Age, Atrial Fibrillation, and Structural Heart Disease Are the Main Determinants of Left Atrial Fibrosis Detected by Delayed‐Enhanced Magnetic Resonance Imaging in a General Cardiology Population
Abstract
Atrial Fibrosis on MRI in Patients: Introduction: We studied the extent and distribution of left atrial (LA) fibrosis on delayed‐enhanced (DE) MRI in a general cardiology population. Methods and Results: One hundred ninety consecutive patients referred for cardiac MRI underwent DE imaging using a free breathing method. The population comprised 60 AF patients and 130 patients without AF, including 75 with structural heart disease (SHD). DE was quantified using histogram thresholding, expressed in % of the wall. Regression analysis was performed to identify predictors of DE. Additionally, DE was registered on a template to study its distribution in subpopulations. In the total population, age, AF, and SHD were independently associated with DE. DE was increasingly observed from 11.1 ± 4.7% in patients with no SHD nor AF, 18.8 ± 7.8% in SHD and no AF history, 22.9 ± 7.8% in paroxysmal AF, to 27.8 ± 7.7% in persistent AF. Among non‐AF patients, age and SHD were independently associated with DE. Among AF patients, female gender and AF persistence were independently associated with DE. DE was variably distributed but more frequently detected in the posterior wall. Conclusion: Age, history of AF, and SHD are the most powerful predictors of atrial fibrosis, as detected by MRI, in a general cardiology population. Atrial fibrosis predominates in the posterior LA wall.
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The link between female sex and stroke might vary across populations and age groups.
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From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [82]
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- Authors
- COCHET, H., MOURIES, A., NIVET, H., SACHER, F., DERVAL, N., DENIS, A., MERLE, M., RELAN, J., HOCINI, M., HAÏSSAGUERRE, M., LAURENT, F., MONTAUDON, M., & JAÏS, P.
- Affiliations
- Université de Bordeaux (FR)
- Department of cardiac pacing and electrophysiology CHU/Université de Bordeaux Pessac France
- Institut national de recherche en sciences et technologies du numérique (FR)
- Corresponding author
- COCHET, HUBERT
- Venue
- Journal of Cardiovascular Electrophysiology
- Publisher
- Wiley
- Published
- 2015-04-22
- Volume
- 26
- Issue
- 5
- Pages
- 484-492
- ISSN
- 1045-3873 (ISSN-L)
- 1540-8167
- OpenAlex
- W2104551165
- Cited by
- 199
- References
- 28
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 18 · 2023: 15 · 2022: 23 · 2021: 26 · 2020: 13 · 2019: 23 · 2018: 22 · 2017: 19 · 2016: 13 · 2015: 2
- FWCI
- 13.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cardiovascular Electrophysiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Union Seventh Framework Program (HEALTH-F2-2010-261057)
- Agence Nationale de la Recherche (ANR-10-IAHU-04; ANR-11-EQPX-0030)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- left atrial fibrosis, atrial fibrillation, structural heart disease, delayed-enhanced MRI, age, paroxysmal atrial fibrillation, persistent atrial fibrillation
- MeSH terms
- Adult, Age Factors, Atrial Fibrillation, Female, Fibrosis, France, Heart Atria, Heart Diseases, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Risk Factors, Reproducibility of Results, Prevalence
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