The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Treatment of Irritable Bowel Syndrome With Chinese Herbal Medicine: A Randomized Controlled Trial
Open accessAbstract
CONTEXT: Irritable bowel syndrome (IBS) is a common functional bowel disorder for which there is no reliable medical treatment. OBJECTIVE: To determine whether Chinese herbal medicine (CHM) is of any benefit in the treatment of IBS. DESIGN: Randomized, double-blind, placebo-controlled trial conducted during 1996 through 1997. SETTING: Patients were recruited through 2 teaching hospitals and 5 private practices of gastroenterologists, and received CHM in 3 Chinese herbal clinics. PATIENTS: A total of 116 patients who fulfilled the Rome criteria, an established standard for diagnosis of IBS. INTERVENTION: Patients were randomly allocated to 1 of 3 treatment groups: individualized Chinese herbal formulations (n = 38), a standard Chinese herbal formulation (n = 43), or placebo (n = 35). Patients received 5 capsules 3 times daily for 16 weeks and were evaluated regularly by a traditional Chinese herbalist and by a gastroenterologist. Patients, gastroenterologists, and herbalists were all blinded to treatment group. MAIN OUTCOME MEASURES: Change in total bowel symptom scale scores and global improvement assessed by patients and gastroenterologists and change in the degree of interference in life caused by IBS symptoms assessed by patients. RESULTS: Compared with patients in the placebo group, patients in the active treatment groups (standard and individualized CHM) had significant improvement in bowel symptom scores as rated by patients (P=.03) and by gastroenterologists (P=.001), and significant global improvement as rated by patients (P=.007) and by gastroenterologists (P=.002). Patients reported that treatment significantly reduced the degree of interference with life caused by IBS symptoms (P=.03). Chinese herbal formulations individually tailored to the patient proved no more effective than standard CHM treatment. On follow-up 14 weeks after completion of treatment, only the individualized CHM treatment group maintained improvement. CONCLUSION: Chinese herbal formulations appear to offer improvement in symptoms for some patients with IBS.
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Cites
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Self-citationCredibility of analogue therapy rationales
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“Stayed the same 19 (63) 7 (19) 12 (40) .”
Epidemiology of colonic symptoms and the irritable bowel syndrome
Talley, N. J., Zinsmeister, A. R., van Dyke, C., & Melton, L. J. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90717-y · Cited by 648
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Guidelines on the irritable bowel syndrome: mechanisms and practical management
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Challenges and guidelines for clinical trial of herbal drugs
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An Evidence-Based Systematic Review on the Management of Irritable Bowel Syndrome
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Comorbidity of irritable bowel syndrome in psychiatric patients: A review
Garakani, A., Win, T., Virk, S., Gupta, S., Kaplan, D., & Masand, P. S. (2003) · American Journal of Therapeutics · doi:10.1097/00045391-200301000-00014 · Cited by 149
Irritable bowel syndrome: a disease still searching for pathogenesis, diagnosis and therapy.
(2014) · PubMed Central · doi:10.3748/wjg.v20.i27.8807 · Cited by 132
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Defining the predictors of the placebo response in irritable bowel syndrome
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Pharmacologic and Complementary and Alternative Medicine Therapies for Irritable Bowel Syndrome
Chey, W. D., Maneerattaporn, M., & Saad, R. (2011) · Gut and Liver · doi:10.5009/gnl.2011.5.3.253 · Cited by 89
“05).(127) A recent Cochrane review which assessed over 70 different herbal therapies for IBS identified 75 trials which enrolled almost 8,000 participants.”
BackgroundRandomised clinical trial: pregabalin vs placebo for irritable bowel syndrome
Saito, Y. A., Almazar, A. E., Tilkes, K. E., Choung, R. S., Van Norstrand, M. D., Schleck, C. D., Zinsmeister, A. R., & Talley, N. J. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15077 · Cited by 79
Self-citationHutchings, H. A., Wareham, K., Baxter, J. N., Atherton, P., Kingham, J. G. C., Duane, P., Thomas, L., Thomas, M., Ch'ng, C. L., & Williams, J. G. (2011) · ISRN Gastroenterology · doi:10.5402/2011/206103 · Cited by 37
Metadata
- Authors
- Bensoussan, A., Talley, N. J., Hing, M., Menzies, R., Guo, A., & Ngu, M.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1998-11-11
- Volume
- 280
- Issue
- 18
- Pages
- 1585
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2021569946
- Cited by
- 419
- References
- 3
- FWCI
- 17.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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