Cited by 1,425Influenza Virus Research StudiesRespiratory Support and MechanismsRespiratory viral infections research

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Critically Ill Patients With 2009 Influenza A(H1N1) Infection in Canada

Kumar, Anand·2009·JAMA

DOI 10.1001/jama.2009.1496

Open this paper in CoChat — free account

Abstract

CONTEXT: Between March and July 2009, the largest number of confirmed cases of 2009 influenza A(H1N1) infection occurred in North America. OBJECTIVE: To describe characteristics, treatment, and outcomes of critically ill patients in Canada with 2009 influenza A(H1N1) infection. DESIGN, SETTING, AND PATIENTS: A prospective observational study of 168 critically ill patients with 2009 influenza A(H1N1) infection in 38 adult and pediatric intensive care units (ICUs) in Canada between April 16 and August 12, 2009. MAIN OUTCOME MEASURES: The primary outcome measures were 28-day and 90-day mortality. Secondary outcomes included frequency and duration of mechanical ventilation and duration of ICU stay. RESULTS: Critical illness occurred in 215 patients with confirmed (n = 162), probable (n = 6), or suspected (n = 47) community-acquired 2009 influenza A(H1N1) infection. Among the 168 patients with confirmed or probable 2009 influenza A(H1N1), the mean (SD) age was 32.3 (21.4) years; 113 were female (67.3%) and 50 were children (29.8%). Overall mortality among critically ill patients at 28 days was 14.3% (95% confidence interval, 9.5%-20.7%). There were 43 patients who were aboriginal Canadians (25.6%). The median time from symptom onset to hospital admission was 4 days (interquartile range [IQR], 2-7 days) and from hospitalization to ICU admission was 1 day (IQR, 0-2 days). Shock and nonpulmonary acute organ dysfunction was common (Sequential Organ Failure Assessment mean [SD] score of 6.8 [3.6] on day 1). Neuraminidase inhibitors were administered to 152 patients (90.5%). All patients were severely hypoxemic (mean [SD] ratio of Pao(2) to fraction of inspired oxygen [Fio(2)] of 147 [128] mm Hg) at ICU admission. Mechanical ventilation was received by 136 patients (81.0%). The median duration of ventilation was 12 days (IQR, 6-20 days) and ICU stay was 12 days (IQR, 5-20 days). Lung rescue therapies included neuromuscular blockade (28% of patients), inhaled nitric oxide (13.7%), high-frequency oscillatory ventilation (11.9%), extracorporeal membrane oxygenation (4.2%), and prone positioning ventilation (3.0%). Overall mortality among critically ill patients at 90 days was 17.3% (95% confidence interval, 12.0%-24.0%; n = 29). CONCLUSION: Critical illness due to 2009 influenza A(H1N1) in Canada occurred rapidly after hospital admission, often in young adults, and was associated with severe hypoxemia, multisystem organ failure, a requirement for prolonged mechanical ventilation, and the frequent use of rescue therapies.

Integrity signals

Registry

Crossref · 10.1001/jama.2009.1496

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

APACHE II-A Severity of Disease Classification System
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00028 · Cited by 13,379
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
Kumar, A., Roberts, D., Wood, K. E., Light, B., Parrillo, J. E., Sharma, S., Suppes, R., Feinstein, D., Zanotti, S., Taiberg, L., et al. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000217961.75225.e9 · Cited by 6,109
Self-citation
The epidemiology of sepsis in the United States from 1979 through 2000
Martin, G. S., Mannino, D. M., Eaton, S., & Moss, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022139 · Cited by 5,841
Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans
Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0903810 · Cited by 3,063
Influenza-Associated Hospitalizations in the United States
Thompson, W. W. (2004) · JAMA · doi:10.1001/jama.292.11.1333 · Cited by 2,213
Updating the accounts: global mortality of the 1918–1920 "Spanish" influenza pandemic.
Johnson, N. P. A. S., & Mueller, J. (2002) · Bulletin of the History of Medicine · doi:10.1353/bhm.2002.0022 · Cited by 1,980
PRISM III
Pollack, M. M., Patel, K. M., & Ruttimann, U. E. (1996) · Critical Care Medicine · doi:10.1097/00003246-199605000-00004 · Cited by 1,790
Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: Recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America
Kaplan, J. E., Benson, C. A., Holmes, K. K., Brooks, J. T., Pau, A. K., & Masur, H. (2009) · PsycEXTRA Dataset · doi:10.1037/e537722009-001 · Cited by 1,341
APACHE II-A Severity of Disease Classification System
Gall, J. L., Loirat, P., & Alpcrovitch, A. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00027 · Cited by 1,253
Association Between Hyperglycemia and Increased Hospital Mortality in a Heterogeneous Population of Critically Ill Patients
Krinsley, J. S. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.12.1471 · Cited by 1,165

