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Association of Daily Step Count and Step Intensity With Mortality Among US Adults
Open accessAbstract
Importance: It is unclear whether the number of steps per day and the intensity of stepping are associated with lower mortality. Objective: Describe the dose-response relationship between step count and intensity and mortality. Design, Setting, and Participants: Representative sample of US adults aged at least 40 years in the National Health and Nutrition Examination Survey who wore an accelerometer for up to 7 days ( from 2003-2006). Mortality was ascertained through December 2015. Exposures: Accelerometer-measured number of steps per day and 3 step intensity measures (extended bout cadence, peak 30-minute cadence, and peak 1-minute cadence [steps/min]). Accelerometer data were based on measurements obtained during a 7-day period at baseline. Main Outcomes and Measures: The primary outcome was all-cause mortality. Secondary outcomes were cardiovascular disease (CVD) and cancer mortality. Hazard ratios (HRs), mortality rates, and 95% CIs were estimated using cubic splines and quartile classifications adjusting for age; sex; race/ethnicity; education; diet; smoking status; body mass index; self-reported health; mobility limitations; and diagnoses of diabetes, stroke, heart disease, heart failure, cancer, chronic bronchitis, and emphysema. Results: A total of 4840 participants (mean age, 56.8 years; 2435 [54%] women; 1732 [36%] individuals with obesity) wore accelerometers for a mean of 5.7 days for a mean of 14.4 hours per day. The mean number of steps per day was 9124. There were 1165 deaths over a mean 10.1 years of follow-up, including 406 CVD and 283 cancer deaths. The unadjusted incidence density for all-cause mortality was 76.7 per 1000 person-years (419 deaths) for the 655 individuals who took less than 4000 steps per day; 21.4 per 1000 person-years (488 deaths) for the 1727 individuals who took 4000 to 7999 steps per day; 6.9 per 1000 person-years (176 deaths) for the 1539 individuals who took 8000 to 11 999 steps per day; and 4.8 per 1000 person-years (82 deaths) for the 919 individuals who took at least 12 000 steps per day. Compared with taking 4000 steps per day, taking 8000 steps per day was associated with significantly lower all-cause mortality (HR, 0.49 [95% CI, 0.44-0.55]), as was taking 12 000 steps per day (HR, 0.35 [95% CI, 0.28-0.45]). Unadjusted incidence density for all-cause mortality by peak 30 cadence was 32.9 per 1000 person-years (406 deaths) for the 1080 individuals who took 18.5 to 56.0 steps per minute; 12.6 per 1000 person-years (207 deaths) for the 1153 individuals who took 56.1 to 69.2 steps per minute; 6.8 per 1000 person-years (124 deaths) for the 1074 individuals who took 69.3 to 82.8 steps per minute; and 5.3 per 1000 person-years (108 deaths) for the 1037 individuals who took 82.9 to 149.5 steps per minute. Greater step intensity was not significantly associated with lower mortality after adjustment for total steps per day (eg, highest vs lowest quartile of peak 30 cadence: HR, 0.90 [95% CI, 0.65-1.27]; P value for trend = .34). Conclusions and Relevance: Based on a representative sample of US adults, a greater number of daily steps was significantly associated with lower all-cause mortality. There was no significant association between step intensity and mortality after adjusting for total steps per day.
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“with an increase of only 500 steps/day associated with 2 -9% decreased risk of cardiovascular morbidity and all-cause mortality rates (105 -107).”
From Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) (2022) · cites this paper as [107]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Prior studies consistently show that taking fewer steps per day1–6 is associated with higher risk of all-cause mortality and cardiovascular disease.”
From Association of step counts over time with the risk of chronic disease in the All of Us Research Program (2022) · cites this paper as [1]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Second, prior studies have focused on a relatively targeted set of outcomes limited to mortality, diabetes and cardiovascular disease.”
From Association of step counts over time with the risk of chronic disease in the All of Us Research Program (2022) · cites this paper as [1]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Physical activity is a key determinant of healthy aging, mitigating physiological decline, reducing the risk of chronic diseases, and preserving functional independence [84,85].”
From The Power of Environment: A Comprehensive Review of the Exposome's Role in Healthy Aging, Longevity, and Preventive Medicine-Lessons from Blue Zones and Cilento (2025) · cites this paper as [84]
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“Moreover, no information is reported about activity levels between the baseline period and when outcomes are assessed at follow-up, often many years later.”
From Association of step counts over time with the risk of chronic disease in the All of Us Research Program (2022) · cites this paper as [1]
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“First, prior studies assessed physical activity either by self-reported questionnaires or by having participants wear a research-grade device for a brief monitoring period (most often 7 days)1–4.”
From Association of step counts over time with the risk of chronic disease in the All of Us Research Program (2022) · cites this paper as [1]
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“The National Health and Nutrition Examination Survey study, which quantified steps over a 7-day monitoring period and assessed mortality over an average of 10.1 years, found a 51% lower mortality at 8,000 steps per day compared with 4,000 steps per day1.”
