Salience Network Resting-State Activity: Prediction of Frontotemporal Dementia Progression
Open accessAbstract
IMPORTANCE: Noninvasive measures of activity within intrinsic brain networks may be clinically relevant, providing a marker of neurodegenerative disease and predicting clinical behaviors. OBJECTIVE: To correlate baseline resting-state measures within the salience network and changes in behavior among patients with frontotemporal dementia. DESIGN: Baseline resting-state functional magnetic resonance imaging data and longitudinal clinical measures were obtained from prospectively accrued patients during 8 weeks. SETTING: Tertiary academic care center specializing in the assessment and management of patients with neurodegenerative disease. PARTICIPANTS: Fifteen patients with clinically diagnosed frontotemporal dementia (5 behavioral variant and 10 semantic dementia). MAIN OUTCOMES AND MEASURES: Baseline resting-state functional magnetic resonance imaging data measured within regions of interest were regressed on serial behavioral measures from prospectively accrued patients with frontotemporal dementia to determine the ability of baseline resting-state activity to account for changes in behavior. RESULTS: Low-frequency fluctuations in the left insula significantly predicted changes in Frontal Behavioral Inventory scores (standard β = 0.51, P = .049), accounting for 28% of the change variance. The trend was driven by changes in measures of apathy independent of dementia severity. CONCLUSION AND RELEVANCE: Baseline measures of salience network connectivity involving the left insula may predict behavioral changes in patients with frontotemporal dementia.
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Specific salience network connectivity patterns (e.g., decreased right fronto-dorsal SN) were associated with increased apathy measured with FBI in a small study with limited longitudinal data (8 weeks).
“specific SN connectivity patterns (e.g., decreased right fronto-dorsal SN) were associated with increased apathy measured with FBI (Day et al., 2013)”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Day et al., 2013
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Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047 · see citing works
Self-citationRegional homogeneity approach to fMRI data analysis.
Zang, Y., Jiang, T., Lu, Y., He, Y., & Tian, L. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.12.030 · Cited by 2,614 · see citing works
Neurodegenerative Diseases Target Large-Scale Human Brain Networks
Seeley, W. W., Crawford, R. K., Zhou, J., Miller, B. L., & Greicius, M. D. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.024 · Cited by 2,350 · see citing works
Zou, Q., Zhu, C.-Z., Yang, Y., Zuo, X., Long, X., Cao, Q., Wang, Y., & Zang, Y. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.04.012 · Cited by 2,169 · see citing works
Zhou, J., Greicius, M. D., Gennatas, E. D., Growdon, M. E., Jang, J. Y., Rabinovici, G. D., Kramer, J. H., Weiner, M., Miller, B. L., & Seeley, W. W. (2010) · Brain · doi:10.1093/brain/awq075 · Cited by 1,016 · see citing works
Frontal behavioral inventory: diagnostic criteria for frontal lobe dementi
Kertesz, A., Davidson, W., & Fox, H. (1997) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100021053 · Cited by 571 · see citing works
Frontal Paralimbic Network Atrophy in Very Mild Behavioral Variant Frontotemporal Dementia
Seeley, W. W., Crawford, R., Rascovsky, K., Kramer, J. H., Weiner, M., Miller, B. L., & Gorno-Tempini, M. L. (2008) · Archives of Neurology · doi:10.1001/archneurol.2007.38 · Cited by 506 · see citing works
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Faber, R., & Neary, D. (1999) · Neurology · doi:10.1212/wnl.53.5.1158-b · Cited by 371 · see citing works
Reliability of the Washington University Clinical Dementia Rating
Burke, W. J., Miller, J. P., Rubin, E. H., Morris, J. C., Coben, L. A., Duchek, J. M., Wittels, I. G., & Berg, L. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520250037015 · Cited by 327 · see citing works
Brambati, S. M., Rankin, K. P., Narvid, J. A., Seeley, W. W., Dean, D., Rosen, H. J., Miller, B. L., Ashburner, J., & Gorno‐Tempini, M. L. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.014 · Cited by 230 · see citing works
Boxer, A. L., Knopman, D. S., Kaufer, D. I., Grossman, M., Onyike, C., Graf-Radford, N., Mendez, M., Kerwin, D., Lerner, A., Wu, C.-K., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70320-4 · Cited by 228 · see citing works
