Diet, cognition, and alzheimer’s disease: food for thought

Adherence to a Mediterranean diet and survival in a Greek population

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Clinical and biomarker changes in dominantly inherited Alzheimer's disease

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Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

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Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline

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Mediterranean diet pyramid: a cultural model for healthy eating

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A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

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Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275 · see citing works

Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease

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Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment

Petersen, R. C., Thomas, R. G., Grundman, M., Bennett, D., Doody, R., Ferris, S., Galasko, D., Jin, S., Kaye, J., Levey, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050151 · Cited by 1,844 · see citing works

Omega-3 Fatty Acids and Cardiovascular Disease

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Brain Infarction and the Clinical Expression of Alzheimer Disease<subtitle>The Nun Study</subtitle>

Snowdon, D. A. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540340047031 · Cited by 1,590 · see citing works

Folate, Vitamin B12, and Serum Total Homocysteine Levels in Confirmed Alzheimer Disease

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Diet and overall survival in elderly people

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Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease

Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Bennett, D. A., Wilson, R. S., Aggarwal, N., & Schneider, J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.7.940 · Cited by 1,135 · see citing works

Mediterranean diet and risk for Alzheimer's disease

Scarmeas, N., Stern, Y., Tang, M., Mayeux, R., & Luchsinger, J. A. (2006) · Annals of Neurology · doi:10.1002/ana.20854 · Cited by 1,103 · see citing works

Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials

Vivekananthan, D. P., Penn, M. S., Sapp, S. K., Hsu, A., & Topol, E. J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13637-9 · Cited by 1,083 · see citing works

Dietary Intake of Antioxidants and Risk of Alzheimer Disease

Engelhart, M. J. (2002) · JAMA · doi:10.1001/jama.287.24.3223 · Cited by 1,080 · see citing works

2012 Alzheimer's disease facts and figures Alzheimer's Association ∗

Thies, W. H., & Bleiler, L. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.02.001 · Cited by 984 · see citing works

Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007176.pub2 · Cited by 924 · see citing works

Physical Activity, Diet, and Risk of Alzheimer Disease

Scarmeas, N. (2009) · JAMA · doi:10.1001/jama.2009.1144 · Cited by 916 · see citing works

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study.

Snowdon, D. A., Greiner, L. H., Mortimer, J. A., et al. (1997) · PubMed · Cited by 846 · see citing works

Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial

Smith, A. D., Smith, S. M., de Jager, C. A., Whitbread, P., Johnston, C., Agacinski, G., Oulhaj, A., Bradley, K. M., Jacoby, R., & Refsum, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012244 · Cited by 813 · see citing works

Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis

Praticò, D., Uryu, K., Leight, S., Trojanoswki, J. Q., & Lee, V. M.-Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04183.2001 · Cited by 777 · see citing works

Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Trial

Quinn, J. F., Raman, R., Thomas, R. G., Yurko-Mauro, K., Nelson, E. B., Van Dyck, C., Galvin, J. E., Emond, J., Jack, C. R., Weiner, M., et al. (2010) · JAMA · doi:10.1001/jama.2010.1510 · Cited by 764 · see citing works

Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: A randomised, double blind, controlled trial

Durga, J., van Boxtel, M. P., Schouten, E. G., Kok, F. J., Jolles, J., Katan, M. B., & Verhoef, P. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60109-3 · Cited by 758 · see citing works

Mediterranean Diet and Mild Cognitive Impairment

Scarmeas, N., Stern, Y., Mayeux, R., Manly, J. J., Schupf, N., & Luchsinger, J. A. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.536 · Cited by 757 · see citing works

Adherence to a Mediterranean Diet, Cognitive Decline, and Risk of Dementia

Féart, C. (2009) · JAMA · doi:10.1001/jama.2009.1146 · Cited by 757 · see citing works

ω-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study: A Randomized Double-blind Trial

Freund-Levi, Y., Eriksdotter-Jönhagen, M., Cederholm, T., Basun, H., Faxén-Irving, G., Garlind, A., Vedin, I., Vessby, B., Wahlund, L.-O., & Palmblad, J. (2006) · Archives of Neurology · doi:10.1001/archneur.63.10.1402 · Cited by 751 · see citing works

Dietary patterns and risk of dementia: The Three-City cohort study

Barberger-Gateau, P., Raffaitin, C., Letenneur, L., Berr, C., Tzourio, C., Dartigues, J. F., & Alpérovitch, A. (2007) · Neurology · doi:10.1212/01.wnl.0000278116.37320.52 · Cited by 700 · see citing works

A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model

Lim, G. P., Calon, F., Morihara, T., Yang, F., Teter, B., Ubeda, O. J., Salem, N., Frautschy, S. A., & Cole, G. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4225-04.2005 · Cited by 687 · see citing works

