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Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial
Open accessAbstract
IMPORTANCE: Observational data have suggested that high dietary intake of saturated fat and low intake of vegetables may be associated with increased risk of Alzheimer disease. OBJECTIVE: To test the effects of oral supplementation with nutrients on cognitive function. DESIGN, SETTING, AND PARTICIPANTS: In a double-masked randomized clinical trial (the Age-Related Eye Disease Study 2 [AREDS2]), retinal specialists in 82 US academic and community medical centers enrolled and observed participants who were at risk for developing late age-related macular degeneration (AMD) from October 2006 to December 2012. In addition to annual eye examinations, several validated cognitive function tests were administered via telephone by trained personnel at baseline and every 2 years during the 5-year study. INTERVENTIONS: Long-chain polyunsaturated fatty acids (LCPUFAs) (1 g) and/or lutein (10 mg)/zeaxanthin (2 mg) vs placebo were tested in a factorial design. All participants were also given varying combinations of vitamins C, E, beta carotene, and zinc. MAIN OUTCOMES AND MEASURES: The main outcome was the yearly change in composite scores determined from a battery of cognitive function tests from baseline. The analyses, which were adjusted for baseline age, sex, race, history of hypertension, education, cognitive score, and depression score, evaluated the differences in the composite score between the treated vs untreated groups. The composite score provided an overall score for the battery, ranging from -22 to 17, with higher scores representing better function. RESULTS: A total of 89% (3741/4203) of AREDS2 participants consented to the ancillary cognitive function study and 93.6% (3501/3741) underwent cognitive function testing. The mean (SD) age of the participants was 72.7 (7.7) years and 57.5% were women. There were no statistically significant differences in change of scores for participants randomized to receive supplements vs those who were not. The yearly change in the composite cognitive function score was -0.19 (99% CI, -0.25 to -0.13) for participants randomized to receive LCPUFAs vs -0.18 (99% CI, -0.24 to -0.12) for those randomized to no LCPUFAs (difference in yearly change, -0.03 [99% CI, -0.20 to 0.13]; P = .63). Similarly, the yearly change in the composite cognitive function score was -0.18 (99% CI, -0.24 to -0.11) for participants randomized to receive lutein/zeaxanthin vs -0.19 (99% CI, -0.25 to -0.13) for those randomized to not receive lutein/zeaxanthin (difference in yearly change, 0.03 [99% CI, -0.14 to 0.19]; P = .66). Analyses were also conducted to assess for potential interactions between LCPUFAs and lutein/zeaxanthin and none were found to be significant. CONCLUSIONS AND RELEVANCE: Among older persons with AMD, oral supplementation with LCPUFAs or lutein/zeaxanthin had no statistically significant effect on cognitive function. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00345176.
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“In the AREDS2 study, dietary intervention with 350 mg DHA and 650 mg EPA for 5 years did not have a significant effect on cognitive function in 3,501 older adults (mean age 72.7 years) with age-related macular degeneration [74].”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [74]
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Citations
Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
2013 Alzheimer's disease facts and figures
Thies, W. H., & Bleiler, L. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.02.003 · Cited by 3,372
A Standardized Memory Scale for Clinical Use
Wechsler, D. (1945) · The Journal of Psychology · doi:10.1080/00223980.1945.9917223 · Cited by 2,949
Telephone Interview for Cognitive Status
Brandt, J., Spencer, M., & Folstein, M. F. (1988) · PsycTESTS Dataset · doi:10.1037/t28542-000 · Cited by 1,504
Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.21.1550 · Cited by 1,255
Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Trial
Quinn, J. F., Raman, R., Thomas, R. G., Yurko-Mauro, K., Nelson, E. B., Van Dyck, C., Galvin, J. E., Emond, J., Jack, C. R., Weiner, M., et al. (2010) · JAMA · doi:10.1001/jama.2010.1510 · Cited by 764
Verbal fluency in aging and dementia
Rosen, W. G. (1980) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688638008403788 · Cited by 597
Polyunsaturated Fatty Acids, Antioxidants, and Cognitive Function in Very Old Men
Kalmijn, S., Feskens, E. J. M., Launer, L. J., & Kromhout, D. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009029 · Cited by 453
Self-citationThe Age-related Eye Disease Study 2 (AREDS2)
Chew, E. Y., Clemons, T. E., SanGiovanni, J. P., Danis, R. P., Domalpally, A., McBee, W. L., Sperduto, R. D., & Ferris, F. L. (2012) · Ophthalmology · doi:10.1016/j.ophtha.2012.05.027 · Cited by 434
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Items 101–190 of 190
Combined drug triads for synergic neuroprotection in retinal degeneration
Maneu, V., Lax, P., de Diego, A. M. G., Cuenca, N., & de Diego, A. M. G. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112911 · Cited by 23
Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome
Wang, W., Li, J., Cui, S., Li, J., Ye, X., Wang, Z., Zhang, T., Jiang, X. J., Kong, Y., Chen, X., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj7813 · Cited by 22
Green, M., Prado‐Cabrero, A., Moran, R., Power, T., Gómez‐Mascaraque, L. G., Stack, J., & Nolan, J. M. (2020) · Antioxidants · doi:10.3390/antiox9080767 · Cited by 21
Lifestyles and Cognitive Health
Gill, S. S., & Seitz, D. P. (2015) · JAMA · doi:10.1001/jama.2015.9526 · Cited by 21
Zhou, T., Yang, Z., Ni, B., Zhou, H. Q., Xu, H., Lin, X., Li, Y., Liu, C., Ju, R., Ge, J., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05433-0 · Cited by 20
Zhao, H., Han, X., Zhang, X., Li, L., Li, Y., Wang, W., McIntyre, R. S., Teopiz, K. M., Guo, L., & Lu, C. (2023) · Antioxidants · doi:10.3390/antiox12010162 · Cited by 22
“For example, in a study of Alzheimer’s disease, also a neurological disorder, an RCT of about 4000 people found no statistically significant effect of antioxidant supplementation on cognitive function [57], and a recent MR study of circulating antioxidants and Alzheimer’s disease also showed that higher levels of asco…”
BackgroundTeo, L., Crawford, C. C., Yehuda, R., Jaghab, D., Bingham, J. J., Chittum, H. K., Gallon, M. D., O’Connell, M. L., Arzola, S. M., & Berry, K. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux008 · Cited by 21
Associations of Microbiota and Nutrition with Cognitive Impairment in Diseases
Młynarska, E., Jakubowska, P., Frąk, W., Gajewska, A., Sornowska, J., Skwira, S., Wasiak, J., Rysz, J., & Franczyk, B. (2024) · Nutrients · doi:10.3390/nu16203570 · Cited by 19
“Nonetheless, these studies have shown no statistically significant effect on cognitive function [138–141].”
BackgroundEffect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine
Snigdha, S., de Rivera, C., Milgram, N. W., & Cotman, C. W. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.09.015 · Cited by 19
Dietary beta‐carotene and lutein metabolism is modulated by the APOE genotype
Huebbe, P., Lange, J., Lietz, G., & Rimbach, G. H. (2016) · BioFactors · doi:10.1002/biof.1284 · Cited by 21
Plasma antioxidants and risk of dementia in older adults
Koch, M., Furtado, J. D., Cronjé, H. T., DeKosky, S. T., Fitzpatrick, A. L., López, O. L., Kuller, L. H., Mukamal, K. J., & Jensen, M. K. (2021) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12208 · Cited by 19
Huang, Y., Deng, Y., Zhang, P., Lin, J., Guo, D., Yang, L., Liu, D., Xu, B., Huang, C., & Zhang, H. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.910977 · Cited by 18
“Other larger clinical trials, however, have reported inconsistent and mixed results (Andreeva et al., 2011; Chew et al., 2015).”
