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Effects of Conjugated Equine Estrogen in Postmenopausal Women With Hysterectomy: The Women's Health Initiative Randomized Controlled Trial
Open accessAbstract
CONTEXT: Despite decades of use and considerable research, the role of estrogen alone in preventing chronic diseases in postmenopausal women remains uncertain. OBJECTIVE: To assess the effects on major disease incidence rates of the most commonly used postmenopausal hormone therapy in the United States. DESIGN, SETTING, AND PARTICIPANTS: A randomized, double-blind, placebo-controlled disease prevention trial (the estrogen-alone component of the Women's Health Initiative [WHI]) conducted in 40 US clinical centers beginning in 1993. Enrolled were 10 739 postmenopausal women, aged 50-79 years, with prior hysterectomy, including 23% of minority race/ethnicity. INTERVENTION: Women were randomly assigned to receive either 0.625 mg/d of conjugated equine estrogen (CEE) or placebo. MAIN OUTCOME MEASURES: The primary outcome was coronary heart disease (CHD) incidence (nonfatal myocardial infarction or CHD death). Invasive breast cancer incidence was the primary safety outcome. A global index of risks and benefits, including these primary outcomes plus stroke, pulmonary embolism (PE), colorectal cancer, hip fracture, and deaths from other causes, was used for summarizing overall effects. RESULTS: In February 2004, after reviewing data through November 30, 2003, the National Institutes of Health (NIH) decided to end the intervention phase of the trial early. Estimated hazard ratios (HRs) (95% confidence intervals [CIs]) for CEE vs placebo for the major clinical outcomes available through February 29, 2004 (average follow-up 6.8 years), were: CHD, 0.91 (0.75-1.12) with 376 cases; breast cancer, 0.77 (0.59-1.01) with 218 cases; stroke, 1.39 (1.10-1.77) with 276 cases; PE, 1.34 (0.87-2.06) with 85 cases; colorectal cancer, 1.08 (0.75-1.55) with 119 cases; and hip fracture, 0.61 (0.41-0.91) with 102 cases. Corresponding results for composite outcomes were: total cardiovascular disease, 1.12 (1.01-1.24); total cancer, 0.93 (0.81-1.07); total fractures, 0.70 (0.63-0.79); total mortality, 1.04 (0.88-1.22), and the global index, 1.01 (0.91-1.12). For the outcomes significantly affected by CEE, there was an absolute excess risk of 12 additional strokes per 10 000 person-years and an absolute risk reduction of 6 fewer hip fractures per 10 000 person-years. The estimated excess risk for all monitored events in the global index was a nonsignificant 2 events per 10 000 person-years. CONCLUSIONS: The use of CEE increases the risk of stroke, decreases the risk of hip fracture, and does not affect CHD incidence in postmenopausal women with prior hysterectomy over an average of 6.8 years. A possible reduction in breast cancer risk requires further investigation. The burden of incident disease events was equivalent in the CEE and placebo groups, indicating no overall benefit. Thus, CEE should not be recommended for chronic disease prevention in postmenopausal women.