Static and dynamic characteristics of cerebral blood flow during the resting state
Zou, Q., Wu, C. W., Stein, E. A., Zang, Y., & Yang, Y. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.07.006 · Cited by 206 · see citing works
Kim, E.-J., Sidhu, M., Gaus, S. E., Huang, E. J., Hof, P. R., Miller, B. L., DeArmond, S. J., & Seeley, W. W. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr004 · Cited by 204 · see citing works
Abnormal network connectivity in frontotemporal dementia: Evidence for prefrontal isolation
Farb, N. A. S., Grady, C. L., Strother, S. C., Tang‐Wai, D. F., Masellis, M., Black, S. E., Freedman, M., Pollock, B. G., Campbell, K. L., Hasher, L., et al. (2012) · Cortex · doi:10.1016/j.cortex.2012.09.008 · Cited by 191 · see citing works
Self-citationNeuronal Activity of the Human Subthalamic Nucleus in the Parkinsonian and Nonparkinsonian State
Steigerwald, F., Pötter, M., Herzog, J., Pinsker, M. O., Kopper, F., Mehdorn, H. M., Deuschl, G., & Volkmann, J. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90574.2008 · Cited by 175 · see citing works
Seeley, W. W., Allman, J. M., Carlin, D. A., Crawford, R. K., Macedo, M. N., Greicius, M. D., DeArmond, S. J., & Miller, B. L. (2007) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31815c0f14 · Cited by 165 · see citing works
Trajectories of behavioral disturbance in dementia
Chow, T. W., Fridhandler, J. D., Binns, M. A., Lee, A., Merrilees, J., Rosen, H. J., Ketelle, R., & Miller, B. L. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-111916 · Cited by 32 · see citing works
Self-citationOpen-label study of the short-term effects of memantine on FDG-PET in frontotemporal dementia
Chow, T. W., Verhoeff, N., Black, S. E., Pollock, B. G., Graff-Guerrero, Binns, Tang-Wai, Freedman, M., Masellis, M., Wilson, et al. (2011) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s22635 · Cited by 22 · see citing works
Self-citationKim, E., Sidhu, M., Gaus, S. E., Huang, E. J., Hof, P. R., Miller, B. L., DeArmond, S. J., & Seeley, W. W. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw012 · Cited by 15 · see citing works
A case of semantic variant primary progressive aphasia with severe insular atrophy
Chow, T. W., Links, K. A., Masterman, D. L., Mendez, M. F., & Vinters, H. V. (2011) · Neurocase · doi:10.1080/13554794.2011.627343 · Cited by 8 · see citing works
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Flagged first, then by citations
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Sorted by citations
Salience processing and insular cortical function and dysfunction
Uddin, L. Q. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3857 · Cited by 2,083 · see citing works
Hohenfeld, C., Werner, C. J., & Reetz, K. (2018) · NeuroImage: Clinical · doi:10.1016/j.nicl.2018.03.013 · Cited by 232 · see citing works
Imaging and fluid biomarkers in frontotemporal dementia
Meeter, L. H., Kaat, L. D., Rohrer, J. D., & van Swieten, J. C. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.75 · Cited by 210 · see citing works
García-Cordero, I., Sedeño, L., de la Fuente, L., Slachevsky, A., Forno, G., Klein, F., Lillo, P., Ferrari, J., Rodriguez, C., Bustin, J., et al. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0006 · Cited by 199 · see citing works
Frontotemporal dementia: latest evidence and clinical implications
Young, J. J., Lavakumar, M., Tampi, D. J., Balachandran, S., & Tampi, R. R. (2017) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125317739818 · Cited by 183 · see citing works
Christidi, F., Migliaccio, R., Santamaría‐García, H. A., Santangelo, G., & Trojsi, F. (2018) · Behavioural Neurology · doi:10.1155/2018/1849794 · Cited by 147 · see citing works
Neuronal network disintegration: common pathways linking neurodegenerative diseases
Ahmed, R. M., Devenney, E. M., Irish, M., Ittner, A., Naismith, S., Ittner, L. M., Rohrer, J. D., Halliday, G. M., Eisen, A., Hodges, J. R., et al. (2016) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-308350 · Cited by 128 · see citing works
Melloni, M., Billeke, P. B., Báez, S., Hesse, E., de la Fuente, L., Forno, G., Birba, A., Cordero, I. R. G., Serrano, C. M., Plastino, A., et al. (2016) · Brain · doi:10.1093/brain/aww231 · Cited by 133 · see citing works
Guo, C. C., Sturm, V. E., Zhou, J. H., Gennatas, E. D., Trujillo, A. J., Hua, A. Y., Crawford, R. K., Stables, L. A., Kramer, J. H., Rankin, K. P., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509184113 · Cited by 125 · see citing works