ResultDietary Nutrients and Prevention of Alzheimer’s Disease
Chauhan, P., Yadav, D., & Arukha, A. P. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210405141123 · Cited by 18
Marine n‐3 fatty acids and cognitive change among older adults in the VITAL randomized trial
Kang, J. H., Vyas, C. M., Okereke, O. I., Ogata, S., Albert, M. A., Lee, I.-M. M., D’Agostino, D., Buring, J. E., Cook, N. R., Grodstein, F., et al. (2022) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12288 · Cited by 18
Self-citationLeckie, R. L., Lehman, D. E., Gianaros, P. J., Erickson, K. I., Sereika, S. M., Kuan, D. C.-H., Manuck, S. B., Ryan, C. M., Yao, J. K., & Muldoon, M. F. (2019) · Psychological Medicine · doi:10.1017/s0033291719002617 · Cited by 21
Vitamins: a nutritional intervention to modulate the Alzheimer’s disease progression
Alam, J. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1826762 · Cited by 18
Norouziasl, R., Zeraattalab-Motlagh, S., Jayedi, A., & Shab‐Bidar, S. (2023) · British Journal Of Nutrition · doi:10.1017/s0007114523002052 · Cited by 18
Pineda-Vadillo, C., Nau, F., Guérin‐Dubiard, C., Bourlieu‐Lacanal, C., Capozzi, F., Bordoni, A., & Dupont, D. (2020) · Foods · doi:10.3390/foods10010006 · Cited by 16
Lê, J. T., Agrón, E., Keenan, T. D. L., Clemons, T. E., Brenowitz, W. D., Yaffe, K. S., & Chew, E. Y. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12473 · Cited by 16
Self-citationCardiac aging: Molecular mechanisms and therapeutic interventions
Li, X., Pang, X., Sun, H., Zhang, B., Wang, H., Wu, N., & Yang, L. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107954 · Cited by 16
Wang, S., Cu, Y., Wang, C., Xie, W., Ma, L., Zhu, J., Zhang, Y., Dang, R., Wang, D., Wu, Y., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143135 · Cited by 15
“Recently, the nutritional interventions study in humans suggested that supplementation with the macular carotenoids has the benefits on the patients with AD because of the improvements of visual function [21], while oral supplementation with long-chain polyunsaturated fatty acids or lutein/ zeaxanthin had no statistic…”
BackgroundDietary nutrient intake and cognitive function in the Age‐Related Eye Disease Studies 1 and 2
Keenan, T. D. L., Agrón, E., & Chew, E. Y. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13033 · Cited by 14
Self-citationBanasiak‐Cieślar, H., Wiener, D., Kuszczyk, M. A., Dobrzyńska, K., & Polanowski, A. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3187 · Cited by 12
“Although the test battery was designed and developed for patients with diagnosed cognitive impairments, scientific reports exhibit the usage of those to assess cognitive outcomes within healthy individuals (Chew et al., 2015; Danthiir et al., 2011; Power et al., 2022).”
BackgroundWelty, F. K., Daher, R., & Garelnabi, M. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318125 · Cited by 14
Koch, M., Furtado, J. D., DeKosky, S. T., Fitzpatrick, A. L., López, O. L., Kuller, L. H., Mukamal, K. J., & Jensen, M. K. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab087 · Cited by 13
Nutrition, Genes, and Age-Related Macular Degeneration: What Have We Learned from the Trials?
Chew, E. Y. (2017) · Ophthalmologica · doi:10.1159/000473865 · Cited by 14
Self-citationNuevas dianas terapéuticas en el tratamiento de la degeneración macular asociada a la edad
Muñoz-Ramón, P., Martínez, P. H., & Muñoz-Negrete, F. J. (2019) · Archivos de la Sociedad Española de Oftalmología · doi:10.1016/j.oftal.2019.09.011 · Cited by 13
Rathod, R. S., Khaire, A. A., Kale, A. A., & Joshi, S. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.10.018 · Cited by 12
“Similarly, studies have shown conflicting results for the effects of n-3 PUFA on cognitive functioning wherein some have reported positive (Karr et al., 2012, Stonehouse et al., 2013) while few studies have shown no impact on cognition (Antypa et al., 2009, Chew et al., 2015).”
