Inflammation, Immune Activation, and CVD Risk in Individuals With HIV Infection
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HAART does not protect patients from persistent immune activation, chronic inflammation, and excess risk of developing CVD and frailty.
“However, this therapy does not protect patients from the persistent immune activation, chronic inflammation, and excess risk of developing CVD and frailty131–135.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [135]
Cites
. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection.
Kuller, L. H., Tracy, R., Belloso, W., Wit, S. D., Drummond, F., Lane, H. C., Ledergerber, B., Lundgren, J., Neuhaus, J., Nixon, D., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050203 · Cited by 1,617 · see citing works
Triant, V. A., Lee, H., Hadigan, C., & Grinspoon, S. K. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2190 · Cited by 1,613 · see citing works
. Plasma levels of soluble CD14 independently predict mortality in HIV infection.
Sandler, N. G., Wand, H., Roque, A., Law, M., Nason, M. C., Nixon, D. E., Pedersen, C., Ruxrungtham, K., Lewin, S. R., Emery, S., et al. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiq118 · Cited by 1,106 · see citing works
Arterial Inflammation in Patients With HIV
Subramanian, S. S., Tawakol, A. A., Burdo, T. H., Abbara, S., Wei, J., Vijayakumar, J., Corsini, E. M., Abdelbaky, A., Zanni, M. V., Hoffmann, U., et al. (2012) · JAMA · doi:10.1001/jama.2012.6698 · Cited by 463 · see citing works
The Strategies for Management of Antiretroviral Therapy (SMART) Study Group (2008) · The Journal of Infectious Diseases · doi:10.1086/586713 · Cited by 400 · see citing works
Westlake, S. L., Colebatch, A. N., Baird, J., Kiely, P., Quinn, M., Choy, E., Ostor, A. J. K., & Edwards, C. J. (2010) · Rheumatology · doi:10.1093/rheumatology/kep366 · Cited by 357 · see citing works
Association of C-Reactive Protein and HIV Infection With Acute Myocardial Infarction
Triant, V. A., Meigs, J. B., & Grinspoon, S. K. (2009) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181a9992c · Cited by 338 · see citing works
Obel, N., Thomsen, H. F., Kronborg, G., Larsen, C. S., Hildebrandt, P. R., Sørensen, H. T., & Gerstoft, J. (2007) · Clinical Infectious Diseases · doi:10.1086/518285 · Cited by 331 · see citing works
Torriani, F. J., Komarow, L., Parker, R. A., Cotter, B. R., Currier, J. S., Dubé, M. P., Fichtenbaum, C. J., Gerschenson, M., Mitchell, C. K. C., Murphy, R. L., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.04.049 · Cited by 300 · see citing works
Self-citationPaton, N. I., Goodall, R. L., Dunn, D. T., Franzen, S., Collaço‐Moraes, Y., Gazzard, B., Williams, I. G., Fisher, M., Winston, A., Fox, J., et al. (2012) · JAMA · doi:10.1001/jama.2012.6936 · Cited by 163 · see citing works
Sacré, K., Hunt, P. W., Hsue, P. Y., Maidji, E., Martin, J. N., Deeks, S. G., Autran, B., & McCune, J. M. (2012) · AIDS · doi:10.1097/qad.0b013e328351f780 · Cited by 86 · see citing works
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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690 · see citing works
Ageing and inflammation in patients with HIV infection
Nasi, M., De Biasi, S., Gibellini, L., Bianchini, E., Pecorini, S., Bacca, V, Guaraldi, G., Mussini, C., Pinti, M., & Cossarizza, A. (2016) · Clinical and Experimental Immunology · doi:10.1111/cei.12814 · Cited by 277 · see citing works
Linking the Microbiota, Chronic Disease, and the Immune System
Hand, T. W., Vujkovic-Cvijin, I., Ridaura, V. K., & Belkaid, Y. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.08.003 · Cited by 247 · see citing works
- Authors
- Stein, J. H., & Hsue, P. Y.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2012-07-25
- Volume
- 308
- Issue
- 4
- Pages
- 405
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2085036275
- Cited by
- 94
- References
- 11
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 7 · 2019: 13 · 2018: 13 · 2017: 8 · 2016: 13 · 2015: 7 · 2014: 7 · 2013: 3 · 2012: 2
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- HIV infection, inflammation, immune activation, cardiovascular risk, cardiovascular risk factors
- MeSH terms
- Anti-Inflammatory Agents, Aorta, Cardiovascular Diseases, Female, Humans, Hydroxychloroquine, Inflammation, Lymphocyte Activation, Male, Radionuclide Imaging, HIV Infections
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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