From Association of step counts over time with the risk of chronic disease in the All of Us Research Program (2022) · cites this paper as [1]
In the citing paper
“beneficial effects can be observed with minimum step counts ranging from 4,000 to 12,000 steps per day [[62], [63], [64], [65]]”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [64]
In the citing paper
“Epidemiological studies examining the relationship between daily step counts and health outcomes have produced varied evidence, indicating that beneficial effects can be observed with minimum step counts ranging from 4,000 to 12,000 steps per day [[62], [63], [64], [65]].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [64]
In the citing paper
“Even an additional 500 steps a day may decrease cardiovascular and all-cause mortality by 2-9%.”
From The Impact of Physical Activity in Patients With Type 2 Diabetes (2025) · cites this paper as [65]
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Citations
Cites
‘Small Changes' to Diet and Physical Activity Behaviors for Weight Management
Hills, A. P., Byrne, N. M., Lindstrom, R. C., & Hill, J. O. (2013) · Obesity Facts · doi:10.1159/000345030 · Cited by 9,526
Physical Activity in the United States Measured by Accelerometer
TROIANO, R. P., BERRIGAN, D., DODD, K. W., MÂSSE, L. C., TILERT, T., & MCDOWELL, M. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31815a51b3 · Cited by 7,638
Self-citationGait speed and survival in older adults.
Studenski, S. (2011) · JAMA · doi:10.1001/jama.2010.1923 · Cited by 4,558
Dose‐response analyses using restricted cubic spline functions in public health research
Desquilbet, L., & Mariotti, F. (2010) · Statistics in Medicine · doi:10.1002/sim.3841 · Cited by 2,016
Higgins (2002) · doi:10.1002/(issn)1097-0258 · Cited by 1,248
Physical Activity Is the Strongest Predictor of All-Cause Mortality in Patients With COPD
Waschki, B., Kirsten, A., Holz, O., Müller, K.-C., Meyer, T., Watz, H., & MAGNUSSEN, H. (2011) · CHEST Journal · doi:10.1378/chest.10-2521 · Cited by 974
(2001) · PubMed · Cited by 612
Association of Step Volume and Intensity With All-Cause Mortality in Older Women
Lee, I.-M., Shiroma, E. J., Kamada, M., Bassett, D. R., Matthews, C. E., & Buring, J. E. (2019) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2019.0899 · Cited by 604
Self-citationStep Counting: A Review of Measurement Considerations and Health-Related Applications
Bassett, D. R., Toth, L. P., LaMunion, S. R., & Crouter, S. E. (2017) · Sports Medicine · doi:10.1007/s40279-016-0663-1 · Cited by 460
Self-citationLobelo, F., Rohm Young, D., Sallis, R., Garber, M. D., Billinger, S. A., Duperly, J., Hutber, A., Pate, R. R., Thomas, R. J., Widlansky, M. E., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000559 · Cited by 402
Flagged first, then by citations
2 of the 27 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- SAS Institute, 2013, SAS/STAT 13.1 User’s Guide: Volume 62, 5172
- 2018, 2018 Physical Activity Guidelines Advisory Committee Scientific Report
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Sorted by citations
Items 101–200 of 659
Master, H., Bley, J. A., Coronado, R. A., Robinette, P. E., White, D. K., Pennings, J. S., & Archer, K. R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263562 · Cited by 29
“Taking more steps per day is known to improve health outcomes and reduce the risk of all-cause mortality [11, 43], which suggest that wearables may play an integral role in enhancing postoperative recovery following total knee or hip arthroplasty [44].”
BackgroundThe value of walking: A systematic review on mobility and healthcare costs
Wohlrab, M., Klenk, J., Delgado-Ortiz, L., Chambers, M., Rochester, L., Zuchowski, M., Schwab, M., Becker, C., & Jaeger, S. U. (2022) · European Review of Aging and Physical Activity · doi:10.1186/s11556-022-00310-3 · Cited by 26
“For example, taking more steps per day is associated with progressively lower all-cause mortality for young-middle age adults as well as for older adults [6].”
BackgroundSmall, S. R., Chan, S., Walmsley, R., von Fritsch, L., Acquah, A., Mertes, G., Feakins, B. G., Creagh, A. P., Strange, A., Matthews, C. E., et al. (2024) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003478 · Cited by 48
Self-citationChang, Q., Zhu, Y., Liu, Z., Cheng, J. S., Liang, H., Lin, F., Li, D., Peng, J., Pan, P., & Zhang, Y. (2024) · BMC Medicine · doi:10.1186/s12916-024-03599-2 · Cited by 28
“Another NHANES study revealed that a greater number of daily steps was significantly associated with lower all-cause mortality, independent of the step intensity [22].”