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Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889
Hulley, S. (1998) · JAMA · doi:10.1001/jama.280.7.605 · Cited by 6,216
A Multiple Testing Procedure for Clinical Trials
O'Brien, P. C., & Fleming, T. R. (1979) · Biometrics · doi:10.2307/2530245 · Cited by 3,311
Breast cancer and hormone-replacement therapy in the Million Women Study
Beral, V. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14065-2 · Cited by 2,986
Design of the Women’s Health Initiative Clinical Trial and Observational Study
The Women’s Health Initiative Study Group (1998) · Controlled Clinical Trials · doi:10.1016/s0197-2456(97)00078-0 · Cited by 2,580
Calle, E. E., Heath Jr., C. W., Coates, R. J., Liff, J. M., Franceschi, S., Talamini, R., Chantarakul, N., Koetsawang, S., Rachawat, D., Morabia, A., et al. (1997) · The Lancet · doi:10.1016/s0140-6736(97)08233-0 · Cited by 2,450
Hormone Therapy To Prevent Disease and Prolong Life in Postmenopausal Women
Grady, D., Rubin, S. M., Petitti, D. B., Fox, C. S., Black, D. M., Ettinger, B. B., Ernster, V. L., & Cummings, S. R. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-12-1016 · Cited by 2,329
Impact of High-Normal Blood Pressure on the Risk of Cardiovascular Disease
Vasan, R. S., Larson, M. G., Leip, E. P., Evans, J. C., O’Donnell, C. J., Kannel, W. B., & Levy, D. A. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa003417 · Cited by 2,098
Estrogen plus Progestin and the Risk of Coronary Heart Disease
Manson, J. E., Hsia, J., Johnson, K. C., Rossouw, J. E., Assaf, A. R., Lasser, N. L., Trevisan, M., Black, H. R., Heckbert, S. R., Detrano, R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030808 · Cited by 2,065
Cardiovascular Disease Outcomes During 6.8 Years of Hormone Therapy
Grady, D. G., Herrington, D. M., Bittner, V., Blumenthal, R. S., Davidson, M., Hlatky, M. A., Hsia, J. A., Hulley, S. B., Herd, A. J., Khan, S. S., et al. (2002) · JAMA · doi:10.1001/jama.288.1.49 · Cited by 1,921
Chlebowski, R. T., Hendrix, S. L., Langer, R. D., Stefanick, M. L., Gass, M. L. S., Lane, D. S., Rodabough, R. J., Gilligan, M. A., Cyr, M. G., Thomson, C. A., et al. (2003) · JAMA · doi:10.1001/jama.289.24.3243 · Cited by 1,871
Stampfer, M. J., & Colditz, G. A. (1991) · Preventive Medicine · doi:10.1016/0091-7435(91)90006-p · Cited by 1,611
Bush, T. L., Barrett-Connor, E. L., Cowan, L. D., Criqui, M. H., Wallace, R. B., Suchindran, C., Tyroler, H. A., & Rifkind, B. M. (1987) · Circulation · doi:10.1161/01.cir.75.6.1102 · Cited by 1,346
Effects of Estrogen Replacement on the Progression of Coronary-Artery Atherosclerosis
Herrington, D. M., Reboussin, D. M., Brosnihan, K. B., Sharp, P. C., Shumaker, S. A., Snyder, T. E., Furberg, C. D., Kowalchuk, G. J., Stuckey, T. D., Rogers, W. J., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008243430801 · Cited by 1,242
Cauley, J. A. (2003) · JAMA · doi:10.1001/jama.290.13.1729 · Cited by 1,229
Effect of Estrogen Plus Progestin on Stroke in Postmenopausal Women
Wassertheil-Smoller, S. W., Hendrix, S. L., Limacher, M. C., HEISS, G. M., Kooperberg, C. L., Baird, A. E., Kotchen, T. A., Curb, J. D., Black, H. R., Rossouw, J. E., et al. (2003) · JAMA · doi:10.1001/jama.289.20.2673 · Cited by 1,160
Postmenopausal Hormone Replacement Therapy: Scientific Review
Nelson, H. D., Humphrey, L. L., Nygren, P., Teutsch, S. M., & Allan, J. D. (2002) · JAMA · doi:10.1001/jama.288.7.872 · Cited by 990
A Clinical Trial of Estrogen-Replacement Therapy after Ischemic Stroke
Viscoli, C. M., Brass, L. M., Kernan, W. N., Sarrel, P. M., Suissa, S., & Horwitz, R. I. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010534 · Cited by 919
