Burden of Neurological Disorders Across the US From 1990-2017: A Global Burden of Disease Study
Open accessAbstract
Importance: Accurate and up-to-date estimates on incidence, prevalence, mortality, and disability-adjusted life-years (burden) of neurological disorders are the backbone of evidence-based health care planning and resource allocation for these disorders. It appears that no such estimates have been reported at the state level for the US. Objective: To present burden estimates of major neurological disorders in the US states by age and sex from 1990 to 2017. Design, Setting, and Participants: This is a systematic analysis of the Global Burden of Disease (GBD) 2017 study. Data on incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) of major neurological disorders were derived from the GBD 2017 study of the 48 contiguous US states, Alaska, and Hawaii. Fourteen major neurological disorders were analyzed: stroke, Alzheimer disease and other dementias, Parkinson disease, epilepsy, multiple sclerosis, motor neuron disease, migraine, tension-type headache, traumatic brain injury, spinal cord injuries, brain and other nervous system cancers, meningitis, encephalitis, and tetanus. Exposures: Any of the 14 listed neurological diseases. Main Outcome and Measure: Absolute numbers in detail by age and sex and age-standardized rates (with 95% uncertainty intervals) were calculated. Results: The 3 most burdensome neurological disorders in the US in terms of absolute number of DALYs were stroke (3.58 [95% uncertainty interval [UI], 3.25-3.92] million DALYs), Alzheimer disease and other dementias (2.55 [95% UI, 2.43-2.68] million DALYs), and migraine (2.40 [95% UI, 1.53-3.44] million DALYs). The burden of almost all neurological disorders (in terms of absolute number of incident, prevalent, and fatal cases, as well as DALYs) increased from 1990 to 2017, largely because of the aging of the population. Exceptions for this trend included traumatic brain injury incidence (-29.1% [95% UI, -32.4% to -25.8%]); spinal cord injury prevalence (-38.5% [95% UI, -43.1% to -34.0%]); meningitis prevalence (-44.8% [95% UI, -47.3% to -42.3%]), deaths (-64.4% [95% UI, -67.7% to -50.3%]), and DALYs (-66.9% [95% UI, -70.1% to -55.9%]); and encephalitis DALYs (-25.8% [95% UI, -30.7% to -5.8%]). The different metrics of age-standardized rates varied between the US states from a 1.2-fold difference for tension-type headache to 7.5-fold for tetanus; southeastern states and Arkansas had a relatively higher burden for stroke, while northern states had a relatively higher burden of multiple sclerosis and eastern states had higher rates of Parkinson disease, idiopathic epilepsy, migraine and tension-type headache, and meningitis, encephalitis, and tetanus. Conclusions and Relevance: There is a large and increasing burden of noncommunicable neurological disorders in the US, with up to a 5-fold variation in the burden of and trends in particular neurological disorders across the US states. The information reported in this article can be used by health care professionals and policy makers at the national and state levels to advance their health care planning and resource allocation to prevent and reduce the burden of neurological disorders.
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Therapeutic Approaches to the Neurologic Manifestations of COVID-19
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Thrombin, a Key Driver of Pathological Inflammation in the Brain
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Global Variability in Deep Brain Stimulation Practices for Parkinson’s Disease
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Effectiveness of physical therapy interventions on post-stroke spasticity: An umbrella review
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US Burden of Disorders Affecting the Nervous System
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Nanovesicular-Mediated Intranasal Drug Therapy for Neurodegenerative Disease
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“Advanced” Parkinson's disease: A review
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Coherent neural oscillations inform early stroke motor recovery
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Recent Trend of Ultrasound-Mediated Nanoparticle Delivery for Brain Imaging and Treatment
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- Authors
- Collaborators, G. 2. U. N. D., Feigin, V. L., Vos, T., Alahdab, F., Amit, A. M. L., Bärnighausen, T. W., Beghi, E., Beheshti, M., Chavan, P. P., Criqui, M. H., Desai, R., Dhamminda Dharmaratne, S., Dorsey, E. R., Wilder Eagan, A., Elgendy, I. Y., Filip, I., Giampaoli, S., Giussani, G., Hafezi-Nejad, N., Hole, M. K., Ikeda, T., Owens Johnson, C., Kalani, R., Khatab, K., Khubchandani, J., Kim, D., Koroshetz, W. J., Krishnamoorthy, V., Krishnamurthi, R. V., Liu, X., Lo, W. D., Logroscino, G., Mensah, G. A., Miller, T. R., Mohammed, S., Mokdad, A. H., Moradi-Lakeh, M., Morrison, S. D., Shivamurthy, V. K. N., Naghavi, M., Nichols, E., Norrving, B., Odell, C. M., Pupillo, E., Radfar, A., Roth, G. A., Shafieesabet, A., Sheikh, A., Sheikhbahaei, S., Shin, J. I., Singh, J. A., Steiner, T. J., Stovner, L. J., Wallin, M. T., Weiss, J., Wu, C., Zunt, J. R., Adelson, J. D., & Murray, C. J. L.
