Salience processing and insular cortical function and dysfunction

Uddin, Lucina Q.

doi:10.1038/nrn3857

Cited by 2,083Neural and Behavioral Psychology StudiesFunctional Brain Connectivity StudiesPsychosomatic Disorders and Their Treatments

Salience processing and insular cortical function and dysfunction

Uddin, Lucina Q.·2015·Nature Reviews Neuroscience

DOI 10.1038/nrn3857

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Abstract

The brain is constantly bombarded by stimuli, and the relative salience of these inputs determines which are more likely to capture attention. A brain system known as the 'salience network', with key nodes in the insular cortices, has a central role in the detection of behaviourally relevant stimuli and the coordination of neural resources. Emerging evidence suggests that atypical engagement of specific subdivisions of the insula within the salience network is a feature of many neuropsychiatric disorders.

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Fitzsimmons, J., Kubicki, M., & Shenton, M. E. (2013) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32835d9e6a · Cited by 277 · see citing works
Beyond the Tripartite Cognition–Emotion–Interoception Model of the Human Insular Cortex
Uddin, L. Q., Kinnison, J., Pessoa, L., & Anderson, M. L. (2014) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00462 · Cited by 275 · see citing works
Self-citation
The human cortex responds to an interoceptive challenge
Critchley, H. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401510101 · Cited by 251 · see citing works
The Embodiment of Emotional Feelings in the Brain
Harrison, N. A., Gray, M. A., Gianaros, P. J., & Critchley, H. D. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1725-10.2010 · Cited by 250 · see citing works
Involvement of the dorsal and ventral attention networks in oddball stimulus processing: A meta‐analysis
Kim, H. (2013) · Human Brain Mapping · doi:10.1002/hbm.22326 · Cited by 237 · see citing works
Volitional Control of Autonomic Arousal: A Functional Magnetic Resonance Study
Critchley, H. (2002) · NeuroImage · doi:10.1006/nimg.2002.1147 · Cited by 225 · see citing works
Systematic Meta-Analysis of Insula Volume in Schizophrenia
Shepherd, A. M., Matheson, S. L., Laurens, K. R., Carr, V. J., & Green, M. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.020 · Cited by 207 · see citing works
Progressive Right Frontotemporal Degeneration: Clinical, Neuropsychological and SPECT Characteristics
Miller, B. L., Chang, L., Mena, I. G., Boone, K. B., & Lesser, I. M. (1993) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107324 · Cited by 206 · see citing works
Selective frontoinsular von Economo neuron and fork cell loss in early behavioral variant frontotemporal dementia
Kim, E.-J., Sidhu, M., Gaus, S. E., Huang, E. J., Hof, P. R., Miller, B. L., DeArmond, S. J., & Seeley, W. W. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr004 · Cited by 204 · see citing works
Chapter 10 Saccades, salience and attention: the role of the lateral intraparietal area in visual behavior
Goldberg, M. E., Bisley, J. W., Powell, K. D., & Gottlieb, J. P. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)55010-1 · Cited by 202 · see citing works
Neural correlates of the prolonged salience of painful stimulation
Downar, J. H., Mikulis, D. J., & Davis, K. D. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00407-5 · Cited by 200 · see citing works
Interoceptive basis to craving