Show all 47 references

Sorted by citations

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study
Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Wu, Y., Zhang, L., Yu, Z., Fang, M., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30079-5 · Cited by 10,066
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827e83af · Cited by 9,694
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Intensive Care Medicine · doi:10.1007/s00134-012-2769-8 · Cited by 7,371
Kidney disease is associated with in-hospital death of patients with COVID-19
Cheng, Y., Luo, R., Wang, K., Zhang, M., Wang, Z., Dong, L., Li, J., Yao, Y., Ge, S., & Xu, G. (2020) · Kidney International · doi:10.1016/j.kint.2020.03.005 · Cited by 3,016
Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices—United States, 2018–19 Influenza Season
Grohskopf, L. A., Sokolow, L. Z., Broder, K. R., Walter, E. B., Fry, A. M., & Jernigan, D. B. (2018) · MMWR Recommendations and Reports · doi:10.15585/mmwr.rr6703a1 · Cited by 1,640
Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis
Langford, B. J., So, M., Raybardhan, S., Leung, V., Westwood, D. J., MacFadden, D. R., Soucy, J.-P. R., & Daneman, N. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.07.016 · Cited by 1,589
Critical care and the global burden of critical illness in adults
Adhikari, N. K. J., Fowler, R., Bhagwanjee, S., & Rubenfeld, G. D. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60446-1 · Cited by 1,371
Viral pneumonia
Ruuskanen, O., Lahti, E., Jennings, L., & Murdoch, D. R. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61459-6 · Cited by 1,241
Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection
Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic (H1N1) 2009 Influenza (2010) · New England Journal of Medicine · doi:10.1056/nejmra1000449 · Cited by 1,056
Pandemic 2009 Influenza A(H1N1) Virus Illness Among Pregnant Women in the United States
Siston, A. M. (2010) · JAMA · doi:10.1001/jama.2010.479 · Cited by 1,031
Referral to an Extracorporeal Membrane Oxygenation Center and Mortality Among Patients With Severe 2009 Influenza A(H1N1)
Noah, M. A., Peek, G. J., Finney, S. J., Griffiths, M., Harrison, D. A., Grieve, R., Sadique, Z., Sekhon, J. S., McAuley, D. F., Firmin, R. K., et al. (2011) · JAMA · doi:10.1001/jama.2011.1471 · Cited by 838
Impact of Treatment Strategy on Outcomes in Patients with Candidemia and Other Forms of Invasive Candidiasis: A Patient-Level Quantitative Review of Randomized Trials
Andes, D. R., Safdar, N., Baddley, J. W., Playford, G., Reboli, A. C., Rex, J. H., Sobel, J. D., Pappas, P. G., Kullberg, B. J., & for the Mycoses Study Group (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis021 · Cited by 793
The co-pathogenesis of influenza viruses with bacteria in the lung.
McCullers, J. A. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3231 · Cited by 722
Risk Factors for Severe Outcomes following 2009 Influenza A (H1N1) Infection: A Global Pooled Analysis
Kerkhove, M. D. V., Vandemaele, K., Shinde, V., Jaramillo-Gutierrez, G., Koukounari, A., Donnelly, C. A., Carlino, L. O., Owen, R., Paterson, B., Pelletier, L., et al. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001053 · Cited by 707
Severe 2009 H1N1 Influenza in Pregnant and Postpartum Women in California
Louie, J. K., Acosta, M., Jamieson, D. J., & Honein, M. A. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0910444 · Cited by 650
Critical care crisis and some recommendations during the COVID-19 epidemic in China
Xie, J., Tong, Z., Guan, X., Du, B., Qiu, H., & Slutsky, A. S. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05979-7 · Cited by 628
Prevention and Control of Seasonal Influenza with Vaccines
Grohskopf, L. A., Sokolow, L. Z., Broder, K. R., Olsen, S. J., Karron, R. A., Jernigan, D. B., & Bresee, J. (2016) · MMWR Recommendations and Reports · doi:10.15585/mmwr.rr6505a1 · Cited by 602
Pandemic Preparedness and Response — Lessons from the H1N1 Influenza of 2009
Fineberg, H. V. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1208802 · Cited by 562
Influenza virus-related critical illness: pathophysiology and epidemiology
