Emergence of a Novel SARS-CoV-2 Variant in Southern California

Zhang, Wenjuan; Davis, Brian D.; Chen, Stephanie S.; Sincuir Martinez, Jorge M.; Plummer, Jasmine T.; Vail, Eric

doi:10.1001/jama.2021.1612

Cited by 371SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesSARS-CoV-2 detection and testing

Emergence of a Novel SARS-CoV-2 Variant in Southern California

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Zhang, Wenjuan, Davis, Brian D., Chen, Stephanie S., Sincuir Martinez, Jorge M., Plummer, Jasmine T., Vail, Eric·2021·JAMA

DOI 10.1001/jama.2021.1612PMC PMC7879386

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Abstract

This research describes findings of sequencing and phylogenetic analyses of SARS-CoV-2 isolates from symptomatic patients cared for at Cedar-Sinai Medical Center in November-December 2020 during a regional surge in cases and hospitalizations.

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Epsilon, first identified in California in 2021, showed a 20% increase in transmission possibly attributed to L452R and D614G substitutions.
“The Epsilon (GH/452R.V1) variant first identified in California, the USA in 2021, showed a 20% increase in transmission possibly attributed to the L452R and D614G substitutions in the spike protein [36].”
From Waves and variants of SARS-CoV-2: understanding the causes and effect of the COVID-19 catastrophe (2022) · cites this paper as [36]
The Results passage (page not specified) identifies a Southern California variant, CAL.20C, with an L452R spike substitution, but says it was first observed in July 2020, not 2021. The Discussion says its effect on infectivity remained uncertain; the paper does not report a 20% transmission increase or attribute one to L452R and D614G. (LLM, conf=0.90)
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Authors: Zhang, W., Davis, B. D., Chen, S. S., Sincuir Martinez, J. M., Plummer, J. T., & Vail, E.
Affiliations: Cedars-Sinai Medical Center (US)
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California
Corresponding author: Plummer, Jasmine T.
ORCID: Zhang, Wenjuan
Davis, Brian D.
Plummer, Jasmine T.
Vail, Eric
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2021-04-06
Volume: 325
Issue: 13
Pages: 1324
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2021.1612
PMC: PMC7879386
OpenAlex: W3127156551
Cited by: 371
References: 10
Citations by year: 2026: 2 · 2025: 7 · 2024: 19 · 2023: 21 · 2022: 86 · 2021: 232 · 2020: 2
FWCI: 28.34
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: other-oa
Locations: JAMA (publishedVersion, other-oa)
medRxiv (acceptedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
Keywords: SARS-CoV-2, COVID-19 pandemic, novel variants, viral variant emergence, phylogenetic analysis, viral genome sequencing, symptomatic patients, Southern California
MeSH terms: COVID-19, SARS-CoV-2, California, Humans, Mutation, Sequence Analysis, RNA, Spike Glycoprotein, Coronavirus

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