Gray, M. A., & Critchley, H. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.024 · Cited by 189 · see citing works
Resting-State Networks in Schizophrenia
Karbasforoushan, H., & Woodward, N. D. (2012) · Current Topics in Medicinal Chemistry · doi:10.2174/156802612805289863 · Cited by 189 · see citing works
Describing functional diversity of brain regions and brain networks
Anderson, M. L., Kinnison, J., & Pessoa, L. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.01.071 · Cited by 182 · see citing works
Disruption of anterior insula modulation of large-scale brain networks in schizophrenia
Moran, L. V., Tagamets, M. A., Sampath, H., O’Donnell, A., Stein, E. A., Kochunov, P., & Hong, L. E. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.029 · Cited by 181 · see citing works
Book Review: Two Phylogenetic Specializations in the Human Brain
Allman, J., Hakeem, A., & Watson, K. (2002) · The Neuroscientist · doi:10.1177/107385840200800409 · Cited by 178 · see citing works
Differences and Similarities in Insular and Temporal Pole MRI Gray Matter Volume Abnormalities in First-Episode Schizophrenia and Affective Psychosis
Kasai, K., Shenton, M. E., Salisbury, D. F., Onitsuka, T., Toner, S. K., Yurgelun-Todd, D. A., Kikinis, R., Jolesz, F. A., & McCarley, R. W. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.11.1069 · Cited by 172 · see citing works
Lateralization in intrinsic functional connectivity of the temporoparietal junction with salience- and attention-related brain networks
Kucyi, A., Hodaie, M., & Davis, K. D. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00674.2012 · Cited by 169 · see citing works
Beyond metaphor: Contrasting mechanisms of social and physical pain
Iannetti, G. D., Salomons, T. V., Moayedi, M., Mouraux, A., & Davis, K. D. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.06.002 · Cited by 166 · see citing works
Neural networks in frontotemporal dementia—A meta-analysis
Schroeter, M. L., Raczka, K. A., Neumann, J., & von Cramon, D. Y. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.10.023 · Cited by 164 · see citing works
Anterior insula degeneration in frontotemporal dementia
Seeley, W. W. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0263-z · Cited by 162 · see citing works
Brain State Differentiation and Behavioral Inflexibility in Autism
Uddin, L. Q., Supekar, K., Lynch, C. J., Cheng, K. M., Odriozola, P., Barth, M. E., Phillips, J. M., Feinstein, C., Abrams, D. A., & Menon, V. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu161 · Cited by 153 · see citing works
Self-citation
Total number and volume of Von Economo neurons in the cerebral cortex of cetaceans
Butti, C., Sherwood, C. C., Hakeem, A. Y., Allman, J. M., & Hof, P. R. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.22055 · Cited by 148 · see citing works
Frontotemporal Dementia
Seeley, W. W., Zhou, J. H., & Kim, E. J. (2011) · The Neuroscientist · doi:10.1177/1073858411410354 · Cited by 147 · see citing works
Developmental Maturation of Dynamic Causal Control Signals in Higher-Order Cognition: A Neurocognitive Network Model
Supekar, K., & Menon, V. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002374 · Cited by 137 · see citing works
Distinctive Neurons of the Anterior Cingulate and Frontoinsular Cortex: A Historical Perspective
Seeley, W. W., Merkle, F. T., Gaus, S. E., Craig, A. D., Allman, J. M., Hof, P. R., & von Economo, C. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr005 · Cited by 126 · see citing works
The self in autism: An emerging view from neuroimaging