Effect of Hormone Replacement Therapy on Breast Cancer Risk: Estrogen Versus Estrogen Plus Progestin
Ross, R. K. (2000) · Journal of the National Cancer Institute · doi:10.1093/jnci/92.4.328 · Cited by 877
Estrogen Replacement Therapy and Fractures in Older Women
Cauley, J. A., Seeley, D. G., Ensrud, K. E., Ettinger, B., Black, D., & Cummings, S. R. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-1-199501010-00002 · Cited by 808
Decreased Risk of Fractures of the Hip and Lower Forearm with Postmenopausal Use of Estrogen
Weiss, N. S., Ure, C. L., Ballard, J. H., Williams, A. R., & Daling, J. R. (1980) · New England Journal of Medicine · doi:10.1056/nejm198011203032102 · Cited by 774
Implementation of the women's health initiative study design
Anderson, G. L., Manson, J. E., Wallace, R. B., Lund, B., Hall, D., Davis, S., Shumaker, S. A., Wang, C., Stein, E. A., & Prentice, R. L. (2003) · Annals of Epidemiology · doi:10.1016/s1047-2797(03)00043-7 · Cited by 757
The women's health initiative recruitment methods and results
Hays-Grudo, J., Hunt, J. R., Hubbell, F. A., Anderson, G. L., Limacher, M. C., Allen, C. I., & Rossouw, J. E. (2003) · Annals of Epidemiology · doi:10.1016/s1047-2797(03)00042-5 · Cited by 743
Outcomes ascertainment and adjudication methods in the women's health initiative
Curb, J. D., McTiernan, A., Heckbert, S. R., Kooperberg, C. L., Stanford, J. L., Nevitt, M. C., Johnson, K., Proulx-Burns, L., Pastore, L. M., Criqui, M. H., et al. (2003) · Annals of Epidemiology · doi:10.1016/s1047-2797(03)00048-6 · Cited by 700
A Meta-analysis of the Effect of Estrogen Replacement Therapy on the Risk of Breast Cancer
STEINBERG, K. K. (1991) · JAMA · doi:10.1001/jama.1991.03460150089030 · Cited by 648
Waters, D. D., Alderman, E. L., Hsia, J. A., Howard, B. V., Cobb, F. R., Rogers, W. J., Ouyang, P., Thompson, P. D., Tardif, J., Higginson, L., et al. (2002) · JAMA · doi:10.1001/jama.288.19.2432 · Cited by 580
Hormone Replacement Therapy and Prevention of Nonvertebral Fractures
Torgerson, D. J., & Bell-Syer, S. E. (2001) · JAMA · doi:10.1001/jama.285.22.2891 · Cited by 528
Li, C. I. (2003) · JAMA · doi:10.1001/jama.289.24.3254 · Cited by 415
Postmenopausal Hormone Therapy and Risk of Stroke
Simon, J. A., Hsia, J. A., Cauley, J. A., Richards, C., Harris, F., Fong, J., Barrett-Connor, E. L., & Hulley, S. B. (2001) · Circulation · doi:10.1161/01.cir.103.5.638 · Cited by 402
Effects of Estrogen and Estrogen–Progestin on Mammographic Parenchymal Density
Greendale, G. A., Reboussin, B. A., Sie, A., Singh, H. R., Olson, L. K., Gatewood, O. B., Bassett, L. W., Wasilauskas, C. H., Bush, T. L., Barrett-Connor, E. L., et al. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-4_part_1-199902160-00003 · Cited by 400
Hormone Therapy and the Progression of Coronary-Artery Atherosclerosis in Postmenopausal Women
Hodis, H. N., Mack, W. J., Azen, S. P., Lobo, R. A., Shoupe, D., Mahrer, P. R., Faxon, D. P., Cashin-Hemphill, L., Sanmarco, M. E., French, W. J., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030830 · Cited by 386
Wells, G., Tugwell, P., Shea, B., Guyatt, G. H., Peterson, J., Zytaruk, N. L., Robinson, V. A., Henry, D. A., O’Connell, D., Cranney, A., et al. (2002) · Endocrine Reviews · doi:10.1210/er.2001-5002 · Cited by 370
Menopausal Estrogen Replacement Therapy and Breast Cancer
Dupont, W. D. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.1991.00400010089011 · Cited by 368
Clarke, S., Kelleher, J., Lloyd‐Jones, H., Slack, M. C., & Schofield, P. M. (2002) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2002.01544.x · Cited by 267
Postmenopausal Hormone-Replacement Therapy
Martin, K. A., & Freeman, M. W. (1993) · New England Journal of Medicine · doi:10.1056/nejm199304153281509 · Cited by 253