Kalil, A. C., & Thomas, P. G. (2019) · Critical Care · doi:10.1186/s13054-019-2539-x · Cited by 524
Projecting hospital utilization during the COVID-19 outbreaks in the United States
Moghadas, S. M., Shoukat, A., Fitzpatrick, M. C., Wells, C. R., Sah, P., Pandey, A., Sachs, J. D., Wang, Z., Meyers, L. A., Singer, B. H., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004064117 · Cited by 493
Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia.
Hanada, S., Pirzadeh, M., Carver, K. Y., & Deng, J. C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02640 · Cited by 495
Morbid Obesity as a Risk Factor for Hospitalization and Death Due to 2009 Pandemic Influenza A(H1N1) Disease
Morgan, O. W., Bramley, A. M., Fowlkes, A. L., Freedman, D. S., Taylor, T. H., Gargiullo, P. M., Belay, B., Jain, S., Cox, C. L., Kamimoto, L., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009694 · Cited by 445
Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps
Jenne, C. N., Wong, C. H. Y., Zemp, F. J., McDonald, B., Rahman, M. M., Forsyth, P. A., McFadden, G., & Kubes, P. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.01.005 · Cited by 457
COVID-19 and multiorgan failure: A narrative review on potential mechanisms
Mokhtari, T., Hassani, F., Ghaffari, N., Ebrahimi, B., Yarahmadi, A., & Hassanzadeh, G. (2020) · Journal of Molecular Histology · doi:10.1007/s10735-020-09915-3 · Cited by 449
2009 Pandemic Influenza A (H1N1)
Shieh, W.-J., Blau, D. M., Denison, A. M., DeLeon-Carnes, M., Adem, P., Bhatnagar, J., Sumner, J., Liu, L., Patel, M., Batten, B., et al. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100115 · Cited by 429
A Novel Risk Factor for a Novel Virus: Obesity and 2009 Pandemic Influenza A (H1N1)
Louie, J. K., Acosta, M. Y., Samuel, M., Schechter, R., Vugia, D. J., Harriman, K. H., Matyas, B. T., & the California Pandemic (H1N1) Working Group (2011) · Clinical Infectious Diseases · doi:10.1093/cid/ciq152 · Cited by 425
Mortality from pandemic A/H1N1 2009 influenza in England: public health surveillance study
Donaldson, L. J., Rutter, P. D., Ellis, B. M., Greaves, F., Mytton, O. T., Pebody, R. G., & Yardley, I. E. (2009) · BMJ · doi:10.1136/bmj.b5213 · Cited by 421
Prevention and control of seasonal influenza with vaccines. Recommendations of the Advisory Committee on Immunization Practices--United States, 2013-2014.
Grohskopf, L. A., Shay, D. K., Shimabukuro, T. T., Sokolow, L. Z., Keitel, W. A., Bresee, J., & Cox, N. J. (2013) · PubMed · Cited by 471
Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States.
Rice, T. W., Rubinson, L., Uyeki, T. M., Vaughn, F. L., John, B. B., Miller, R. R., Higgs, E., Randolph, A. G., Smoot, B. E., & Thompson, B. T. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182416f23 · Cited by 391
Bacterial Coinfection in Influenza: A Grand Rounds Review
Chertow, D. S., & Memoli, M. J. (2013) · JAMA · doi:10.1001/jama.2012.194139 · Cited by 390
Managing ICU surge during the COVID-19 crisis: Rapid guidelines.
Aziz, S., Arabi, Y. M., Alhazzani, W., Evans, L., Citerio, G., Fischkoff, K., Salluh, J., Meyfroidt, G., Alshamsi, F., Oczkowski, S., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06092-5 · Cited by 380
Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza
Bermejo-Martín, J. F., de Lejarazu, R. O., Pumarola, T., Rello, J., Almansa, R., Ramírez, P., Martín‐Loeches, I., Varillas‐Delgado, D., Gallegos, M. C., Arbeloa, C. S., et al. (2009) · Critical Care · doi:10.1186/cc8208 · Cited by 373
The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks
Patroniti, N. A., Zangrillo, A., Pappalardo, F., Peris, A., Cianchi, G., Braschi, A., Iotti, G. A., Arcadipane, A. F., Panarello, G., Ranieri, V. M., et al. (2011) · Intensive Care Medicine · doi:10.1007/s00134-011-2301-6 · Cited by 359
Outcomes from pandemic influenza A H1N1 infection in recipients of solid-organ transplants: a multicentre cohort study
Kumar, D., Michaels, M. G., Morris, M. I., Green, M., Avery, R. K., Liu, C., Danziger‐Isakov, L. A., Stosor, V., Estabrook, M., Gantt, S. M., et al. (2010) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(10)70133-x · Cited by 361
Diabetes and the Severity of Pandemic Influenza A (H1N1) Infection
