Cited by 1,241Chronic Kidney Disease and DiabetesAcute Kidney Injury ResearchBlood Pressure and Hypertension Studies

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Predictors of New-Onset Kidney Disease in a Community-Based Population

Fox, Caroline S.·2004·JAMA

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Abstract

Context Kidney disease is associated with an increased risk for the development of cardiovascular disease and end-stage renal disease; however, risk factors for kidney disease have not been well studied. Objective To identify predictors of the development of new-onset kidney disease. Design, setting, and participants A community-based, longitudinal cohort study of 2585 participants who attended both a baseline examination in 1978-1982 and a follow-up examination in 1998-2001, and who were free of kidney disease at baseline. Main outcome measures Kidney disease was assessed by the Modification of Diet in Renal Disease Study equation and defined by a glomerular filtration rate (GFR) in the fifth or lower percentile ( Results At baseline, there were 1223 men and 1362 women, with a mean age of 43 years, who were free of preexisting kidney disease. After a mean follow-up of 18.5 years, 244 participants (9.4%) had developed kidney disease. In multivariable models, baseline age (odds ratio [OR], 2.36 per 10-year increment; 95% confidence interval [CI], 2.00-2.78), GFR ( or =120 mL/min per 1.73 m2), a mildly reduced GFR ( Conclusions Established cardiovascular disease risk factors are associated with the development of new-onset kidney disease. Patients with a mildly reduced GFR should be monitored for progression to kidney disease.

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Crossref · 10.1001/jama.291.7.844

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A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation
Levey, A. S., Bosch, J. P., Lewis, J. B., Greene, T., Rogers, N., Roth, D., & for the Modification of Diet in Renal Disease Study Group* (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-6-199903160-00002 · Cited by 15,079
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
Brenner, B. M., Cooper, M. E., de Zeeuw, D., Keane, W. F., Mitch, W. E., Parving, H.-H., Remuzzi, G., Snapinn, S. M., Zhang, Z., & Shahinfar, S. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011161 · Cited by 7,493
Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
Lewis, E. J., Hunsicker, L. G., Clarke, W. R., Berl, T., Pohl, M. A., Lewis, J. B., Ritz, E., Atkins, R. C., Rohde, R., & Raz, I. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011303 · Cited by 5,987
The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease
Klahr, S., Levey, A. S., Beck, G. J., Caggiula, A. W., Hunsicker, L., Kusek, J. W., & Striker, G. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403313301301 · Cited by 2,328

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Estimation of serum creatinine, serum urea, glomerular filtration rate and proteinuria among apparently healthy adults to assess the renal impairment and its association with body mass index: An observational hospital-based study
Ray, A., Kare, P., Makwane, H., Saxena, T., & Garg, C. (2020) · doi:10.17511/ijmrr.2020.i02.09 · Cited by 7
Body mass index is an independent predictive factor for kidney function evaluated by glomerular filtration rate in a community-dwelling population
Duan, Y.-Y., Wang, X.-N., Zhang, J., Ye, P., Cao, R., Yang, X., Bai, Y.-Y., & Wu, H.-M. (2019) · Eating and Weight Disorders · doi:10.1007/s40519-017-0434-5 · Cited by 7
Outcomes of single kidney transplantation from pediatric donors: A single‐center experience
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High-normal albuminuria and incident chronic kidney disease in a male nondiabetic population
Ashitani, A., Ueno, T., Nakashima, A., Doi, S., Yamane, K., & Masaki, T. (2017) · Clinical and Experimental Nephrology · doi:10.1007/s10157-017-1522-6 · Cited by 7
“The previous studies have reported that age, DM, obesity, hypertension, smoking, and low HDL cholesterol levels are risk factors for incident CKD [21, 22].”
Background
Obesity modulates the association between systolic blood pressure and albuminuria
Fotheringham, J., Kawar, B., McKane, W. S., & Ellam, T. (2017) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfx081 · Cited by 8
“These findings support the concept of ‘metabolically healthy obesity’ and contrast with previous reports that obesity is a predictor of ESRD and CKD even in analyses adjusted for other metabolic factors [1, 2, 4].”