Plasma Phosphatidylcholine Docosahexaenoic Acid Content and Risk of Dementia and Alzheimer Disease: The Framingham Heart Study

Schaefer, E. J., Bongard, V., Beiser, A. S., Lamon-Fava, S., Robins, S. J., Au, R., Tucker, K. L., Kyle, D. J., Wilson, P. W. F., & Wolf, P. A. (2006) · Archives of Neurology · doi:10.1001/archneur.63.11.1545 · Cited by 686 · see citing works

Dietary Intake of Antioxidant Nutrients and the Risk of Incident Alzheimer Disease in a Biracial Community Study

Morris, M. C. (2002) · JAMA · doi:10.1001/jama.287.24.3230 · Cited by 678 · see citing works

Intake of flavonoids and risk of dementia

Commenges, D., Scotet, V., Renaud, S., Jacqmin‐Gadda, H., Barberger‐Gateau, P., & Dartigues, J. (2000) · European Journal of Epidemiology · doi:10.1023/a:1007614613771 · Cited by 647 · see citing works

Hundred days of cognitive training enhance broad cognitive abilities in adulthood: findings from the COGITO study

Schmiedek (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00027 · Cited by 607 · see citing works

Physiological compartmental analysis of α-linolenic acid metabolism in adult humans

Pawlosky, R. J., Hibbeln, J. R., Novotny, J. A., & Salem, N. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31576-5 · Cited by 593 · see citing works

Increase of Brain Oxidative Stress in Mild Cognitive Impairment

Praticò, D., Clark, C. M., Liun, F., Lee, V., & Trojanowski, J. Q. (2002) · Archives of Neurology · doi:10.1001/archneur.59.6.972 · Cited by 587 · see citing works

Beneficial effects of docosahexaenoic acid on cognition in age‐related cognitive decline

Yurko‐Mauro, K., McCarthy, D., Rom, D., Nelson, E. B., Ryan, A. S., Blackwell, A. D., Salem, N., Stedman, M., & MIDAS Investigators (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.01.013 · Cited by 584 · see citing works

World Alzheimer Report 2010: The global economic impact of dementia

Wimo, A. B., & Prince, M. J. (2010) · Cited by 559 · see citing works

High-Dose B Vitamin Supplementation and Cognitive Decline in Alzheimer Disease

Aisen, P. S. S. (2008) · JAMA · doi:10.1001/jama.300.15.1774 · Cited by 557 · see citing works

Evidence of increased oxidative damage in subjects with mild cognitive impairment

Keller, J. N., Schmitt, F. A., Scheff, S. W., Ding, Q., Chen, Q., Butterfield, D. A., & Markesbery, W. R. (2005) · Neurology · doi:10.1212/01.wnl.0000156156.13641.ba · Cited by 539 · see citing works

Fruit and Vegetable Juices and Alzheimer’s Disease: The Kame Project

Dai, Q., Borenstein, A. R., Wu, Y., Jackson, J. C., & Larson, E. B. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.03.045 · Cited by 524 · see citing works

Dietary intake of fatty acids and fish in relation to cognitive performance at middle age

Kalmijn, S., van Boxtel, M. P. J., Ocké, M., Verschuren, W. M. M., Kromhout, D., & Launer, L. J. (2004) · Neurology · doi:10.1212/01.wnl.0000103860.75218.a5 · Cited by 524 · see citing works

Fatty acid analysis of blood plasma of patients with alzheimer's disease, other types of dementia, and cognitive impairment

Conquer, J. A., Tierney, M. C., Zecevic, J., Bettger, W. J., & Fisher, R. H. (2000) · Lipids · doi:10.1007/s11745-000-0646-3 · Cited by 523 · see citing works

Homocysteine and folate as risk factors for dementia and Alzheimer disease

Ravaglia, G., Forti, P., Maioli, F., Martelli, M., Servadei, L., Brunetti, N., Porcellini, E., & Licastro, F. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.3.636 · Cited by 500 · see citing works

Homocysteine and folate as risk factors for dementia and Alzheimer disease

Ravaglia, G., Forti, P., Maioli, F., Martelli, M., Servadei, L., Brunetti, N., Porcellini, E., & Licastro, F. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.3.636 · Cited by 500 · see citing works

Fish, meat, and risk of dementia: cohort study

Barberger‐Gateau, P. (2002) · BMJ · doi:10.1136/bmj.325.7370.932 · Cited by 486 · see citing works

Flavonoid Intake and Cognitive Decline over a 10-Year Period

Letenneur, L., Proust‐Lima, C., Gouge, A. L., Dartigues, J. F., & Barberger‐Gateau, P. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm036 · Cited by 484 · see citing works