Interoception primes emotional processing: multimodal evidence from neurodegeneration
Salamone, P. C., Legaz, A., Sedeño, L., Moguilner, S., Fraile-Vazquez, M., Campo, C. G., Fittipaldi, S., Yoris, A., Miranda, M., Birba, A., et al. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.2578-20.2021 · Cited by 103 · see citing works
Boissoneault, J., Letzen, J. E., Lai, S., O’Shea, A. M., Craggs, J. G., Robinson, M. E., & Staud, R. M. (2015) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2015.12.008 · Cited by 105 · see citing works
Physiological changes in neurodegeneration—mechanistic insights and clinical utility
Ahmed, R. M., Ke, Y. D., Vucic, S., Ittner, L. M., Seeley, W., Hodges, J. R., Piguet, O., Halliday, G., & Kiernan, M. C. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2018.23 · Cited by 91 · see citing works
Hafkemeijer, A., Möller, C., Dopper, E. G. P., Jiskoot, L. C., Schouten, T. M., Swieten, J. C. V., van der Flier, W. M., Vrenken, H., Pijnenburg, Y. A. L., Barkhof, F., et al. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00474 · Cited by 81 · see citing works
Apathy: A neurocircuitry model based on frontotemporal dementia
Ducharme, S., Price, B. H., & Dickerson, B. C. (2018) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-316277 · Cited by 69 · see citing works
Brain Network Organization and Social Executive Performance in Frontotemporal Dementia
Sedeño, L., Couto, B., Cordero, I. R. G., Melloni, M., Báez, S., Sepúlveda, J. P. M., Fraiman, D., Huepe, D., Hurtado, E., Matallana, D., et al. (2016) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617715000703 · Cited by 73 · see citing works
Distinct network topology in Alzheimer’s disease and behavioral variant frontotemporal dementia
Ng, A. S. L., Wang, J., Ng, K. K., Chong, J. S. X., Qian, X., Lim, J. K. W., Tan, Y. J., Yong, A. C. W., Chander, R. J., Hameed, S., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00752-w · Cited by 61 · see citing works
Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia
Rittman, T., Borchert, R. J., Jones, S., Swieten, J. C. V., Borroni, B., Galimberti, D., Masellis, M., Tartaglia, M. C., Graff, C., Tagliavini, F., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.12.009 · Cited by 59 · see citing works
Self-citationAgosta, F., Weiler, M., & Filippi, M. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12410 · Cited by 56 · see citing works
Neuropsychiatric Symptoms and Functional Connectivity in Mild Cognitive Impairment
Munro, C. E., Donovan, N. J., Guercio, B. J., Wigman, S. E., Schultz, A. P., Amariglio, R. E., Rentz, D. M., Johnson, K. A., Sperling, R. A., & Marshall, G. A. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150017 · Cited by 57 · see citing works
Modulation of motivational salience processing during the early stages of psychosis
Smieskova, R., Roiser, J. P., Chaddock, C. A., Schmidt, A., Harrisberger, F., Bendfeldt, K., Simon, A., Walter, A., Fusar-Poli, P., McGuire, P. K., et al. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.04.036 · Cited by 56 · see citing works
FTD spectrum: Neuroimaging across the FTD spectrum
Whitwell, J. L. (2019) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2019.05.009 · Cited by 53 · see citing works
Alterations of resting‐state fMRI measurements in individuals with cervical dystonia
Li, Z., Prudente, C. N., Stilla, R. F., Sathian, K., Jinnah, H. A., & Hu, X. P. (2017) · Human Brain Mapping · doi:10.1002/hbm.23651 · Cited by 50 · see citing works
McIntosh, R. C., Rosselli, M., Uddin, L. Q., & Antoni, M. H. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.008 · Cited by 50 · see citing works
Evolutionary appearance of von Economo’s neurons in the mammalian cerebral cortex
Cauda, F., Geminiani, G. C., & Vercelli, A. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00104 · Cited by 48 · see citing works
Imaging Frontotemporal Lobar Degeneration
Diehl‐Schmid, J., Onur, O. A., Kuhn, J., GRUPPE, T. L., & Drzezga, A. E. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0489-x · Cited by 47 · see citing works
Model-based whole-brain perturbational landscape of neurodegenerative diseases
Perl, Y. S., Fittipaldi, S., Campo, C. G., Moguilner, S., Cruzat, J., Fraile-Vazquez, M. E., Herzog, R. A., Kringelbach, M. L., Deco, G., Prado, P., et al. (2023) · eLife · doi:10.7554/elife.83970 · Cited by 47 · see citing works
