Genetic Variants of SARS-CoV-2—What Do They Mean?
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This Viewpoint discusses emerging genetic variants of SARS-CoV-2, including new “UK” and “mink” variants and the significance of the new variants to coronavirus transmissibility, spread, virulence, and efforts to vaccinate the population against COVID-19.
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Antibody levels from plasma cells decline with time, yet durable immune memory can remain in expanded memory B cell clones.
“Although circulating antibodies derived from plasma cells wane over time, long-lived immune memory can persist in expanded clones of memory B cells7,20.”
From mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants (2021) · cites this paper as [20]
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Self-citation
- Authors
- Lauring, A. S., & Hodcroft, E. B.
- Affiliations
- University of Michigan (US)
- University of Bern (CH)
- Corresponding author
- Lauring, Adam S.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2021-02-09
- Volume
- 325
- Issue
- 6
- Pages
- 529
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W3119231619
- Cited by
- 604
- References
- 12
- Citations by year
- 2026: 9 · 2025: 20 · 2024: 39 · 2023: 72 · 2022: 197 · 2021: 264 · 2020: 2
- FWCI
- 45.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- JAMA (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Keywords
- SARS-CoV-2, genetic variants, UK variant, COVID-19 pandemic, transmissibility, virulence, COVID-19 vaccination, viral evolution
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Vaccines, Animals, Humans, Mink, Mutation, Phylogeny, Genetic Variation, Spike Glycoprotein, Coronavirus
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