BackgroundNew principles, the benefits, and practices for fostering a physically active lifestyle
Rozanski, A. (2023) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2023.04.002 · Cited by 32
Aliberti, S. M., & Capunzo, M. (2025) · Nutrients · doi:10.3390/nu17040722 · Cited by 29
Breast cancer and cardiovascular health
López‐Fernández, T., Clement, I. M., Aznar, M. C., Barac, A., Bergler-Klein, J. K., Meattini, I., Scott, J. M., Cardinale, D. M., & Dent, S. F. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae637 · Cited by 31
Exercise physiology in cirrhosis and the potential benefits of exercise interventions: A review
West, J., Gow, P. J., Testro, A., Chapman, B., & Sinclair, M. J. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15474 · Cited by 28
Buttery, S. C., Williams, P. J., Alghamdi, S. M., Philip, K. E. J., Perkins, A., Kallis, C., Quint, J. K., Polkey, M. I., Breuls, S., Buekers, J., et al. (2023) · European Respiratory Review · doi:10.1183/16000617.0134-2023 · Cited by 28
Ito, K., Suzuki, Y., Sakaguchi, T., Fujiwara, K., Nishii, Y., Yasui, H., Taguchi, O., & Hataji, O. (2024) · JAMA Oncology · doi:10.1001/jamaoncol.2024.0023 · Cited by 26
Inactivity Causes Resistance to Improvements in Metabolism After Exercise
Coyle, E. F., Burton, H. M., & Satiroglu, R. (2022) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000280 · Cited by 26
Against the Little-v Hypothesis
Horváth, J., & Siloni, T. (2002) · Cited by 26
Person-specific dose-finding for a digital messaging intervention to promote physical activity.
Hojjatinia, S., Hojjatinia, S., Lagoa, C. M., Brunke-Reese, D., & Conroy, D. E. (2021) · Health Psychology · doi:10.1037/hea0001117 · Cited by 28
Lin, F., Bloomer, P. M., Grubbs, R. K., Rockette‐Wagner, B., Tevar, A. D., Dunn, M. A., & Duarte‐Rojo, A. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2022.03.012 · Cited by 25
Accurate Step Count with Generalized and Personalized Deep Learning on Accelerometer Data
Luu, L., Pillai, A., Lea, H., Buendía, R., Khan, F. M., & Dennis, G. (2022) · Sensors · doi:10.3390/s22113989 · Cited by 26
Yamada, Y., Yoshida, T., Nakagata, T., Nanri, H., & Miyachi, M. (2021) · The journal of nutrition health & aging · doi:10.1007/s12603-021-1662-y · Cited by 24
Consumer-based activity trackers in evaluation of physical activity in myositis patients
Saygın, D., Rockette‐Wagner, B., Oddis, C. V., Neiman, N., Koontz, D. C., Moghadam‐Kia, S., & Aggarwal, R. (2021) · Rheumatology · doi:10.1093/rheumatology/keab700 · Cited by 26
Nadimi-Shahraki, M. H., Mohammadi, S., Zamani, H., Gandomi, M., & Gandomi, A. H. (2021) · Electronics · doi:10.3390/electronics10243167 · Cited by 24
The Evidence for Exercise in Medicine — A New Review Series
Guseh, J. S., Lieberman, D. E., & Baggish, A. L. (2022) · NEJM Evidence · doi:10.1056/evidra2100002 · Cited by 24
López-Nava, I. H., Valentín-Coronado, L. M., García-Constantino, M., & Favela, J. (2020) · Sensors · doi:10.3390/s20174756 · Cited by 24
“In some studies, the adult population has been found to walk between 6000 to 9000 steps per day [8,9].”
BackgroundFanaroff, A. C., Patel, M. S., Chokshi, N., Coratti, S., Farraday, D., Norton, L., Rareshide, C., Zhu, J., Szymczak, J. E., Russell, L. B., et al. (2023) · American Heart Journal · doi:10.1016/j.ahj.2023.02.014 · Cited by 23
Cadence (steps/min) and relative intensity in 21 to 60-year-olds: the CADENCE-adults study
McAvoy, C. R., Moore, C. C., Aguiar, E. J., Ducharme, S. W., Schuna, J. M., Barreira, T. V., Chase, C. J., Gould, Z. R., Amalbert‐Birriel, M. A., Chipkin, S. R., et al. (2021) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-021-01096-w · Cited by 23
“Although the benefits of accumulating a high daily volume of steps are understood [8, 9], a focus on volume overlooks the rate or frequency of stepping (i.”
BackgroundA Clinician’s Guide to Smartwatch “Interrogation”
Gupta, S. K., Mahmoud, A., & Massoomi, M. R. (2022) · Current Cardiology Reports · doi:10.1007/s11886-022-01718-0 · Cited by 24
“Furthermore, the benefits of increased steps per day are continuous, meaning an increase in just 1000 steps a day is associated with lower mortality, especially those with lower baseline step counts [7, 8].”
