Cited by 2,835Peripheral Artery Disease ManagementDiabetic Foot Ulcer Assessment and ManagementVascular Procedures and Complications

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Peripheral Arterial Disease Detection, Awareness, and Treatment in Primary Care

Hirsch, Alan T.·2001·JAMA

DOI 10.1001/jama.286.11.1317

Open this paper in CoChat — free account

Abstract

Context Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerosis that is common and is associated with an increased risk of death and ischemic events, yet may be underdiagnosed in primary care practice. Objective To assess the feasibility of detecting PAD in primary care clinics, patient and physician awareness of PAD, and intensity of risk factor treatment and use of antiplatelet therapies in primary care clinics. Design and setting The PAD Awareness, Risk, and Treatment: New Resources for Survival (PARTNERS) program, a multicenter, cross-sectional study conducted at 27 sites in 25 cities and 350 primary care practices throughout the United States in June-October 1999. Patients A total of 6979 patients aged 70 years or older or aged 50 through 69 years with history of cigarette smoking or diabetes were evaluated by history and by measurement of the ankle-brachial index (ABI). PAD was considered present if the ABI was 0.90 or less, if it was documented in the medical record, or if there was a history of limb revascularization. Cardiovascular disease (CVD) was defined as a history of atherosclerotic coronary, cerebral, or abdominal aortic aneurysmal disease. Main outcome measures Frequency of detection of PAD; physician and patient awareness of PAD diagnosis; treatment intensity in PAD patients compared with treatment of other forms of CVD and with patients without clinical evidence of atherosclerosis. Results PAD was detected in 1865 patients (29%); 82…

Integrity signals

Registry

Crossref · 10.1001/jama.286.11.1317

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women
Hulley, S. (1998) · JAMA · doi:10.1001/jama.280.7.605 · Cited by 6,216
Primary Prevention of Acute Coronary Events With Lovastatin in Men and Women With Average Cholesterol Levels: Results of AFCAPS/TexCAPS
Downs, J. R., Clearfield, M., Weis, S., Whitney, E., Shapiro, D. R., Beere, P. A., Langendorfer, A., Stein, E. A., Kruyer, W., Gotto, Jr., et al. (1998) · JAMA · doi:10.1001/jama.279.20.1615 · Cited by 5,236