Uddin, L. Q. (2011) · Neurocase · doi:10.1080/13554794.2010.509320 · Cited by 124 · see citing works
Self-citation
Disrupted resting-state functional connectivity in minimally treated chronic schizophrenia
Wang, X., Xia, M., Lai, Y., Dai, Z., Cao, Q., Zhang, C., Han, X., Yang, L., Yuan, Y., Zhang, Y., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.03.033 · Cited by 93 · see citing works
Neural Correlates of Emotion Regulation in Patients with Schizophrenia and Non-Affected Siblings
van der Meer, L., Swart, M., van der Velde, J., Pijnenborg, G. H. M., Wiersma, D., Bruggeman, R., & Aleman, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099667 · Cited by 91 · see citing works
Developmental Meta-Analysis of the Functional Neural Correlates of Autism Spectrum Disorders
Dickstein, D. P., Pescosolido, M. F., Reidy, B. L., Galvan, T., Kim, K. L., Seymour, K. E., Laird, A. R., Martino, A. D., & Barrett, R. P. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.12.012 · Cited by 85 · see citing works
The concept of salience network dysfunction in schizophrenia: from neuroimaging observations to therapeutic opportunities.
Palaniyappan, L., White, T., & Liddle, P. (2012) · Current Topics in Medicinal Chemistry · doi:10.2174/156802612805289881 · Cited by 81 · see citing works
Salience Network Resting-State Activity: Prediction of Frontotemporal Dementia Progression
Day, G. S., Farb, N. A. S., Tang-Wai, D. F., Masellis, M., Black, S. E., Freedman, M., Pollock, B. G., & Chow, T. W. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.3258 · Cited by 73 · see citing works
von E conomo neurones are selectively targeted in frontotemporal dementia
Santillo, A. F., Nilsson, C., & Englund, E. M. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12021 · Cited by 72 · see citing works
A parcellation scheme based on von Mises-Fisher distributions and Markov random fields for segmenting brain regions using resting-state fMRI
Ryali, S., Chen, T., Supekar, K., & Menon, V. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.09.067 · Cited by 68 · see citing works
Perceptual Illusion of “Paradoxical Heat” Engages the Insular Cortex
Davis, K. D., Pope, G. E., Crawley, A. P., & Mikulis, D. J. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00084.2004 · Cited by 62 · see citing works
No reduction of spindle neuron number in frontoinsular cortex in autism
Kennedy, D. P., Semendeferi, K., & Courchesne, E. (2007) · Brain and Cognition · doi:10.1016/j.bandc.2007.01.007 · Cited by 54 · see citing works
Parietal control of attentional guidance: The significance of sensory, motivational and motor factors
Gottlieb, J. P., Balan, P. F., Oristaglio, J., & Mototaka Suzuki, A. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.09.013 · Cited by 46 · see citing works
Prefrontal/accumbal catecholamine system processes emotionally driven attribution of motivational salience
Puglisi‐Allegra, S., & Ventura, R. (2012) · Reviews in the Neurosciences · doi:10.1515/revneuro-2012-0076 · Cited by 45 · see citing works
Development and neural bases of face recognition in autism
Carver, L. J., & Dawson, G. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001168 · Cited by 45 · see citing works
Clinical features of pathologic subtypes of behavioral--variant frontotemporal dementia.
Hu, W. T., Mandrekar, J., Parisi, J., Knopman, D., Boeve, B., Petersen, R., Hutton, M., Dickson, D., & Josephs, K. (2007) · Archives of Neurology · doi:10.1001/archneur.64.11.1611 · Cited by 35 · see citing works