Stefanick, M. L., Cochrane, B. B., Hsia, J. A., Barad, D. H., LIU, J. H., & Johnson, S. R. (2003) · Annals of Epidemiology · doi:10.1016/s1047-2797(03)00045-0 · Cited by 231
Postmenopausal Hormone-Replacement Therapy
Manson, J. E., & Martin, K. A. (2001) · New England Journal of Medicine · doi:10.1056/nejm200107053450106 · Cited by 198
Use of Menopausal Estrogens and Medroxyprogesterone in the United States, 1982-1992
Wysowski, D. K. (1995) · Obstetrics and Gynecology · doi:10.1016/0029-7844(94)00339-f · Cited by 195
Impact of high-normal blood pressure on the risk of cardiovascular disease
Vasan, R. S., Larson, M. G., & Leip, E. P. (2002) · ACC Current Journal Review · doi:10.1016/s1062-1458(02)00536-6 · Cited by 171
A Clinical Trial of Estrogen-Replacement Therapy After Ischemic Stroke
Viscoli, C. M., Brass, L. M., Kernan, W. N., Sarrel, P. M., Suissa, S., & Horwitz, R. I. (2002) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-200203000-00019 · Cited by 125
Chlebowski, R. T., Hendrix, S. L., Langer, R. D., Stefanick, M. L., Gass, M. L. S., Lane, D. S., Rodabough, R. J., Gilligan, M. A., Cyr, M. G., Thomson, C. A., et al. (2003) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000093674.44946.d6 · Cited by 119
A meta-analysis of the effect of estrogen replacement therapy on the risk of breast cancer
STEINBERG, K. K. (1991) · JAMA · doi:10.1001/jama.265.15.1985 · Cited by 116
Freedman, L. S., Anderson, G. L., Kipnis, V., Prentice, R. L., Wang, C. Y., Rossouw, J. E., Wittes, J. T., & DeMets, D. L. (1996) · Controlled Clinical Trials · doi:10.1016/s0197-2456(96)00016-5 · Cited by 102
Venous Thromboembolic Events Associated With Hormone Replacement Therapy
Grady, D. G. (1997) · JAMA · doi:10.1001/jama.1997.03550060053030 · Cited by 94
Hormone therapy to prevent disease and prolong life in postmenopausal women
Grady, D., Rubin, S., Petitti, D. B., Fox, C. S., Black, D., Ettinger, B. B., Ernster, V. L., & Cummings, S. R. (1993) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(93)90679-q · Cited by 87
Estrogen plus progestin and the risk of coronary heart disease
Manson, J. E., Hsia, J., & Johnson, K. C. (2003) · ACC Current Journal Review · doi:10.1016/j.accreview.2003.09.012 · Cited by 87
Fred Hutchinson Cancer Research Center
Colditz, G. A. (2007) · Encyclopedia of Cancer and Society · doi:10.4135/9781412953979.n241 · Cited by 81
Menopausal estrogen replacement therapy and breast cancer
Dupont, W. D. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.151.1.67 · Cited by 65
Hill, D. A., Weiss, N. S., & LaCroix, A. Z. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(00)70210-9 · Cited by 57
Wassertheil-Smoller, S. W., Hendrix, S. L., Limacher, M. C., et al. (2003) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000093671.39203.32 · Cited by 52
Effects of Estrogen Replacement on the Progression of Coronary-Artery Atherosclerosis
Herrington, D. M., Reboussin, D. M., Brosnihan, K. B., Sharp, P. C., Shumaker, S. A., Snyder, T. E., Furberg, C. D., Kowalchuk, G. J., Stuckey, T., Rogers, W. J., et al. (2001) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-200101000-00020 · Cited by 52
Hsia, J. A., Barad, D. H., Margolis, K. L., Rodabough, R. J., McGovern, P. G., Limacher, M. C., Oberman, A., & Smoller, S. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00621-0 · Cited by 36
95007346 Estrogen replacement therapy and fractures in older women
Cauley, J. A., Seeley, D. G., Ensrud, K. E., Ettinger, B. B., Black, D., & Cummings, S. R. (1995) · Maturitas · doi:10.1016/0378-5122(95)99336-z · Cited by 34
Waters, D. D., Alderman, E. L., Hsia, J. A., et al. (2003) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000055762.75837.f8 · Cited by 28