Show all 0 references

Sorted by citations

Items 401–500 of 1,042

A systematic review of the limitations and approaches to improve detection and management of peripheral arterial disease in Hispanics
Rosero, E. B., Kane, K., Clagett, G. P., & Timaran, C. H. (2010) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2009.08.085 · Cited by 23
Randomized Trial of a Vascular Care Team vs Education for Patients With Peripheral Artery Disease
Hess, C. N., Daffron, A., Nehler, M. R., Morrison, J. T., Buchanan, C. E., Szarek, M. J., Anderson, V. E., Cannon, C. P., Hsia, J. A., Saseen, J. J., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.04.034 · Cited by 25
Detection and Severity Assessment of Peripheral Occlusive Artery Disease via Deep Learning Analysis of Arterial Pulse Waveforms: Proof-of-Concept and Potential Challenges
Kim, S.-H., Hahn, J., & Youn, B. D. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00720 · Cited by 26
Contemporary outcomes of infrapopliteal atherectomy with angioplasty versus balloon angioplasty alone for critical limb ischemia.
Zia, S., Juneja, A., Shams, S., Faheem, B., Shariff, M., Singh, K., Schor, J., & Deitch, J. (2019) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2019.08.254 · Cited by 23
Thermographic Characteristics of the Diabetic Foot With Peripheral Arterial Disease Using the Angiosome Concept.
Carabott, M., Formosa, C., Mizzi, A., Papanas, N., & Gatt, A. (2019) · Experimental and clinical endocrinology & diabetes · doi:10.1055/a-0838-5209 · Cited by 23
Pooled Analysis of the CONFIRM Registries
Lee, M. S., Canan, T., Rha, S., Mustapha, J. A., & Adams, G. L. (2015) · Journal of Endovascular Therapy · doi:10.1177/1526602814564367 · Cited by 25
Multidetector CT angiography versus arterial duplex USG in diagnosis of mild lower extremity peripheral arterial disease: is multidetector CT a valuable screening tool?
Kayhan, A., Palabıyık, F., Serinsoz, S., Kırış, A., Bayramoğlu, S., Williams, J. T. B., & Ci̇mi̇lli̇, T. (2012) · European Journal of Radiology · doi:10.1016/j.ejrad.2011.01.100 · Cited by 23
Comprehensive Medical Management of Peripheral Arterial Disease
Gandhi, S., Weinberg, I., Margey, R., & Jaff, M. R. (2011) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2011.02.004 · Cited by 24
ACCF/AHA/ACR/SCAI/SIR/SVM/SVN/SVS 2010 performance measures for adults with peripheral artery disease
Olin, J. W., Allie, D. E., Belkin, M., Bonow, R. O., Casey, D. E., Creager, M. A., Gerber, T. C., Hirsch, A. T., Jaff, M. R., Kaufman, J. A., et al. (2010) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2010.10.065 · Cited by 25
Self-citation
Concomitant peripheral artery disease and asymptomatic coronary artery disease: a management strategy.
Her, K., Choi, C.-W., Park, Y., Shin, H., & Won, Y. (2008) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2008.01.010 · Cited by 23
Management of Peripheral Arterial Disease
Steffen, L. M., Duprez, D. A., Boucher, J. L., Ershow, A. G., & Hirsch, A. T. (2008) · Diabetes Spectrum · doi:10.2337/diaspect.21.3.171 · Cited by 41
Self-citation
High prevalence of subclinical peripheral artery disease in Greek hospitalized patients.
Antonopoulos, S., Kokkoris, S., Stasini, F., Mylonopoulou, M., Lepeniotis, G., Mikros, S., Korantzopoulos, P., & Giannoulis, G. (2005) · European journal of internal medicine · doi:10.1016/j.ejim.2005.02.002 · Cited by 23
“In the USA PARTNERS study [5], 35% of 1835 patients with PAD also had cardiovascular disease.”
Background
Association between platelet P2Y12 haplotype and risk of cardiovascular events in chronic coronary disease.
Schettert, I., Pereira, A., Lopes, N., Hueb, W., & Krieger, J. (2006) · Thrombosis Research · doi:10.1016/j.thromres.2005.11.009 · Cited by 23
“In addition, it should be noted that the process leading to coronary artery disease and peripheral artery disease are both related to atherogenesis and thrombogenesis where platelet has a major function but are different in epidemiological aspects [20].”
Background
Management of Peripheral Artery Disease in Adults With Diabetes: 2025 ACC Scientific Statement
Das, S. R., Bonaca, M. P., Creager, M. A., Maruthur, N. M., Nordanstig, J., Pop‐Busui, R., & Ujueta, F. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.11.027 · Cited by 18
Nailfold Capillaroscopy: A Comprehensive Review on Its Usefulness in Both Clinical Diagnosis and Improving Unhealthy Dietary Lifestyles
Komai, M., Takeno, D., Fujii, C., Nakano, J., Ohsaki, Y., & Shirakawa, H. (2024) · Nutrients · doi:10.3390/nu16121914 · Cited by 34
“Nutritional advice and weight management are of paramount significance in PAD management [76].”
Background
Validating fatty acid binding protein 3 as a diagnostic and prognostic biomarker for peripheral arterial disease: A three-year prospective follow-up study
Zamzam, A., Syed, M., Rotstein, O., Eikelboom, J., Klein, D. J., Singh, K. K., Abdin, R., & Qadura, M. (2022) · EClinicalMedicine · doi:10.1016/j.eclinm.2022.101766 · Cited by 22
Impact of Low Ankle-Brachial Index on the Risk of Recurrent Vascular Events
Abboud, H., Tavares, L. M., Labreuche, J., Araúz, A., Bryer, A., Lavados, P. M., Massaro, A. R., Collazos, M. M., Steg, P. G., Yamout, B., et al. (2019) · Stroke · doi:10.1161/strokeaha.118.022180 · Cited by 24
The peripheral atherosclerotic profile in patients with type 1 diabetes warrants a thorough vascular assessment of asymptomatic patients