Allard, R., Leclerc, P., Tremblay, C., & Tannenbaum, T.-N. (2010) · Diabetes Care · doi:10.2337/dc09-2215 · Cited by 297
Comparison of Hospitalized Patients With ARDS Caused by COVID-19 and H1N1
Tang, X., Du, R.-H., Wang, R., Cao, T., Guan, L., Yang, C.-Q., Zhu, Q., Hu, M., Li, X.-Y., Li, Y., et al. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.03.032 · Cited by 339
2009 pandemic influenza A (H1N1) in pregnancy: a systematic review of the literature
Mosby, L. G., Rasmussen, S. A., & Jamieson, D. J. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.12.033 · Cited by 343
Early Corticosteroids in Severe Influenza A/H1N1 Pneumonia and Acute Respiratory Distress Syndrome
Brun‐Buisson, C., Richard, J.-C., Mercat, A., Thiébaut, A. C. M., & Brochard, L. J. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201101-0135oc · Cited by 335
The role of pneumonia and secondary bacterial infection in fatal and serious outcomes of pandemic influenza a(H1N1)pdm09.
MacIntyre, C. R., Chughtai, A. A., Barnes, M., Ridda, I., Seale, H., Toms, R., & Heywood, A. (2018) · BMC Infectious Diseases · doi:10.1186/s12879-018-3548-0 · Cited by 323
Severity of 2009 Pandemic Influenza A (H1N1) Virus Infection in Pregnant Women
Creanga, A. A., Johnson, T. F., Graitcer, S. B., Hartman, L. K., Al‐Samarrai, T., Schwarz, A. G., Chu, S. Y., Sackoff, J. E., Jamieson, D. J., Fine, A. D., et al. (2010) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3181d57947 · Cited by 322
International Journal of Collaborative Research on Internal Medicine & Public Health
Valdivia, J. R. M. (2021) · Journal of Womens Health Issues and Care · Cited by 300
Epidemiology, microbiology, and treatment considerations for bacterial pneumonia complicating influenza
Metersky, M. L., Masterton, R. G., Lode, H., File, T. M., & Babinchak, T. (2012) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2012.01.003 · Cited by 293
Platelets in inflammation and infection
Jenne, C. N., & Kubes, P. (2015) · Platelets · doi:10.3109/09537104.2015.1010441 · Cited by 272
Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection
Zarychanski, R., Stuart, T. L., Kumar, A., Doucette, S. P., Elliott, L. J., Kettner, J., & Plummer, F. A. (2010) · Canadian Medical Association Journal · doi:10.1503/cmaj.091884 · Cited by 270
Self-citation
Corticosteroids as adjunctive therapy in the treatment of influenza
Rodrigo, C., Leonardi‐Bee, J., Nguyen‐Van‐Tam, J. S., & Lim, W. S. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010406.pub2 · Cited by 267
Invasive pulmonary aspergillosis is a frequent complication of critically ill H1N1 patients: a retrospective study
Wauters, J., Baar, I., Meersseman, P., Meersseman, W., Dams, K., Paep, R. D., Lagrou, K., Wilmer, A. P., Jorens, P. G., & Hermans, G. (2012) · Intensive Care Medicine · doi:10.1007/s00134-012-2673-2 · Cited by 268
Critical care management of adults with community-acquired severe respiratory viral infection
Arabi, Y. M., Fowler, R., & Hayden, F. G. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05943-5 · Cited by 263
Elevated 17β-Estradiol Protects Females from Influenza A Virus Pathogenesis by Suppressing Inflammatory Responses
Robinson, D. P., Lorenzo, M. E., Jian, W., & Klein, S. L. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002149 · Cited by 269
Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009)
Nguyen‐Van‐Tam, J. S., Openshaw, P., Hashim, A., Gadd, E. M., Lim, W. S., Semple, M. G., Read, R. C., Taylor, B. L., Brett, S. J., McMenamin, J., et al. (2010) · Thorax · doi:10.1136/thx.2010.135210 · Cited by 245
High frequency oscillation in patients with acute lung injury and acute respiratory distress syndrome (ARDS): systematic review and meta-analysis
Sud, S., Sud, M. K., Friedrich, J. O., Meade, M., Ferguson, N. D., Wunsch, H., & Adhikari, N. K. J. (2010) · BMJ · doi:10.1136/bmj.c2327 · Cited by 245
Clinical course and predictors of 60-day mortality in 239 critically ill patients with COVID-19: a multicenter retrospective study from Wuhan, China
Xu, J., Yang, X., Yang, L., Zou, X., Wang, Y., Wu, Y., Zhou, T., Yuan, Y., Qi, H., Fu, S., et al. (2020) · Critical Care · doi:10.1186/s13054-020-03098-9 · Cited by 239
Complications of seasonal and pandemic influenza
