Cited by 737Frailty in Older AdultsPalliative Care and End-of-Life IssuesInsurance, Mortality, Demography, Risk Management

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Prognostic Indices for Older Adults: A Systematic Review

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Yourman, Lindsey C., Lee, Sei J., Schonberg, Mara A., Widera, Eric W., Smith, Alexander K.·2012·JAMA

DOI 10.1001/jama.2011.1966PMC PMC3792853

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Abstract

CONTEXT: To better target services to those who may benefit, many guidelines recommend incorporating life expectancy into clinical decisions. OBJECTIVE: To assess the quality and limitations of prognostic indices for mortality in older adults through systematic review. DATA SOURCES: We searched MEDLINE, EMBASE, Cochrane, and Google Scholar from their inception through November 2011. STUDY SELECTION: We included indices if they were validated and predicted absolute risk of mortality in patients whose average age was 60 years or older. We excluded indices that estimated intensive care unit, disease-specific, or in-hospital mortality. DATA EXTRACTION: For each prognostic index, we extracted data on clinical setting, potential for bias, generalizability, and accuracy. RESULTS: We reviewed 21,593 titles to identify 16 indices that predict risk of mortality from 6 months to 5 years for older adults in a variety of clinical settings: the community (6 indices), nursing home (2 indices), and hospital (8 indices). At least 1 measure of transportability (the index is accurate in more than 1 population) was tested for all but 3 indices. By our measures, no study was free from potential bias. Although 13 indices had C statistics of 0.70 or greater, none of the indices had C statistics of 0.90 or greater. Only 2 indices were independently validated by investigators who were not involved in the index's development. CONCLUSION: We identified several indices for predicting overall mortality in different patient groups; future studies need to independently test their accuracy in heterogeneous populations and their ability to improve clinical outcomes before their widespread use can be recommended.

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“However, a consensus on how to best assess prognosis in geriatric patients is lacking, and timely transition from therapeutic to palliative care is challenging.(8,9) As a result, palliative care is often delayed in older adults and non-cancer patients,(10) and some important factors, such as functional, cognitive and…”
Mini-Cog to predict postoperative mortality in geriatric elective surgical patients under general anesthesia: a prospective cohort study
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Background
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“79 is considered as good.(22) Calibration is the extent to which the predicted risk of the outcome matches the actual risk of the outcome.”
BackgroundMethod
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Karter, A. J., Parker, M. M., Moffet, H. H., Lipska, K. J., Laiteerapong, N., Grant, R. W., Lee, C., & Huang, E. S. (2023) · Journal of General Internal Medicine · doi:10.1007/s11606-023-08219-y · Cited by 13
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“On the other hand, a growing literature suggests that life expectancy in the range of a few years impacts a number of clinical decisions [1, 4–9].”
Background
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Result
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BackgroundSelf-citation
Defining the Scope of Prognosis: Primary Care Clinicians' Perspectives on Predicting the Future Health of Older Adults
Thomas, J. M., & Fried, T. R. (2018) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2018.01.017 · Cited by 12
“for prognostication, expanding on recent proposals that have focused on using prognostic estimates to prompt scaling back on interventions.(3,14,26) The examples provided by clinicians in our study also call attention to the choice clinicians sometimes face in deciding whether clinical decline or risk is reversible, a…”
Background
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Background
Association Between Receipt of Cancer Screening and All-Cause Mortality in Older Adults
Schoenborn, N. L., Sheehan, O. C., Roth, D. L., Cidav, T., Huang, J., Chung, S.-E., Zhang, T., Lee, S., Xue, Q., & Boyd, C. M. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.12062 · Cited by 12
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Controversial issues in the management of older adults with early breast cancer
Mislang, A. R., Cheung, K., Hamaker, M. E., Kunkler, I. H., Markopoulos, C. J., Orecchia, R., Brain, E. G. C., & Biganzoli, L. (2017) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2017.05.004 · Cited by 11
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BackgroundInfluential
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Receipt of Cancer Screening Is a Predictor of Life Expectancy
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Authors: Yourman, L. C., Lee, S. J., Schonberg, M. A., Widera, E. W., & Smith, A. K.
Affiliations: University of California, San Francisco (US)
San Francisco VA Medical Center (US)
Beth Israel Deaconess Medical Center (US)
Corresponding author: Smith, Alexander K.
ORCID: Yourman, Lindsey C.
Lee, Sei J.
Schonberg, Mara A.
Widera, Eric W.
Smith, Alexander K.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2012-01-11
Volume: 307
Issue: 2
Pages: 182
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2011.1966
PMC: PMC3792853
OpenAlex: W2025056766
Cited by: 736
References: 74
Citations by year: 2026: 25 · 2025: 18 · 2024: 26 · 2023: 42 · 2022: 50 · 2021: 53 · 2020: 65 · 2019: 62 · 2018: 57 · 2017: 60 · 2016: 74 · 2015: 57 · 2014: 59 · 2013: 45 · 2012: 42
FWCI: 31.93
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (K23AG040772, K23AG040779, T32AG000212)
National Center for Research Resources (UL1RR024131, KL2RR024130)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
Social Sciences › Demography › Insurance, Mortality, Demography, Risk Management
Keywords: prognostic score, mortality prediction, older adults, life expectancy, risk stratification, generalizability, transportability, index validation, concordance index, nursing homes, in-hospital mortality, community-dwelling older adults
MeSH terms: Aged, Aged, 80 and over, Decision Making, Patient Care, Humans, Life Expectancy, Middle Aged, Mortality, Predictive Value of Tests, Prognosis, Risk

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Prognostic Indices for Older Adults: A Systematic Review

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