- Affiliations
- University of Washington (US)
- Mayo Clinic (US)
- Harvard University (US)
- Mario Negri Institute for Pharmacological Research (IT)
- New York University (US)
- University of California San Diego (US)
- University of Peradeniya (LK)
- Institute for Health Metrics and Evaluation, University of Washington, Seattle
- Tufts Medical Center (US)
- Department of Global Health and Social Medicine, Harvard University, Boston, Massachusetts
- Kaiser Permanente (US)
- Johns Hopkins University (US)
- Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland
- Auckland University of Technology (NZ)
- Ball State University (US)
- Northeastern University (US)
- National Institutes of Health (US)
- Duke University (US)
- University of Michigan (US)
- Nationwide Children's Hospital (US)
- Curtin University (AU)
- Iran University of Medical Sciences (IR)
- Preventive Medicine and Public Health Research Center, Iran University of Medical Sciences, Tehran, Iran
- Emory University (US)
- Lund University (SE)
- University of Central Florida (US)
- United States Department of Veterans Affairs (US)
- Norwegian University of Science and Technology (NO)
- University of Maryland, Baltimore (US)
- Corresponding author
- GBD 2017 US Neurological Disorders Collaborators
- Feigin, Valery L.
- ORCID
- Feigin, Valery L.
- Vos, Theo
- Alahdab, Fares
- Amit, Arianna Maever L.
- Bärnighausen, Till Winfried
- Beghi, Ettore
- Beheshti, Mahya
- Chavan, Prachi P.
- Criqui, Michael H.
- Desai, Rupak
- Dorsey, E. Ray
- Elgendy, Islam Y.
- Filip, Irina
- Giampaoli, Simona
- Giussani, Giorgia
- Khatab, Khaled
- Khubchandani, Jagdish
- Kim, Daniel
- Koroshetz, Walter J.
- Krishnamoorthy, Vijay
- Krishnamurthi, Rita V.
- Liu, Xuefeng
- Lo, Warren David
- Logroscino, Giancarlo
- Mensah, George A.
- Miller, Ted R.
- Mohammed, Salahuddin
- Mokdad, Ali H.
- Morrison, Shane Douglas
- Shivamurthy, Veeresh Kumar N.
- Naghavi, Mohsen
- Nichols, Emma
- Pupillo, Elisabetta
- Radfar, Amir
- Roth, Gregory A.
- Shafieesabet, Azadeh
- Sheikh, Aziz
- Sheikhbahaei, Sara
- Shin, Jae Il
- Singh, Jasvinder A.
- Steiner, Timothy J.
- Stovner, Lars Jacob
- Wallin, Mitchell Taylor
- Weiss, Jordan
- Wu, Chenkai
- Zunt, Joseph Raymond
- Murray, Christopher J. L.
- Venue
- JAMA Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2021-02-01
- Volume
- 78
- Issue
- 2
- Pages
- 165
- ISSN
- 2168-6149 (ISSN-L)
- PMC
- PMC7607495
- OpenAlex
- W3095385778
- Cited by
- 622
- References
- 31
- Citations by year
- 2026: 67 · 2025: 142 · 2024: 142 · 2023: 118 · 2022: 101 · 2021: 52
- FWCI
- 10.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- JAMA Neurology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- SHURA (Sheffield Hallam University Research Archive) (Sheffield Hallam University) (acceptedVersion)
- Tuwhera (Auckland University of Technology) (submittedVersion, cc-by)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Lund University Publications (Lund University) (submittedVersion)
- Greater South Information System
- Funders
- U.S. Department of Veterans Affairs
- Alexander von Humboldt-Stiftung
- Massachusetts General Hospital
- Kaiser Permanente
- Ohio State University
- Emory University
- Tufts Medical Center
- George Washington University
- Harvard University
- Nationwide Children's Hospital
- University of Washington
- Johns Hopkins University
- University of Central Florida
- Auckland University of Technology, New Zealand
- Ball State University
- University of Alabama at Birmingham
- Norges Teknisk-Naturvitenskapelige Universitet
- Sheffield Hallam University
- University of Alabama
- Iran University of Medical Sciences
- A.T. Still University
- Istituto di Ricerche Farmacologiche Mario Negri - IRCCS
- Imperial College London
- Department of Social Services, Australian Government
- Curtin University of Technology
- Yonsei University
- Lunds Universitet
- Istituto Superiore di Sanità
- Tehran University of Medical Sciences and Health Services
- Universita degli Studi di Bari Aldo Moro
- University of Cape Town
- Duke Kunshan University
- Center for Stroke Research Berlin
- National Institutes of Health
- Duke Global Health Institute, Duke University
- Yonsei University College of Medicine
- National Institute on Aging (T32AG000247)
- Topics
- Health Sciences › Health Professions › Health Information Management › Global Health and Epidemiology
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- neurological disorders, disease burden, disability-adjusted life years, stroke, Parkinson's disease, epilepsy, multiple sclerosis, migraine, traumatic brain injury, spinal cord injury, meningitis, encephalitis, tetanus, nervous system cancer, incidence, prevalence, mortality, population aging, United States, age and sex differences, healthcare resource allocation
- MeSH terms
- Global Burden of Disease, Disability-Adjusted Life Years, Humans, Nervous System Diseases, United States, Global Health, Cost of Illness
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