Ageing and inflammation in patients with HIV infection

Frailty in elderly people

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Microbial translocation is a cause of systemic immune activation in chronic HIV infection

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Updated research nosology for HIV-associated neurocognitive disorders

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Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis

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Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies.

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Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease

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Class of Antiretroviral Drugs and the Risk of Myocardial Infarction

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HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

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HIV Infection, Inflammation, Immunosenescence, and Aging

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A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1

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. Plasma levels of soluble CD14 independently predict mortality in HIV infection.

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Adverse effects of antiretroviral therapy

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Estrogen deficiency and bone loss: an inflammatory tale

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Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review

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Markers of Inflammation, Coagulation, and Renal Function Are Elevated in Adults with HIV Infection

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The Mechanism of Insulin Resistance Caused by HIV Protease Inhibitor Therapy

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A Meta-Analysis of the Incidence of Non-AIDS Cancers in HIV-Infected Individuals

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Fracture Prevalence among Human Immunodeficiency Virus (HIV)-InfectedVersusNon-HIV-Infected Patients in a Large U.S. Healthcare System

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Arterial Inflammation in Patients With HIV

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HIV protease inhibitors: a review of molecular selectivity and toxicity

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Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity

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. HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty.

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Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study

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HIV Infection Is Associated with an Increased Risk for Lung Cancer, Independent of Smoking

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The effect of HAART-induced HIV suppression on circulating markers of inflammation and immune activation

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Fat distribution and metabolic changes in patients with HIV infection

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Residual Immune Dysregulation Syndrome in Treated HIV infection

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Inflammaging as a Major Characteristic of Old People: Can It Be Prevented or Cured?

Franceschi, C. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00358.x · Cited by 342 · see citing works

Inflammation markers predicting frailty and mortality in the elderly

Martinis, M. D., Franceschi, C., Monti, D., & Ginaldi, L. (2006) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2005.11.004 · Cited by 341 · see citing works

Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment

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Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: A key mechanism in osteoporosis

D'Amelio, P., Grimaldi, A., Di Bella, S., Brianza, S. Z. M., Cristofaro, M. A., Tamone, C., Giribaldi, G., Ulliers, D., Pescarmona, G. P., & Isaia, G. (2008) · Bone · doi:10.1016/j.bone.2008.02.017 · Cited by 331 · see citing works

Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo

Gills, J. J., LoPiccolo, J., Tsurutani, J., Shoemaker, R. H., Best, C. J. M., Abu-Asab, M. S., Borojerdi, J. P., Warfel, N. A., Gardner, E. R., Danish, M., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0161 · Cited by 320 · see citing works

Loss of Bone Mineral Density After Antiretroviral Therapy Initiation, Independent of Antiretroviral Regimen

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Prevalence of Metabolic Syndrome in HIV-Infected Patients Receiving Highly Active Antiretroviral Therapy Using International Diabetes Foundation and Adult Treatment Panel III Criteria

Samaras, K., Wand, H. C., Law, M. G., Emery, S., Cooper, D. A., & Carr, A. D. (2006) · Diabetes Care · doi:10.2337/dc06-1075 · Cited by 310 · see citing works

HIV and aging: time for a new paradigm.

Justice, A. C. (2010) · Current HIV/AIDS Reports · doi:10.1007/s11904-010-0041-9 · Cited by 309 · see citing works

Inflammaging as a Major Characteristic of Old People: Can It Be Prevented or Cured?

Franceschi, C. (2007) · Nutrition Reviews · doi:10.1301/nr.2007.dec.s173-s176 · Cited by 306 · see citing works

Low CD4+T Cell Count Is a Risk Factor for Cardiovascular Disease Events in the HIV Outpatient Study

Lichtenstein, K. A., Armon, C., Buchacz, K. A., Chmiel, J. S., Buckner, K., Tedaldi, E., Wood, K. C., Holmberg, S. D., & Brooks, J. T. (2010) · Clinical Infectious Diseases · doi:10.1086/655144 · Cited by 295 · see citing works

Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis

Schacker, T. W., Nguyen, P., Beilman, G. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216413 · Cited by 282 · see citing works

Normalisation of CD4 counts in patients with HIV-1 infection and maximum virological suppression who are taking combination antiretroviral therapy: an observational cohort study

Mocroft, A., Phillips, A., Gatell, J., Ledergerber, B., Fisher, M., Clumeck, N., Losso, M., Lazzarin, A., Fatkenheuer, G., & Lundgren, J. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60948-9 · Cited by 259 · see citing works