Nattero-Chávez, L., López, S. R., Alonso-Díaz, S., Ureña, M. G., Fernández-Durán, E., Escobar-Morreale, H., & Luque-Ramírez, M. (2018) · Diabetes/Metabolism Research Reviews · doi:10.1002/dmrr.3088 · Cited by 22
“3%,(24) with approximately 90% of patients being asymptomatic.(10) We concluded that we would need 284 subjects to assume an expected proportion of 5.”
Background
MiR-323b-5p acts as a novel diagnostic biomarker for critical limb ischemia in type 2 diabetic patients
Cheng, B., Li, J.-Y., Li, X.-C., Wang, X.-F., Wang, Z.-J., Liu, J., & Deng, A.-P. (2018) · Scientific Reports · doi:10.1038/s41598-018-33310-4 · Cited by 22
Comparison of Accuracy of Two Different Methods to Determine Ankle-Brachial Index to Predict Peripheral Arterial Disease Severity Confirmed by Angiography
Jeevanantham, V., Chehab, B., Austria, É., Shrivastava, R. K., Wiley, M. A., Tadros, P., Dawn, B., Vacek, J. L., & Gupta, K. (2014) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2014.07.023 · Cited by 22
Perceptions of Canadian Vascular Surgeons toward Pharmacological Risk Reduction in Patients with Peripheral Arterial Disease
Al-Omran, M., Lindsay, T., Major, J., Jawas, A., Leiter, L., & Verma, S. (2006) · Annals of Vascular Surgery · doi:10.1007/s10016-006-9110-3 · Cited by 22
The economic implications of treating atherothrombotic disease in australia, from the government perspective
Ademi, Z., Liew, D., Hollingsworth, B. P., Wolfe, R. S., Steg, P. G., Bhatt, D. L., & Reid, C. M. (2010) · Clinical Therapeutics · doi:10.1016/j.clinthera.2010.01.009 · Cited by 19
Peripheral artery disease diagnosis based on deep learning-enabled analysis of non-invasive arterial pulse waveforms
Shahrbabak, S. M., Kim, S., Youn, B. D., Cheng, H., Chen, C., Mukkamala, R., & Hahn, J. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.107813 · Cited by 23
Inflammatory and Prothrombotic Biomarkers, DNA Polymorphisms, MicroRNAs and Personalized Medicine for Patients with Peripheral Arterial Disease
Poredoš, P., Šabovič, M., Mijovski, M. B., Starčević, J. N., Antignani, P. L., Paraskevas, K. I., Mikhailidis, D. P., & Blinc, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231912054 · Cited by 23
“Hypertension which is present in about 80% of PAD patients, also promotes inflammation [32].”
Background
Reassessing the normal toe-brachial index in young healthy adults.
Quong, W., Fung, A. T., Yu, R. Y., & Hsiang, Y. (2016) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2015.09.019 · Cited by 21
Comparison of lipid management in patients with coronary versus peripheral arterial disease.
Sharma, S., Thapa, R., Jeevanantham, V., Myers, T., Hu, C., Brimacombe, M., Vacek, J., Dawn, B., & Gupta, K. (2014) · American Journal of Cardiology · doi:10.1016/j.amjcard.2014.01.405 · Cited by 21
Prevalence and treatment patterns of lower extremity peripheral arterial disease among patients at risk in ambulatory health settings.
Makowsky, M. J., McMurtry, M. S., Elton, T. C., Rosenthal, M. M., Gunther, M., Percy, M., Wong, K., Fok, J., Sebastianski, M., & Tsuyuki, R. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2010.12.029 · Cited by 21
Vascular Regeneration: Engineering the Stem Cell Microenvironment
Sun, G., & Gerecht, S. (2009) · Regenerative Medicine · doi:10.2217/rme.09.1 · Cited by 22
Intermittent claudication in the Erfurt Male Cohort (ERFORT) Study: its determinants and the impact on mortality. A population-based prospective cohort study with 30 years of follow-up.
Kollerits, B., Heinrich, J., Pichler, M., Rantner, B., Klein-Weigel, P., Wölke, G., Brasche, S., Strube, G., & Kronenberg, F. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.09.012 · Cited by 21
Atherothrombosis — Wave Goodbye to Combined Anticoagulation and Antiplatelet Therapy?
Mohler, E. R. (2007) · New England Journal of Medicine · doi:10.1056/nejme078106 · Cited by 21
Gait kinematics and kinetics are affected more by peripheral arterial disease than age
Myers, S., Applequist, B., Huisinga, J., Pipinos, I., & Johanning, J. M. (2016) · Journal of rehabilitation research and development · doi:10.1682/jrrd.2015.02.0027 · Cited by 21
Pulse volume recording does not enhance segmental pressure readings for peripheral arterial disease stratification.
Eslahpazir, B. A., Allemang, M., Lakin, R. O., Carman, T., Trivonovich, M. R., Wong, V. L., Wang, J. C., Baele, H., & Kashyap, V. (2014) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2013.06.015 · Cited by 21
Artificial Intelligence of Arterial Doppler Waveforms to Predict Major Adverse Outcomes Among Patients Evaluated for Peripheral Artery Disease
McBane, R. D., Murphree, D. H., Liedl, D., López-Jiménez, F., Attia, I., Arruda-Olson, A., Scott, C., Prodduturi, N., Nowakowski, S. E., Rooke, T., et al. (2023) · medRxiv · doi:10.1161/jaha.123.031880 · Cited by 20
“PAD is often poorly recognized despite patient complaints of exertional leg discomfort and patients with asymptomatic disease are only rarely identified (9,15-17).”
Background
NLRP3 Inflammasome Activation in Peripheral Arterial Disease
Bartoli-Leonard, F., Zimmer, J., Sonawane, A., Perez, K. A., Turner, M. E., Kuraoka, S., Pham, T., Li, F., Aikawa, M., Singh, S. A., et al. (2023) · Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease · doi:10.1161/jaha.122.026945 · Cited by 20