Result
Combined body mass index with high-sensitivity C-reactive protein as independent predictors for chronic kidney disease in a relatively healthy population in Taiwan
Tsai, Y.-W., Lu, M.-C., Lin, Y.-H., Lee, Y., Li, W., Chen, J.-Y., & Chang, S.-S. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.28 · Cited by 7
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de Goeij, M. D., Rotmans, J., Matthijssen, X., de Jager, D. D., Dekker, F., & Halbesma, N. (2015) · Nephron Extra · doi:10.1159/000371410 · Cited by 7
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Risks of Decreased Renal Function and Increased Albuminuria for Glycemic Status and Metabolic Syndrome Components: Taichung Community Health Study
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“Hyperglycemia, high blood pressure, hyperlipidemia, and abdominal obesity are related to the development of newonset kidney disease [25, 26].”
Background
Role of Dyslipidemia in Patients With Chronic Kidney Disease
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Vlek, A., van der Graaf, Y., Braam, B., Moll, F., Nathoe, H., & Visseren, F. (2009) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2009.07.007 · Cited by 7
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MANAGEMENT AND TREATMENT OF Chronic Kidney Disease
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Background
Animal models of obesity-associated chronic kidney disease.
Mak, R., Kuo, H.-J., & Cheung, W. (2006) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2006.07.003 · Cited by 7
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“This relationship was found in the general population but studies are conflicting and difficult to compare taking into consideration that they relate to different races, different populations and different markers used to quantify obesity [8,9] Preventing CKD and obesity and clarifying the relationship between them is…”
Background
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Obesity and Risk of Kidney Outcomes in Heart Failure With Preserved Ejection Fraction
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Relationship between bmi and glomerular filtration rate in a large cohort initiating a weight loss program: differential contributions of fat mass, fat-free mass, and abdominal fat compartments
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“Numerous studies have established that obesity significantly contributes to both the onset of CKD [6–8] and progression to end-stage renal disease [9].”
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Wu, T., Li, R., Chen, J., Tian, X.-Q., Zhang, R., & Hou, X.-T. (2025) · Renal Failure · doi:10.1080/0886022x.2024.2444401 · Cited by 6
Perinatal Obesity Sensitizes for Premature Kidney Aging Signaling
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The Association between Anthropometric Indices of Obesity and Chronic Kidney Disease in Middle-aged Japanese Men and Women: A Cohort Study
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“Previous Western and Asian cohort studies have reported that the BMI is associated with the risk of CKD (1, 7-9, 11, 12, 18-23), consistent with our results.”
Result
Predictors of abnormality in thallium myocardial perfusion scans for type 2 diabetes
Lu, C.-H., Pei, D., Wu, C.-Z., Kua, H., Liang, Y.-J., Chen, Y.-L., & Lin, J.-D. (2020) · Heart and Vessels · doi:10.1007/s00380-020-01681-2 · Cited by 6
Cystatin C Predicts Incident Cardiovascular Disease in Twins
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Effect of Non-Alcoholic Fatty Liver Disease on Estimated Glomerular Filtration Rate Could Be Dependent on Age
Shen, Z., Munker, S., Luo, F., Ma, H., Yu, C.-H., & Li, Y.-M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130614 · Cited by 6
“Renal dysfunction and injury is also a common health problem in modern society; and similar to NAFLD, CKD has also been linked to metabolic syndrome and its individual components [21,22].”
Background
Estimating the glomerular filtration rate in the Spanish working population: chronic kidney disease prevalence and its association with risk factors
Sánchez-chaparro, M., Calvo-Bonacho, E., González-Quintela, A., Cabrera, M., Quevedo-aguado, L., Fernández-labandera, C., Ruiz-Moraga, M., Sainz-Gutiérrez, J. C., Gómez-Martínez, P., Román-García, J., et al. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000267 · Cited by 6
Kidney Disease in the Obese Patient
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“These values compare favorably with 102 mg/day reported in jejunoileal bypass.45 When oxalate nephropathy develops, it usually presents with acute renal failure (ARF) or nephrolithiasis, often superimposed on CKD.”
