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Association of Light Physical Activity Measured by Accelerometry and Incidence of Coronary Heart Disease and Cardiovascular Disease in Older Women
Open accessAbstract
Importance: To our knowledge, no studies have examined light physical activity (PA) measured by accelerometry and heart disease in older women. Objective: To investigate whether higher levels of light PA were associated with reduced risks of coronary heart disease (CHD) or cardiovascular disease (CVD) in older women. Design, Setting, and Participants: Prospective cohort study of older women from baseline (March 2012 to April 2014) through February 28, 2017, for up to 4.91 years. The setting was community-dwelling participants from the Women's Health Initiative. Participants were ambulatory women with no history of myocardial infarction or stroke. Exposures: Data from accelerometers worn for a requested 7 days were used to measure light PA. Main Outcomes and Measures: Cox proportional hazards regression models estimated hazard ratios (HRs) and 95% CIs for physician-adjudicated CHD and CVD events across light PA quartiles adjusting for possible confounders. Light PA was also analyzed as a continuous variable with and without adjustment for moderate to vigorous PA (MVPA). Results: Among 5861 women (mean [SD] age, 78.5 [6.7] years), 143 CHD events and 570 CVD events were observed. The HRs for CHD in the highest vs lowest quartiles of light PA were 0.42 (95% CI, 0.25-0.70; P for trend <.001) adjusted for age and race/ethnicity and 0.58 (95% CI, 0.34-0.99; P for trend = .004) after additional adjustment for education, current smoking, alcohol consumption, physical functioning, comorbidity, and self-rated health. Corresponding HRs for CVD in the highest vs lowest quartiles of light PA were 0.63 (95% CI, 0.49-0.81; P for trend <.001) and 0.78 (95% CI, 0.60-1.00; P for trend = .004). The HRs for a 1-hour/day increment in light PA after additional adjustment for MVPA were 0.86 (95% CI, 0.73-1.00; P for trend = .05) for CHD and 0.92 (95% CI, 0.85-0.99; P for trend = .03) for CVD. Conclusions and Relevance: The present findings support the conclusion that all movement counts for the prevention of CHD and CVD in older women. Large, pragmatic randomized trials are needed to test whether increasing light PA among older women reduces cardiovascular risk.
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“The existing evidence regarding associations between LPA and risks for developing cardiovascular events in the general population is conflicting.13, 14, 15, 16”
From Accelerometer-measured physical activity, sedentary behavior, and incidence of macrovascular and microvascular events in individuals with type 2 diabetes mellitus and prediabetes (2025) · cites this paper as [13]
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Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Delling, F. N., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000757 · Cited by 9,175
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Metadata
- Authors
- LaCroix, A. Z., Bellettiere, J., Rillamas-Sun, E., Di, C., Evenson, K. R., Lewis, C. E., Buchner, D. M., Stefanick, M. L., Lee, I.-M., Rosenberg, D. E., LaMonte, M. J., & (WHI), F. T. W. H. I.
- Affiliations
- University of California San Diego (US)
- San Diego State University (US)
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington
- Fred Hutch Cancer Center (US)
- University of North Carolina at Chapel Hill (US)
- University of Alabama at Birmingham (US)
- University of Illinois at Urbana-Champaign, Champaign
- Stanford Medicine (US)
- Brigham and Women's Hospital (US)
- Kaiser Permanente Washington Health Research Institute (US)
- University at Buffalo, State University of New York (US)
- Corresponding author
- LaCroix, Andrea Z.
- ORCID
- Venue
- JAMA Network Open
- Publisher
- American Medical Association (AMA)
- Published
- 2019-03-15
- Volume
- 2
- Issue
- 3
- Pages
- e190419
- ISSN
- 2574-3805 (ISSN-L)
- PMC
- PMC6484645
- OpenAlex
- W2921167015
- Cited by
- 162
- References
- 43
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 22 · 2023: 15 · 2022: 27 · 2021: 30 · 2020: 28 · 2019: 11
- FWCI
- 16.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- JAMA Network Open (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UA Campus Repository (The University of Arizona) (acceptedVersion, cc-by)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- U.S. Department of Health and Human Services
- Women's Health Initiative
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HHSN268201600018C, HHSN268201600004C, HHSN268201600001C, HHSN268201600003C, HHSN268201600002C, R01HL130483, T32HL079891)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079626)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- light physical activity, accelerometry, coronary artery disease, cardiovascular disease, older women, moderate-to-vigorous physical activity, heart disease risk, Women's Health Initiative, community-dwelling women, physical activity measurement
- MeSH terms
- Aged, Cardiovascular Diseases, Coronary Disease, Female, Humans, Prospective Studies, Risk Factors, United States, Cohort Studies, Exercise, Proportional Hazards Models, Risk Reduction Behavior, Independent Living, Accelerometry
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