“2,7 Thus, a multitude of clinical trials have been conducted or are underway (NCT001684678, NCT00681226, NCT00720577, NCT03240068) seeking to address the inflammatory mechanisms at play.”
Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial
Razquín, C., Ruiz‐Canela, M., Toledo, E., Clish, C. B., Guasch‐Ferré, M., García-Gavilán, J. F., Wittenbecher, C., Alonso‐Gómez, Á. M., Fitó, M., Liang, L., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010270 · Cited by 20
“Although symptoms of PAD may appear, such as intermittent claudication or atypical leg symptoms [11], PAD is still commonly underdiagnosed in primary care, with a consequent increase in the aforementioned risks of other hard cardiovascular events and premature death [7].”
Background
Relationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences
Jelani, Q., Mena‐Hurtado, C., Burg, M. M., Soufer, R., GOSCH, K. L., Jones, P. G., Spertus, J. A., Safdar, B., & Smolderen, K. G. E. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.014583 · Cited by 27
Missed Opportunities for Timely Recognition of Chronic Limb Threatening Ischaemia in Patients Undergoing a Major Amputation: A Population Based Cohort Study Using the UK's Clinical Practice Research Datalink
Nickinson, A., Coles, B., Zaccardi, F., Gray, L. J., Payne, T. J., Bown, M. J., Davies, R., Khunti, K. K., & Sayers, R. D. (2020) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2020.05.010 · Cited by 31
Vascular disease in the lower limb in type 1 diabetes
EDMONDS, M. E. (2019) · Cardiovascular Endocrinology & Metabolism · doi:10.1097/xce.0000000000000168 · Cited by 27
Life’s Simple 7 and Peripheral Artery Disease: The Multi-Ethnic Study of Atherosclerosis
Unkart, J. T., Allison, M., Criqui, M., McDermott, M., Wood, A. C., Folsom, A., Lloyd-Jones, D., Rasmussen-Torvik, L., Allen, N., Burke, G., et al. (2018) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2018.09.021 · Cited by 20
Eight weeks of nitrate supplementation improves blood flow and reduces the exaggerated pressor response during forearm exercise in peripheral artery disease
Kruse, N. T., Ueda, K., Hughes, W. E., & Casey, D. P. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00015.2018 · Cited by 24
“Peripheral artery disease (PAD), a progressive atherosclerotic disease of the upper and lower extremities, is closely linked to cardiovascular and cerebrovascular mortality (9, 14).”
Use of hyperspectral imaging to assess endothelial dysfunction in peripheral arterial disease
Sumpio, B. J., Citoni, G., Chin, J. A., & Sumpio, B. E. (2016) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2016.03.463 · Cited by 25
Association between estimated glomerular filtration rate and peripheral arterial disease
Yamasaki, S., Izawa, A., Koshikawa, M., Saigusa, T., Ebisawa, S., Miura, T., Shiba, Y., Tomita, T., Miyashita, Y., Koyama, J., et al. (2015) · Journal of Cardiology · doi:10.1016/j.jjcc.2015.01.011 · Cited by 21
“Although ABI measurement is a noninvasive and effective means of diagnosing PAD [23], with high sensitivity and specificity [3,6,24,25], clinicians should select candidates for PAD screening with minimum unnecessary workups because the morbidity of PAD is low (2–4%) in healthy individuals [26,27].”
Background
A Comparison of Clinical Outcomes for Diabetic and Nondiabetic Patients Following Directional Atherectomy in the DEFINITIVE LE Claudicant Cohort
Garcia, L., Jaff, M., Rocha-Singh, K., Zeller, T., Bosarge, C., Kamat, S., & Mckinsey, J. (2015) · Journal of Endovascular Therapy · doi:10.1177/1526602815599550 · Cited by 20
Cilostazol attenuates the severity of peripheral arterial occlusive disease in patients with type 2 diabetes: the role of plasma soluble receptor for advanced glycation end-products
Liu, J.-S., Chuang, T.-J., Chen, J.-H., Lee, C.-H., Hsieh, C.-H., Lin, T.-K., Hsiao, F.-C., & Hung, Y.-J. (2015) · Endocrine · doi:10.1007/s12020-015-0545-6 · Cited by 20
Lumbar sympathectomy versus prostanoids for critical limb ischaemia due to non-reconstructable peripheral arterial disease
Sen, I., Agarwal, S. K., Tharyan, P., & Forster, R. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009366.pub2 · Cited by 28
Escore de risco Dante Pazzanese para síndrome coronariana aguda sem supradesnivelamento do segmento ST
dos Santos, E. S., Timerman, A., Baltar, V. T., Castillo, M. T. C., Pereira, M. P. T., Minuzzo, L., & Piegas, L. S. (2009) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2009001000006 · Cited by 22
Risk attitudes to treatment among patients with severe intermittent claudication.
Letterstål, A., Forsberg, C., Olofsson, P., & Wahlberg, E. (2008) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2007.12.055 · Cited by 20
Antiplatelet therapy for atherothrombotic disease: an update for the primary care physician.
Kikano, G., & Brown, M. T. (2007) · Mayo Clinic proceedings · doi:10.4065/82.5.583 · Cited by 20
Peripheral arterial disease: recognition and medical management.
Almahameed, A. (2006) · Cleveland Clinic journal of medicine · doi:10.3949/ccjm.73.7.621 · Cited by 20
Impact of extracardiac vascular disease on acute prognosis in patients who undergo percutaneous coronary interventions (data from the Blue Cross & Blue Shield of Michigan Cardiovascular Consortium [BMC2]).
Mukherjee, D., Eagle, K. A., Smith, D. E., Kline-Rogers, E., Chetcuti, S., Grossman, P., Nallamothu, B., O'Donnell, M. J., Defranco, A., Maxwell-Eward, A., et al. (2003) · American Journal of Cardiology · doi:10.1016/s0002-9149(03)00981-0 · Cited by 20