BackgroundInfluential
Is there an obesity-related epidemic of CKD starting already in childhood?
Tullus, K. (2013) · Nephrology, Dialysis and Transplantation · doi:10.1093/ndt/gft335 · Cited by 6
New-onset microalbuminuria following allogeneic myeloablative SCT is a sign of near-term decrease in renal function
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Chronic Kidney Disease Update
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Decrease in glomerular filtration rate by plasma low-density lipoprotein cholesterol in subjects with normal kidney function assessed by urinalysis and plasma creatinine.
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“Blood ressure which is a well known important risk factor of chronic idney disease (CKD) [3,4,9–12] was not high in low e-GFR groups n subjects with normal kidney function assessed by urinalysis and lasma creatinine.”
Background
Risk Factors for ESRD: Lessons From a Community Study and Implications for Public Health
Weiner, D. (2010) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2009.11.004 · Cited by 6
Renal Manifestations and Visceral Adiposity in Apparently Healthy Korean Women
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“In most previous studies, accurate methods to measure adiposity were not used, and only a few studies have focused specifically on relationships between renal function within normal range and visceral adiposity in a healthy population. It is not clear whether central obesity alone or other competing risk factors are a…”
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Nwankwo, A. E., Wudiri, W. W., & Akinsola, A. (2007) · doi:10.3923/jms.2007.579.584 · Cited by 6
What have we learned from clinical trials on prevention?
Pellicano, R., Kerr, P. G., & Atkins, R. C. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.09424.x · Cited by 3
[Hypertensive vascular disease: evolution of its incidence in the period 1991-2007 and survival prior to end-stage renal disease].
Robles, N., Romero, B., Bureo, N., Macías, R., Casado, E., & Cubero, J. (2010) · Nefrología · doi:10.3265/nefrologia.pre2010.apr.10363 · Cited by 6
Self-efficacy, Self-management and Their Impact on Hypertensive Patients’ Outcomes: A Study from Primary Health Centers in Indonesia
Rikmasari, Y., Kristina, S., Endarti, D., Andayani, T., & Vo, T. (2025) · Indonesian Journal of Pharmaceutics · doi:10.22146/ijp.5359 · Cited by 5
“Hypertension is a chronic disease often found in primary health care and causes cardiovascular, cerebrovascular, kidney failure, and death due to sub-optimal blood pressure (Fox et al., 2004; Gakidou et al., 2017; Hsu et al., 2005; James et al., 2014).”
Serum Osmolality as a Predictor of Renal Function Decline: A Retrospective Cohort Study
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Impact of metabolic abnormalities on the association between normal-range urinary albumin-to-creatinine ratio and cardiovascular mortality: evidence from the NHANES 1999–2018
Li, M.-H., Ji, R., Li, Z., Zhao, S., Liu, R., Liu, X., & Wu, Y. (2024) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-024-01488-5 · Cited by 5
“There is a well-defined bidirectional relationship between metabolic and renal health [16, 23, 24].”
Background
Predictors of chronic kidney disease survival in type 2 diabetes: a 12-year retrospective cohort study utilizing estimated glomerular filtration rate
Jairoun, A. A., Ping, C. C., & Ibrahim, B. (2024) · Scientific Reports · doi:10.1038/s41598-024-58574-x · Cited by 7
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“[16] Secondly, published work pointed out that a reduced eGFR was associated with increased extracellular calcium and phosphorus concentrations, which might lead to vascular calcification, thereby increasing the risk of death in CVD patients.”
Comorbidity, life-style factors and healthcare utilization in incident chronic kidney disease: sex-specific analyses of claims data
Colombo, M., Förster, C., Wallwiener, S., Hassdenteufel, K., Hawighorst-Knapstein, S., Kirtschig, G., Chaudhuri, A., Dally, S., & Joos, S. (2022) · Nephrology, Dialysis and Transplantation · doi:10.1093/ndt/gfac245 · Cited by 5
“The Framingham Offspring study found incident kidney disease in 9400/100 000 of their community-based cohort with amean age of 43 years [22].”