BackgroundDuan, N., Norman, D., Schmid, C. H., Sim, I., & Kravitz, R. L. (2022) · Harvard Data Science Review · doi:10.1162/99608f92.8439a336 · Cited by 24
Watanabe, D., Yamada, Y., Yoshida, T., Watanabe, Y., Hatamoto, Y., Fujita, H., Miyachi, M., & Kimura, M. (2022) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14234 · Cited by 23
Small, S. R., Chan, S., Walmsley, R., Fritsch, L. V., Acquah, A., Mertes, G., Feakins, B. G., Creagh, A., Strange, A., Matthews, C. E., et al. (2023) · doi:10.1101/2023.02.20.23285750 · Cited by 22
Self-citationAssociation of daily step count and serum testosterone among men in the United States
Giudice, F. D., Glover, F. E., Belladelli, F., BERARDINIS, E. D., Sciarra, A., Salciccia, S., Kasman, A. M., Chen, T., & Eisenberg, M. L. (2021) · Endocrine · doi:10.1007/s12020-021-02631-2 · Cited by 22
Howe, C. A., Corrigan, R. J., de Faria, F. R., Johanni, Z., Chase, P. J., & Hillman, A. R. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182211935 · Cited by 22
“7% of adults over 40 years reached a minimum of 8000 steps/day, which declines with age [1].”
BackgroundZhou, Y., Sun, X., Yang, G., Ding, N., Pan, X., Zhong, A., Guo, T., Peng, Z., & Chai, X. (2023) · Heart & Lung · doi:10.1016/j.hrtlng.2023.07.009 · Cited by 22
The evolution of human step counts and its association with the risk of chronic disease
Raichlen, D. A., & Lieberman, D. E. (2022) · Current Biology · doi:10.1016/j.cub.2022.09.030 · Cited by 21
Parikh, R. B., Hasler, J., Zhang, Y., Liu, M., Chivers, C., Ferrell, W. J., Gabriel, P. E., Lerman, C. E., Bekelman, J. E., & Chen, J. (2022) · JCO Clinical Cancer Informatics · doi:10.1200/cci.22.00073 · Cited by 25
“Prior retrospective studies have found that adverse quality of life and symptoms such as depression, fatigue, and pain are independently associated with poorer survival.(21,47,48) However, few studies have demonstrated the independent prognostic value of PROs in contemporary machine learning algorithms.”
BackgroundLiu, L., Yan, Y.-Q., Qiu, J., Chen, Q., Zhang, Y., Liu, Y., Zhong, X., Liu, Y., & Tan, R. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04622-1 · Cited by 21
“Evidence supporting the encouragement of exercise comes from observational studies, which showed that walking more steps per day is negatively related to the risk of mortality and is related to walking intensity (gait frequency) [50].”
BackgroundLefferts, E. C., Bakker, E. A., Carbone, S., Lavie, C. J., & Lee, D.-C. (2021) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2021.02.011 · Cited by 20
Jeng, B., Cederberg, K. L. J., Huynh, T. L. T., Šilić, P., Jones, C. D., Feasel, C. D., Sikes, E. M., Baird, J. F., Silveira, S. L., Sasaki, J. E., et al. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.103312 · Cited by 21
Clevenger, K. A., Berrigan, D. A., Patel, S., Saint‐Maurice, P. F., & Matthews, C. E. (2023) · Health & Place · doi:10.1016/j.healthplace.2023.102983 · Cited by 20
Self-citationDaily steps and all-cause mortality: An umbrella review and meta-analysis
Rodríguez-Gutiérrez, E., Torres-Costoso, A., del Pozo Cruz, B., de Arenas-Arroyo, S. N., Pascual-Morena, C., Bizzozero-Peroni, B., & Martínez-Vizcaíno, V. (2024) · Preventive Medicine · doi:10.1016/j.ypmed.2024.108047 · Cited by 19
Ward, W. H., Meeker, C. R., Handorf, E. R., Hill, M. V., Einarson, M. B., Alpaugh, R. K., Holden, T. L., Astsaturov, I. A., Denlinger, C. S., Hall, M. J., et al. (2021) · JCO Clinical Cancer Informatics · doi:10.1200/cci.20.00117 · Cited by 19
Han, M., Preciado, P., Thwin, O., Tao, X., Silva, L. M. T., Fuentes, L. R., Hakim, M. I., Patel, A. U., Tisdale, L., Zhang, H., et al. (2021) · Blood Purification · doi:10.1159/000514935 · Cited by 19
Zhang, F., Ren, Y., Wang, H., Bai, Y., & Huang, L. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.842423 · Cited by 19
“Being physically active is a healthy lifestyle considered a core part of the general and CKD populations (2).”
BackgroundMethodInfluentialKim, J., Yang, P., Park, B., Kang, T. S., Lim, S., Cho, S., Lee, S., Chung, Y. H., Lee, M., Kim, D., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.859277 · Cited by 19
“study (29), based on a representative sample of US adults (mean age, 56.”