Sex disparities in level of amputation.
Lefebvre, K., & Chevan, J. (2011) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2010.10.005 · Cited by 20
Beta 2 Microglobulin as a Biomarker in Peripheral Arterial Disease: Proteomic Profiling and Clinical Studies
Wilson, A., Kimura, E., Harada, R. K., Narasimhan, B., Meng, X., Zhang, F., Beck, K. R., Olin, J. W., Fung, E. T., & Cooke, J. P. (2007) · Heart Lung and Circulation · doi:10.1016/j.hlc.2007.06.199 · Cited by 14
Accuracy of ankle-brachial index in screening for peripheral arterial disease in people with diabetes
Cerqueira, M. M. B. D. F., Bastos, N. S. S. G., da Silva, D. A. R., Gregori, D., Magalhães, L. B. N. C., & Pimentel, M. M. W. (2024) · PLoS ONE · doi:10.1371/journal.pone.0309083 · Cited by 14
“Sample size calculation determined the need to examine a total of 262 limbs, considering the following parameters: a confidence level of 95%, ABI sensitivity of 65%, a margin of error of 10%, and a PAD prevalence of 30% among the 2450 locally registered individuals with diabetes [7, 13].”
Background
Clinical use of polygenic risk scores for detection of peripheral artery disease and cardiovascular events
Omiye, J., Ghanzouri, I., Lopez, I., Wang, F., Cabot, J., Amal, S., Ye, J.-Q., Lopez, N., Adebayo-Tijani, F., & Ross, E. (2024) · PLoS ONE · doi:10.1371/journal.pone.0303610 · Cited by 19
“Despite the severity of this condition, PAD often goes undiagnosed [8, 9].”
Mortality Risk Assessment in Peripheral Arterial Disease—The Burden of Cardiovascular Risk Factors over the Years: A Single Center’s Experience
Aursulesei, V. O., Ceasovschih, A., Marcu, D. T. M., Adam, C. A., Mitu, O., & Mitu, F. (2022) · Diagnostics · doi:10.3390/diagnostics12102499 · Cited by 23
Social Deprivation and Peripheral Artery Disease
Nash, D., McClure, G. R., Mastracci, T. M., & Anand, S. S. (2021) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2021.12.011 · Cited by 19
Intensity-dependent effects of exercise therapy on walking performance and aerobic fitness in symptomatic patients with lower-extremity peripheral artery disease: A systematic review and meta-analysis
Fassora, M., Calanca, L., Jaques, C., Mazzolai, L., Kayser, B., & Lanzi, S. (2021) · Vascular Medicine · doi:10.1177/1358863x211034577 · Cited by 32
“The results of our analyses show that (1) few studies clearly report exercise therapy intensity in symptomatic patients with PAD using conventional % heart rate, % peak oxygen uptake, or the rate of perceived exertion cutoffs; (2) for the 19 included studies doing so, light-tomoderate was superior to vigorous exercise…”
Result
Diabetes mellitus: an important risk factor for peripheral vascular disease
Giannopoulos, S., & Armstrong, E. J. (2020) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2020.1736562 · Cited by 27
Outcomes Following Lower Extremity Amputation in Patients with Diabetes Mellitus and Peripheral Arterial Disease.
Pourghaderi, P., Yuquimpo, K., Guetter, C. R., Mansfield, L., & Park, H. (2020) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2019.08.084 · Cited by 19
How To Assess a Claudication and When To Intervene
Hossain, P., Kokkinidis, D. G., & Armstrong, E. J. (2019) · Current Cardiology Reports · doi:10.1007/s11886-019-1227-4 · Cited by 18
Diagnosis and management of chronic and refractory immune cytopenias in children, adolescents, and young adults
Rotz, S. J., Ware, R. E., & Kumar, A. R. (2018) · Pediatric Blood & Cancer · doi:10.1002/pbc.27260 · Cited by 18
Peripheral arterial disease is associated with higher mortality in patients with incident acute myocardial infarction.
Dinser, L., Meisinger, C., Amann, U., Heier, M., Thilo, C., Kuch, B., Peters, A., & Kirchberger, I. (2018) · European journal of internal medicine · doi:10.1016/j.ejim.2018.01.007 · Cited by 19
Aspirin prevents bone loss with little mechanical improvement in high-fat-fed ovariectomized rats.
Lin, S.-E., Lee, W., Huang, M.-L., Fu, Z., Liang, Y., Wu, H.-Y., Xu, L.-L., Suen, C.-W., Huang, J.-P., Wu, T., et al. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.09.018 · Cited by 19
Treatment of hypertension in peripheral arterial disease
Lane, D. A., & Lip, G. Y. H. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003075.pub3 · Cited by 91
Prevalence and clinical features of asymptomatic peripheral artery disease in Japanese stroke patients.
Hoshino, H., Itoh, Y., Yamada, S., & Suzuki, N. (2013) · Journal of Stroke & Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2011.08.011 · Cited by 19
Endovascular interventions for TransAtlantic InterSociety Consensus II C and D femoropopliteal lesions.
Yin, M.-Y., Jiang, M., Huang, X.-T., Lu, M., Lu, X.-W., Huang, Y., & Li, W.-M. (2013) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20122294 · Cited by 19
Prevalence of high ankle-brachial index (ABI) in general population of Southern Italy, risk factor profiles and systemic cardiovascular co-morbidity: an epidemiological study.
Signorelli, S., Fiore, V., Catanzaro, S., Simili, M., Torrisi, B., & Anzaldi, M. (2011) · Archives of gerontology and geriatrics (Print) · doi:10.1016/j.archger.2010.05.020 · Cited by 19
“Many studies have focused on the prevalence of PAD in the general population by using a number of approaches (Criqui et al., 1985; Hirsch et al., 2001).”