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The theory of constructed emotion: an active inference account of interoception and categorization
Barrett, L. F. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw154 · Cited by 1,426 · see citing works
“…adjust its internal model to the conditions of the sensory periphery, again in the service of allostasis (e.g. see Figure 6) This is consistent with the salience network’s role in attention regulation; e.g. ( Power et al ., 2011; Touroutoglou et al. , 2012; Ullsperger et al. , 2014; Uddin, 2015).”
Structure and Function of the Human Insula
Uddin, L. Q., Nomi, J. S., Hébert-Seropian, B., Ghaziri, J., & Boucher, O. (2017) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000000377 · Cited by 1,262 · see citing works
Self-citation
Demystifying cognitive flexibility: Implications for clinical and developmental neuroscience
Dajani, D. R., & Uddin, L. Q. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.07.003 · Cited by 1,046 · see citing works
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Childhood Adversity and Neural Development: A Systematic Review
McLaughlin, K. A., Weissman, D., & Bitrán, D. (2019) · Annual Review of Developmental Psychology · doi:10.1146/annurev-devpsych-121318-084950 · Cited by 892 · see citing works
The insular cortex
Gogolla, N. (2017) · Current Biology · doi:10.1016/j.cub.2017.05.010 · Cited by 851 · see citing works
The frontoparietal network: function, electrophysiology, and importance of individual precision mapping
Marek, S., & Dosenbach, N. U. F. (2018) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2018.20.2/smarek · Cited by 836 · see citing works
Robust prediction of individual creative ability from brain functional connectivity
Beaty, R. E., Kenett, Y. N., Christensen, A. P., Rosenberg, M. D., Benedek, M., Chen, Q., Fink, A., Qiu, J., Kwapil, T. R., Kane, M. J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1713532115 · Cited by 835 · see citing works
Cognitive and behavioural flexibility: Neural mechanisms and clinical considerations
Uddin, L. Q. (2021) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00428-w · Cited by 698 · see citing works
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Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory
Mather, M., Clewett, D., Sakaki, M., & Harley, C. W. (2016) · Behavioral and Brain Sciences · doi:10.1017/s0140525x15000667 · Cited by 695 · see citing works
Towards a universal taxonomy of macro-scale functional human brain networks
Uddin, L. Q., Yeo, B. T. T., & Spreng, R. N. (2019) · Brain Topography · doi:10.1007/s10548-019-00744-6 · Cited by 683 · see citing works
Self-citation
Resting state fMRI: A review on methods in resting state connectivity analysis and resting state networks
Smitha, K. A., Raja, K. A., Arun, K., Rajesh, P. G., Thomas, B., Kapilamoorthy, T., & Kesavadas, C. (2017) · The Neuroradiology Journal · doi:10.1177/1971400917697342 · Cited by 643 · see citing works
Dopamine and glutamate in schizophrenia: biology, symptoms and treatment
McCutcheon, R. A., Krystal, J. H., & Howes, O. D. (2020) · World Psychiatry · doi:10.1002/wps.20693 · Cited by 612 · see citing works
Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis
Wise, T., Radua, J., Via, E., Cardoner, N., Abe, O., Adams, T. M., Amico, F., Cheng, Y., Cole, J. H., de Azevedo Marques Périco, C., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.72 · Cited by 606 · see citing works
The dynamic pain connectome
Kucyi, A., & Davis, K. D. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.006 · Cited by 587 · see citing works
An active inference theory of allostasis and interoception in depression
Barrett, L. F., Quigley, K. S., & Hamilton, P. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0011 · Cited by 554 · see citing works
The insula: an underestimated brain area in clinical neuroscience, psychiatry, and neurology
Namkung, H., Kim, S.-H., & Sawa, A. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.02.002 · Cited by 462 · see citing works
From cognitivism to autopoiesis: towards a computational framework for the embodied mind
Allen, M., & Friston, K. J. (2018) · Synthese · doi:10.1007/s11229-016-1288-5 · Cited by 386 · see citing works
Common Dysfunction of Large-Scale Neurocognitive Networks Across Psychiatric Disorders
Sha, Z., Wager, T. D., Mechelli, A., & He, Y. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.11.011 · Cited by 367 · see citing works
Brain default-mode network dysfunction in addiction
Zhang, R., & Volkow, N. D. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.06.036 · Cited by 365 · see citing works
Nurturing Nature: How Brain Development Is Inherently Social and Emotional, and What This Means for Education