Rothberg, M. B., & Haessler, S. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181c92eeb · Cited by 238
Obesity is associated with higher risk of intensive care unit admission and death in influenza A (H1N1) patients: a systematic review and meta-analysis
Fezeu, L., Julia, C., Henegar, A., Bitu, J., Hu, F. B., Grobbee, D. E., Kengne, A. P., Herçberg, S., & Czernichow, S. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00864.x · Cited by 236
Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications
Iwasaki, M., Saito, J., Zhao, H., Sakamoto, A., Hirota, K., & Ma, D. (2020) · Inflammation · doi:10.1007/s10753-020-01337-3 · Cited by 234
Pandemic 2009 Influenza A in Argentina: A Study of 337 Patients on Mechanical Ventilation
Estenssoro, E., Ríos, F. G., Apezteguía, C., Reina, R., Neira, J., Ceraso, D. H., Orlandi, C., Valentini, R., Tiribelli, N., Brizuela, M., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/201001-0037oc · Cited by 230
Acute respiratory distress syndrome: new definition, current and future therapeutic options.
Fanelli, V., Vlachou, A., Ghannadian, S., Simonetti, U., Slutsky, A. S., & Zhang, H. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2072-1439.2013.04.05 · Cited by 235
Clinical aspects and cytokine response in severe H1N1 influenza A virus infection
Hagău, N., Slavcovici, A., Gonganau, D. N., Oltean, S., Dîrzu, D. S., Brezoszki, E. S., Maxim, M., Ciuce, C., Mleșnițe, M., Gavrus, R. L., et al. (2010) · Critical Care · doi:10.1186/cc9324 · Cited by 227
2009 H1N1 Influenza
Sullivan, S. J., Jacobson, R. M., Dowdle, W. R., & Poland, G. A. (2009) · Mayo Clinic Proceedings · doi:10.4065/mcp.2009.0588 · Cited by 228
Critically Ill Children During the 2009–2010 Influenza Pandemic in the United States
Randolph, A. G., Vaughn, F., Sullivan, R., Rubinson, L., Thompson, B. T., Yoon, G., Smoot, E., Rice, T. W., Loftis, L. L., Helfaer, M., et al. (2011) · Pediatrics · doi:10.1542/peds.2011-0774 · Cited by 222
Mechanisms of sex disparities in influenza pathogenesis
Klein, S. L., Hodgson, A., & Robinson, D. P. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0811427 · Cited by 219
Corticosteroid Treatment in Critically Ill Patients with Pandemic Influenza A/H1N1 2009 Infection: Analytic Strategy Using Propensity Scores
Kim, S.-H., Hong, S., Yun, S.-C., Choi, W.-I., Ahn, J.-J., Lee, Y. J., Lee, H.-B., Lim, C., & Koh, Y. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201101-0110oc · Cited by 219
The conneXion between sex and immune responses
Forsyth, K. S., Jiwrajka, N., Lovell, C. D., Toothacre, N. E., & Anguera, M. C. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-00996-9 · Cited by 236
Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection
Martín‐Loeches, I., Lisboa, T. C., Rhodes, A., Moreno, R. P., Silva, E., Sprung, C. L., Chiche, J., Barahona, D., Villabon, M., Balasini, C., et al. (2010) · Intensive Care Medicine · doi:10.1007/s00134-010-2078-z · Cited by 211
Outcomes of adults hospitalised with severe influenza
Lee, N. L. S., Choi, K. W. Y., Chan, P. K. S., Hui, D. S. C., Lui, G. C.-Y., Wong, B. C. K., Wong, R. Y. K., Sin, W. Y., Hui, W. M., Ngai, K. L. K., et al. (2010) · Thorax · doi:10.1136/thx.2009.130799 · Cited by 209
Influenza virus-related critical illness: prevention, diagnosis, treatment
Chow, E. J., Doyle, J., & Uyeki, T. M. (2019) · Critical Care · doi:10.1186/s13054-019-2491-9 · Cited by 208
Corticosteroids as Adjunctive Therapy in the Treatment of Influenza: An Updated Cochrane Systematic Review and Meta-analysis
Lansbury, L. E., Rodrigo, C., Leonardi-Bee, J., Nguyen-Van-Tam, J., & Shen Lim, W. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004093 · Cited by 207
Community-acquired respiratory coinfection in critically ill patients with pandemic 2009 influenza A(H1N1) virus
Martín-Loeches, I., Sanchez-Corral, A., Diaz, E., Granada, R. M., Zaragoza, R., Villavicencio, C., Albaya, A., Cerdá, E., Catalán, R. M., Luque, P., et al. (2011) · Chest · doi:10.1378/chest.10-1396 · Cited by 203
The weight of obesity on the human immune response to vaccination
Painter, S. D., Ovsyannikova, I. G., & Poland, G. A. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.06.101 · Cited by 208