Pini, L., Pizzini, F. B., Galazzo, I. B., Ferrari, C., Galluzzi, S., Cotelli, M., Gobbi, E., Cattaneo, A., Cotelli, M. S., Geroldi, C., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.11.005 · Cited by 45 · see citing works
Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula
Cordero, I. R. G., Sedeño, L., Fraiman, D., Craiem, D. O., de la Fuente, L. A., Salamone, P., Serrano, C. M., Sposato, L. A., Manes, F. F., & Ibáñez, A. M. (2015) · Stroke · doi:10.1161/strokeaha.115.009598 · Cited by 44 · see citing works
Donnelly-Kehoe, P. A., Pascariello, G. O., García, A. M., Hodges, J. R., Miller, B. L., Rosen, H. J., Manes, F. F., Landín-Romero, R., Matallana, D., Serrano, C. M., et al. (2019) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2019.06.002 · Cited by 44 · see citing works
Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis
Häkkinen, S., Chu, S. A., & Lee, S. E. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105063 · Cited by 42 · see citing works
Distinct neural substrates of affective and cognitive theory of mind impairment in semantic dementia
Bejanin, A., Chételat, G., Laisney, M., Pèlerin, A., Landeau, B., Merck, C., Belliard, S., Sayette, V. D. L., Eustache, F., & Desgranges, B. (2016) · Social Neuroscience · doi:10.1080/17470919.2016.1168314 · Cited by 40 · see citing works
Li, R., Zhang, S., Yin, S., Ren, W., He, R., & Li, J. (2018) · Human Brain Mapping · doi:10.1002/hbm.24247 · Cited by 39 · see citing works
A transdiagnostic review of neuroimaging studies of apathy and disinhibition in dementia
Jenkins, L. M., Wang, L., Rosen, H. J., & Weıntraub, S. (2022) · Brain · doi:10.1093/brain/awac133 · Cited by 38 · see citing works
Diffusion tensor imaging and functional MRI
Filippi, M., & Agosta, F. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53486-6.00056-9 · Cited by 39 · see citing works
Prosocial deficits in behavioral variant frontotemporal dementia relate to reward network atrophy
Sturm, V. E., Perry, D. C., Wood, K., Hua, A. Y., Alcantar, O., Datta, S., Rankin, K. P., Rosen, H. J., Miller, B. L., & Kramer, J. H. (2017) · Brain and Behavior · doi:10.1002/brb3.807 · Cited by 40 · see citing works
Analyzing Dynamical Brain Functional Connectivity as Trajectories on Space of Covariance Matrices
Dai, M., Zhang, Z., & Srivastava, A. (2019) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2019.2931708 · Cited by 39 · see citing works
Multani, N., Taghdiri, F., Anor, C. J., Varriano, B. M., Misquitta, K., Tang‐Wai, D. F., Keren, R., Fox, S. H., Lang, A. E., Vijverman, A. C., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01259 · Cited by 39 · see citing works
Self-citationRaimo, S., Santangelo, G., D’Iorio, A., Trojano, L., & Grossi, D. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9959-0 · Cited by 37 · see citing works
Finger, E. C., Berry, S. M., Cummings, J. L., Coleman, K. K. L., Hsiung, G. R., Feldman, H., & Boxer, A. L. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0427-2 · Cited by 37 · see citing works
Atrophy network mapping of clinical subtypes and main symptoms in frontotemporal dementia
Chu, M., Jiang, D., Li, D., Yan, S., Liu, L., Nan, H., Wang, Y., Wang, Y., Yue, A., Ren, L., et al. (2024) · Brain · doi:10.1093/brain/awae067 · Cited by 35 · see citing works
Brier, M. R., Day, G. S., Snyder, A. Z., Tanenbaum, A., & Ances, B. M. (2016) · Journal of Neurology · doi:10.1007/s00415-016-8083-6 · Cited by 27 · see citing works
Self-citationPsychiatric symptoms of frontotemporal dementia and subcortical (co-)pathology burden: new insights
Scarioni, M., Gami‐Patel, P., Peeters, C. F. W., de Koning, F., Seelaar, H., Mol, M. O., Swieten, J. C. V., Bank, N. B., Rozemüller, A. J. M., Hoozemans, J. J. M., et al. (2022) · Brain · doi:10.1093/brain/awac043 · Cited by 24 · see citing works
Chu, M., Liu, L., Wang, J., Liu, L., Kong, Y., Jing, D., Xie, K.-X., Cui, Y., Cui, B., Zhang, J., et al. (2021) · Journal of Alzheimer's Disease · doi:10.3233/jad-215127 · Cited by 25 · see citing works
A three-dimensional model of neural activity and phenomenal-behavioral patterns
Martino, M., & Magioncalda, P. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02356-w · Cited by 20 · see citing works
Neurological update: neuroimaging in dementia
Rittman, T. (2020) · Journal of Neurology · doi:10.1007/s00415-020-10040-0 · Cited by 19 · see citing works
Frontotemporal dementia. How to deal with its diagnostic complexity?
Antonioni, A., Raho, E. M., Granieri, E., & Koch, G. (2025) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2025.2461758 · Cited by 21 · see citing works
Neuroimaging in Frontotemporal Lobar Degeneration: Research and Clinical Utility
Dev, S. I., Dickerson, B. C., & Touroutoglou, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-51140-1_7 · Cited by 16 · see citing works
Godefroy, V., Batrancourt, B., Charron, S., Bouzigues, A., Bendetowicz, D., Carle, G., Rametti‐Lacroux, A., Bombois, S., Cognat, E., Migliaccio, R., et al. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02519-5 · Cited by 15 · see citing works
Liu, X., TYLER, L. K., Cam‐CAN, Rowe, J. B., & Tsvetanov, K. A. (2022) · Human Brain Mapping · doi:10.1002/hbm.26025 · Cited by 16 · see citing works
Rus, T., Perovnik, M., Vo, A., Nguyen, N., Tang, C. C., Jamšek, J., Popovič, K. Š., Grimmer, T., Yakushev, I. Y., Diehl‐Schmid, J., et al. (2022) · Human Brain Mapping · doi:10.1002/hbm.26140 · Cited by 16 · see citing works
Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS–FTD
Kim, E., White, M. A., Phillips, B. U., López‐Cruz, L., Kim, H., Heath, C. J., Lee, J. E., Saksida, L. M., Sreedharan, J., & Bussey, T. J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01078-9 · Cited by 15 · see citing works
Charting Frontotemporal Dementia: From Genes to Networks
Filippi, M., Agosta, F., & Ferraro, P. M. (2015) · Journal of Neuroimaging · doi:10.1111/jon.12316 · Cited by 13 · see citing works
Behavioral reserve in behavioral variant frontotemporal dementia
Kim, S. H., Kim, Y. J., Lee, B. H., Lee, P., Park, J. H., Seo, S. W., & Jeong, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.875589 · Cited by 8 · see citing works
Dissecting the Many Faces of Frontotemporal Dementia: An Imaging Perspective
Pengo, M., Premi, E., & Borroni, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112867 · Cited by 9 · see citing works
Anterior cingulate sulcation is associated with onset and survival in frontotemporal dementia
Harper, L., de Boer, S., Lindberg, O. E., Lätt, J., Cullen, N. C., Clark, L., Irwin, D. J., Massimo, L. M., Grossman, M., Hansson, O., et al. (2023) · Brain Communications · doi:10.1093/braincomms/fcad264 · Cited by 9 · see citing works
Chen, Y., Zeng, Q., Wang, Y., Luo, X., Sun, Y., Zhang, L., Liu, X., Li, K., Zhang, M., & Peng, G. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.850977 · Cited by 9 · see citing works
Hahn, L., Eickhoff, S. B., Mueller, K., Schilbach, L., Barthel, H., Fassbender, K. C., Fließbach, K., Kornhuber, J., Prudlo, J., Synofzik, M., et al. (2023) · eLife · doi:10.7554/elife.86085 · Cited by 9 · see citing works
Fieldhouse, J. L. P., van Paassen, D. N., van Engelen, M.-P. E., De Boer, S. C. M., Hartog, W. L., Braak, S., Schoonmade, L. J., Schouws, S. N. T. M., Krudop, W. A., Oudega, M. L., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1382593 · Cited by 8 · see citing works
Chu, M. K., Jiang, D., Liu, L., Nie, B., Rosa‐Neto, P., Chen, K., & Wu, L. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.01.004 · Cited by 9 · see citing works
How Do You Feel Now? The Salience Network Functional Connectivity in End-Stage Renal Disease
Hu, R., Gao, L., Chen, P., Wu, B., Wu, X., & Xu, H. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.533910 · Cited by 8 · see citing works
Sfera, A., Thomas, K. A., Ogunjale, I. A., Jafri, N., & Bota, P. G. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13061691 · Cited by 6 · see citing works