Oxidative stress in Alzheimer disease: A possibility for prevention

Bonda, D., Wang, X., Perry, G. L., Nunomura, A., Tabaton, M., Zhu, X., & Smith, M. A. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.04.005 · Cited by 481 · see citing works

Vitamin B 12 and folate in relation to the development of Alzheimer’s disease

Wang, H., Wåhlin, Å., Basun, H., Fastbom, J., Winblad, B. G., & Fratiglioni, L. (2001) · Neurology · doi:10.1212/wnl.56.9.1188 · Cited by 469 · see citing works

Cognitive and clinical outcomes of homocysteine‐lowering B‐vitamin treatment in mild cognitive impairment: a randomized controlled trial

de Jager, C. A., Oulhaj, A., Jacoby, R. J., Refsum, H., & Smith, A. D. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2758 · Cited by 461 · see citing works

Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials

Homocysteine Lowering Trialists’ Collaboration (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.4.806 · Cited by 454 · see citing works

Food Combination and Alzheimer Disease Risk

Gu, Y., Nieves, J., Stern, Y., Luchsinger, J., & Scarmeas, N. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.84 · Cited by 442 · see citing works

Mediterranean Diet, Alzheimer Disease, and Vascular Mediation

Scarmeas, N., Stern, Y., Mayeux, R. P., & Luchsinger, J. A. (2006) · Archives of Neurology · doi:10.1001/archneur.63.12.noc60109 · Cited by 434 · see citing works

Dietary factors and Alzheimer's disease

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Fish Consumption and Cognitive Decline With Age in a Large Community Study

Morris, M. C., Evans, D. A., Tangney, C. C., Bienias, J. L., & Wilson, R. S. (2005) · Archives of Neurology · doi:10.1001/archneur.62.12.noc50161 · Cited by 428 · see citing works

Antioxidant Vitamin Intake and Risk of Alzheimer Disease

Luchsinger, J. A., Tang, M.-X., Shea, S., & Mayeux, R. (2003) · Archives of Neurology · doi:10.1001/archneur.60.2.203 · Cited by 414 · see citing works

S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production

Fuso, A., Seminara, L., Cavallaro, R. A., D’Anselmi, F., & Scarpa, S. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.09.007 · Cited by 408 · see citing works

The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: A preliminary randomized double-blind placebo-controlled study

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National estimates of the prevalence of Alzheimer's disease in the United States

Brookmeyer, R., Evans, D. A., Hebert, L. E., Langa, K. M., Heeringa, S. G., Plassman, B. L., & Kukull, W. A. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.11.007 · Cited by 402 · see citing works

Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population

Tangney, C. C., Kwasny, M. J., Li, H., Wilson, R. S., Evans, D. A., & Morris, M. C. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.007369 · Cited by 397 · see citing works

A Controlled Trial of Homocysteine Lowering and Cognitive Performance

McMahon, J. A., Green, T., Skeaff, C. M., Knight, R. G., Mann, J. I., & Williams, S. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054025 · Cited by 395 · see citing works

Benefits of fatty fish on dementia risk are stronger for those without APOE ε4

Huang, T. L., Zandi, P. P., Tucker, K. L., Fitzpatrick, A. L., Kuller, L. H., Fried, L. P., Burke, G. L., & Carlson, M. C. (2005) · Neurology · doi:10.1212/01.wnl.0000183148.34197.2e · Cited by 384 · see citing works

Effect of fish oil on cognitive performance in older subjects

van de Rest, O., Geleijnse, J. M., Kok, F. J., van Staveren, W. A., Dullemeijer, C., Olde-Rikkert, M. G. M., Beekman, A. T. F., & de Groot, C. P. G. M. (2008) · Neurology · doi:10.1212/01.wnl.0000324268.45138.86 · Cited by 380 · see citing works

Antioxidants for Alzheimer Disease: A Randomized Clinical Trial With Cerebrospinal Fluid Biomarker Measures

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Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats

Hashimoto, M., Hossain, S., Shimada, T., Sugioka, K., Yamasaki, H., Fujii, Y., Ishibashi, Y., Oka, J., & Shido, O. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00905.x · Cited by 364 · see citing works

Cognitive decline and fatty acid composition of erythrocyte membranes—The EVA Study

Heude, B., Ducimetière, P., & Berr, C. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.4.803 · Cited by 363 · see citing works

Vitamin B12 and folate deficiency in later life

Clarke, R., Evans, J. G., Schneede, J., Nexø, E., Bates, C. J., FLETCHER, A. E., Prentice, A., Johnston, C., Ueland, P. M., Refsum, H., et al. (2003) · Age and Ageing · doi:10.1093/ageing/afg109 · Cited by 357 · see citing works

Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment

Krikorian, R., Nash, T. A., Shidler, M. D., Shukitt-Hale, B., & Joseph, J. A. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114509992364 · Cited by 353 · see citing works

High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study

Tucker, K. L., Qiao, N., Scott, T. M., Rosenberg, I. H., & Spiro, A. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.3.627 · Cited by 351 · see citing works

High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study

Tucker, K. L., Qiao, N., Scott, T., Rosenberg, I., & Spiro, A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.3.627 · Cited by 351 · see citing works

Fish consumption, n−3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study

van Gelder, B. M., Tijhuis, M., Kalmijn, S., & Kromhout, D. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.1142 · Cited by 346 · see citing works

Effects of the Dietary Approaches to Stop Hypertension Diet, Exercise, and Caloric Restriction on Neurocognition in Overweight Adults With High Blood Pressure

Smith, P. J., Blumenthal, J. A., Babyak, M. A., Craighead, L. W., Welsh-Bohmer, K. A., Browndyke, J. N., Strauman, T. J., & Sherwood, A. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.146795 · Cited by 343 · see citing works

Association of vitamin E and C supplement use with cognitive function and dementia in elderly men

Olson, D. A. (2000) · Neurology · doi:10.1212/wnl.55.6.901-a · Cited by 342 · see citing works

Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia

Quadri, P., Fragiacomo, C., Pezzati, R., Zanda, E., Forloni, G., Tettamanti, M., & Lucca, U. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.1.114 · Cited by 339 · see citing works

Association of vitamin E and C supplement use with cognitive function and dementia in elderly men

Masaki, K. H., Losonczy, K. G., Izmirlian, G., Foley, D. J., Ross, G. W., Petrovitch, H., Havlik, R., & White, L. R. (2000) · Neurology · doi:10.1212/wnl.54.6.1265 · Cited by 330 · see citing works

Neuronal Oxidative Stress Precedes Amyloid-β Deposition in Down Syndrome

Nunomura, A., Perry, G. L., Pappolla, M. A., Friedland, R. P., Hirai, K., Chiba, S., & Smith, M. A. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.11.1011 · Cited by 322 · see citing works

Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction

Kotani, S., Sakaguchi, E., Warashina, S., Matsukawa, N., Ishikura, Y., Kiso, Y., Sakakibara, M., Yoshimoto, T., Guo, J., & Yamashima, T. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.06.010 · Cited by 321 · see citing works

Fat intake at midlife and cognitive impairment later in life: a population‐based CAIDE study

Eskelinen, M. H., Ngandu, T., Helkala, E., Tuomilehto, J., Nissinen, A., Soininen, H., & Kivipelto, M. (2008) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1969 · Cited by 321 · see citing works

Dietary fat intake and 6-year cognitive change in an older biracial community population

Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C., & Wilson, R. S. (2004) · Neurology · doi:10.1212/01.wnl.0000123250.82849.b6 · Cited by 311 · see citing works

Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case–control study

Tully, A.-M., Roche, H. M., Doyle, R., Fallon, C., Bruce, I., LAWLOR, B. A., Coakley, D., & Gibney, M. J. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2002804 · Cited by 309 · see citing works

Efficacy of Souvenaid in Mild Alzheimer's Disease: Results from a Randomized, Controlled Trial

Scheltens, P., Twisk, J. W. R., Blesa, R., Scarpini, E. A., Arnim, C. A. F. V., Bongers, A., Harrison, J., Willemsen‐Swinkels, S. H. N., Stam, C. J., de Waal, H., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121189 · Cited by 306 · see citing works

Meta-Analysis Comparing Mediterranean to Low-Fat Diets for Modification of Cardiovascular Risk Factors

Nordmann, A. J., Suter, K., Bucher, H. C., Shai, I., Tuttle, K. R., Estruch, R., & Briel, M. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.04.024 · Cited by 304 · see citing works

Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change

Morris, M. C., Evans, D. A., Tangney, C. C., Bienias, J. L., Wilson, R. S., Aggarwal, N. T., & Scherr, P. A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.508 · Cited by 302 · see citing works

Efficacy of a medical food in mild Alzheimer's disease: A randomized, controlled trial

Scheltens, P., Kamphuis, P. J. G. H., Verhey, F. R. J., Rikkert, M. G. M. O., Wurtman, R. J., Wilkinson, D. G., Twisk, J. W. R., & Kurz, A. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.10.003 · Cited by 299 · see citing works

Fat Intake at Midlife and Risk of Dementia and Alzheimer’s Disease: A Population-Based Study

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Effect of 2-y n−3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial

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Long-Term Adherence to the Mediterranean Diet Is Associated with Overall Cognitive Status, but Not Cognitive Decline, in Women

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