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Cited by 180Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersFamily and Disability Support Research

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Recurrence of Autism Spectrum Disorders in Full- and Half-Siblings and Trends Over Time: A Population-Based Cohort Study

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Grønborg, Therese K., Schendel, Diana E., Parner, Erik T.·2013·JAMA Pediatrics
DOI 10.1001/jamapediatrics.2013.2259PMC PMC4610344
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Abstract

IMPORTANCE: To date, this is the first population-based study to examine the recurrence risk for autism spectrum disorders (ASDs), including time trends, and the first study to consider the ASDs recurrence risk for full- and half-siblings. OBJECTIVES: To estimate the relative recurrence risk for ASDs in a Danish population, including recurrence in full- and half-siblings, and to examine time trends in ASDs relative to the recurrence risk. DESIGN, SETTING, AND PARTICIPANTS: Population-based cohort study in Denmark. All children (about 1.5 million) born in Denmark between January 1, 1980, and December 31, 2004, were identified and followed up to December 31, 2010. We identified a maternal sibling subcohort derived from mothers with at least 2 children and a paternal sibling subcohort derived from fathers with at least 2 children. EXPOSURES: Children having an older sibling with ASDs are compared with children not having an older sibling with ASDs. MAIN OUTCOMES AND MEASURES: The adjusted hazard ratio for ASDs among children having an older sibling with ASDs compared with children not having an older sibling with ASDs. RESULTS The overall relative recurrence risk for ASDs was 6.9 (95% CI, 6.1-7.8), and it did not change significantly over time; similar risks were observed in maternal and paternal full-siblings. The relative recurrence risks were 2.4 (95% CI, 1.4-4.1) for maternal half-siblings and 1.5 (95% CI, 0.7-3.4) for paternal half-siblings. CONCLUSIONS AND RELEVANCE: Our population-based recurrence risk estimate is lower than the recently reported estimates from clinical samples. Our results demonstrate no time trend in the ASDs recurrence risk as seen in the ASDs prevalence. The difference in the recurrence risk between full- and half-siblings supports the role of genetics in ASDs, while the significant recurrence risk in maternal half-siblings may support the role of factors associated with pregnancy and the maternal intrauterine environment in ASDs.

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Metadata

Authors
Grønborg, T. K., Schendel, D. E., & Parner, E. T.
Affiliations
  • Aarhus University (DK)
  • Centers for Disease Control and Prevention (US)
Corresponding author
Grønborg, Therese K.
ORCID
Venue
JAMA Pediatrics
Publisher
American Medical Association (AMA)
Published
2013-10-01
Volume
167
Issue
10
Pages
947
ISSN
  • 1072-4710 (ISSN-L)
  • 2168-6203
DOI
10.1001/jamapediatrics.2013.2259
PMC
PMC4610344
OpenAlex
W2150648630
Cited by
180
References
31
Citations by year
2026: 2 · 2025: 5 · 2024: 10 · 2023: 11 · 2022: 11 · 2021: 10 · 2020: 9 · 2019: 12 · 2018: 21 · 2017: 15 · 2016: 24 · 2015: 25 · 2014: 22 · 2013: 2
FWCI
13.29
Type
journal article
Language
en
Open access
Locations
  • Archives of Pediatrics and Adolescent Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (CC999999)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
Keywords
autism spectrum disorder, recurrence risk, siblings, full siblings, half-siblings, genetic risk, intrauterine environment, pregnancy factors, temporal trends
MeSH terms
Child, Child Development Disorders, Pervasive, Denmark, Female, Humans, Male, Recurrence, Registries, Risk, Cohort Studies, Prevalence, Proportional Hazards Models, Siblings

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