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Martínez-Pérez, C., Alvarez-Peregrina, C. C., Villa-Collar, C. C., & Sánchez‐Tena, M. Á. (2022) · Journal of Optometry · doi:10.1016/j.optom.2022.06.005 · Cited by 13
“27 Therefore, AI systems are being developed to improve the diagnosis and treatment of said conditions.”
Yoshida, T., Takagi, Y., Igarashi-Yokoi, T., & Ohno‐Matsui, K. (2023) · Medicine · doi:10.1097/md.0000000000033280 · Cited by 11
Zhang, L.-N., Li, M.-J., Shang, Y.-H., Liu, Y.-R., Han-Chang, H., & Lao, F.-X. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215408 · Cited by 8
Can Diet Supplements of Macular Pigment of Lutein, Zeaxanthin, and Meso-zeaxanthin Affect Cognition?
Wang, H., Wang, G., Billings, R., Li, D., Haase, S. R., Fazeli, P. L., Vance, D. E., & Li, W. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215736 · Cited by 7
New therapeutic targets in the treatment of age-related macular degeneration
Muñoz-Ramón, P., Martínez, P. H., & Muñoz-Negrete, F. J. (2020) · Archivos de la Sociedad Española de Oftalmología (English Edition) · doi:10.1016/j.oftale.2019.09.013 · Cited by 7
Insulin resistance: fueling oxidative stress and neurodegeneration
Chamorro, L. B., Zulli, B., & Barone, E. (2025) · Journal of Neural Transmission · doi:10.1007/s00702-025-02956-6 · Cited by 8
Rusciano, D. (2025) · Pharmaceuticals · doi:10.3390/ph18060883 · Cited by 6
Macular Pigment, Cognition, and Visual Function in Younger Healthy Adults in Ghana
Akuffo, K. O., Wooten, B. R., Ofori-Asare, W., Duah, I. O., Kumah, D. B., Awuni, M., Obiri-Yeboah, S. R., Horthman, S. E., Addo, E. K., Acquah, E. A., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230233 · Cited by 6
Cuciniello, R., Luongo, D., Maurano, F., Crispi, S., & Bergamo, P. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.01.006 · Cited by 6
Singh, K., Gupta, J. K., Sethi, P., Mathew, S., Bhatt, A., Sharma, M. C., Saha, S., Khan, S., & Kumar, S. (2024) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266305736240725052825 · Cited by 6
The neuropharmacological and clinical effects of lutein: a systematic review
Firozjae, A. A., Shiran, M. R., & Rashidi, M. (2024) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2024-0053 · Cited by 6
Blumen, H. M., Ayers, E. I., Wang, C., Ambrose, A. F., & Verghese, J. (2020) · Neurodegenerative Disease Management · doi:10.2217/nmt-2020-0002 · Cited by 9
Chen, X., Wei, D.-D., Lin, M., Wang, X.-S., Kang, H.-J., Ni, L., Qian, D., Guo, S., & Duan, J. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117889 · Cited by 6
Omega-3 Fatty Acids and Cognitive Behavior
Giles, G. E., Mahoney, C. R., & Kanarek, R. B. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815238-6.00020-1 · Cited by 5
Das, S., Tiwari, G. J., & Ghosh, A. (2020) · 3 Biotech · doi:10.1007/s13205-020-02537-2 · Cited by 5
“developing AMD (Chew et al. 2015) and prevent damage from high-energy blue and ultraviolet light (Carneiro and Andrade 2017).”