BackgroundEvaluation of physical health status beyond daily step count using a wearable activity sensor
Xu, Z., Zahradka, N., Ip, S., Koneshloo, A., Roemmich, R. T., Sehgal, S., Highland, K. B., & Searson, P. C. (2022) · npj Digital Medicine · doi:10.1038/s41746-022-00696-5 · Cited by 19
“There are three key factors that contribute to the relatively high usage in this study: (1) the device is wrist worn and has a small form factor, (2) the battery life is up to 7–10 days, (3) many models are waterproof and hence do not need to be taken off between charges.”
BackgroundMethodBianchini, E., Galli, S., Alborghetti, M., Carolis, L. D., Zampogna, A., Hansen, C., Vuillerme, N., Suppa, A., & Pontieri, F. E. (2023) · Sensors · doi:10.3390/s23218971 · Cited by 19
“More importantly, daily step count has been reported to be associated with general mortality [5,11–14] as well as with the incidence of several pathological conditions such as cancer [15], cardiovascular disease [15], and dementia [16] in older adults.”
BackgroundBeyond Detection: Towards Actionable Sensing Research in Clinical Mental Healthcare
Adler, D. A., Yang, Y., Viranda, T., Xu, X., Mohr, D. C., Meter, A. V., Tartaglia, J., Jacobson, N. C., Wang, F., Estrin, D. L., et al. (2024) · Proceedings of the ACM on Interactive Mobile Wearable and Ubiquitous Technologies · doi:10.1145/3699755 · Cited by 27
“[94, 102, 142], and have also identified associations between passive data and symptom reduction [1].”
Kamada, M., HAYASHI, H., Shiba, K., TAGURI, M., KONDO, N., Lee, I.-M. M., & Kawachi, I. I. (2021) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002770 · Cited by 22
Suau, Q., Bianchini, E., Bellier, A., Chardon, M., Milane, T., Hansen, C., & Vuillerme, N. (2024) · Sensors · doi:10.3390/s24030825 · Cited by 23
The Impact of Physical Activity in Patients With Type 2 Diabetes
Bassin, S. R., & Srinath, R. (2025) · American Journal of Lifestyle Medicine · doi:10.1177/15598276231180541 · Cited by 17
“65 Of note, these studies were observational trials, and therefore, the impacts of walking cannot be directly causational to the mentioned outcomes.”
Nguyen, S., Bellettiere, J., Anuskiewicz, B., Di, C., Carlson, J., Natarajan, L., LaMonte, M. J., & LaCroix, A. Z. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.031156 · Cited by 17
“29 The adjusted population attributable risks were calculated using the confounder-adjusted (model 3) Cox regression models as ( R − Rc )∕ R where the observed mortality rate was calculated as R = I ∑ r i with I as the baseline hazard rate and r i as the estimated relative risk for participant i…”
MethodLifestyle Intervention for Sustained Remission of Metabolic Syndrome
Powell, L. H., Berkley‐Patton, J., Drees, B. M., Karavolos, K., Lohse, B., Masters, K. S., Nicklas, J. M., Rothschild, S. K., Yeh, C., Zimmermann, L. J., et al. (2025) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2025.5900 · Cited by 20
Page, A., Yung, N. C. W., Auinger, P., Venuto, C. S., Glidden, A. M., Macklin, E. A., Omberg, L., Schwarzschild, M. A., & Dorsey, E. R. (2022) · Digital Biomarkers · doi:10.1159/000521232 · Cited by 17
Meigh, N. J., Keogh, J., Schram, B. L., Hing, W. A., & Rathbone, E. N. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-02958-z · Cited by 22
“Faster walking speed, and greater walking distance, are also associated with significant reductions in cardiovascular disease and all-cause mortality compared to slower, shorter walks, with a more pronounced dose–response effect in those over 50 years of age [37, 38].”
BackgroundShi, C., Babiker, N., Urbanek, J. K., Grossman, R. L., Huisingh-Scheetz, M. J., & Rzhetsky, A. (2022) · npj Aging · doi:10.1038/s41514-022-00087-w · Cited by 17
Hornby, T. G., Plawecki, A., Lotter, J. K., Scofield, M., Lucas, E., & Henderson, C. E. (2022) · Physical Therapy · doi:10.1093/ptj/pzac073 · Cited by 19
Tashiro, H., & Takahashi, K. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041631 · Cited by 20
“A multicenter, cohort analysis in the US showed that a greater number of daily steps measured by accelerometer is significantly associated with lower all-cause mortality [39].”
BackgroundTamai, K., Terai, H., Takahashi, S., Katsuda, H., Shimada, N., Habibi, H., & Nakamura, H. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03316-9 · Cited by 17
“Regular physical activity and/or exercise, play an important role in preventing adverse health outcomes [6, 7].”
BackgroundModerate-intensity stepping in older adults: insights from treadmill walking and daily living
Yates, T., Henson, J., Mcbride, P., Maylor, B., Herring, L., Sargeant, J., Davies, M., Dempsey, P., Rowlands, A., & Edwardson, C. (2023) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-023-01429-x · Cited by 16
“This is supported by observational studies showing that associations between step cadence and health outcomes are largely attenuated after adjustment for overall stepping volume [9, 11], including in older adults [8, 10].”
