Cited by 187Nanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryBarrier Structure and Function Studies

Lipid nanoparticle-mediated drug delivery to the brain

Khare, Purva, Edgecomb, Sara X., Hamadani, Christine M., Tanner, Eden E.L., S Manickam, Devika·2023·Advanced Drug Delivery Reviews

Abstract

Lipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech and Moderna COVID-19 mRNA vaccines. While LNPs have been extensively studied for the delivery of RNA drugs to muscle and liver targets, their potential to deliver drugs to challenging tissue targets such as the brain remains underexplored. Multiple brain disorders currently lack safe and effective therapies and therefore repurposing LNPs could potentially be a game changer for improving drug delivery to cellular targets both at and across the blood-brain barrier (BBB). In this review, we will discuss (1) the rationale and factors involved in optimizing LNPs for brain delivery, (2) ionic liquid-coated LNPs as a potential approach for increasing LNP accumulation in the brain tissue and (3) considerations, open questions and potential opportunities in the development of LNPs for delivery to the brain.

Integrity signals

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Crossref · 10.1016/j.addr.2023.114861

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Authors
Khare, P., Edgecomb, S. X., Hamadani, C. M., Tanner, E. E. L., & S Manickam, D.
Affiliations
  • Duquesne University (US)
  • University of Mississippi (US)
Corresponding author
Tanner, Eden E.L.
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2023-06
Volume
197
Pages
114861
ISSN
0169-409X (ISSN-L)
OpenAlex
W4372198073
Cited by
187
References
260
Citations by year
2026: 52 · 2025: 82 · 2024: 40 · 2023: 13
FWCI
3.26
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Duquesne University
  • Office of Research, University of Kansas
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
lipid nanoparticles, brain drug delivery, blood-brain barrier, ionic liquid coating
MeSH terms
COVID-19, Brain, Humans, Lipids, Liposomes, RNA, Small Interfering, Nanoparticles

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