Method
Association between Three Waist Circumference-Related Obesity Metrics and Estimated Glomerular Filtration Rates
Lee, D. Y., Yu, G., Kim, Y., Kim, M. K., Shin, M., & Lee, M.-Y. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11102876 · Cited by 5
“Obesity is known as the leading cause of chronic kidney disease (CKD), and anthropometric indices, such as the body mass index (BMI), have been used to assess whether individuals are obese [2,3].”
Background
Development of chronic kidney disease influenced by serum urate and body mass index based on young-to-middle-aged Japanese men: a propensity score-matched cohort study
Kuma, A., Mafune, K., Uchino, B., Ochiai, Y., Enta, K., & Kato, A. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-049540 · Cited by 5
Cardiovascular disease protein biomarkers are associated with kidney function: The Framingham Heart Study
Keshawarz, A., Hwang, S.-J., Lee, G., Yu, Z., Yao, C., Köttgen, A., & Levy, D. (2022) · medRxiv · doi:10.1371/journal.pone.0268293 · Cited by 5
“Serum creatinine was measured using the modified Jaffe method (Roche Diagnostics, Indianapolis, IN) and calibrated to National Health and Nutrition Examination Survey (NHANES) III creatinine values [6].”
BackgroundMethod
Body weight fluctuation is associated with rapid kidney function decline
Joo, Y. S., Nam, K., Jhee, J., Yun, H., Lee, S.-M., Han, S., Yoo, T., Kang, S.-W., & Park, J. (2021) · Obesity · doi:10.1002/oby.23326 · Cited by 5
“Obesity is a significant risk factor for CKD (3,4).”
Background
Association of body mass index with kidney function and mortality in high cardiovascular risk population: A nationwide prospective cohort study
Aiumtrakul, N., Kittithaworn, A., Supasyndh, O., Krittayaphong, R., Phrommintikul, A., & Satirapoj, B. (2021) · Nephrology · doi:10.1111/nep.13970 · Cited by 5
The risk of consequent nephropathy following initial weight loss in diabetic patients treated with sodium glucose cotransporter 2 inhibitors
Chan, Y., Chen, S., Chao, T., Kao, Y., Huang, C.-Y., & Chu, P. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01361-z · Cited by 7
Obesity is a risk factor for progression to kidney transplant waitlisting after liver transplantation
Locke, J. E., Shelton, B. A., Orandi, B. J., Olthoff, K. M., Pomfret, E. A., Forde, K. A., Sawinski, D. L., Gray, M. E., & Ascher, N. L. (2021) · Clinical Transplantation · doi:10.1111/ctr.14317 · Cited by 5
Chronic kidney disease progression in aged patients
Tuğcu, M., & Ataş, D. B. (2021) · International Urology and Nephrology · doi:10.1007/s11255-021-02806-w · Cited by 5
Cystatin C-based estimated GFR and albuminuria are independently associated with all-cause and CVD mortality in Korean population: The Dong-gu Study.
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Blood pressure control in patients with chronic kidney disease according to office and home blood pressures
Chantrel, F., Ott, J., Dimitrov, Y., Babici, D., Fourcade, J., Hanon, O., Achard, J., Jaboureck, O., Ducher, M., & Fauvel, J. (2020) · Blood Pressure Monitoring · doi:10.1097/mbp.0000000000000463 · Cited by 5
Nutrition in Kidney Disease
Byham-Gray, L., Burrowes, J., & Chertow, G. (2020) · doi:10.1007/978-3-030-44858-5 · Cited by 5
“A small study in Mexico reported that 9.2% of the individuals had proteinuria, whereas in Chile 14.2% had proteinuria and 21% had a creatinine clearance 80 ml/min.”