Immordino‐Yang, M. H., Darling‐Hammond, L., & Krone, C. R. (2019) · Educational Psychologist · doi:10.1080/00461520.2019.1633924 · Cited by 348 · see citing works
The role of the salience network in cognitive and affective deficits
Schimmelpfennig, J., Topczewski, J., Zajkowski, W. K., & Jankowiak-Siuda, K. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1133367 · Cited by 347 · see citing works
Finding the self by losing the self: neural correlates of ego-dissolution under psilocybin
Lebedev, A. V., Lövdén, M., Rosenthal, G., Feilding, A., Nutt, D. J., & Carhart-Harris, R. L. (2015) · Human Brain Mapping · doi:10.1002/hbm.22833 · Cited by 339 · see citing works
Increased Functional Connectivity Between Subcortical and Cortical Resting-State Networks in Autism Spectrum Disorder
Cerliani, L., Mennes, M., Thomas, R. M., Di Martino, A., Thioux, M., & Keysers, C. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0101 · Cited by 339 · see citing works
The contribution of network organization and integration to the development of cognitive control
Marek, S., Hwang, K., Foran, W., Hallquist, M. N., & Luna, B. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002328 · Cited by 337 · see citing works
ABERRANT RESTING-STATE BRAIN ACTIVITY IN POSTTRAUMATIC STRESS DISORDER: A META-ANALYSIS AND SYSTEMATIC REVIEW: Theoretical Review: Brain Activity in PTSD during Rest
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Depression and Anxiety · doi:10.1002/da.22478 · Cited by 334 · see citing works
Why fish do not feel pain
Key, B. (2016) · Animal Sentience · doi:10.51291/2377-7478.1011 · Cited by 318 · see citing works
Anterior insula as a gatekeeper of executive control
Molnar-Szakacs, I., & Uddin, L. Q. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104736 · Cited by 307 · see citing works
Self-citation
Time to connect: bringing social context into addiction neuroscience
Heilig, M., Epstein, D. H., Nader, M. A., & Shaham, Y. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.67 · Cited by 298 · see citing works
Brain correlates of hypnosis: A systematic review and meta-analytic exploration
Landry, M., Lifshitz, M., & Raz, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.020 · Cited by 295 · see citing works
Default mode contributions to automated information processing
Vatansever, D., Menon, D. K., & Stamatakis, E. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710521114 · Cited by 281 · see citing works
Thalamocortical Dysrhythmia: A Theoretical Update in Tinnitus
Ridder, D. D., Vanneste, S., Langguth, B., & Llinás, R. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00124 · Cited by 276 · see citing works
The anatomy of pain and suffering in the brain and its clinical implications
Ridder, D. D., Adhia, D. B., & Vanneste, S. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.08.013 · Cited by 276 · see citing works
Beyond the Tripartite Cognition–Emotion–Interoception Model of the Human Insular Cortex
Uddin, L. Q., Kinnison, J., Pessoa, L., & Anderson, M. L. (2014) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00462 · Cited by 275 · see citing works
Self-citation
Developmental changes in large-scale network connectivity in autism
Nomi, J. S., & Uddin, L. Q. (2015) · NeuroImage: Clinical · doi:10.1016/j.nicl.2015.02.024 · Cited by 274 · see citing works
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Single-neuron projectome of mouse prefrontal cortex
Gao, L., Liu, S., Gou, L., Hu, Y., Liu, Y., Deng, L., Ma, D., Wang, H., Yang, Q., Chen, Z., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01041-5 · Cited by 264 · see citing works
Network Mechanisms of Clinical Response to Transcranial Magnetic Stimulation in Posttraumatic Stress Disorder and Major Depressive Disorder
Philip, N. S., Barredo, J., Wout‐Frank, M. V. ‘., Tyrka, A. R., Price, L. H., & Carpenter, L. L. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.07.021 · Cited by 254 · see citing works
Insects have the capacity for subjective experience
Klein, C., & Barron, A. B. (2016) · Animal Sentience · doi:10.51291/2377-7478.1113 · Cited by 243 · see citing works
A Systems Neuroscience Approach to Migraine
Brennan, K. C., & Pietrobon, D. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.029 · Cited by 243 · see citing works
Empathic Care and Distress: Predictive Brain Markers and Dissociable Brain Systems
Ashar, Y. K., Andrews‐Hanna, J. R., Dimidjian, S., & Wager, T. D. (2017) · Neuron · doi:10.1016/j.neuron.2017.05.014 · Cited by 231 · see citing works
Dynamic Brain Network Correlates of Spontaneous Fluctuations in Attention
Kucyi, A., Hove, M. J., Esterman, M. S., Hutchison, R. M., & Valera, E. M. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw029 · Cited by 225 · see citing works
The Locus Coeruleus- Norepinephrine System in Stress and Arousal: Unraveling Historical, Current, and Future Perspectives