Metabolic Syndrome Among HIV-Infected Patients

Jericó, C. R., Knobel, H., Montero, M., Ordóñez‐Llanos, J., Guelar, A., Gimeno, J. L., Saballs, P., López-Colomés, J. L., & Pedro‐Botet, J. (2005) · Diabetes Care · doi:10.2337/diacare.28.1.132 · Cited by 257 · see citing works

Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations

Murata, H., Hruz, P. W., & Mueckler, M. M. (2002) · AIDS · doi:10.1097/00002030-200204120-00005 · Cited by 251 · see citing works

Accelerated immune senescence and HIV-1 infection

APPAY, V, ALMEIDA, J., SAUCE, D., AUTRAN, B., & PAPAGNO, L. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2006.12.003 · Cited by 236 · see citing works

Enhancing antiretroviral therapy for human immunodeficiency virus cognitive disorders

Letendre, S. L., McCutchan, J. A., Childers, M. E., Woods, S. P., Lazzaretto, D., Heaton, R. K., Grant, I., Ellis, R. J., & the HNRC Group (2004) · Annals of Neurology · doi:10.1002/ana.20198 · Cited by 221 · see citing works

HIV-1 associated dementia: symptoms and causes

Ghafouri, M., Amini, S., Khalili, K., & Sawaya, B. E. (2006) · Retrovirology · doi:10.1186/1742-4690-3-28 · Cited by 215 · see citing works

Age, Comorbidities, and AIDS Predict a Frailty Phenotype in Men Who Have Sex With Men

Althoff, K. N., Jacobson, L. P., Cranston, R., Detels, R., Phair, J., Li, X., & Margolick, J. B. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt148 · Cited by 212 · see citing works

Does an Index Composed of Clinical Data Reflect Effects of Inflammation, Coagulation, and Monocyte Activation on Mortality Among Those Aging With HIV?

Justice, A. C., Freiberg, M. S., Tracy, R. P., Kuller, L. H., Tate, J., Goetz, M. B., Fiellin, D. A., Vanasse, G. J., Butt, A. A., Rodriguez‐Barradas, M. C., et al. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cir989 · Cited by 204 · see citing works

Gut epithelial barrier and systemic inflammation during chronic HIV infection

Somsouk, M., Estes, J. D., Deléage, C., Dunham, R. M., Albright, R. G., Inadomi, J. M., Martin, J. N., Deeks, S. G., McCune, J. M., & Hunt, P. W. (2014) · AIDS · doi:10.1097/qad.0000000000000511 · Cited by 203 · see citing works

Assessment of Second-Line Antiretroviral Regimens for HIV Therapy in Africa

Paton, N. I., Kityo, C. M., Hoppé, A., Reid, A., Kambugu, A. D., Lugemwa, A., van Oosterhout, J. J., Kiconco, M., Siika, A. M., Mwebaze, R. M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1311274 · Cited by 203 · see citing works

Weight Change After Antiretroviral Therapy and Mortality

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Cytomegalovirus-Specific T Cells Persist at Very High Levels during Long-Term Antiretroviral Treatment of HIV Disease

Naeger, D. M., Martin, J. N., Sinclair, E., Hunt, P. W., Bangsberg, D. R., Hecht, F. M., Hsue, P. Y., McCune, J. M., & Deeks, S. G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008886 · Cited by 190 · see citing works

Obesity Is an Important Determinant of Baseline Serum C-Reactive Protein Concentration in Monozygotic Twins, Independent of Genetic Influences

Greenfield, J. R., Samaras, K., Jenkins, A. B., Kelly, P. J., Spector, T. D., Gallimore, J. R., Pepys, M. B., & Campbell, L. V. (2004) · Circulation · doi:10.1161/01.cir.0000130640.77501.79 · Cited by 189 · see citing works

Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART

Anzinger, J. J., Butterfield, T. R., Angelovich, T. A., Crowe, S. M., & Palmer, C. S. (2014) · Journal of Immunology Research · doi:10.1155/2014/569819 · Cited by 185 · see citing works

Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load

McLaren, P. J., Coulonges, C., Bartha, I., Lenz, T. L., Deutsch, A. J., Bashirova, A. A., Buchbinder, S., Carrington, M. N., Cossarizza, A., Dalmau, J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514867112 · Cited by 180 · see citing works