BackgroundEnvironmental and Nutritional Determinants of Macular Pigment in a Mexican Population
Green, M., Moran, R., Stringham, J. M., Hernández-Alcaraz, C., Mendoza-Herrera, K., Fromow-Guerra, J., Prado‐Cabrero, A., & Nolan, J. M. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.9.18 · Cited by 5
Holmes, H. M., Beck, M. S., & Rowe, J. H. (2016) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2016.06.002 · Cited by 4
Cerna, J., Edwards, C., Martell, S. G., Anaraki, N. S. A., Walk, A., Robbs, C. M., Adamson, B., Flemming, I. R., Labriola, L. T., Motl, R. W., et al. (2023) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2023.03.002 · Cited by 4
Linking the microbiome to the complement system in geographic atrophy
Spörri, L. A., Studer, J. M., Kreuzer, M., Rotzetter, J., Schärer, D., Largiadèr, C. R., Jaggi, D., Zinkernagel, M. S., & Zysset‐Burri, D. C. (2026) · npj Genomic Medicine · doi:10.1038/s41525-026-00550-7 · Cited by 3
Morovati, A., Moussa, Y., Kalupahana, N. S., Zu, Y., Jun, H., Fokar, M., & Moustaïd‐Moussa, N. (2026) · Journal of Nutrition · doi:10.1016/j.tjnut.2026.101407 · Cited by 3
Effects of Oral Supplementation with Paprika Xanthophylls on Human Skin Moisture
Yatsuhashi, H., Takumi, H., Terada, Y., & Kuriki, T. (2022) · Journal of Oleo Science · doi:10.5650/jos.ess21427 · Cited by 4
Hammond, B. R., & Renzi‐Hammond, L. M. (2016) · Advances in Nutrition · doi:10.3945/an.115.011866 · Cited by 3
“In 2015, an ancillary study of AREDS2 was published that used the same complex design with “cognition” as the outcome variable (24).”
Dadgar, N., Fung, K., McClintic, S. M., Metea, C., Llorenç, V., Saleh, M. G. A., Nakamura, Y., Jahrig, C., Kiang, L., Janowitz, C., et al. (2025) · Ophthalmology Science · doi:10.1016/j.xops.2025.100920 · Cited by 2
“Lifestyle modifications, such as the Mediterranean diet, smoking avoidance, and Age-Related Eye Disease Studies (AREDS) supplementation, can slow AMD progression, 1,4,5 yet the mechanisms of these modifications are poorly understood.”
Zinc in eye health, retinal biology and disease
McKay, B. S., Grabrucker, A. M., Thompson, R. B., Chew, E. Y., Lengyel, I., & González‐Iglesias, H. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101404 · Cited by 4
Self-citation"Cognition and Omega-3 Fatty Acids: A Narrative Review of the Literature"
Javier, G. (2021) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2021.40.006488 · Cited by 2
Patil, M., Banakar, R., Manjunath, B. H., & Gupta, M. M. (2023) · Journal of Clinical Ophthalmology and Research · doi:10.4103/jcor.jcor_24_23 · Cited by 2
Nutrition and neurodegenerative diseases: Alzheimer's disease and others
Bianchi, V. E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91747-6.00013-5 · Cited by 2
Foroushan, S. K., Shokri-Naei, S., Malaekeh-Nikouei, A., Fadaei, M. R., Rahimi, V. B., & Askari, V. R. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106436 · Cited by 2
Over-the-Counter Medications, Vitamins, Minerals, Biologicals, and Herbal Supplements
Bilder, G. E., & Brown-O’Hara, P. (2025) · Springer eBooks · doi:10.1007/978-3-031-84831-5_9 · Cited by 2
Hart, J. A., & Glickman-Simon, R. (2015) · EXPLORE · doi:10.1016/j.explore.2015.12.011 · Cited by 2
Apoaequorin for memory enhancement?