Background
The prevalence and prognostic implications of polyvascular atherosclerotic disease in patients with chronic kidney disease.
van Kuijk, J., Flu, W., Chonchol, M., Welten, G., Verhagen, H., Bax, J. J., & Poldermans, D. (2010) · Nephrology, Dialysis and Transplantation · doi:10.1093/ndt/gfp756 · Cited by 19
Smoking and postprandial triglycerides are associated with vascular disease in patients with type 2 diabetes.
Valdivielso, P., Hidalgo, A., Rioja, J., Aguilar, I., Ariza, M., González-Alegre, T., & González-Sántos, P. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.08.006 · Cited by 19
Prognostic relevance of ischemia-modified albumin and NT-proBNP in patients with peripheral arterial occlusive disease
Falkensammer, J., Frech, A., Duschek, N., Gasteiger, S., Stojaković, T., Scharnagl, H., Huber, K., Fraedrich, G., & Greiner, A. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.08.031 · Cited by 20
Effects of NAD+ supplementation with oral nicotinamide riboside on vascular health and cognitive function in older adults with peripheral artery disease: Results from a pilot 4-week open-label clinical trial
Szarvas, Z., Reyff, Z., Péterfi, A., Pinto, C. B., Owens, C. D., Kaposzta, Z., Mukli, P., Pinaffi‐Langley, A. C. D. C., Adams, C., Muranyi, M., et al. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103607 · Cited by 19
A systematic review and meta-analysis of GLASS staging system in the endovascular treatment of chronic limb threatening ischemia.
Bontinis, V., Bontinis, A., Koutsoumpelis, A., Giannopoulos, A., & Ktenidis, K. (2022) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2022.07.183 · Cited by 18
Does the Introduction of a Vascular Limb Salvage Service Improve One Year Amputation Outcomes for Patients with Chronic Limb-Threatening Ischaemia?
Nickinson, A., Dimitrova, J., Houghton, J. S. M., Rate, L., Dubkova, S., Lines, H., Gray, L. J., Nduwayo, S., Payne, T. J., Sayers, R. D., et al. (2021) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2020.12.007 · Cited by 26
Trends in statin utilization among adults with severe peripheral artery disease including critical limb ischemia in an integrated healthcare delivery system
Reynolds, K., Mues, K., Harrison, T. N., Qian, L., Chen, S., Hsu, J.-W. Y., Philip, K., Monda, K., Reading, S., & Brar, S. (2019) · Vascular Medicine · doi:10.1177/1358863x19871100 · Cited by 18
Clinical Applications for Radiotracer Imaging of Lower Extremity Peripheral Arterial Disease and Critical Limb Ischemia
Chou, T.-H., & Stacy, M. R. (2019) · Molecular Imaging and Biology · doi:10.1007/s11307-019-01425-3 · Cited by 18
Peripheral artery disease patients are poorly aware of their disease
Builytė, I. U., Baltrūnas, T., Butkutė, E., Srinanthalogen, R., Skrebūnas, A., Urbonavičius, S., & Ručinskas, K. (2019) · Scandinavian Cardiovascular Journal · doi:10.1080/14017431.2019.1645350 · Cited by 22
Ankle‐brachial index in patients with intermittent claudication is a poor indicator of patient‐centered and clinician‐based evaluations of functional status
Johnston, A., Vemulapalli, S., Gosch, K., Aronow, H., Abbott, D., Patel, M., Smolderen, K., Shishebor, M., Spertus, J., & Jones, S. W. (2019) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2018.07.039 · Cited by 18
Dual vs single antiplatelet therapy in patients with lower extremity peripheral artery disease – A meta-analysis
Navarese, E. P., Wernly, B., Lichtenauer, M., Petrescu, A. M., Kołodziejczak, M. M., Lauten, A., Frediani, L., Veulemanns, V., Wańha, W., Wojakowski, W., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.07.009 · Cited by 18
Disruption of mitochondrial quality control in peripheral artery disease: New therapeutic opportunities
Ueta, C. B., Gomes, M. K., Ribeiro, M. A. C., Mochly‐Rosen, D., & Ferreira, J. C. B. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.11.016 · Cited by 22
Comparison of lipid control in patients with coronary versus peripheral artery disease following the first vascular intervention.
Pereg, D., Neuman, Y., Elis, A., Minha, S., Mosseri, M., Segev, D., Lishner, M., & Hermoni, D. (2012) · American Journal of Cardiology · doi:10.1016/j.amjcard.2012.06.030 · Cited by 18
The role of combined assessment of defense against oxidative stress and inflammation in the evaluation of peripheral arterial disease.
Rull, A., Garcia, R., Fernández-Sénder, L., Beltrán-Debón, R., Aragonès, G., Alegret, J., Alonso-Villaverde, C., Mackness, B., Mackness, M., Camps, J., et al. (2011) · Current molecular medicine · doi:10.2174/156652411796268713 · Cited by 18
“This is usually the effect of a sustained and silent progression of the disease in which adequate and effective prevention measures are either applied too late or not implemented at all [1-6].”
Background
The influence of polyvascular disease on the obesity paradox in vascular surgery patients.
van Kuijk, J., Flu, W., Galal, W., Chonchol, M., Goei, D., Verhagen, H., Bax, J. J., & Poldermans, D. (2011) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2010.08.048 · Cited by 18
Cardiovascular Ischemic Event Rates in Outpatients With Symptomatic Atherothrombosis or Risk Factors in the United States
Eagle, K. A., Hirsch, A. T., Califf, R. M., Alberts, M. J., Steg, P. G., Cannon, C. P., Brennan, D. M., & Bhatt, D. L. (2009) · Critical Pathways in Cardiology A Journal of Evidence-Based Medicine · doi:10.1097/hpc.0b013e3181a84613 · Cited by 17