Simon, J. A., Hsia, J., & Cauley, J. A. (2001) · ACC Current Journal Review · doi:10.1016/s1062-1458(01)00300-2 · Cited by 25
91146870 A meta-analysis of the effect of estrogen replacement therapy on the risk of breast cancer
STEINBERG, K. K., Thacker, S. B., Smith, S. J., Stroup, D. F., Zack, M. M., Flanders, W. D., & Berkelman, R. L. (1991) · Maturitas · doi:10.1016/0378-5122(91)90165-m · Cited by 22
National Heart, Lung, and Blood Institute
National Cancer Institute (2020) · Definitions · doi:10.32388/afgal0 · Cited by 18
Torgerson, D. J., & Bell-Syer, S. E. M. (2001) · White Rose Research Online (University of Leeds, The University of Sheffield, University of York) · Cited by 18
Duthie, E. H., SIMPSON, D. E., Marcdante, K., et al. (2004) · Academic Medicine · doi:10.1097/00001888-200407001-00042 · Cited by 16
Simon, J. A., Hsia, J. A., Cauley, J. A., Richards, C., Harris, F., Fong, J., Barrett-Connor, E. L., & Hulley, S. B. (2001) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-200107000-00021 · Cited by 15
Hormone therapy and the progression of coronary-artery atherosclerosis in postmenopausal women
Hodis, H. N., Mack, W. J., & Azen, S. (2003) · ACC Current Journal Review · doi:10.1016/j.accreview.2003.09.014 · Cited by 13
&NA; (1999) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-199901000-00011 · Cited by 8
Rush-Presbyterian-St. Lukeʼs Medical Center
(1979) · Neurosurgery · doi:10.1227/00006123-197907010-00046 · Cited by 8
Research works printed but not linked: 6
- Grady D, Hulley SB, Furberg C. Venous throm- boembolic events associated with hormone replace- ment therapy [letter]. JAMA. 1997;278:477.
- Anderson GL, Manson J, Wallace R, et al. Imple- mentation of the Women's Health Initiative study de- sign. Ann Epidemiol. 2003;13:S5-S17.
- Cox DR. Regression analysis and life tables. J R Stat Soc. 1972;34:187-220.
- ESPRIT Team. Oestrogen therapy for prevention of reinfarction in postmenopausal women: a random- ized placebo controlled trial. Lancet. 2002;360:2001- 2008.
- Nelson HD, Humphrey LL, Nygren P, et al. Post- menopausal hormone replacement therapy. JAMA. 2002;288:872-881.
- Ross RK, Paganini-Hill A, Wan PC, Pike MC. Effect of hormone replacement therapy on breast cancer risk. J Natl Cancer Inst. 2000;92:328-332.
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Metadata
- Authors
- The Women's Health Initiative Steering Committee*
- Affiliations
- Fred Hutch Cancer Center (US)
- Corresponding author
- The Women's Health Initiative Steering Committee*
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2004-04-14
- Volume
- 291
- Issue
- 14
- Pages
- 1701
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1586699954
- Cited by
- 4,534
- References
- 64
- Citations by year
- 2026: 78 · 2025: 67 · 2024: 90 · 2023: 87 · 2022: 145 · 2021: 109 · 2020: 101 · 2019: 142 · 2018: 125 · 2017: 147 · 2016: 137 · 2015: 160 · 2014: 177 · 2013: 226 · 2012: 229
- FWCI
- 284.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
- Keywords
- conjugated equine estrogens, postmenopausal women, hysterectomy, coronary artery disease, breast cancer, stroke, pulmonary embolism, colorectal cancer, hip fracture, cardiovascular disease, risk-benefit assessment, Women's Health Initiative, early trial termination, disease prevention, racial and ethnic minorities, cardiovascular risk factors, menopausal symptoms, hot flashes
- MeSH terms
- Aged, Breast Neoplasms, Cause of Death, Coronary Disease, Double-Blind Method, Estrogens, Conjugated (USP), Estrogens, Female, Hip Fractures, Humans, Hysterectomy, Middle Aged, Pulmonary Embolism, Colorectal Neoplasms, Estrogen Replacement Therapy, Proportional Hazards Models, Postmenopause, Risk Assessment, Stroke
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