ResultHsueh, M., Rutherford, R., Chou, C., Park, J., Park, H.-T., & Liao, Y. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-034645 · Cited by 16
O’Mara, S. M. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.654122 · Cited by 16
Hamaya, R., Mori, M., Miyake, K., & Lee, I.-M. M. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.025689 · Cited by 14
Júdice, P. B., Sousa‐Sá, E., & Palmeira, A. L. (2023) · Journal of Prevention · doi:10.1007/s10935-023-00724-4 · Cited by 21
“Also, the number of deaths assigned to this unhealthy lifestyle is belligerently increasing in adults (Pratt et al., 2020; Saint-Maurice et al., 2020).”
BackgroundPowell, L. H., Daniels, B. T., Drees, B. M., Karavolos, K., Lohse, B., Masters, K. S., Nicklas, J. M., Ruder, E. H., Suzuki, S., Trabold, N., et al. (2024) · American Heart Journal · doi:10.1016/j.ahj.2023.12.016 · Cited by 16
Bishop, L., Demers, M., Rowe, J. B., Zondervan, D. K., & Winstein, C. J. (2024) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2024.01.020 · Cited by 16
Characterizing Longitudinal Changes in Physical Activity and Fear of Falling after Falls in Glaucoma
Jian‐Yu, E., Mihailović, A., Schrack, J. A., Li, T., Friedman, D. S., West, S. K., Gitlin, L. N., & Ramulu, P. Y. (2021) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17014 · Cited by 16
Opinion paper: Exercise for healthy aging
Erkkola, R. U., Vasankari, T. J., & Erkkola, R. A. (2020) · Maturitas · doi:10.1016/j.maturitas.2020.10.012 · Cited by 15
de Buisonjé, D. R., Reijnders, T., Rodrigues, T. C., Santhanam, P., Kowatsch, T., Lipman, S. A., Bijmolt, T. H. A., Breeman, L. D., Janssen, V. R., Kraaijenhagen, R. A., et al. (2022) · Journal of Medical Internet Research · doi:10.2196/38339 · Cited by 20
“This is a large and clinically relevant effect with a mortality-reducing potential [5,6].”
Salerno, E. A., Saint‐Maurice, P. F., Wan, F., Peterson, L. L., Park, Y., Cao, Y., Duncan, R. P., Troiano, R. P., & Matthews, C. E. (2023) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkad007 · Cited by 17
“Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for covariates based on previous research (28,30), and included age, sex, race and ethnicity, education, diet, smoking status, BMI, self-reported health, mobility limitations, and diagnose…”
MethodSelf-citationMazéas, A., Forestier, C., Harel, G., Duclos, M., & Chalabaëv, A. (2024) · Journal of Medical Internet Research · doi:10.2196/47116 · Cited by 15
“The daily step count is a trusted proxy for PA [29].”
Schrier, E., Xiong, N., Thompson, E., Poort, H., Schumer, S., Liu, J. F., Krasner, C. N., Campos, S. M., Horowitz, N. S., Feltmate, C. M., et al. (2021) · Gynecologic Oncology · doi:10.1016/j.ygyno.2021.02.023 · Cited by 15
del Pozo-Cruz, J., Álvarez‐Barbosa, F., Gallardo‐Gómez, D., & Cruz, B. D. P. (2022) · Diabetes Care · doi:10.2337/dc22-0524 · Cited by 18
Stanesby, O., Greaves, S. P., Jose, K., Sharman, M. J., Blizzard, C. L., Palmer, A. J., Evans, J. T., Cooper, K., Morse, M., & Cleland, V. J. (2023) · Journal of Transport & Health · doi:10.1016/j.jth.2023.101624 · Cited by 16
Beneficial Effects of Physical Activity on Subjects with Neurodegenerative Disease
Vizzi, L., Padua, E., D’Amico, A. G., Tancredi, V., D’Arcangelo, G., Cariati, I., Scimeca, M., Maugeri, G., D’Agata, V., & Montorsi, M. (2020) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk5040094 · Cited by 16
“Exercise can be effective in improving cognition, independent functioning, and psychological health in adults over 65 and sedentary adults with the diseases mentioned above [10,11].”
BackgroundPrice, J. C., Santos, H. O., & Bueno, A. A. (2022) · Digital Health · doi:10.1177/20552076221091351 · Cited by 13
“36 37 – 39 Kim et al. 24 found that a combination of a smartphone application for daily self-monitoring and wearable tracker was associated with signi fi cant weight reduction.”
BackgroundMaharaj, M. M., Natarajan, P., Fonseka, R. D., Khanna, S., Choy, W. J., Rooke, K., Phan, K. H., & Mobbs, R. J. (2022) · Journal of Spine Surgery · doi:10.21037/jss-22-5 · Cited by 14
Soulard, J., Carlin, T., Knitza, J., & Vuillerme, N. (2022) · JMIR mhealth and uhealth · doi:10.2196/34734 · Cited by 15
“The number of daily steps remains the outcome of choice for monitoring an individual’s activity level [44,76-78].”
