Behavioral reserve in behavioral variant frontotemporal dementia
Open accessAbstract
“Reserve” refers to the individual clinical differences in response to a neuropathological burden. We explored the behavioral reserve (BR) and associated neural substrates in 40 participants with behavioral variant frontotemporal dementia (bvFTD) who were assessed with the frontal behavioral inventory (FBI) and magnetic resonance imaging. Because neuroimaging abnormality showed a high negative correlation with the FBI negative (but not positive) symptom scores, we developed a linear model only to calculate the nBR (BR for negative symptoms) marker using neuroimaging abnormalities and the FBI score. Participants were divided into high nBR and low nBR groups based on the nBR marker. The FBI negative symptom score was lower in the high nBR group than in the low nBR group having the same neuroimaging abnormalities. However, the high nBR group noted a steeper decline in cortical atrophy and showed less atrophy in the left frontotemporal cortices than the low nBR group. In addition, the fractional anisotropy (FA) values were greater in the high nBR than in the low nBR group, except in the sensory-motor and occipital areas. We identified an nBR-related functional network composed of bilateral frontotemporal areas and the left occipital pole. We propose the concept of BR in bvFTD, and these findings can help predict the disease progression.
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The concept of behavioral reserve was proposed when individuals with less negative behavioral symptoms showed a steeper decline in frontotemporal atrophy.
“The concept of behavioral reserve, i.e., behavioral differences in response to a neuropathological burden, was proposed when individuals with less (negative) behavioral symptoms showed a steeper decline in frontotemporal atrophy (Kim et al., 2022).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Kim et al., 2022
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Fieldhouse, J. L. P., van Paassen, D. N., van Engelen, M.-P. E., De Boer, S. C. M., Hartog, W. L., Braak, S., Schoonmade, L. J., Schouws, S. N. T. M., Krudop, W. A., Oudega, M. L., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1382593 · Cited by 8 · see citing works
- Authors
- Kim, S. H., Kim, Y. J., Lee, B. H., Lee, P., Park, J. H., Seo, S. W., & Jeong, Y.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- Samsung (South Korea) (KR)
- Corresponding author
- Seo, Sang Won
- Jeong, Yong
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2022-06-20
- Volume
- 14
- Pages
- 875589-875589
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC9252599
- OpenAlex
- W4283207272
- Cited by
- 8
- References
- 46
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 2 · 2022: 1
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Research Foundation of Korea
- Ministry of Trade, Industry and Energy
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- behavioral variant frontotemporal dementia, negative symptoms, Frontal Behavioral Inventory, cortical atrophy, fractional anisotropy, white matter integrity, disease progression prediction, neuroimaging biomarkers
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