Hume, A. L. (2015) · Pharmacy Today · doi:10.1016/s1042-0991(15)30157-2 · Cited by 2
RICHER, S. P. (2017) · Advances in Ophthalmology & Visual System · doi:10.15406/aovs.2017.07.00219 · Cited by 2
Mattumpuram, J., Maniya, M. T., Noman, A., Fernandes, C. A. L., Tahir, M. F., Khan, R., Hamza, M., Jaiswal, V., Ali, K., Sathian, B., et al. (2025) · Clinical and Translational Discovery · doi:10.1002/ctd2.70094 · Cited by 1
Multispectral imaging for zeaxanthin content in the exocarp of chili peppers
Liang, W., Gao, W., Lv, X., Zhao, J.-X., Tian, X., Di, S., Li, Q., Zhang, D., Luo, S.-X., & Chen, X.-P. (2026) · Food Chemistry: X · doi:10.1016/j.fochx.2026.103992 · Cited by 1
“…can safeguard eye health and reduce the risk of macular degeneration and cataracts (Addo et al., 2024; Hu et al., 2010; Li et al., 2013), prevent cardiovascular diseases (Li et al., 2011; Mares-Perlman et al., 2002), and improve cognitive function (Chew et al., 2015; Zhou, Huang, et al., 2017).”
Mousavi, M. R. A., Milajerdi, A., Keshteli, A. H., Esmaillzadeh, A., Afshar, H., & Adibi, P. (2018) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1
Artificial Intelligence in Retinal Diseases
Kumar, A., Menia, N. K., & Agarwal, A. K. (2021) · Current practices in ophthalmology · doi:10.1007/978-981-16-0634-2_7 · Cited by 1
Oral Nutrient Supplementation and Cognitive Function
Renzi‐Hammond, L. M., Miller, L. S., & Hammond, B. R. (2016) · JAMA · doi:10.1001/jama.2015.16443
Oral Nutrient Supplementation and Cognitive Function
Yurko‐Mauro, K., NELSON, E. B., & Salem, N. (2016) · JAMA · doi:10.1001/jama.2015.16452
Supplemente für Kognitionserhalt ungeeignet
Holzapfel, C. (2015) · MMW - Fortschritte der Medizin · doi:10.1007/s15006-015-7616-8
Heat Diffusion Kernel Algorithm-Based Interpretation of the Disease Intervention Mechanism for DHA
Quan, Y., Zhang, H., Xiong, J., Xu, R., & Gao, M. (2020) · Genes · doi:10.3390/genes11070754
Novotny, K., Fritz, K., & Parmar, M. S. (2021) · StatPearls
Health and Social Concerns in Elderly Men
Roy, P. G., Bhardwaj, R., & Goel, A. (2021) · Springer eBooks · doi:10.1007/978-981-16-4764-2_7
Cognitive decline and Alzheimer’s disease
Leray, C. (2017) · CRC Press eBooks · doi:10.1201/9781315268828-5
(2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811351-6.00026-7
Maurya, M. R., Munshi, R., Thakur, S., & Zambare, S. (2022) · Journal of Exploratory Research in Pharmacology · doi:10.14218/jerp.2022.00066
Dow, C. T. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15500-0.00007-4
Nutritional Supplements for Brain Health
Hasbal‐Celikok, G. (2024) · doi:10.69860/nobel.9786053359241.10
Literature Review: The Effect of Lutein Compounds on Cognitive Function in Adulthood
Maheswari, N. A. (2025) · Jurnal Kesmas dan Gizi (JKG) · doi:10.35451/jkg.v7i2.2712
Xu, Y., Zou, M., Fu, J., Yi, Z., & Zhu, Y. (2025) · Medicine · doi:10.1097/md.0000000000043380 · Cited by 1
Mulargia, R., Ribaldi, F., Mutel, S., Sayin, O., Khachvani, G., Volpara, G., Remoli, G., Nencha, U., Giannoni‐Luza, S., Cappa, S. F., et al. (2025) · Clinical and Translational Neuroscience · doi:10.3390/ctn9030034
“…three studies used fish oil [18,21,29], one used flaxseed oil [13], two used perilla frutescens seed oil [14,19], six used capsules containing DHA and EPA [16,22–24,31 Some studies used additional supplements either as an add-on to n-3 FA supplementation or as comparators in the control group.”
Potential of Hairless Canary Seed as a Food-Based Remedy for Celiac Disease and Diabetes
Abdel‐Aal, E. M., & Gamel, T. H. (2025) · Foods · doi:10.3390/foods14173011
“Lutein plays significant roles in promoting the health of eyes [65,66] and brain [67,68] and in reducing the risk of age-related macular degeneration [69], cataracts [70], breast cancer [71], and cardiovascular disease [72].”
