Cited by 604SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesCOVID-19 epidemiological studies

Genetic Variants of SARS-CoV-2—What Do They Mean?

Open access
Lauring, Adam S., Hodcroft, Emma B.·2021·JAMA

Abstract

This Viewpoint discusses emerging genetic variants of SARS-CoV-2, including new “UK” and “mink” variants and the significance of the new variants to coronavirus transmissibility, spread, virulence, and efforts to vaccinate the population against COVID-19.

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Crossref · 10.1001/jama.2020.27124

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  • Antibody levels from plasma cells decline with time, yet durable immune memory can remain in expanded memory B cell clones.

    “Although circulating antibodies derived from plasma cells wane over time, long-lived immune memory can persist in expanded clones of memory B cells7,20.”

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Authors
Lauring, A. S., & Hodcroft, E. B.
Affiliations
  • University of Michigan (US)
  • University of Bern (CH)
Corresponding author
Lauring, Adam S.
Venue
JAMA
Published
2021-02-09
Volume
325
Issue
6
Pages
529
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
OpenAlex
W3119231619
Cited by
604
References
12
Citations by year
2026: 9 · 2025: 20 · 2024: 39 · 2023: 72 · 2022: 197 · 2021: 264 · 2020: 2
FWCI
45.16
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • JAMA (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
Keywords
SARS-CoV-2, genetic variants, UK variant, COVID-19 pandemic, transmissibility, virulence, COVID-19 vaccination, viral evolution
MeSH terms
COVID-19, SARS-CoV-2, COVID-19 Vaccines, Animals, Humans, Mink, Mutation, Phylogeny, Genetic Variation, Spike Glycoprotein, Coronavirus

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