Incidence of Metabolic Syndrome in a Cohort of HIV-Infected Adults and Prevalence Relative to the US Population (National Health and Nutrition Examination Survey)

Jacobson, D. L., Tang, A., Spiegelman, D. L., Thomas, A. M., Skinner, S. C., Gorbach, S. L., & WANKE, C. A. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000243093.34652.41 · Cited by 175 · see citing works

A frailty index predicts survival and incident multimorbidity independent of markers of HIV disease severity

Guaraldi, G., Brothers, T. D., Zona, S., Stentarelli, C., Carli, F., Malagoli, A., Santoro, A., Menozzi, M., Mussi, C., Mussini, C., et al. (2015) · AIDS · doi:10.1097/qad.0000000000000753 · Cited by 171 · see citing works

Association of Functional Impairment with Inflammation and Immune Activation in HIV Type 1–Infected Adults Receiving Effective Antiretroviral Therapy

Erlandson, K. M., Allshouse, A. A., Jankowski, C. M., Lee, E. J., Rufner, K. M., Palmer, B. E., Wilson, C. C., MaWhinney, S., Kohrt, W. M., & Campbell, T. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit147 · Cited by 166 · see citing works

Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls

McLaren, P. J., Coulonges, C., Ripke, S., van den Berg, L. H., Buchbinder, S., Carrington, M. N., Cossarizza, A., Dalmau, J., Deeks, S. G., Delaneau, O., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003515 · Cited by 150 · see citing works

HIV effects on age-associated neurocognitive dysfunction: premature cognitive aging or neurodegenerative disease?

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Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic rats

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Infectious aetiology of Hodgkin and non‐Hodgkin lymphomas: a review of the epidemiological evidence

Hjalgrim, H., & Engels, E. A. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.02031.x · Cited by 145 · see citing works

Frailty in People Aging With Human Immunodeficiency Virus (HIV) Infection

Brothers, T. D., Kirkland, S., Guaraldi, G., Falutz, J., Theou, O., Johnston, B. L., & Rockwood, K. (2014) · Journal of Infectious Diseases · doi:10.1093/infdis/jiu258 · Cited by 136 · see citing works

Metabolic syndrome in HIV-infected individuals: underlying mechanisms and epidemiological aspects

de Paula, A. A., Falcão, M., & Pacheco, A. G. (2013) · AIDS Research and Therapy · doi:10.1186/1742-6405-10-32 · Cited by 132 · see citing works

Adipocytes Targets and Actors in the Pathogenesis of HIV-Associated Lipodystrophy and Metabolic Alterations

Gougeon, M., Pénicaud, L., Fromenty, B., Leclercq, P., Viard, J., & Capeau, J. (2004) · Antiviral Therapy · doi:10.1177/135965350400900206 · Cited by 129 · see citing works

Thymic output and functionality of the IL‐7/IL‐7 receptor system in centenarians: implications for the neolymphogenesis at the limit of human life

Nasi, M., Troiano, L., Lugli, E., Pinti, M., Ferraresi, R., Monterastelli, E., Mussi, C., Salvioli, G., Franceschi, C., & Cossarizza, A. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00204.x · Cited by 127 · see citing works

Coronary Aging in HIV‐Infected Patients

Guaraldi, G., Zona, S., Alexopoulos, N. A., Orlando, G., Carli, F., Ligabue, G., Fiocchi, F., Lattanzi, A., Rossi, R., Modena, M. G., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/648080 · Cited by 123 · see citing works

HIV-1 Vpr enhances production of receptor of activated NF-κB ligand (RANKL) via potentiation of glucocorticoid receptor activity

Fakruddin, J. M., & Laurence, J. (2004) · Archives of Virology · doi:10.1007/s00705-004-0395-7 · Cited by 117 · see citing works

Association of Upper Trunk and Visceral Adipose Tissue Volume With Insulin Resistance in Control and HIV-Infected Subjects in the FRAM Study

Grunfeld, C., Rimland, D., Gibert, C. L., Powderly, W. G., Sidney, S., Shlipak, M. G., Bacchetti, P., Scherzer, R., Haffner, S. M., & Heymsfield, S. B. (2007) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31814b94e2 · Cited by 114 · see citing works

Energy expenditure in HIV infection

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Effect of highly active antiretroviral therapy on biomarkers of B-lymphocyte activation and inflammation