Suh, S. W., Lim, E., Burm, S.-Y., Lee, H., Bae, J. B., Han, J. W., & Kim, K. W. (2024) · Figshare · doi:10.6084/m9.figshare.25389461
The Role of Lutein and Zeaxanthin in Visual and Cognitive Function
Cannataro, R., & Abrego-Guandique, D. M. (2026) · Springer eBooks · doi:10.1007/978-3-032-05253-7_14
Mobilisation de l'acide arachidonique et sensibilité au peptide ß-amyloïde
Thomas, M. H. (2015) · theses.fr (ABES) · doi:10.70675/904987d5zc8c8z4104z95dfz2f7e680d8be3
Gu, X., Terebuh, P., Xu, R., Kaelber, D. C., & Davis, P. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261438849
Associations of early life dietary diversity and child neurodevelopment: a prospective cohort study
Tan, T., Chen, L., Cai, X., Zhou, A., Yang, M., Cao, Z., Yu, L., Li, R., Zhou, S., & Xiao, H. (2026) · Nutrition Journal · doi:10.1186/s12937-026-01328-4
“For instance, long-chain polyunsaturated fatty acids are crucial for cognitive function [9], while minerals like iron and zinc are closely related to the development of children’s cognitive and motor skills [10].”
Editorial: Nutrition in neurodegeneration: bridging diet, brain, and eye health
Gong, X., Roccati, E., & Shang, X. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1869273
Dietary factors and cognitive aging: Mapping epidemiological evidence and the role of gut microbiota
Chen, H., Shen, J., Liu, X., Ni, J., Rong, S., Zheng, J.-S., Xu, W., Huang, G., Luo, B., Zheng, Y., et al. (2026) · The Innovation Nutrition · doi:10.59717/j.xinn-nutri.2026.100030 · Cited by 1
Manjunatha, H. J., Mahalingappa, G., Varadaraju, S. R., Manjunath, S. H., Prashantha, K., Damle, A., Lee, C., & Kumar, A. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103288
Li, X., Jin, Y., Li, X., Chen, M., Kang, C., Lu, H., Gao, H., & Jiang, X. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108479
Metadata
- Authors
- Chew, E. Y., Clemons, T. E., Agrón, E., Launer, L. J., Grodstein, F., & Bernstein, P. S.
- Affiliations
- National Institutes of Health (US)
- Emmes (United States) (US)
- Brigham and Women's Hospital (US)
- University of Utah (US)
- Corresponding author
- Chew, Emily Y.
- ORCID
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2015-08-25
- Volume
- 314
- Issue
- 8
- Pages
- 791
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC5369607
- OpenAlex
- W2164097888
- Cited by
- 191
- References
- 29
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 16 · 2023: 17 · 2022: 19 · 2021: 22 · 2020: 24 · 2019: 9 · 2018: 18 · 2017: 19 · 2016: 17 · 2015: 9
- FWCI
- 20.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 EY999999)
- U.S. Public Health Service (HHS-N-260-2005-00007-C)
- National Eye Institute (ZIAEY000485, N01-EY-5-0007)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- omega-3 fatty acids, long-chain polyunsaturated fatty acids, lutein, zeaxanthin, cognitive function, age-related macular degeneration, AREDS2, dietary supplementation, vitamin E, vitamin C, beta-carotene, zinc, cognitive decline, Alzheimer's disease risk, macular pigment, older adults
- MeSH terms
- Aged, Aged, 80 and over, Algorithms, Ascorbic Acid, Cognition, Copper, Docosahexaenoic Acids, Double-Blind Method, Female, Hispanic or Latino, Humans, Macular Degeneration, Male, Middle Aged, Neuropsychological Tests, Time Factors, Vitamins, Lutein, Zinc Oxide, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Outcome Assessment, Health Care, beta Carotene, Dietary Supplements, Racial Groups, Medication Adherence, Lost to Follow-Up, Zeaxanthins
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