BackgroundMethodInfluential
Awareness and Knowledge Among Internal Medicine Resident Trainees for Dose Adjustment of Analgesics and Neuropsychotropic Medications in CKD
Saad, C., Fogel, J., & Rubinstein, S. (2018) · Southern medical journal (Birmingham, Ala. Print) · doi:10.14423/smj.0000000000000781 · Cited by 5
Relationship of High‐Density Lipoprotein Cholesterol With Renal Function in Patients Treated With Atorvastatin
Kwok, L.-O., Waters, D., Fayyad, R., Vogt, L., Melamed, S., Demicco, D., Rye, K., & Barter, P. (2018) · Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease · doi:10.1161/jaha.117.007387 · Cited by 5
FimAsartaN proTeinuriA SusTaIned reduCtion in comparison with losartan in diabetic chronic kidney disease (FANTASTIC): study protocol for randomized controlled trial
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Effect of low and high HDL-C levels on the prognosis of lupus nephritis patients: a prospective cohort study
Yin, P.-R., Zhou, Y., Li, B., Hong, L.-Y., Chen, W., & Yu, X.-Q. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0622-3 · Cited by 5
Kidney Disease and Psoriasis. A New Comorbidity
González-Parra, E., Daudén, E., Carrascosa, J., Olveira, A., Botella, R., Bonanad, C., & Rivera, R. (2016) · Actas Dermo-Sifiliográficas · doi:10.1016/j.adengl.2016.05.025 · Cited by 5
Prevalence, associated factors and impact on mortality of chronic kidney disease in nursing home residents: A single‐center experience
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“Most long-term PD patients show abnormal peritoneal histology (2,3).”
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Living kidney donors: the need to minimise long term risk.
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Prevención y tratamiento de la enfermedad renal crónica (ERC)
Orozco, B. (2010) · doi:10.1016/s0716-8640(10)70600-3 · Cited by 5
“4% presentó al fin del seguimiento una ERC definida por una VFG < 60 ml/min (7).”
Background
Kidney Function and Estimated Vascular Risk in Patients with Primary Dyslipidemia
Τζιόμαλος, Κ., Ganotakis, E. S., Gazi, I. F., Nair, D. R., & Mikhailidis, D. P. (2009) · The Open Cardiovascular Medicine Journal · doi:10.2174/1874192400903010057 · Cited by 5
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Sleep-disordered breathing and reductions in renal function: are they associated in the elderly?
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Metabolic Syndrome—What We Know and What We Don't Know
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Implications and Management of Obesity in Kidney Disease
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Rao, M.-Y. K., & Anderson, S. (2009) · doi:10.1016/b978-1-4160-5185-5.00051-1 · Cited by 5
Relationship Between the Severity of Coronary Artery Disease and Renal Function
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“CKD risk factors are similar to those associated with cardiovascular disease including, older age, smoking, hypertension, obesity, and type 2 diabetes mellitus (T2DM) [8].”
Background
One anastomosis gastric bypass ameliorates diabetic nephropathy via regulating the GLP-1-mediated Sirt1/AMPK/PGC1α pathway
Han, L., Chen, X., Wan, D.-W., Xie, M., & Ouyang, S. (2024) · Clinical and Experimental Nephrology · doi:10.1007/s10157-024-02516-4 · Cited by 4
“High body mass index (BMI) is one of the most powerful risk factors for new-onset chronic kidney disease [15], and higher baseline BMI is still an independent factor for the prediction for ESRD after adjustments for DM and blood pressure [19].”
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“Previous studies have demonstrated that patients with mildly reduced eGFR were more likely to develop CKD compared to those with a normal eGFR [9, 10].”
Background
Estimation of Glomerular Filtration Rate in Obese Patients: Utility of a New Equation
Fernández, P., Nores, M., Douthat, W., de Arteaga, J., Luján, P., Campazzo, M., Fuente, J. D. L., & Chiurchiu, C. (2023) · Nutrients · doi:10.3390/nu15051233 · Cited by 4
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“In addition to CAD, T2DM is also considered a strong pathogenic factor for having another major microvascular complication, diabetic nephropathy (DN) [71].”
Background
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Bae, E., Rocco, M., Lee, J., Park, J., Kwon, H., Yoo, K. D., Kim, E. Y., Park, D., Lim, C., Kim, Y. S., et al. (2021) · Journal of Hypertension · doi:10.1097/hjh.0000000000002983 · Cited by 4
Effectiveness and Tolerability of Nifedipine GITS in Patients with Chronic Kidney Disease and Uncontrolled Hypertension: A Prospective, Multicenter, Observational Study (ADRENAL)
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“Untreated or inadequately controlled hypertension is considered as one of the most important risk factors for the progression of CKD [2], leading to the development of end-stage renal disease (ESRD) in both men and women [3].”