Self-citation
Association of the -250G/A promoter polymorphism of the hepatic lipase gene with the risk of peripheral arterial disease in type 2 diabetic patients.
Valdivielso, P., Ariza, M., de la Vega-Román, C., González-Alegre, T., Rioja, J., Ulzurrun, E., & González-Sántos, P. (2008) · Journal of diabetes and its complications · doi:10.1016/j.jdiacomp.2007.06.011 · Cited by 18
L’artériopathie des membres inférieurs en médecine générale. Quelle prise en charge ?
Priollet, P., Mourad, J., Cacoub, P., Lévesque, H., Luizy, F., Benelbaz, J., Herrmann, M., Guerillot, M., & Blacher, J. (2004) · doi:10.1016/s0398-0499(04)96769-8 · Cited by 18
Peripheral arterial disease: diagnosis, treatment, and systemic implications
Federman, D. G., & Kravetz, J. D. (2007) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2006.09.006 · Cited by 18
Influence of Changes in Sedentary Time on Outcomes of Supervised Exercise Therapy in Individuals with Comorbid Peripheral Artery Disease and Type 2 Diabetes
Whipple, M. O., Schorr, E. N., Talley, K. M. C., Wolfson, J., Lindquist, R., Bronas, U. G., & Treat-Jacobson, D. (2020) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2020.03.040 · Cited by 18
Lifetime risk of lower extremity peripheral arterial disease: a Danish nationwide longitudinal study
Søgaard, M., Behrendt, C., Eldrup, N., & Skjøth, F. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae867 · Cited by 20
Trends of Concomitant Diabetes and Peripheral Artery Disease and Lower Extremity Amputation in US Medicare Patients, 2007 to 2019
Fowler, X. P., Eid, M. A., Barnes, J. A., Gladders, B. H., Austin, A. M., Goodney, E. J., Moore, K., Kearing, S. A., Feinberg, M. W., Bonaca, M. P., et al. (2023) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.122.009531 · Cited by 21
Aspirin effect on bone remodeling and skeletal regeneration: Review article.
Fattahi, R., Mohebichamkhorami, F., Khani, M., Soleimani, M., & Hosseinzadeh, S. (2022) · Tissue & Cell · doi:10.1016/j.tice.2022.101753 · Cited by 17
Ankle‐Brachial Index and Subsequent Risk of Severe Ischemic Leg Outcomes: The ARIC Study
Paskiewicz, A., Wang, F. M., Yang, C., Ballew, S. H., Kalbaugh, C. A., Selvin, E., Salameh, M., HEISS, G. M., Coresh, J., & Matsushita, K. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.021801 · Cited by 26
Perceptions of Canadian Vascular Surgeons Toward Pharmacologic Risk Reduction in Patients with Peripheral Artery Disease: 2018 Update
Li, B., Salata, K., de Mestral, C., Hussain, M. A., Aljabri, B. A., Lindsay, T. F., Verma, S., & Al-Omran, M. (2019) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2018.11.034 · Cited by 20
Clinical Significance of Brachial-Ankle Pulse Wave Velocity in Patients With Heart Failure With Reduced Left Ventricular Ejection Fraction.
Takae, M., Yamamoto, E., Tokitsu, T., Oike, F., Nishihara, T., Fujisue, K., Sueta, D., Usuku, H., Motozato, K., Ito, M., et al. (2019) · American Journal of Hypertension · doi:10.1093/ajh/hpz048 · Cited by 17
Pharmacological profile of adenosine A2A receptors in patients with lower extremity peripheral artery disease and associated coronary artery disease: A pilot study
Gaudry, M., Marlinge, M., Deharo, P., Vairo, D., Bottone, S., Mottola, G., Kipson, N., Criado, C., Mace, P., Chefrour, M., et al. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.02.055 · Cited by 23
“Accordingly, LE-PAD is often underdiagnosed and thus mistreated [3].”
Background
Association of sex and height with a lower ankle brachial index in the general population
Kapoor, R., Ayers, C. R., Visotcky, A. M., Mason, P., & Kulinski, J. P. (2018) · Vascular Medicine · doi:10.1177/1358863x18774845 · Cited by 26
Presenting symptoms, pre-hospital delay time and 28-day case fatality in patients with peripheral arterial disease and acute myocardial infarction from the MONICA/KORA Myocardial Infarction Registry
Kirchberger, I., Amann, U., Heier, M., Kuch, B., Thilo, C., Peters, A., & Meisinger, C. (2016) · European Journal of Preventive Cardiology · doi:10.1177/2047487316676123 · Cited by 16
Poor Prognosis in Critical Limb Ischemia Without Pre-Onset Intermittent Claudication
Shirasu, T., Hoshina, K., Yamamoto, S., Shigematsu, K., Miyata, T., & Watanabe, T. (2015) · Circulation Journal · doi:10.1253/circj.cj-15-0017 · Cited by 17
Prevalence of severe subclinical coronary artery disease on cardiac CT and MRI in patients with extra-cardiac arterial disease.
den Dekker, M. D., van den Dungen, J. V. D., Tielliu, I., Tio, R., Jaspers, M. W. M., Oudkerk, M., & Vliegenthart, R. (2013) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2013.08.013 · Cited by 17
Utilization of lower extremity arterial disease diagnostic and revascularization procedures in Medicare beneficiaries 2000-2007.
Harris, T., Zafar, A., & Murphy, T. (2011) · AJR. American journal of roentgenology · doi:10.2214/ajr.10.6132 · Cited by 17
“© American Roentgen Ray Society P eripheral arterial disease (PAD) is common, afflicting 4% of American adults [1] and up to 29% of high-risk populations [2].”
Background
Suboptimal use of risk reduction therapy in peripheral arterial disease patients at a major teaching hospital
Al-Omran, M. A., Verma, S., & Lindsay, T. F. (2011) · Annals of Saudi Medicine · doi:10.4103/0256-4947.83219 · Cited by 16

