Trends in Lipids and Lipoproteins in US Adults, 1988-2010
Abstract
Context Serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) contribute to atherosclerosis and its clinical consequences. Between the periods 1988-1994 and 1999-2002, mean TC and mean LDL-C declined in adults. During this time, there was an increase in the percentage of adults receiving lipid-lowering medications. Geometric mean triglyceride levels increased but mean high-density lipoprotein cholesterol (HDL-C) remained unchanged. OBJECTIVE To examine trends in serum lipids in adults between 1988 and 2010. DESIGN, SETTING, AND PARTICIPANTS Three distinct US cross-sectional National Health and Nutrition Examination Surveys, 1988-1994 (n = 16,573), 1999-2002 (n = 9471), and 2007-2010 (n = 11,766). Main outcome measures Mean TC, LDL-C, HDL-C, non-HDL-C, and geometric mean triglyceride levels and the prevalence of lipid-lowering medication use. Results Mean TC declined from 206 (95% CI, 205-207) mg/dL in 1988-1994 to 196 (95% CI, 195-198) mg/dL in 2007-2010 (P Conclusion Between 1988 and 2010, favorable trends in lipid levels have occurred among adults in the United States.
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Reference intervals for biomarkers can sometimes deviate considerably by reported ethnicity.
“Consequently, reference intervals for biomarkers can sometimes deviate considerably by reported ethnicity66–68.”
From Clinical use of current polygenic risk scores may exacerbate health disparities (2019) · cites this paper as [66]
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“Over recent decades, the prevalence of hypertriglyceridemia has risen to levels comparable to those of type 2 diabetes and obesity [3 ], particularly affecting one-third of adult men and one-fifth of women, with risk increasing with age [ 4].”
- Authors
- Carroll, M. D., Kit, B. K., Lacher, D. A., Shero, S. T., & Mussolino, M. E.
- Affiliations
- Centers for Disease Control and Prevention (US)
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2012-10-17
- Volume
- 308
- Issue
- 15
- Pages
- 1545
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2040719017
- Cited by
- 282
- References
- 2
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 13 · 2023: 13 · 2022: 15 · 2021: 17 · 2020: 21 · 2019: 20 · 2018: 20 · 2017: 29 · 2016: 26 · 2015: 26 · 2014: 32 · 2013: 30 · 2012: 4
- FWCI
- 29.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (Y1-HC-8039)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- serum lipids, total cholesterol, LDL cholesterol, HDL cholesterol, non-HDL cholesterol, triglycerides, atherosclerosis, cardiovascular risk, NHANES, adults, United States, temporal trends, sex differences, age differences, racial and ethnic differences, socioeconomic status
- MeSH terms
- Adult, Aged, Hypolipidemic Agents, Cross-Sectional Studies, Female, Humans, Hyperlipidemias, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Nutrition Surveys, Obesity, Triglycerides, United States, Prevalence
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