pometta, D., & Fumelli, P. (1993) · Diabetologia · doi:10.1007/bf00399955 · Cited by 18
Apolipoprotein E phenotypes in hyperlipidaemic patients and their implications for treatment
Janus, E. D., Grant, S., Lintott, C. J., & Wardell, M. R. (1985) · Atherosclerosis · doi:10.1016/0021-9150(85)90038-3 · Cited by 15
Pediatric familial type III hyperlipoproteinemia
Glueck, C. J., Fallat, R. W., Mellies, M. J., & Steiner, P. M. (1976) · Metabolism · doi:10.1016/s0026-0495(76)80010-8 · Cited by 13
The rapid molecular diagnosis of genetic cardiovascular risk factors
Funke, H., & Assmann, G. (1993) · Current Opinion in Lipidology · doi:10.1097/00041433-199312000-00006 · Cited by 5
Risk Factors for Atherosclerotic Vascular Diseases with Special Reference to the Relationship between Apolipoprotein E Mutations and Hyperlipidemia
Yamamoto, A., Yamamura, T., & Tajima, S. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb42276.x · Cited by 4

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Authors: Wilson, P. W. F.
Corresponding author: Wilson, Peter W. F.
ORCID: Wilson, Peter W. F.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 1994-12-07
Volume: 272
Issue: 21
Pages: 1666
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1994.03520210050031
OpenAlex: W4237709179
Cited by: 468
References: 59
Citations by year: 2025: 1 · 2024: 3 · 2023: 10 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 2 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 14 · 2012: 9
FWCI: 21.68
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: apolipoprotein E, apolipoprotein E ε4 allele, dyslipidemia, coronary artery disease, LDL cholesterol, triglycerides, sex differences, genetic risk factors, Framingham Offspring Study

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Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study

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