Authors: Hirsch, A. T.
Affiliations: University of Minnesota (US)
Corresponding author: Hirsch, Alan T.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2001-09-19
Volume: 286
Issue: 11
Pages: 1317
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.286.11.1317
OpenAlex: W2140136269
Cited by: 2,835
References: 0
Citations by year: 2026: 59 · 2025: 77 · 2024: 89 · 2023: 102 · 2022: 113 · 2021: 127 · 2020: 100 · 2019: 105 · 2018: 147 · 2017: 105 · 2016: 135 · 2015: 122 · 2014: 160 · 2013: 145 · 2012: 166
FWCI: 62.22
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k07hl003435-05)
National Heart, Lung, and Blood Institute (1-K07-HL03435-01)
Topics: Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vascular Procedures and Complications
Keywords: peripheral arterial disease, ankle-brachial index, underdiagnosis, patient awareness, physician awareness, cardiovascular disease, atherosclerosis, antiplatelet therapy, smoking cessation, diabetes mellitus, intermittent claudication, primary care, older adults, limb revascularization, cardiovascular risk stratification, diabetes self-management education
MeSH terms: Aged, Arteriosclerosis, Cardiovascular Diseases, Cross-Sectional Studies, Family Practice, Female, Humans, Intermittent Claudication, Health Knowledge, Attitudes, Practice, Male, Middle Aged, Platelet Aggregation Inhibitors, Risk Factors, Ultrasonography, Doppler

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Peripheral Arterial Disease Detection, Awareness, and Treatment in Primary Care

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks