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Cited by 242

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Ventilatory Management of Acute Lung Injury and Acute Respiratory Distress Syndrome

Fan, Eddy·2005·JAMA

Abstract

CONTEXT: The acute lung injury and acute respiratory distress syndrome are critical illnesses associated with significant morbidity and mortality. Mechanical ventilation is the cornerstone of supportive therapy. However, despite several important advances, the optimal strategy for ventilation and adjunctive therapies for patients with acute lung injury and acute respiratory distress syndrome is still evolving. EVIDENCE ACQUISITION: To identify reports of invasive ventilatory and adjunctive therapies in adult patients with acute lung injury and acute respiratory distress syndrome, we performed a systematic English-language literature search of MEDLINE (1966-2005) using the Medical Subject Heading respiratory distress syndrome, adult, and related text words, with emphasis on randomized controlled trials and meta-analyses. EMBASE and the Cochrane Central Register of Controlled Trials were similarly searched. The search yielded 1357 potential articles of which 53 were relevant to the study objectives and considered in this review. EVIDENCE SYNTHESIS: There is strong evidence to support the use of volume- and pressure-limited lung-protective ventilation in adult patients with acute lung injury and acute respiratory distress syndrome. The benefit of increased levels of positive end-expiratory pressure and recruitment maneuvers is uncertain and is being further evaluated in ongoing trials. Existing randomized controlled trials of alternative ventilation modes, such as high-frequency oscillation and adjunctive therapies, including inhaled nitric oxide and prone positioning demonstrate no significant survival advantage. However, they may have a role as rescue therapy for patients with acute respiratory distress syndrome with refractory life-threatening hypoxemia. CONCLUSIONS: Volume- and pressure-limited ventilation strategies should be used in managing adult acute lung injury and acute respiratory distress syndrome patients. Further research is needed to identify barriers to widespread adoption of this strategy, as well as the role of alternative ventilation modes and adjunctive therapies.

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Metadata

Authors
Fan, E.
Venue
JAMA
Published
2005-12-14
Volume
294
Issue
22
Pages
2889
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
OpenAlex
W2029661393
Cited by
242
References
10
FWCI
14.80
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Ventilatory Management of Acute Lung Injury and Acute Respiratory Distress Syndrome. https://app.cochat.ai/papers/10.1001/jama.294.22.2889
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Fan, E. (2005). Ventilatory Management of Acute Lung Injury and Acute Respiratory Distress Syndrome. JAMA. https://doi.org/10.1001/jama.294.22.2889

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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