Noninvasive Ventilation for Acute Respiratory Failure
HESS, D. R. (2013) · Respiratory Care · doi:10.4187/respcare.02319 · Cited by 201
Hospitalization and Critical Care of 109 Decedents with COVID-19 Pneumonia in Wuhan, China
Du, R., Liu, L., Yin, W., Wang, W., Guan, L., Yuan, M.-L., Li, Y.-L., Hu, Y., Li, X., Sun, B., et al. (2020) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202003-225oc · Cited by 198
Obesity and Respiratory Hospitalizations During Influenza Seasons in Ontario, Canada: A Cohort Study
Kwong, J. C., Campitelli, M. A., & Rosella, L. C. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir442 · Cited by 196
Determinants of health literacy and health behavior regarding infectious respiratory diseases: a pathway model
Sun, X., Shi, Y., Zeng, Q., Wang, Y., Du, W., Wei, N., Xie, R., & Chang, C. J. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-261 · Cited by 194
Impact of Neuraminidase Inhibitor Treatment on Outcomes of Public Health Importance During the 2009-2010 Influenza A(H1N1) Pandemic: A Systematic Review and Meta-Analysis in Hospitalized Patients
Muthuri, S. G., Myles, P. R., Venkatesan, S., Leonardi‐Bee, J., & Nguyen‐Van‐Tam, J. S. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis726 · Cited by 193
Corticosteroids as adjunctive therapy in the treatment of influenza
Lansbury, L., Rodrigo, C., Leonardi‐Bee, J., Nguyen‐Van‐Tam, J. S., & Lim, W. S. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010406.pub3 · Cited by 200
Inhaled Nitric Oxide Does Not Reduce Mortality in Patients With Acute Respiratory Distress Syndrome Regardless of Severity
Adhikari, N. K. J., Dellinger, R. P., Lundin, S., Payen, D. M., Vallet, B., Gerlach, H., Park, K. J., Mehta, S., Slutsky, A. S., & Friedrich, J. O. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182a27909 · Cited by 189
Immortal time bias in observational studies of time-to-event outcomes
Jones, M., & Fowler, R. (2016) · Journal of Critical Care · doi:10.1016/j.jcrc.2016.07.017 · Cited by 190
Platelets in Immune Response to Virus and Immunopathology of Viral Infections
Hottz, E. D., Bozza, F. A., & Bozza, P. T. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00121 · Cited by 185
Epidemiology of 2009 Pandemic Influenza A (H1N1) in the United States
Jhung, M. A., Swerdlow, D. L., Olsen, S. J., Jernigan, D. B., Biggerstaff, M., Kamimoto, L., Kniss, K. L., Reed, C., Fry, A. M., Brammer, L., et al. (2010) · Clinical Infectious Diseases · doi:10.1093/cid/ciq008 · Cited by 187
Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study
Xie, J., Wu, W., Li, S., Hu, Y., Hu, M., Li, J., Yang, Y., Huang, T., Zheng, K. C., Wang, Y., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06211-2 · Cited by 187
Distinct phenotypes require distinct respiratory management strategies in severe COVID-19
Robba, C., Battaglini, D., Ball, L., Patroniti, N. A., Loconte, M., Brunetti, I., Vena, A., Giacobbe, D. R., Bassetti, M., Rocco, P. R. M., et al. (2020) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2020.103455 · Cited by 188
Risk of severe outcomes among patients admitted to hospital with pandemic (H1N1) influenza
Campbell, A., Rodin, R., Kropp, R., Mao, Y., Hong, Z., Vachon, J., Spika, J. S., & Pelletier, L. (2010) · Canadian Medical Association Journal · doi:10.1503/cmaj.091823 · Cited by 183
Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Infection
Kadel, S., & Kovats, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01653 · Cited by 186
Coronavirus Disease 2019 as Cause of Viral Sepsis: A Systematic Review and Meta-Analysis*
Karakike, E., Giamarellos‐Bourboulis, E. J., Kyprianou, M., Fleischmann-Struzek, C., Pletz, M. W., Netea, M. G., Reinhart, K., & Kyriazopoulou, E. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005195 · Cited by 188
F ifty Y ears of R esearch in ARDS. Is Acute Respiratory Distress Syndrome a Preventable Disease?
Yadav, H., Thompson, B., & Gajic, O. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201609-1767ci · Cited by 181
Impact of Seasonal and Pandemic Influenza on Emergency Department Visits, 2003–2010, Ontario, Canada
Schanzer, D. L., & Schwartz, B. (2013) · Academic Emergency Medicine · doi:10.1111/acem.12111 · Cited by 175
