Leisure-time physical activity levels and risk of coronary heart disease and death. The Multiple Risk Factor Intervention Trial
Abstract
The relation of self-selected leisure-time physical activity (LTPA) to first major coronary heart disease (CHD) events and overall mortality was studied in 12,138 middle-aged men participating in the Multiple Risk Factor Intervention Trial. Total LTPA over the preceding year was quantitated in mean minutes per day at baseline by questionnaire, with subjects classified into tertiles (low, moderate, and high) based on LTPA distribution. During seven years of follow-up, moderate LTPA was associated with 63% as many fatal CHD events and sudden deaths, and 70% as many total deaths as low LTPA (P less than .01). Mortality rates with high LTPA were similar to those in moderate LTPA; however, combined fatal and nonfatal major CHD events were 20% lower with high as compared with low LTPA (P less than .05). These risk differentials persisted after statistical adjustments for possible confounding variables, including other baseline risk factors and Multiple Risk Factor Intervention Trial group assignments. It is concluded that LTPA has a modest inverse relation to CHD and overall mortality in middle-aged men at high risk for CHD.
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Regular exercise is associated with a reduction in the long-term risk of coronary events.
“numerous studies5,24-31 have found that regular exercise is associated with a reduction in the long-term risk of coronary events.”
From Triggering of Acute Myocardial Infarction by Heavy Physical Exertion -- Protection against Triggering by Regular Exertion (1993) · cites this paper as [27]
People who exercise regularly have a lower baseline risk of myocardial infarction.
“People who exercise regularly not only have a lower base-line risk of myocardial infarction, but as demonstrated by this study, they also have a lower relative risk that an infarction will be triggered by heavy physical exertion.”
From Triggering of Acute Myocardial Infarction by Heavy Physical Exertion -- Protection against Triggering by Regular Exertion (1993) · cites this paper as [27]
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- Authors
- Leon, A. S.
- Corresponding author
- Leon, Arthur S.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1987-11-06
- Volume
- 258
- Issue
- 17
- Pages
- 2388
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W4233400457
- Cited by
- 842
- References
- 0
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 3 · 2023: 9 · 2022: 7 · 2021: 6 · 2020: 8 · 2019: 10 · 2018: 12 · 2017: 10 · 2016: 12 · 2015: 17 · 2014: 14 · 2013: 20 · 2012: 22
- FWCI
- 17.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Keywords
- leisure-time physical activity, coronary artery disease, mortality, Multiple Risk Factor Intervention Trial, middle-aged men, sudden death, cardiovascular risk factors
- MeSH terms
- Adult, Death, Sudden, Physical Exertion, Humans, Leisure Activities, Male, Middle Aged, Mortality, Myocardial Infarction, Prospective Studies, Surveys and Questionnaires, Regression Analysis, Risk Factors
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