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Predictors of New-Onset Kidney Disease in a Community-Based Population
Abstract
Context Kidney disease is associated with an increased risk for the development of cardiovascular disease and end-stage renal disease; however, risk factors for kidney disease have not been well studied. Objective To identify predictors of the development of new-onset kidney disease. Design, setting, and participants A community-based, longitudinal cohort study of 2585 participants who attended both a baseline examination in 1978-1982 and a follow-up examination in 1998-2001, and who were free of kidney disease at baseline. Main outcome measures Kidney disease was assessed by the Modification of Diet in Renal Disease Study equation and defined by a glomerular filtration rate (GFR) in the fifth or lower percentile ( Results At baseline, there were 1223 men and 1362 women, with a mean age of 43 years, who were free of preexisting kidney disease. After a mean follow-up of 18.5 years, 244 participants (9.4%) had developed kidney disease. In multivariable models, baseline age (odds ratio [OR], 2.36 per 10-year increment; 95% confidence interval [CI], 2.00-2.78), GFR ( or =120 mL/min per 1.73 m2), a mildly reduced GFR ( Conclusions Established cardiovascular disease risk factors are associated with the development of new-onset kidney disease. Patients with a mildly reduced GFR should be monitored for progression to kidney disease.
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“While dyslipidemia is a risk factor for progressive kidney disease (8,10,20,21)”
From Effects of Fibrates in Kidney Disease (2012) · cites this paper as [8]
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“Serum creatinine was easured by the Jaffé method, and a 2-step calibration rocess was used, as previously described.(19)”
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“CVD risk factors are associated with the development of kidney disease [9], and the prevalence of traditional and novel CVD risk factors is elevated among those with kidney disease [7,10].”
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Metadata
- Authors
- Fox, C. S.
- Affiliations
- Framingham Heart Study (US)
- Corresponding author
- Fox, Caroline S.
- ORCID
- Fox, Caroline S.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2004-02-18
- Volume
- 291
- Issue
- 7
- Pages
- 844
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1992283514
- Cited by
- 1,241
- References
- 0
- Citations by year
- 2026: 21 · 2025: 28 · 2024: 50 · 2023: 37 · 2022: 53 · 2021: 62 · 2020: 62 · 2019: 47 · 2018: 49 · 2017: 59 · 2016: 81 · 2015: 49 · 2014: 79 · 2013: 83 · 2012: 68
- FWCI
- 28.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (N01‐HC25195)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- chronic kidney disease, risk factors, glomerular filtration rate, diabetes mellitus, smoking, body mass index, age, MDRD equation, cardiovascular disease, end-stage renal disease, community-based cohort, risk prediction model, renal function decline, hyperlipidemia, antihypertensive drugs, antihypertensive medication adherence
- MeSH terms
- Adult, Aged, Cardiovascular Diseases, Female, Glomerular Filtration Rate, Humans, Kidney Diseases, Longitudinal Studies, Male, Middle Aged, Risk Factors, Logistic Models
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