BackgroundFree-Living Peak Cadence in Multiple Sclerosis: A New Measure of Real-World Walking?
Zheng, P., Jeng, B., Huynh, T. L. T., Aguiar, E. J., & Motl, R. W. (2023) · Neurorehabilitation and neural repair · doi:10.1177/15459683231206741 · Cited by 14
“12,13,17 Walking cadence has been applied for classifying PA intensity in MS and there is initial validity for this application among individuals of varying disability levels.”
MethodHarada, S., Hamai, S., Shiomoto, K., Kawahara, S., Hara, D., Harada, T., & Nakashima, Y. (2023) · International Orthopaedics · doi:10.1007/s00264-023-06022-2 · Cited by 14
“Smaller numbers of daily steps were associated with higher risk of mortality [31].”
Xu, C., Jia, J., Zhao, B., Yuan, M., Luo, N., Zhang, F., & Wang, H. (2024) · BMJ Open · doi:10.1136/bmjopen-2024-088524 · Cited by 14
“Using the furthest parking spot.”
Steffen, J., Schlichtiger, J., Brunner, S., & Huber, B. C. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02899-y · Cited by 14
“They have been established as an overall measure of PA and an excellent prognostic marker for all-cause mortality [10].”
BackgroundKeller, J. L., Tian, F., Fitzgerald, K. C., Mische, L., Ritter, J., Costello, M. G., Mowry, E. M., Zippunikov, V., & Zackowski, K. M. (2022) · Journal of Rehabilitation and Assistive Technologies Engineering · doi:10.1177/20556683211067362 · Cited by 14
“Recent studies have turned to the use of motion sensors, such as accelerometers, aiming to develop a new gold standard for quantifying walking mobility.(5,6,7) The wearable accelerometer is a non-invasive, objective, and inexpensive technology that records human movement in realtime in a real-world context.”
BackgroundMiller, A. E., Collier, Z. K., & Reisman, D. S. (2022) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-022-01091-7 · Cited by 13
“Measures of activity volume, specifically ASPD, was associated with all-cause mortality in a large sample of adults living in the United States [52], suggesting that measures of activity volume may have important health implications.”
BackgroundMethodInfluentialFrancis, S. L., Simmering, J. E., Polgreen, L. A., Evans, N. J., Hosteng, K. R., Carr, L. J., Cremer, J. F., Coe, S., Cavanaugh, J. E., Segre, A. M., et al. (2021) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2021.101426 · Cited by 13
“(Saint-Maurice et al., 2020) Another recent study found S.L. Francis et al. older women walking 4,400 steps/day had a 41% lower mortality rate compared to women walking 2,700 steps/day.”
BackgroundMethodInfluentialLiew, S. J., Petrunoff, N., Neelakantan, N., van Dam, R. M., & Müller‐Riemenschneider, F. (2022) · AJPM Focus · doi:10.1016/j.focus.2022.100054 · Cited by 17
“Finally, the meta-analyses included 5 studies 38,39,43,44,46 for CVD mortality and 15 studies 21,36,38 − 40 The association between TPA and CVD mortality was investigated in 3 studies.”
BackgroundMethodFukuie, T., Inoue, K., & Yamaguchi, A. (2023) · American Journal of Lifestyle Medicine · doi:10.1177/15598276231156546 · Cited by 14
Kuo, F.-C., Lin, Y.-T., Chueh, T., Chang, Y., Hung, T., & Chen, Y.-C. (2023) · European Journal of Applied Physiology · doi:10.1007/s00421-023-05278-1 · Cited by 14
“…activity assessed via pedometer is an easy metric of measurement that help generally quantifying daily activity and which has been well-recognised to be strongly associated with the risk of obesity, CVD and type 2 diabetes in the clinical research (Jayedi et al. 2022; Saint-Maurice et al. 2020).”
Reducing Mortality and Cardiovascular Disease
Lavie, C. J., German, C. A., & Sanchis‐Gomar, F. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.08.007 · Cited by 13
Step count and multiple health outcomes: An umbrella review
Ao, Z., He, H., Shi, H., & Liu, H. (2024) · Journal of Evidence-Based Medicine · doi:10.1111/jebm.12596 · Cited by 13
Evolution of the Olympic Movement: Adapting to Contemporary Global Challenges
Theodorakis, Y., Georgiadis, K., & Hassandra, M. (2024) · Social Sciences · doi:10.3390/socsci13070326 · Cited by 13
“Simple solutions, like walking, remain underutilized, even though studies link higher daily step counts to lower all-cause mortality (Jayedi et al. 2022; Saint-Maurice et al. 2020).”