Risk Factors for Severe Illness with 2009 Pandemic Influenza A (H1N1) Virus Infection in China
Yu, H., Feng, Z., Uyeki, T. M., Liao, Q., Zhou, L., Feng, S., Ye, M., Xiang, N., Huai, Y., Yuan, Y., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/ciq144 · Cited by 175
Host adaptive immunity deficiency in severe pandemic influenza
Bermejo-Martín, J. F., Martín‐Loeches, I., Rello, J., Antón, A., Almansa, R., Xu, L., López–Campos, G., Pumarola, T., Ran, L., Ramírez, P., et al. (2010) · Critical Care · doi:10.1186/cc9259 · Cited by 174
Extracorporeal life support devices and strategies for management of acute cardiorespiratory failure in adult patients: a comprehensive review
Shekar, K., Mullany, D. V., Thomson, B., Ziegenfuss, M. D., Platts, D. G., & Fraser, J. F. (2014) · Critical Care · doi:10.1186/cc13865 · Cited by 168
Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses
Moser, J. S., Galindo‐Fraga, A., Ortiz-Hernández, A. A., Gu, W., Hunsberger, S., Galán‐Herrera, J., Guerrero, M. L., Ruiz-Palacios, G. M., Beigel, J. H., & The La Red ILI 002 Study Group (2018) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12618 · Cited by 169
Surge Capacity Logistics
Einav, S., Hick, J. L., Hanfling, D., Erstad, B. L., Toner, E. S., Branson, R. D., Kanter, R. K., Kissoon, N. “., Dichter, J. R., Devereaux, A. V., et al. (2014) · CHEST Journal · doi:10.1378/chest.14-0734 · Cited by 167
Obesity predisposes to the risk of higher mortality in young COVID‐19 patients
Zhang, F., Xiong, Y., Wei, Y., Hu, Y., Wang, F., Li, G., Liu, K., Du, R., Wang, C., & Zhu, W. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26039 · Cited by 165
Recommendations for intensive care unit and hospital preparations for an influenza epidemic or mass disaster: summary report of the European Society of Intensive Care Medicine’s Task Force for intensive care unit triage during an influenza epidemic or mass disaster
Sprung, C. L., Zimmerman, J. L., Christian, M. D., Joynt, G. M., Hick, J. L., Taylor, B., Richards, G. A., Sandrock, C., Cohen, R., & Adini, B. B. (2010) · Intensive Care Medicine · doi:10.1007/s00134-010-1759-y · Cited by 167
Projecting demand for critical care beds during COVID-19 outbreaks in Canada
Shoukat, A., Wells, C. R., Langley, J. M., Singer, B. H., Galvani, A. P., & Moghadas, S. M. (2020) · Canadian Medical Association Journal · doi:10.1503/cmaj.200457 · Cited by 166
Clinical Findings and Demographic Factors Associated With ICU Admission in Utah Due to Novel 2009 Influenza A(H1N1) Infection
Miller, R. R., Markewitz, B. A., Rolfs, R. T., Brown, S. M., Dascomb, K. K., Grissom, C. K., Friedrichs, M. D., Mayer, J., Hirshberg, E. L., Conklin, J., et al. (2009) · CHEST Journal · doi:10.1378/chest.09-2517 · Cited by 157
H1N1 influenza A virus-associated acute lung injury: response to combination oseltamivir and prolonged corticosteroid treatment
Quispe-Laime, A. M., Bracco, J. D., Barberio, P. A., Campagne, C. G., Rolfo, V. E., Umberger, R. A., & Meduri, G. U. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1727-6 · Cited by 157
COVID-19 pandemic and non invasive respiratory management: Every Goliath needs a David. An evidence based evaluation of problems
Winck, J. C., & Ambrosino, N. (2020) · Pulmonology · doi:10.1016/j.pulmoe.2020.04.013 · Cited by 157
Biomarkers of inflammation and the etiology of sepsis
Grondman, I., Pîrvu, A., Riza, A. L., Ioana, M. I., & Netea, M. G. (2020) · Biochemical Society Transactions · doi:10.1042/bst20190029 · Cited by 153
Treatment and Prevention of Pandemic H1N1 Influenza
Rewar, S., Mirdha, D., & Rewar, P. (2016) · Annals of Global Health · doi:10.1016/j.aogh.2015.08.014 · Cited by 148
Clinical Characteristics and 30-Day Outcomes for Influenza A 2009 (H1N1), 2008-2009 (H1N1), and 2007-2008 (H3N2) Infections
Belongia, E. A. (2010) · JAMA · doi:10.1001/jama.2010.1277 · Cited by 146
Interleukin-6 Is a Potential Biomarker for Severe Pandemic H1N1 Influenza A Infection
Paquette, S. G., Banner, D., Zhao, Z., Yuan, F., Huang, S. S. H., Leon, A. J., Ng, D. C. K., Almansa, R., Martín‐Loeches, I., Ramírez, P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038214 · Cited by 144

