Effectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy
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Abstract
To evaluate the effectiveness of the BNT162b2 messenger RNA vaccine in pregnant women, we conducted an observational cohort study of pregnant women aged 16 years or older, with no history of SARS-CoV-2, who were vaccinated between 20 December 2020 and 3 June 2021. A total of 10,861 vaccinated pregnant women were matched to 10,861 unvaccinated pregnant controls using demographic and clinical characteristics. Study outcomes included documented infection with SARS-CoV-2, symptomatic COVID-19, COVID-19-related hospitalization, severe illness and death. Estimated vaccine effectiveness from 7 through to 56 d after the second dose was 96% (95% confidence interval 89-100%) for any documented infection, 97% (91-100%) for infections with documented symptoms and 89% (43-100%) for COVID-19-related hospitalization. Only one event of severe illness was observed in the unvaccinated group and no deaths were observed in either group. In summary, the BNT162b2 mRNA vaccine was estimated to have high vaccine effectiveness in pregnant women, which is similar to the effectiveness estimated in the general population.
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A recent observational study in a cohort of 10,861 pregnant women showed that BNT162b2 had 96% effectiveness in the prevention of COVID-19.
“A recent observational study in a cohort of 10,861 pregnant women showed that BNT162b2 had 96% effectiveness in the prevention of COVID-19.115”
From COVID-19 mRNA vaccines: Platforms and current developments (2022) · cites this paper as [115]
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- Authors
- Dagan, N., Barda, N., Biron-Shental, T., Makov-Assif, M., Key, C., Kohane, I. S., Hernán, M. A., Lipsitch, M., Hernandez-Diaz, S., Reis, B. Y., & Balicer, R. D.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- Clalit Health Services (IL)
- Harvard University (US)
- Boston Children's Hospital (US)
- Corresponding author
- Balicer, Ran D.
- ORCID
- Venue
- Nature Medicine
- Published
- 2021-09-07
- Volume
- 27
- Issue
- 10
- Pages
- 1693-1695
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W3180834485
- Cited by
- 312
- References
- 13
- Citations by year
- 2026: 12 · 2025: 27 · 2024: 38 · 2023: 86 · 2022: 130 · 2021: 19
- FWCI
- 21.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature Medicine (publishedVersion)
- Research Square (acceptedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (acceptedVersion)
- Funders
- Ivan and Francesca Berkowitz Family Living Laboratory at Harvard Medical School
- Morris-Singer Fund
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Obstetrics and Gynecology › COVID-19 Impact on Reproduction
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- BNT162b2 mRNA vaccine, COVID-19 vaccines, pregnancy, vaccine effectiveness, COVID-19 pandemic, COVID-19 hospitalization, maternal immunization
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Vaccines, BNT162 Vaccine, Adolescent, Adult, Female, Humans, Pregnancy, Pregnancy Complications, Infectious, Cohort Studies, Incidence, Young Adult
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