Regidor, D. L., Detels, R., Breen, E. C., Widney, D. P., Jacobson, L. P., Palella, F. J., Rinaldo, C. R., Bream, J. H., & Martı́nez-Maza, O. (2010) · AIDS · doi:10.1097/qad.0b013e32834273ad · Cited by 111 · see citing works

HIV‐1 triggers apoptosis in primary osteoblasts and HOBIT cells through TNFα activation

Gibellini, D., Crignis, E. D., Ponti, C., Cimatti, L., Borderi, M., Tschon, M., Giardino, R., & Re, M. C. (2008) · Journal of Medical Virology · doi:10.1002/jmv.21266 · Cited by 110 · see citing works

Physiologic Frailty and Fragility Fracture in HIV-Infected Male Veterans

Womack, J. A., Goulet, J. L., Gibert, C. L., Brandt, C., Skanderson, M., Gulanski, B., Rimland, D., Rodriguez‐Barradas, M. C., Tate, J., Yin, M. T., et al. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit056 · Cited by 109 · see citing works

T cell subsets and mortality in older community-dwelling women

Semba, R. D., Margolick, J. B., Leng, S. X., Walston, J. D., Ricks, M. O., & Fried, L. P. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.09.006 · Cited by 107 · see citing works

Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis

Schacker, T. W., Nguyen, P. L., Beilman, G. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16413 · Cited by 106 · see citing works

Ten-year incidence and risk factors of bone fractures in a cohort of treated HIV1-infected adults

Collin, F., Duval, X., Moing, V. L., Piroth, L., Kaied, F. A., Massip, P., Villes, V., Chêne, G., & Raffi, F. (2009) · AIDS · doi:10.1097/qad.0b013e3283292195 · Cited by 105 · see citing works

Cardiovascular Diseases and Diabetes as Economic and Developmental Challenges in Africa

Kengne, A. P., Mchiza, Z. J., Amoah, A. G. B., & Mbanya, J. C. (2013) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2013.10.011 · Cited by 103 · see citing works

Placenta and Cord Blood Mitochondrial DNA Toxicity in HIV-Infected Women Receiving Nucleoside Reverse Transcriptase Inhibitors During Pregnancy

Shiramizu, B. T., Shikuma, K. M., Kamemoto, L. E., et al. (2003) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200304010-00004 · Cited by 103 · see citing works

Anti-HIV drugs and the mitochondria

Pinti, M., Salomoni, P., & Cossarizza, A. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.05.001 · Cited by 102 · see citing works

HIV protease inhibitors activate the unfolded protein response and disrupt lipid metabolism in primary hepatocytes

Zhou, H., Gurley, E. C., Brimson, S. J., Ding, H., Fang, Y., Xu, Z., Pandak, W. M., & Hylemon, P. B. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00182.2006 · Cited by 101 · see citing works

Inflammation, Immune Activation, and CVD Risk in Individuals With HIV Infection

Stein, J. H., & Hsue, P. Y. (2012) · JAMA · doi:10.1001/jama.2012.8488 · Cited by 94 · see citing works

The relationship of physical performance with HIV disease and mortality

Greene, M. L., Covinsky, K. E., Astemborski, J. A., Piggott, D. A., Brown, T. T., Leng, S. X., Galai, N., Mehta, S. H., Guralnik, J. M., Patel, K. V., et al. (2014) · AIDS · doi:10.1097/qad.0000000000000507 · Cited by 88 · see citing works

Persistent inflammation in HIV infection: Established concepts, new perspectives

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T‐Lymphocytes Expressing CC Chemokine Receptor‐5 Are Increased in Frail Older Adults

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Different origin of adipogenic stem cells influences the response to antiretroviral drugs

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HIV-1 Infection and the Aging of the Immune System: Facts, Similarities and Perspectives

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Decreased Mitochondrial Dna Content in Subcutaneous Fat from HIV-Infected Women Taking Antiretroviral Therapy as Measured at Delivery

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Liposome Encapsulated All Trans Retinoic Acid (ATRA) has Enhanced Immunomodulatory and Inflammation Reducing Activities in Mice Model

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Successful Treatment of HIV-1 Infection Increases the Expression of a Novel, Short Transcript for IL-18 Receptor α Chain

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Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin

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Targeted Mitochondrial COQ10 Delivery Attenuates Antiretroviral-Drug-Induced Senescence of Neural Progenitor Cells

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Mitochondrial DNA and Exercise: Implications for Health and Injuries in Sports

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Exploring the neurocognome: Neurocognitive network organization in healthy young adults

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