Background
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Martin-Alemañy, G., Pérez-Navarro, M., Rosas-Herrera, A., Hinojosa-Heredia, H., Fuentes-Mendez, L. C., & Valdez-Ortiz, R. (2021) · Nutrición Hospitalaria · doi:10.20960/nh.03646 · Cited by 4
“In a cohort of 2,585 patients who have been monitored since 1978, it was found that for each unit of standard deviation of BMI, obesity increased the risk of developing kidney disease by 23 % (20).”
Background
Insulin Resistance is Associated with Subclinical Vascular Injury in Patients with a Kidney Disease
Adeva‐Andany, M. M., Fernández‐Fernández, C., Adeva-Contreras, L., Carneiro-Freire, N., Domínguez-Montero, A., & Mouriño-Bayolo, D. (2020) · Current Cardiology Reviews · doi:10.2174/1573403x16999201210200012 · Cited by 4
“Additionally, the risk for incident CKD increases progressively with a higher number of components of the metabolic syndrome at baseline, after adjustment for confounding factors [196, 198, 201, 204-210].”
Background
Risk factors for incident kidney disease in older adults: an Australian prospective population‐based study
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“High blood glucose is closely related to age because the prevalence of diabetes increases with advancing age (27).”
Background
Study of serum sodium and serum potassium level in chronic renal failure
Singh, P., Deshwali, S. K., Potey, G. G., & Sharma, A. (2017) · International Journal of Advanced Research in Biological Sciences (IJARBS) · doi:10.22192/ijarbs.2017.04.11.13 · Cited by 3
Characteristics of the Lipid Profile in Patients with Diabetes Mellitus and Chronic Kidney Disease
Albai, O., Timar, B., Roman, D., & Timar, R. (2017) · Romanian Journal of Diabetes Nutrition and Metabolic Diseases · doi:10.1515/rjdnmd-2017-0029 · Cited by 4
Can cardiovascular disease guidelines that advise treatment decisions based on absolute risk be improved?
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Diseases of Renal Microcirculation: Diabetic Nephropathy
Riphagen, I. J., Heerspink, H. J. L., Gans, R. O. B., & Gaillard, S. (2014) · Springer eBooks · doi:10.1007/978-3-642-37393-0_149-1 · Cited by 3
“Obesity and especially a central body fat distribution or visceral adiposity are associated with an increased risk of hyperfiltration, albuminuria, decline in GFR, as well as onset and progression of CKD in the general population (Fox et al. 2004; Kwakernaak et al. 2013; PintoSietsma et al. 2003).”
Background
Elevated Blood Pressure and Serum γ -Glutamyltransferase as Significant Characteristics of Smokers With Chronic Kidney Disease
Noborisaka, Y., Ishizaki, M., Yamazaki, M., Honda, R., & Yamada, Y. (2014) · Nephro-Urology Monthly · doi:10.5812/numonthly.20746 · Cited by 4
“These findings are reasonable since high BP (5-7), serum TG (8, 9), and GGT (10, 11) have been reported to predict the future development of CKD.”
Background
Pediatric chronic kidney disease rates in Southern Israel are higher than reported
Landau, D., Schreiber, R., Kleinman, A., Vodonos, A., & Shalev, H. (2013) · F1000Research · doi:10.12688/f1000research.2-186.v1 · Cited by 4
The Obesity Epidemic and Kidney Disease: A Literature Review
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Analysis of Early Kidney Damage in Hospitalized Patients with Chronic Kidney Disease: A Multicenter Study
Chen, N., Pan, X.-X., Gu, Y., Mao, P., Ni, Z., Ding, X., Zhang, J.-H., Wang, N.-S., Yuan, W., & Zhang, J.-Y. (2012) · Renal Failure · doi:10.3109/0886022x.2011.647303 · Cited by 4
Risk factors for metabolic syndrome in stable Italian renal transplant patients
Fabbian, F., Bergami, M., Molino, C., Giorgi, A. D., Pala, M., Longhini, C., & Portaluppi, F. (2011) · Clinical and Experimental Nephrology · doi:10.1007/s10157-011-0422-4 · Cited by 4
“MS and cardiovascular risk factors are associated with the development of chronic renal disease [ 7 , 8]. It has been shown that RTR with MS have an increased risk for CVD [9].”
