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Predictors of New-Onset Kidney Disease in a Community-Based Population
Abstract
Context Kidney disease is associated with an increased risk for the development of cardiovascular disease and end-stage renal disease; however, risk factors for kidney disease have not been well studied. Objective To identify predictors of the development of new-onset kidney disease. Design, setting, and participants A community-based, longitudinal cohort study of 2585 participants who attended both a baseline examination in 1978-1982 and a follow-up examination in 1998-2001, and who were free of kidney disease at baseline. Main outcome measures Kidney disease was assessed by the Modification of Diet in Renal Disease Study equation and defined by a glomerular filtration rate (GFR) in the fifth or lower percentile ( Results At baseline, there were 1223 men and 1362 women, with a mean age of 43 years, who were free of preexisting kidney disease. After a mean follow-up of 18.5 years, 244 participants (9.4%) had developed kidney disease. In multivariable models, baseline age (odds ratio [OR], 2.36 per 10-year increment; 95% confidence interval [CI], 2.00-2.78), GFR ( or =120 mL/min per 1.73 m2), a mildly reduced GFR ( Conclusions Established cardiovascular disease risk factors are associated with the development of new-onset kidney disease. Patients with a mildly reduced GFR should be monitored for progression to kidney disease.
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“While dyslipidemia is a risk factor for progressive kidney disease (8,10,20,21)”
From Effects of Fibrates in Kidney Disease (2012) · cites this paper as [8]
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Litwin, M., & Niemirska, A. (2013) · Pediatric Nephrology · doi:10.1007/s00467-013-2500-1 · Cited by 31
The Effect of Biliopancreatic Diversion Surgery on Renal Function—a Retrospective Study
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“Renal biopsy has shown that patients with a raised BMI are more likely to develop a specific pattern of kidney damage with glomerulomegaly and focal segmental glomerulosclerosis [12, 13].”
BackgroundInfluentialOdden, M. C., Tager, I. B., Gansevoort, R. T., Bakker, S. J. L., Fried, L. F., Newman, A. B., Katz, R., Satterfield, S., Harris, T. B., Sarnak, M. J., et al. (2013) · Annals of Epidemiology · doi:10.1016/j.annepidem.2012.12.004 · Cited by 26
Obesity in renal failure--health or disease?
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Independent influence of dietary protein on markers of kidney function and disease in obesity.
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What is the Optimal Fat Mass in Peritoneal Dialysis Patients?
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“A persistently elevated serum creatinine is a risk factor for chronic kidney disease (CKD) and an independent factor for progression of CKD to kidney failure (9).”
InfluentialDietary protein safety and resistance exercise: what do we really know?
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Epidemiology of Obesity and Pharmacologic Treatment Options
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“Obesity is an independent risk factor for the development and progression of chronic kidney disease.(204) Intentional weight loss in obese subjects (by lifestyle interventions, antiobesity agents, or weight loss surgery) with altered glomerular filtration rate or proteinuria improves proteinuria, albuminuria, and norm…”
BackgroundIqbal, J., Wu, H.-X., Nawaz, M., Jiang, H.-L., Xu, S.-N., Huang, B.-L., Li, L., Cai, J.-M., & Zhou, H.-D. (2023) · Obesity Reviews · doi:10.1111/obr.13656 · Cited by 26
Lipid accumulation product, visceral adiposity index and risk of chronic kidney disease
Bullen, A., Katz, R., Kumar, U., Gutiérrez, O. M., Sarnak, M., Kramer, H., Shlipak, M., H., J., Judd, S., Cushman, M., et al. (2022) · BMC Nephrology · doi:10.1186/s12882-022-03026-9 · Cited by 26
“Introduction Obesity is associated with incident hypertension, diabetes, cardiovascular disease (CVD), and kidney disease [1, 2].”
BackgroundGao, J.-L., Wang, A.-T., Li, X., Li, J.-J., Zhao, H.-L., Zhang, J., Liang, J.-T., Chen, S.-H., & Wu, S.-L. (2019) · Kidney & Blood Pressure Research · doi:10.1159/000504251 · Cited by 26
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A prospective cohort study of insomnia and chronic kidney disease in Japanese workers
Sasaki, S., Yoshioka, E., Saijo, Y., Bannai, A., Kita, T., Tamakoshi, A., & Kishi, R. (2017) · Sleep And Breathing · doi:10.1007/s11325-017-1508-3 · Cited by 28
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“Even mild renal insufficiency increases the risk of cardiovascular events [5,6] and is predictive of the progression of kidney disease [7].”
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“73 m(2) was the most important risk factor of renal progression, as observed in other studies [8,28].”
ResultJi, B., Zhang, S.-H., Gong, L.-L., Wang, Z.-H., Ren, W., Li, Q.-F., & Li, R. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.01.011 · Cited by 26
Circulatory Syndrome: An Evolution of the Metabolic Syndrome Concept!
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“patients with chronic renal disease, hypertension and diabetes[14, 47-49].”
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“Of interest, in this study cohort measures of obesity, hypertension, dyslipidemia and insulin resistance, which were found to be associated adversely with eGFR in previous studies [13, 33, 34], did not show any such independent adverse relationships.”
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Kidney function decline and physical function in women
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“We adjusted for several independent predictors of CKD identified in population-based studies including diabetes [2,28], hypertension [2,28], higher BMI [28,29] and cigarette smoking [28], which were also inversely associated with PFS in our cohort.”
Method
Metadata
- Authors
- Fox, C. S.
- Affiliations
- Framingham Heart Study (US)
- Corresponding author
- Fox, Caroline S.
- ORCID
- Fox, Caroline S.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2004-02-18
- Volume
- 291
- Issue
- 7
- Pages
- 844
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1992283514
- Cited by
- 1,241
- References
- 0
- Citations by year
- 2026: 21 · 2025: 28 · 2024: 50 · 2023: 37 · 2022: 53 · 2021: 62 · 2020: 62 · 2019: 47 · 2018: 49 · 2017: 59 · 2016: 81 · 2015: 49 · 2014: 79 · 2013: 83 · 2012: 68
- FWCI
- 28.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (N01‐HC25195)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- chronic kidney disease, risk factors, glomerular filtration rate, diabetes mellitus, smoking, body mass index, age, MDRD equation, cardiovascular disease, end-stage renal disease, community-based cohort, risk prediction model, renal function decline, hyperlipidemia, antihypertensive drugs, antihypertensive medication adherence
- MeSH terms
- Adult, Aged, Cardiovascular Diseases, Female, Glomerular Filtration Rate, Humans, Kidney Diseases, Longitudinal Studies, Male, Middle Aged, Risk Factors, Logistic Models
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