CoChat
Sign Up
Cited by 439Nutritional Studies and DietFatty Acid Research and HealthNuts composition and effects

The DOI matches its Crossref record; 55 of the 57 references it cites were found in a registry or an index.

Association of Specific Dietary Fats With Total and Cause-Specific Mortality

Open access
Wang, Dong D., Li, Yanping, Chiuve, Stephanie E., Stampfer, Meir J., Manson, JoAnn E., Rimm, Eric B., Willett, Walter C., Hu, Frank B.·2016·JAMA Internal Medicine
DOI 10.1001/jamainternmed.2016.2417PMC PMC5123772
Open this paper in CoChat — free accountOpen PDF

Abstract

IMPORTANCE: Previous studies have shown distinct associations between specific dietary fat and cardiovascular disease. However, evidence on specific dietary fat and mortality remains limited and inconsistent. OBJECTIVE: To examine the associations of specific dietary fats with total and cause-specific mortality in 2 large ongoing cohort studies. DESIGN, SETTING, AND PARTICIPANTS: This cohort study investigated 83 349 women from the Nurses' Health Study (July 1, 1980, to June 30, 2012) and 42 884 men from the Health Professionals Follow-up Study (February 1, 1986, to January 31, 2012) who were free of cardiovascular disease, cancer, and types 1 and 2 diabetes at baseline. Dietary fat intake was assessed at baseline and updated every 2 to 4 years. Information on mortality was obtained from systematic searches of the vital records of states and the National Death Index, supplemented by reports from family members or postal authorities. Data were analyzed from September 18, 2014, to March 27, 2016. MAIN OUTCOMES AND MEASURES: Total and cause-specific mortality. RESULTS: During 3 439 954 person-years of follow-up, 33 304 deaths were documented. After adjustment for known and suspected risk factors, dietary total fat compared with total carbohydrates was inversely associated with total mortality (hazard ratio [HR] comparing extreme quintiles, 0.84; 95% CI, 0.81-0.88; P < .001 for trend). The HRs of total mortality comparing extreme quintiles of specific dietary fats were 1.08 (95% CI, 1.03-1.14) for saturated fat, 0.81 (95% CI, 0.78-0.84) for polyunsaturated fatty acid (PUFA), 0.89 (95% CI, 0.84-0.94) for monounsaturated fatty acid (MUFA), and 1.13 (95% CI, 1.07-1.18) for trans-fat (P < .001 for trend for all). Replacing 5% of energy from saturated fats with equivalent energy from PUFA and MUFA was associated with estimated reductions in total mortality of 27% (HR, 0.73; 95% CI, 0.70-0.77) and 13% (HR, 0.87; 95% CI, 0.82-0.93), respectively. The HR for total mortality comparing extreme quintiles of ω-6 PUFA intake was 0.85 (95% CI, 0.81-0.89; P < .001 for trend). Intake of ω-6 PUFA, especially linoleic acid, was inversely associated with mortality owing to most major causes, whereas marine ω-3 PUFA intake was associated with a modestly lower total mortality (HR comparing extreme quintiles, 0.96; 95% CI, 0.93-1.00; P = .002 for trend). CONCLUSIONS AND RELEVANCE: Different types of dietary fats have divergent associations with total and cause-specific mortality. These findings support current dietary recommendations to replace saturated fat and trans-fat with unsaturated fats.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1001/jamainternmed.2016.2417

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

1 retracted

Flagged first, then by citations

2 of the 57 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

See all 439

Related

See all

Metadata

Authors
Wang, D. D., Li, Y., Chiuve, S. E., Stampfer, M. J., Manson, J. E., Rimm, E. B., Willett, W. C., & Hu, F. B.
Affiliations
  • Harvard University (US)
  • Brigham and Women's Hospital (US)
Corresponding author
Hu, Frank B.
ORCID
Venue
JAMA Internal Medicine
Publisher
American Medical Association (AMA)
Published
2016-08-01
Volume
176
Issue
8
Pages
1134
ISSN
2168-6106 (ISSN-L)
DOI
10.1001/jamainternmed.2016.2417
PMC
PMC5123772
OpenAlex
W2470745271
Cited by
439
References
57
Citations by year
2026: 19 · 2025: 30 · 2024: 33 · 2023: 34 · 2022: 39 · 2021: 54 · 2020: 46 · 2019: 53 · 2018: 69 · 2017: 38 · 2016: 21
FWCI
59.83
Type
journal article
Language
en
Open access
Locations
  • JAMA Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
  • California Walnut Commission
  • National Institutes of Health (DK46200, UM1-CA167552, CA-167552, CA186107, CA 87969)
  • National Heart, Lung, and Blood Institute (R01HL060712, R01HL035464, R01HL034594, R01HL088521)
  • National Cancer Institute (P01CA087969, UM1CA186107, UM1CA167552)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK046200)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
Keywords
dietary fat, all-cause mortality, cause-specific mortality, saturated fat, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, fat replacement, cardiovascular disease, cancer mortality, cardiovascular mortality, Nurses' Health Study, Health Professionals Follow-up Study, dietary assessment, men, cohort studies, mortality risk factors
MeSH terms
Adult, Aged, Cardiovascular Diseases, Cause of Death, Dietary Fats, Dietary Fats, Unsaturated, Female, Follow-Up Studies, Food Preferences, Humans, Male, Middle Aged, Myocardial Infarction, Cohort Studies, Fast Foods, Food, Preserved

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review