Background
Screening of chronic diseases and chronic disease risk factors in two rural communities in Kosovo.
Gorgieva, G. S., Stasević, Z., Vasić, S., Ristić, S., Ležaić, V., & Djukanović, L. (2010) · Central European Journal of Public Health · doi:10.21101/cejph.a3582 · Cited by 4
Low birth weight, metabolic syndrome and theirassociations with the global crisis of 1930 - 1945,rapidly growing economy and coronary heart disease inCentral Africa
Longo-Mbenza, B., Ngoma, D. V., & Fuele, S. M. (2010) · International Journal of Nutrition and Metabolism · doi:10.5897/ijnam.9000024 · Cited by 4
Facial wrinkles as a predictor of decreased renal function
Park, B., Lee, S., Park, J.-W., Kim, K.-A., Kim, H.-U., Lee, J., Koh, D.-H., Youm, J., Yoo, N., Park, S.-K., et al. (2008) · Nephrology · doi:10.1111/j.1440-1797.2008.00977.x · Cited by 4
Development of end stage renal disease following an acute cardiac event.
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“Diabetes and hypertension are both well-described risk factors for progression of kidney disease.(13,14) Anemia, although a risk factor, may not be a causal link for ESRD development, but is more likely associated with other risk factors for progression such as inflammation, comorbidity, or more advanced renal insuffi…”
Background
Renal hemodynamics in overweight and obesity: pathogenetic factors and targets for intervention
Kwakernaak, A. J., Tent, H., Rook, M., Krikken, J. A., & Navis, G. J. (2007) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2.4.539 · Cited by 3
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Evaluación de la función renal en pacientes hipertensos: subdiagnóstico de la enfermedad renal
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“n 145 (100%) 2 (1,4%) 8 (5,5%) 135 (93,1%) MDRD (mil/min/1,73 m2) 47,2 ± 10,4 13,6 ± 0,3 24 ± 4,3 49 ±7,9 Creatinina (mg/dl) 1,49 ± 0,56 4,27 ± 0,88 2,65 ± 0,56 1,38 ±0,32 Edad (años) 67,2 ± 9,1 53,5 ± 13,4 65,8 ± 9,7 67,5 ±8,9 Varones n (%) 74 (51) 1 (50) 5 (62,5) 68 (50,4) PAS (mm Hg) 146 ± 18 157 ± 15 148 ± 18 146…”
Aging and Kidney Disease
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Authors: Fox, C. S.
Affiliations: Framingham Heart Study (US)
Corresponding author: Fox, Caroline S.
ORCID: Fox, Caroline S.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2004-02-18
Volume: 291
Issue: 7
Pages: 844
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.291.7.844
OpenAlex: W1992283514
Cited by: 1,241
References: 0
Citations by year: 2026: 21 · 2025: 28 · 2024: 50 · 2023: 37 · 2022: 53 · 2021: 62 · 2020: 62 · 2019: 47 · 2018: 49 · 2017: 59 · 2016: 81 · 2015: 49 · 2014: 79 · 2013: 83 · 2012: 68
FWCI: 28.73
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01hc25195-41-0-1)
National Heart, Lung, and Blood Institute (N01‐HC25195)
Topics: Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: chronic kidney disease, risk factors, glomerular filtration rate, diabetes mellitus, smoking, body mass index, age, MDRD equation, cardiovascular disease, end-stage renal disease, community-based cohort, risk prediction model, renal function decline, hyperlipidemia, antihypertensive drugs, antihypertensive medication adherence
MeSH terms: Adult, Aged, Cardiovascular Diseases, Female, Glomerular Filtration Rate, Humans, Kidney Diseases, Longitudinal Studies, Male, Middle Aged, Risk Factors, Logistic Models

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Predictors of New-Onset Kidney Disease in a Community-Based Population

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