Cited by 493Heart Failure Treatment and ManagementCardiovascular Function and Risk FactorsBlood Pressure and Hypertension Studies

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Plasma Natriuretic Peptides for Community Screening for Left Ventricular Hypertrophy and Systolic Dysfunction: The Framingham Heart Study

Vasan, Ramachandran S., Benjamin, Emelia J., Larson, Martin G., Leip, Eric P., Wang, Thomas J., Wilson, Peter W. F., Levy, Daniel·2002·JAMA

DOI 10.1001/jama.288.10.1252

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Abstract

CONTEXT: Several reports have suggested the usefulness of plasma brain natriuretic peptide (BNP) as a screening test for left ventricular hypertrophy (LVH) and systolic dysfunction (LVSD). Prior studies were limited by small sample sizes and selection bias and none compared the diagnostic performance of these peptides in men and women. OBJECTIVES: To examine the usefulness of natriuretic peptides for screening for elevated LV mass and LVSD in the community. DESIGN, SETTING, AND PARTICIPANTS: Community-based prospective cohort study of 3177 participants (1707 women) from the Framingham Study who attended a routine examination in 1995-1998. MAIN OUTCOME MEASURES: Receiver operating characteristic (ROC) curves, test sensitivity, specificity, positive and negative predictive values, and likelihood ratios for identifying elevated LV mass (sex-specific 90th percentile or higher of LV mass/[height](2)), LVSD (ejection fraction < or = 50% and/or fractional shortening <29%), and moderate to severe LVSD (ejection fraction < or = 40% and/or fractional shortening <22%) at different discrimination limits of plasma BNP and N-terminal proatrial natriuretic peptide (NT-ANP), with echocardiography as the criterion standard. RESULTS: The areas under the ROC curves for elevated LV mass or LVSD were at or below 0.75 for both peptides, were higher for men compared with women, and were similar for BNP and NT-ANP. The diagnostic performance of natriuretic peptides for LVSD improved in women but not…

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Authors: Vasan, R. S., Benjamin, E. J., Larson, M. G., Leip, E. P., Wang, T. J., Wilson, P. W. F., & Levy, D.
Affiliations: Framingham Heart Study (US)
Boston University (US)
National Institutes of Health (US)
ORCID: Vasan, Ramachandran S.
Benjamin, Emelia J.
Larson, Martin G.
Wang, Thomas J.
Wilson, Peter W. F.
Levy, Daniel
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2002-09-11
Volume: 288
Issue: 10
Pages: 1252
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.288.10.1252
OpenAlex: W2059920038
Cited by: 493
References: 42
Citations by year: 2026: 3 · 2025: 11 · 2024: 10 · 2023: 14 · 2022: 6 · 2021: 12 · 2020: 12 · 2019: 9 · 2018: 9 · 2017: 13 · 2016: 9 · 2015: 16 · 2014: 14 · 2013: 20 · 2012: 29
FWCI: 27.29
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01hc25195-41-0-1)
National Heart, Lung, and Blood Institute (K24-HL-04334-01A1, N01‐HC25195, R01HL067288, K24HL004334, 1R01HL67288-01)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: natriuretic peptides, brain natriuretic peptide, N-terminal proatrial natriuretic peptide, left ventricular hypertrophy, left ventricular systolic dysfunction, left ventricular mass, cardiovascular screening, diagnostic performance, sex differences, Framingham Heart Study, echocardiography
MeSH terms: Echocardiography, Female, Humans, Male, Mass Screening, Middle Aged, Atrial Natriuretic Factor, Phenotype, Predictive Value of Tests, Prospective Studies, Protein Precursors, ROC Curve, Sensitivity and Specificity, Systole, Biomarkers, Likelihood Functions, Hypertrophy, Left Ventricular, Ventricular Dysfunction, Left, Natriuretic Peptide, Brain

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Plasma Natriuretic Peptides for Community Screening for Left Ventricular Hypertrophy and Systolic Dysfunction: The Framingham Heart Study

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