Yang, Z. X., Sheng, J., Zhang, Q., Zhao, X., Song, Y., Dong, G., Zhang, R., Zhao, H., Wang, J., Pan, R., et al. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin26584 · Cited by 7 · see citing works
Uwisengeyimana, J. D. D., Nguchu, B. A., Wang, Y., Zhang, D., Liu, Y., Jiang, Z., Wang, X., & Qiu, B. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-02067-8 · Cited by 5 · see citing works
Chen, T., Ahmed, R. M., Narasimhan, M., Yang, T., Foxe, D., Piguet, O., & Irish, M. (2025) · Human Brain Mapping · doi:10.1002/hbm.70374 · Cited by 5 · see citing works
Early diagnosis of dementia by resting-state functional MRI
Yamaguchi, S., & Onoda, K. (2014) · Higher Brain Function Research · doi:10.2496/hbfr.34.9 · Cited by 2 · see citing works
Uddin, L. Q. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804593-0.00005-9 · Cited by 2 · see citing works
Future Directions in Salience Network Research
Uddin, L. Q. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804593-0.00006-0 · Cited by 2 · see citing works
Functional Connectivity in Dementia
Botha, H., & Jones, D. T. (2018) · Contemporary clinical neuroscience · doi:10.1007/978-3-319-78926-2_11 · Cited by 2 · see citing works
Connectome-based markers predict the sub-types of frontotemporal dementia
Zeng, X., He, J., Zhang, K., Xu, S., Xia, X., & Yuan, Z. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03290-9 · Cited by 1 · see citing works
Brain Network Patterns in Patients With Multiple System Atrophy
Wang, H., Wang, B., Liao, Y., Jin, N., Kang, Y., Wang, X., Li, J., Wu, S., Zhong, Y., Dou, X., et al. (2026) · Neurology · doi:10.1212/wnl.0000000000214706 · Cited by 1 · see citing works
Liu, X., TYLER, L. K., Cam-CAN, Rowe, J. B., & Tsvetanov, K. A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.22.473894 · Cited by 1 · see citing works
Biomarkers for Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Imaging
Bozzali, M., & Serra, L. (2014) · Springer eBooks · doi:10.1007/978-1-4471-6380-0_10
New Theories on the Anesthetics’ Mechanism of Action
Pavel, B., Maria, C., & Andra, T. I. (2018) · Archives of Emergency Medicine and Intensive Care · doi:10.22259/2638-5007.0102001
- Authors
- Day, G. S., Farb, N. A. S., Tang-Wai, D. F., Masellis, M., Black, S. E., Freedman, M., Pollock, B. G., & Chow, T. W.
- Affiliations
- University of Toronto (CA)
- Rotman Research Institute (CA)
- Sunnybrook Health Science Centre (CA)
- Mount Sinai Hospital (CA)
- Centre for Addiction and Mental Health (CA)
- ORCID
- Venue
- JAMA Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2013-08-19
- Volume
- 70
- Issue
- 10
- Pages
- 1249-53
- ISSN
- 2168-6149 (ISSN-L)
- PMC
- PMC12893382
- OpenAlex
- W1978547012
- Cited by
- 73
- References
- 20
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 9 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 8 · 2017: 5 · 2016: 10 · 2015: 8 · 2014: 5
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- green
- pmc.ncbi.nlm.nih.gov
- Locations
- JAMA Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Institute on Aging (R03AG034413)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- salience network, resting-state functional connectivity, frontotemporal dementia, behavioral variant frontotemporal dementia, semantic dementia, left insula, low-frequency fluctuations, apathy, Frontal Behavioral Inventory, neurodegenerative disease biomarkers
- MeSH terms
- Aged, Brain, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Oxygen, Predictive Value of Tests, Severity of Illness Index, Linear Models, Disease Progression, Frontotemporal Dementia
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