Cited by 285SARS-CoV-2 and COVID-19 ResearchCOVID-19 Impact on ReproductionInfant Nutrition and Health

SARS-CoV-2–Specific Antibodies in Breast Milk After COVID-19 Vaccination of Breastfeeding Women

Open access
Perl, Sivan Haia, Uzan-Yulzari, Atara, Klainer, Hodaya, Asiskovich, Liron, Youngster, Michal, Rinott, Ehud, Youngster, Ilan·2021·JAMA

Abstract

This study found robust secretion of SARS-CoV-2 specific IgA and IgG antibodies in breast milk for 6 weeks after vaccination.IgA secretion was evident as early as 2 weeks after vaccination followed by a spike in IgG after 4 weeks (a week after the second vaccine).A few other studies have shown similar findings in women infected with COVID-19.5 Antibodies found in breast milk of these women showed strong neutralizing effects, suggesting a potential protective effect against infection in the infant.The study has limitations.First, no functional assays were performed.However, previous studies have showed neutralizing capacities of the same antibodies as measured for this study.Second, serum antibody testing or SARS-CoV-2 real-time reverse-transcriptase polymerase chain reaction testing were not performed, which would have provided interesting correlates.

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  • Functional neutralizing antibodies against SARS-CoV-2 were found in infant cord blood and in the breast milk of vaccinated pregnant women.

    “Importantly, functional neutralizing antibodies against SARS-CoV-2 were found in infant cord blood and in the breast milk of vaccinated pregnant women”

    From COVID-19 mRNA vaccines: Platforms and current developments (2022) · cites this paper as [118]

  • The presence of functional neutralizing antibodies in infant cord blood and breast milk suggests a protective effect for newborns.

    “suggesting that there is a protective effect for newborns.116, 117, 118”

    From COVID-19 mRNA vaccines: Platforms and current developments (2022) · cites this paper as [118]

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Authors
Perl, S. H., Uzan-Yulzari, A., Klainer, H., Asiskovich, L., Youngster, M., Rinott, E., & Youngster, I.
Affiliations
  • Assaf Harofeh Medical Center (IL)
  • Ben-Gurion University of the Negev (IL)
  • Tel Aviv University (IL)
Corresponding author
Youngster, Ilan
Venue
JAMA
Published
2021-05-18
Volume
325
Issue
19
Pages
2013
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
OpenAlex
W3155604755
Cited by
285
References
3
Citations by year
2026: 10 · 2025: 12 · 2024: 19 · 2023: 57 · 2022: 102 · 2021: 85
FWCI
20.82
Type
journal article
Language
en
Open access
Locations
  • JAMA (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Obstetrics and Gynecology › COVID-19 Impact on Reproduction
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords
SARS-CoV-2, COVID-19 vaccination, breastfeeding, breast milk, IgA, IgG, maternal antibodies, infant protection, neutralizing antibodies, vaccine response
MeSH terms
COVID-19, COVID-19 Vaccines, Adult, Antibodies, Viral, Breast Feeding, Female, Humans, Immunoglobulin A, Immunoglobulin G, Milk, Human, Prospective Studies

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