BackgroundCheng, Z., Zeng, Q., Zhu, C., Yang, G., & Zhong, L. (2024) · Sleep Health · doi:10.1016/j.sleh.2024.08.005 · Cited by 13
O’Regan, A., Hannigan, A., Glynn, L. G., Bengoechea, E. G., Donnelly, A., Hayes, G., Murphy, A. W., Clifford, A. M., Gallagher, S. M., & Woods, C. B. (2021) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2021.101641 · Cited by 13
Du, L., Zhang, X., Wang, W., He, Q., Li, T., Chen, S., & Pan, Y. (2022) · Geriatric Nursing · doi:10.1016/j.gerinurse.2022.05.001 · Cited by 12
With life there is motion. Activity biomarkers signal important health and performance outcomes
Friedl, K. E., & Looney, D. P. (2023) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2023.01.009 · Cited by 13
Hagedoorn, I. J. M., den Braber, N., Oosterwijk, M. M., Gant, C. M., Navis, G. J., Vollenbroek-Hutten, M. M. R., van Beijnum, B.-J. F., Bakker, S. J. L., & Laverman, G. D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103104 · Cited by 14
“Traditionally, a goal of 10,000 steps per day has been advocated by popular media, although this goal is under debate in scientific literature [6,7].”
BackgroundHillmann, H. A. K., Hohmann, S., Müller‐Leisse, J., Zormpas, C., Eiringhaus, J., Bauersachs, J. K., Veltmann, C., & Duncker, D. (2021) · Sensors · doi:10.3390/s21237798 · Cited by 13
“Just as described above for the resting heart rate, population-based cohort studies showed that a higher number of steps per day correlated with a lower mortality rate in a cohort of adults [44].”
BackgroundDaily Walking Dose and Health-related Quality of Life in Patients With Chronic Kidney Disease
Xiong, J., Peng, H., Yu, Z., Chen, Y., Pu, S., Li, Y., Huang, X., Tang, X., He, J., Shi, Y., et al. (2022) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2022.01.015 · Cited by 14
Fitton, J., Nguyen, D. P., Lechat, B., Scott, H., Toson, B., Manners, J., Dunbar, C., Sansom, K., Pinilla, L., Hudson, A. L., et al. (2025) · Communications Medicine · doi:10.1038/s43856-025-01226-6 · Cited by 13
Group-Based Exercise in CKD Stage 3b to 4: A Randomized Clinical Trial
Anand, S., Ziolkowski, S., Bootwala, A., Li, J., Pham, N. M., Cobb, J., & Lobelo, F. (2021) · Kidney Medicine · doi:10.1016/j.xkme.2021.04.022 · Cited by 14
“and walked a mean of approximately 5,000 steps per day, between about the 10th and 20th percentile of US adults.(54)”
BackgroundConsensus of Chinese experts on exercise therapy for cancer patients
Cong, M., & HanPing, S. H. I. (2022) · Scientia Sinica Vitae · doi:10.1360/ssv-2022-0028 · Cited by 12
de Paula, D., Crochemore‐Silva, I., Griep, R. H., Duncan, B. B., & Schmidt, M. I. (2023) · Journal of Physical Activity and Health · doi:10.1123/jpah.2023-0106 · Cited by 14
Wu, J., Qiu, P., & Li, Y. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.08.184 · Cited by 12
Leisure Time Physical Activity in Relation to Mortality Among African American Women
Li, S., Palmer, J. R., & Rosenberg, L. A. (2020) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2020.05.013 · Cited by 12
Ferrante, J. M., Lulla, A., Williamson, J. D., Devine, K. A., Ohman‐Strickland, P., & Bandera, E. V. (2021) · American Journal of Health Promotion · doi:10.1177/08901171211036700 · Cited by 12
Metadata
- Authors
- Saint-Maurice, P. F., Troiano, R. P., Bassett, D. R., Graubard, B. I., Carlson, S. A., Shiroma, E. J., Fulton, J. E., & Matthews, C. E.
- Affiliations
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland
- National Cancer Institute (US)
- University of Tennessee at Knoxville (US)
- Division of Cancer Epidemiology and Genetics (US)
- Centers for Disease Control and Prevention (US)
- National Institutes of Health (US)
- ORCID
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2020-03-24
- Volume
- 323
- Issue
- 12
- Pages
- 1151
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC7093766
- OpenAlex
- W3012745165
- Cited by
- 660
- References
- 27
- Citations by year
- 2026: 58 · 2025: 102 · 2024: 122 · 2023: 104 · 2022: 124 · 2021: 92 · 2020: 57
- FWCI
- 56.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- daily step count, physical activity, all-cause mortality, cardiovascular mortality, cancer mortality, dose-response relationship, accelerometer-measured activity, cadence, older adults, obesity, sedentary behavior, physical activity guidelines, mortality risk reduction, NHANES
- MeSH terms
- Adult, Aged, Cardiovascular Diseases, Female, Gait, Humans, Male, Middle Aged, Neoplasms, Nutrition Surveys, United States, Incidence, Proportional Hazards Models, Walking, Accelerometry
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