Ross, J. A., & Bockstaele, E. J. V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.601519 · Cited by 223 · see citing works
Abnormal cross-network functional connectivity in chronic pain and its association with clinical symptoms
Hemington, K. S., Wu, Q., Kucyi, A., Inman, R. D., & Davis, K. D. (2016) · Brain Structure and Function · doi:10.1007/s00429-015-1161-1 · Cited by 220 · see citing works
Instability of default mode network connectivity in major depression: a two-sample confirmation study
Wise, T., Marwood, L., Perkins, A. M., Herane-Vives, A., Joules, R., Lythgoe, D. J., Luh, W.-M., Williams, S., Young, A. H., Cleare, A. J., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.40 · Cited by 219 · see citing works
Dynamic salience processing in paraventricular thalamus gates associative learning
Zhu, Y., Nachtrab, G. T., Keyes, P. C., Allen, W. E., Luo, L., & Chen, X. (2018) · Science · doi:10.1126/science.aat0481 · Cited by 217 · see citing works
Resting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: A review and synthesis
Sezer, I., Pizzagalli, D. A., & Sacchet, M. D. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104583 · Cited by 214 · see citing works
“That is, the insular cortex is often used to define the SN while its neuroanatomically neighboring region, the IFG/MFG node, (Vossel et al., 2014), is assigned to the VAN (Farrant and Uddin, 2015).”
BackgroundMethod
Disrupted structural and functional brain networks in Alzheimer's disease
Dai, Z., Lin, Q., Li, T., Wang, X., Yuan, H., Yu, X., Yong He, A., & Wang, H. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.11.005 · Cited by 214 · see citing works
Neural circuitry of impaired emotion regulation in substance use disorders
Wilcox, C. E., Pommy, J. M., & Adinoff, B. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15060710 · Cited by 213 · see citing works
Neuroanatomy and function of human sexual behavior: A neglected or unknown issue?
Calabrò, R. S., Cacciola, A., Bruschetta, D., Milardi, D., Quattrini, F., Sciarrone, F., Rosa, G. L., Bramanti, P., & Anastasi, G. (2019) · Brain and Behavior · doi:10.1002/brb3.1389 · Cited by 208 · see citing works
Anterior insular cortex plays a critical role in interoceptive attention
Wang, X., Wu, Q., Egan, L., Gu, X., Liu, P., Gu, H., Yang, Y., Luo, J., Wu, Y., Gao, Z., et al. (2019) · eLife · doi:10.7554/elife.42265 · Cited by 204 · see citing works
Creative constraints: Brain activity and network dynamics underlying semantic interference during idea production
Beaty, R. E., Christensen, A. P., Benedek, M., Silvia, P. J., & Schacter, D. L. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.01.012 · Cited by 204 · see citing works
Ayahuasca enhances creative divergent thinking while decreasing conventional convergent thinking
Kuypers, K. P. C., Riba, J., de la Fuente Revenga, M., Barker, S., Theunissen, E. L., & Ramaekers, J. G. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4377-8 · Cited by 201 · see citing works
Functional Connectivity Is Associated With Altered Brain Chemistry in Women With Endometriosis-Associated Chronic Pelvic Pain
As-Sanie, S., Kim, J., Schmidt-Wilcke, T., Sundgren, P. C., Clauw, D. J., Napadow, V., & Harris, R. E. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2015.09.008 · Cited by 199 · see citing works
Pain in the body. Altered interoception in chronic pain conditions: a systematic review
Di Lernia, D., Serino, S., & Riva, G. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.015 · Cited by 190 · see citing works
Interactions of the Salience Network and Its Subsystems with the Default-Mode and the Central-Executive Networks in Normal Aging and Mild Cognitive Impairment
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Authors: Uddin, L. Q.
Affiliations: University of Miami (US)
Corresponding author: Uddin, Lucina Q.
ORCID: Uddin, Lucina Q.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2014-11-19
Volume: 16
Issue: 1
Pages: 55-61
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3857
OpenAlex: W2072799373
Cited by: 2,083
References: 128
Citations by year: 2026: 174 · 2025: 202 · 2024: 214 · 2023: 192 · 2022: 226 · 2021: 228 · 2020: 192 · 2019: 181 · 2018: 169 · 2017: 134 · 2016: 110 · 2015: 58 · 2014: 1 · 2013: 2
FWCI: 9.51
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (K01MH092288)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords: insula, salience processing, salience network, attention, neuropsychiatric disorders, stimulus detection
MeSH terms: Mental Disorders, Brain Mapping, Cerebral Cortex, Humans, Nerve Net, Neural Pathways

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Salience processing and insular cortical function and dysfunction

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