Authors: Kumar, A.
Affiliations: Health Sciences Centre (CA)
Corresponding author: Kumar, Anand
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2009-11-04
Volume: 302
Issue: 17
Pages: 1872
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2009.1496
OpenAlex: W2148958087
Cited by: 1,425
References: 47
Citations by year: 2026: 8 · 2025: 11 · 2024: 16 · 2023: 23 · 2022: 28 · 2021: 55 · 2020: 89 · 2019: 38 · 2018: 33 · 2017: 35 · 2016: 53 · 2015: 63 · 2014: 74 · 2013: 128 · 2012: 156
FWCI: 171.68
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Funders: American Thoracic Society
Alberta Health Services
Hamilton Health Sciences
McGill University
London Health Sciences Centre
McMaster University
BC Children's Hospital
McGill University Health Centre
University of Alberta
University of Toronto
Jewish General Hospital
Hospital for Sick Children
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Keywords: pandemic influenza, critically ill patients, intensive care, mortality, mechanical ventilation, hypoxemia, neuraminidase inhibitors, organ dysfunction, shock, Aboriginal Canadians, pediatric patients, treatment outcomes, Canada, influenza A (H1N1) 2009
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Hypoxia, Canada, Child, Child, Preschool, Disease Outbreaks, Female, Humans, Infant, Influenza, Human, Intensive Care Units, Length of Stay, Male, Middle Aged, Multiple Organ Failure, Prospective Studies, Respiration, Artificial, Respiratory Distress Syndrome, Comorbidity, Critical Illness, Age Distribution, Influenza A Virus, H1N1 Subtype, Kaplan-Meier Estimate, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Critically Ill Patients With 2009 Influenza A(H1N1) Infection in Canada

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks