The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Ventilatory Management of Acute Lung Injury and Acute Respiratory Distress Syndrome
Abstract
CONTEXT: The acute lung injury and acute respiratory distress syndrome are critical illnesses associated with significant morbidity and mortality. Mechanical ventilation is the cornerstone of supportive therapy. However, despite several important advances, the optimal strategy for ventilation and adjunctive therapies for patients with acute lung injury and acute respiratory distress syndrome is still evolving. EVIDENCE ACQUISITION: To identify reports of invasive ventilatory and adjunctive therapies in adult patients with acute lung injury and acute respiratory distress syndrome, we performed a systematic English-language literature search of MEDLINE (1966-2005) using the Medical Subject Heading respiratory distress syndrome, adult, and related text words, with emphasis on randomized controlled trials and meta-analyses. EMBASE and the Cochrane Central Register of Controlled Trials were similarly searched. The search yielded 1357 potential articles of which 53 were relevant to the study objectives and considered in this review. EVIDENCE SYNTHESIS: There is strong evidence to support the use of volume- and pressure-limited lung-protective ventilation in adult patients with acute lung injury and acute respiratory distress syndrome. The benefit of increased levels of positive end-expiratory pressure and recruitment maneuvers is uncertain and is being further evaluated in ongoing trials. Existing randomized controlled trials of alternative ventilation modes, such as high-frequency oscillation and adjunctive therapies, including inhaled nitric oxide and prone positioning demonstrate no significant survival advantage. However, they may have a role as rescue therapy for patients with acute respiratory distress syndrome with refractory life-threatening hypoxemia. CONCLUSIONS: Volume- and pressure-limited ventilation strategies should be used in managing adult acute lung injury and acute respiratory distress syndrome patients. Further research is needed to identify barriers to widespread adoption of this strategy, as well as the role of alternative ventilation modes and adjunctive therapies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941
Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R. (1994) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.149.3.7509706 · Cited by 6,746
Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.
Amato, M. B. P., Barbas, C. S. V., Medeiros, D. M., Magaldi, R. B., Schettino, G. P., Lorenzi-Filho, G., Kairalla, R. A., Deheinzelin, D., Munoz, C., Oliveira, R., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802053380602 · Cited by 3,654
One-Year Outcomes in Survivors of the Acute Respiratory Distress Syndrome
Herridge, M. S., Cheung, A. M., Tansey, C. M., Matte-Martyn, A., Diaz-Granados, N., Al-Saidi, F., Cooper, A. B., Guest, C. B., Mazer, C. D., Mehta, S., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022450 · Cited by 2,334
Effect of prone positioning on the survival of patients with acute respiratory failure.
Gattinoni, L., Tognoni, G., Pesenti, A., Taccone, P., Mascheroni, D., Labarta, V., Malacrida, R., Di Giulio, P., Fumagalli, R., Pelosi, P., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010043 · Cited by 1,271
BROCHARD, L., ROUDOT-THORAVAL, F., ROUPIE, E., DELCLAUX, C., CHASTRE, J., FERNANDEZ-MONDÉJAR, E., CLÉMENTI, E., MANCEBO, J., FACTOR, P., MATAMIS, D., et al. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.6.9801044 · Cited by 800
Two-Year Cognitive, Emotional, and Quality-of-Life Outcomes in Acute Respiratory Distress Syndrome
Hopkins, R. O., Weaver, L. K., Collingridge, D., Parkinson, R. B., Chan, K. J., & Orme, J. F. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200406-763oc · Cited by 759
Tidal Volume Reduction in Patients with Acute Lung Injury When Plateau Pressures Are Not High
Hager, D. N., Krishnan, J. A., Hayden, D. L., & Brower, R. G. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200501-048cp · Cited by 509
Eichacker, P. Q., Gerstenberger, E. P., Banks, S. M., Cui, X., & Natanson, C. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200208-956oc · Cited by 423
Ventilatory management of acute respiratory distress syndrome: A consensus of two.
Marini, J. J., & Gattinoni, L. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000104946.66723.a8 · Cited by 168
Cited by
Fan, E., Del Sorbo, L., Goligher, E. C., Hodgson, C. L., Munshi, L., Walkey, A. J., Adhikari, N. K. J., Amato, M. B. P., Branson, R., Brower, R. G., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201703-0548st · Cited by 1,630
Self-citationde Jonge, E., Peelen, L., Keijzers, P. J., Joore, H., de Lange, D., van der Voort, P. H., Bosman, R. J., de Waal, R. A., Wesselink, R., & de Keizer, N. F. (2008) · Critical Care · doi:10.1186/cc7150 · Cited by 425
Needham, D. M., Colantuoni, E., Mendez-Tellez, P. A., Dinglas, V. D., Sevransky, J. E., Dennison Himmelfarb, C. R., Desai, S. V., Shanholtz, C., Brower, R. G., & Pronovost, P. J. (2012) · BMJ · doi:10.1136/bmj.e2124 · Cited by 353
The impact of obesity on outcomes after critical illness: a meta-analysis
Hogue, C. W., Stearns, J. D., Colantuoni, E., Robinson, K. A., Stierer, T., Mitter, N., Pronovost, P. J., & Needham, D. M. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1424-5 · Cited by 329
Recruitment Maneuvers for Acute Lung Injury
Fan, E., Wilcox, M. E., Brower, R. G., Stewart, T. E., Mehta, S., Lapinsky, S. E., Meade, M. O., & Ferguson, N. D. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200802-335oc · Cited by 328
Self-citation
Metadata
- Authors
- Fan, E.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2005-12-14
- Volume
- 294
- Issue
- 22
- Pages
- 2889
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2029661393
- Cited by
- 242
- References
- 10
- FWCI
- 14.80
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Ventilatory Management of Acute Lung Injury and Acute Respiratory Distress Syndrome. https://app.cochat.ai/papers/10.1001/jama.294.22.2889
- The paper
- Fan, E. (2005). Ventilatory Management of Acute Lung Injury and Acute Respiratory Distress Syndrome. JAMA. https://doi.org/10.1001/jama.294.22.2889
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.